DRSC/TRiP Functional Genomics Resources

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Protein Alignment arm and VAC8

DIOPT Version :9

Sequence 1:NP_001259149.1 Gene:arm / 31151 FlyBaseID:FBgn0000117 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_010903.3 Gene:VAC8 / 856702 SGDID:S000000739 Length:578 Species:Saccharomyces cerevisiae


Alignment Length:533 Identity:121/533 - (22%)
Similarity:209/533 - (39%) Gaps:125/533 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 SPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTL-------LQRNNVKFLAIVTDCLQI 311
            ||:......|:|.|...|  :|..::.....|.|:.:.||       |||:.....|.:|:    
Yeast    18 SPIADNEREAVTLLLGYL--EDKDQLDFYSGGPLKALTTLVYSDNLNLQRSAALAFAEITE---- 76

  Fly   312 LAYGNQESK------LIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGG 370
             .|..|.|:      ||:|.|..|...|             .....|..|:|.:.||..||:.||
Yeast    77 -KYVRQVSREVLEPILILLQSQDPQIQV-------------AACAALGNLAVNNENKLLIVEMGG 127

  Fly   371 MQALAMHLGNMSPRLVQN---CLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGIL 432
            ::.|...:...:..:..|   |:..|....|...|:....||: .|.::..|..:.|...|.|.|
Yeast   128 LEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALI-PLTKLAKSKHIRVQRNATGAL 191

  Fly   433 SNLTCNNQRNKATVCQVGGVDALVRTI-------------------INAGDREEI--TEP----- 471
            .|:| :::.|:..:...|.|..||..:                   ::..:|:::  |||     
Yeast   192 LNMT-HSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLAQTEPRLVSK 255

  Fly   472 ---------------AVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGL 521
                           |..|||:|.|   |:......||.. ||..:|||:...| .||:.|.:..
Yeast   256 LVSLMDSPSSRVKCQATLALRNLAS---DTSYQLEIVRAG-GLPHLVKLIQSDS-IPLVLASVAC 315

  Fly   522 IRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTER--------QRSSIATTGSQQPSAYADGV- 577
            |||:::.|.|...:.:.|.:..|||||  .::|:|.        .|:..|::...:...:..|. 
Yeast   316 IRNISIHPLNEGLIVDAGFLKPLVRLL--DYKDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAV 378

  Fly   578 -RMEEI-------VEGTVGA-LHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCE 633
             :.:|:       |:..:.| ..|||....::..:.:.:::...:.:.|::.:.:...||..|..
Yeast   379 EKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALAN 443

  Fly   634 LAADKEG-AEIIE-----QEGATGPLTDLL---HSRNEGVATYAAAVLFRMSEDKPQDYKKRLSI 689
            |.:.... .:|||     .||..|.|...|   ::..|.:|.:....|.....||.:|       
Yeast   444 LCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLESHNDKVED------- 501

  Fly   690 ELTNSLLREDNNI 702
                 |::.|::|
Yeast   502 -----LVKNDDDI 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
armNP_001259149.1 Adaptin_N <150..>314 CDD:331138 16/66 (24%)
armadillo repeat 161..186 CDD:293788
armadillo repeat 193..231 CDD:293788
armadillo repeat 238..270 CDD:293788 5/15 (33%)
armadillo repeat 278..314 CDD:293788 9/42 (21%)
armadillo repeat 320..355 CDD:293788 7/40 (18%)
Arm 361..398 CDD:278915 10/39 (26%)
armadillo repeat 362..397 CDD:293788 9/37 (24%)
armadillo repeat 410..435 CDD:293788 6/24 (25%)
Arm 439..481 CDD:278915 14/82 (17%)
armadillo repeat 443..481 CDD:293788 13/78 (17%)
armadillo repeat 490..525 CDD:293788 13/34 (38%)
Arm 597..636 CDD:278915 5/38 (13%)
armadillo repeat 600..636 CDD:293788 5/35 (14%)
armadillo repeat 641..675 CDD:293788 11/41 (27%)
VAC8NP_010903.3 SRP1 42..>358 CDD:227396 83/342 (24%)
armadillo repeat 119..155 CDD:293788 9/35 (26%)
armadillo repeat 160..194 CDD:293788 9/34 (26%)
armadillo repeat 204..235 CDD:293788 4/30 (13%)
armadillo repeat 242..280 CDD:293788 9/37 (24%)
armadillo repeat 286..319 CDD:293788 13/34 (38%)
armadillo repeat 326..361 CDD:293788 9/36 (25%)
armadillo repeat 369..402 CDD:293788 4/32 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2582
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2332
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.890

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