DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and PUB13

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_190235.1	Gene:	PUB13 / 823804	AraportID:	AT3G46510	Length:	660	Species:	Arabidopsis thaliana

Alignment Length:	760	Identity:	137/760 - (18%)
Similarity:	235/760 - (30%)	Gaps:	287/760 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MVSAKEQTLMWQQNS--YLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDTGFPQNFTQ--- 84
            |.|||:......|.|  ||         |.:...::.|          :.::.....|:.:|
plant    72 MCSAKDYLKFCSQGSKIYL---------VMEREQVTSK----------LMEVSVKLEQSLSQIPY 117

  Fly    85 ---DQVDDMNQQ----LSQTRSQRVRAAMFPETLEEGIEI---PSTQFDPQQPTAVQRLSEPSQM 139
               |..|::.:|    |||.|..:.|..:..:.|.|.::.   .|:..|..|| .::|:::...:
plant   118 EELDISDEVREQVELVLSQFRRAKGRVDVSDDELYEDLQSLCNKSSDVDAYQP-VLERVAKKLHL 181

  Fly   140 LK-----------HAVV----------------------NLINYQDD-----------------A 154
            ::           |.:|                      :.:..:||                 :
plant   182 MEIPDLAQESVALHEMVASSGGDVGENIEEMAMVLKMIKDFVQTEDDNGEEQKVGVNSRSNGQTS 246

  Fly   155 ELATRAIPEL-------IKLLNDEDQVVVSQAAMMVHQLSKK-------------EASRHAIMNS 199
            ..|::.||.:       |.|....|.|:||..........:|             :|.....:..
plant   247 TAASQKIPVIPDDFRCPISLEMMRDPVIVSSGQTYERTCIEKWIEGGHSTCPKTQQALTSTTLTP 311

  Fly   200 PQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAI 264
            ..::.:|:.....:||:|..|.                   .|...|..|...|||.|
plant   312 NYVLRSLIAQWCEANDIEPPKP-------------------PSSLRPRKVSSFSSPAE------- 350

  Fly   265 TTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGP 329
                               |..::.::..|...|.:........:::||..|.::::.|..:|..
plant   351 -------------------ANKIEDLMWRLAYGNPEDQRSAAGEIRLLAKRNADNRVAIAEAGAI 396

  Fly   330 NELVRIMRSYDYEKLLWTTSRV-------LKVLSVCSSNKPAIVDAGGMQALAMHL--GNMSPRL 385
            ..||.::.:.|        ||:       |..||:|.:||.|||.||.:..:...|  |:|..|
plant   397 PLLVGLLSTPD--------SRIQEHSVTALLNLSICENNKGAIVSAGAIPGIVQVLKKGSMEAR- 452

  Fly   386 VQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVG 450
             :|...||.:||                          |:              ..||.|:..:|
plant   453 -ENAAATLFSLS--------------------------VI--------------DENKVTIGALG 476

  Fly   451 GVDALVRTIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLI 515
            .:..|| .::|.|.:....:.|..
plant   477 AIPPLV-VLLNEGTQRGKKDAATA----------------------------------------- 499

  Fly   516 KAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRME 580
                  :.||.:...|.......|.|..|.|||      ||        .||
plant   500 ------LFNLCIYQGNKGKAIRAGVIPTLTRLL------TE--------PGS------------- 531

  Fly   581 EIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIE 645
            .:|:..:..|.||:.....:|:|.....:|..|..:.......:..||.||..|.:. :...::|
plant   532 GMVDEALAILAILSSHPEGKAIIGSSDAVPSLVEFIRTGSPRNRENAAAVLVHLCSG-DPQHLVE 595

  Fly   646 QE--GATGPLTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLS 688
            .:  |..|||.||..:..:.....||.:|.|:|....|..:..:|
plant   596 AQKLGLMGPLIDLAGNGTDRGKRKAAQLLERISRLAEQQKETAVS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	29/200 (15%)
		armadillo repeat	161..186	CDD:293788	8/31 (26%)
		armadillo repeat	193..231	CDD:293788	5/37 (14%)
		armadillo repeat	238..270	CDD:293788	7/31 (23%)
		armadillo repeat	278..314	CDD:293788	4/35 (11%)
		armadillo repeat	320..355	CDD:293788	8/41 (20%)
		Arm	361..398	CDD:278915	15/38 (39%)
		armadillo repeat	362..397	CDD:293788	13/36 (36%)
		armadillo repeat	410..435	CDD:293788	1/24 (4%)
		Arm	439..481	CDD:278915	9/41 (22%)
		armadillo repeat	443..481	CDD:293788	8/37 (22%)
		armadillo repeat	490..525	CDD:293788	0/34 (0%)
		Arm	597..636	CDD:278915	9/38 (24%)
		armadillo repeat	600..636	CDD:293788	9/35 (26%)
		armadillo repeat	641..675	CDD:293788	10/35 (29%)
PUB13	NP_190235.1	Ubox	259..322	CDD:128780	9/62 (15%)
		U-box domain, a modified RING finger	262..300	CDD:319578	7/37 (19%)
		PLN03200	383..>646	CDD:215629	78/384 (20%)
		armadillo repeat	389..421	CDD:293788	8/39 (21%)
		armadillo repeat	428..463	CDD:293788	13/36 (36%)
		armadillo repeat	469..503	CDD:293788	8/81 (10%)
		armadillo repeat	511..544	CDD:293788	12/59 (20%)
		armadillo repeat	551..587	CDD:293788	9/35 (26%)
		armadillo repeat	593..627	CDD:293788	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910