DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and Jup

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_112309.2	Gene:	Jup / 81679	RGDID:	620412	Length:	745	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	452/707 - (63%)
Similarity:	544/707 - (76%)	Gaps:	20/707 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WQQNSYLGDSGIHSGAVTQVPSLSGK---EDEEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQ 96
            ||| :|..|||||||..|.|||:|.|   ::::..|........|.:.|...|.| .|:..|:|.
  Rat    16 WQQ-TYTYDSGIHSGVNTCVPSVSSKGLLDEDDTCGRQYTLKKTTTYTQGVPQSQ-GDLEYQMST 78

  Fly    97 T-RSQRVRAAMFPETL-EEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATR 159
            | |::|||.||.|... |:...:.:||.: .|.|.:|||:||||:||.|:|:|||||||||||||
  Rat    79 TARAKRVREAMCPGVSGEDSSLLLATQVE-GQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATR 142

  Fly   160 AIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVG 224
            |:|||.|||||||.|||::|||:|:|||||||||.|:|.|||:|||:||.:.|::||::.:....
  Rat   143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTS 207

  Fly   225 TLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQK 289
            .||||||||:|||||||||||||||::|||||||||||||||||||||:|:|:|||||||.||||
  Rat   208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQK 272

  Fly   290 MVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKV 354
            ||.||.:||.|||||.|||||:||||||||||||||:|||..||:|||:|.||||||||||||||
  Rat   273 MVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKV 337

  Fly   355 LSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGS 419
            ||||.|||||||:|||||||..||.:.|||||||||||||||||.|||.||||.:|:.||..|..
  Rat   338 LSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLENVLKILVNQLSV 402

  Fly   420 TDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLTSRHV 484
            .||||:|||.|.||||||||.:||..|.|..||:||:..|:.|||:::||||||||||||||||.
  Rat   403 DDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHP 467

  Fly   485 DSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLM 549
            ::|:|||:||||||:..|||||:.|::|||:||.|||||||||||||||||:|...|..||:||:
  Rat   468 EAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLV 532

  Fly   550 RAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVR 614
            :|.||.:|.    ...|:|||  |.|||||||||||..||||||||:..||..|.:.:.||:||:
  Rat   533 KAHQDAQRH----VAAGTQQP--YTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQ 591

  Fly   615 LLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVLFRMSEDK 679
            ||::.:|||||||||||||||.|||.|:.|:.|||:.||.:||||||||.||||||||||:||||
  Rat   592 LLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656

  Fly   680 PQDYKKRLSIELTNSLLREDNNIWANADLGM---GPDLQDMLGPEEAYEGLYGQGPP 733
            ..||:||:|:||||||.:.|...|..|...:   .|...||   :..|..:|....|
  Rat   657 NPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYADDM---DATYRPMYSSDVP 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	124/163 (76%)
		armadillo repeat	161..186	CDD:293788	17/24 (71%)
		armadillo repeat	193..231	CDD:293788	18/37 (49%)
		armadillo repeat	238..270	CDD:293788	29/31 (94%)
		armadillo repeat	278..314	CDD:293788	28/35 (80%)
		armadillo repeat	320..355	CDD:293788	28/34 (82%)
		Arm	361..398	CDD:278915	30/36 (83%)
		armadillo repeat	362..397	CDD:293788	28/34 (82%)
		armadillo repeat	410..435	CDD:293788	14/24 (58%)
		Arm	439..481	CDD:278915	25/41 (61%)
		armadillo repeat	443..481	CDD:293788	23/37 (62%)
		armadillo repeat	490..525	CDD:293788	24/34 (71%)
		Arm	597..636	CDD:278915	23/38 (61%)
		armadillo repeat	600..636	CDD:293788	22/35 (63%)
		armadillo repeat	641..675	CDD:293788	24/33 (73%)
Jup	NP_112309.2	Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		125/164 (76%)
		armadillo repeat	144..169	CDD:293788	17/24 (71%)
		armadillo repeat	186..212	CDD:293788	10/25 (40%)
		armadillo repeat	221..253	CDD:293788	29/31 (94%)
		Arm	221..253	CDD:395413	29/31 (94%)
		armadillo repeat	261..297	CDD:293788	28/35 (80%)
		ARM 5	298..341		36/42 (86%)
		armadillo repeat	305..338	CDD:293788	26/32 (81%)
		PLN03200	<328..>658	CDD:215629	230/335 (69%)
		ARM	341..381	CDD:214547	32/39 (82%)
		ARM 6	342..381		31/38 (82%)
		armadillo repeat	345..380	CDD:293788	28/34 (82%)
		ARM 7	383..420		23/36 (64%)
		armadillo repeat	393..418	CDD:293788	14/24 (58%)
		ARM 8	423..464		24/40 (60%)
		armadillo repeat	426..464	CDD:293788	23/37 (62%)
		ARM 9	470..510		28/39 (72%)
		armadillo repeat	470..508	CDD:293788	26/37 (70%)
		ARM 10	512..551		21/44 (48%)
		armadillo repeat	515..572	CDD:293788	36/62 (58%)
		Interaction with DSC1. /evidence=ECO:0000250	574..661		57/86 (66%)
		armadillo repeat	577..611	CDD:293788	20/33 (61%)
		armadillo repeat	618..652	CDD:293788	24/33 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350611
Domainoid	1	1.000	158	1.000	Domainoid score	I4020
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163964at33208
OrthoFinder	1	1.000	-	-		FOG0002078
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103992
Panther	1	1.100	-	-	O	PTHR45976
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1754
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710