DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and odad2

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001072494.1	Gene:	odad2 / 779949	XenbaseID:	XB-GENE-982927	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	732	Identity:	148/732 - (20%)
Similarity:	274/732 - (37%)	Gaps:	183/732 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NRTMSHNNQYNPPDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMF 72
            |:..:.:.:.:|...|....::::|   ..:|.:..|.:.|    :.|  ..|.||
Frog   387 NQKNTKDEKKDPSKKPTSSESRQRT---NAHSVVRRSALKS----KTP--GAKSDE--------- 433

  Fly    73 DLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEG-IEIPSTQFDPQQPTAVQRLSEP 136
                 |.::.|:.:.|:..                ||..:|| .::||..:..|:  .|:.|...
Frog   434 -----FSESSTESEEDEEQ----------------PERRQEGNTDLPSEYWQIQK--LVKYLKGG 475

  Fly   137 SQMLKHAVVNLINY------QDDAELATR---AIPELIKLLNDEDQVVVSQAAMMVHQLSKKEAS 192
            :|..  .|:.|.:.      |:..:||.|   .:..||.|||.|:......|..::.::|.....
Frog   476 NQTA--TVIALCSIRDFNLAQETCQLAIRDVGGLDILINLLNTEEIKCKIGALKILKEISHNSQI 538

  Fly   193 RHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLS-SPV 256
            |.||.:...:...:  .|.:|.|.:....|..|:.|::..|:....:.:.|||..||.||. :|:
Frog   539 RSAIADLGGLQTMV--GILDSQDKDLKCLAAETIANVAKFRRARRTVRQHGGIRRLVGLLDCAPI 601

  Fly   257 ESVLFYAITTLHNLLLHQD--------------------GSKMAVRLAGGLQKMVTLLQRNNVKF 301
            .|         .||...|:                    .:|.|:|.|||:..:..||:.::...
Frog   602 GS---------SNLSAQQEKDIEVARCGALALWSCSKSTRNKEAIRKAGGIPLLARLLKSSHSNM 657

  Fly   302 LAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSN---KP 363
            |..|...||..| .....:|.|.......:||:.::|.:.|..:...|.:.|    |:.:   :.
Frog   658 LIPVVGTLQECA-SEPSYRLAIKTEKMIEDLVKNLKSENPELQMHCASAIFK----CAEDEETRD 717

  Fly   364 AIVDAGGMQALAMHLGNMSPR----LVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNV 424
            .:...||:|.|||.||....:    .|...:|......|..||.:..: ::::||.:|.:....|
Frog   718 LVRQYGGLQPLAMLLGQFENKELLAAVTGAIWKCSISRDNVTKFQEYK-VIETLVTLLTNQPEEV 781

  Fly   425 VTCAAGILSNLTCNNQ-RNKATVCQVGGVDALVR--------TIIN--------AGDREEIT--- 469
            :....|.|..  |..: .|:|.:.:.||:..||.        .::|        |.|.|.:.
Frog   782 LVNVVGALGE--CGQEPANRAIIRKCGGISPLVNLLSGTNQALLVNVTKAVGACASDPENMVIID 844

  Fly   470 ---------------EP--------AVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSR 511
                           .|        |:|..  :.:.....|:.::.|.   ||.:||.||...::
Frog   845 RLDGVRLLWSLLKNPHPDVQANAAWAICPC--IENAKDAGEMVRSFVG---GLELIVNLLKSENK 904

  Fly   512 WPLIKAVIGLIRNLALCPANHAPLREHGAI---------------HHLVRLLMR---------AF 552
             .::.:|...|.|:|....|.|.:.:||.:               .||...:.|         ||
Frog   905 -EVLASVCAAITNIAKDEENLAVITDHGVVALLSALANTTDDKLRRHLAEAISRCCMWGHNRVAF 968

  Fly   553 QDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLF 617
            .:::.....:....|..|..:          ..|..||:.|:.:::|...:.:..|:.:.:.::.
Frog   969 GESKAVAPLVHYLKSSDPLVH----------RATAQALYQLSEDANNCITMHENGVVKLLIDMVG 1023

  Fly   618 NEIENIQRVAAGVLCEL 634
            :....:|..|||.:..:
Frog  1024 SPDSMLQEAAAGCIANI 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	46/193 (24%)
		armadillo repeat	161..186	CDD:293788	7/24 (29%)
		armadillo repeat	193..231	CDD:293788	9/37 (24%)
		armadillo repeat	238..270	CDD:293788	9/32 (28%)
		armadillo repeat	278..314	CDD:293788	12/35 (34%)
		armadillo repeat	320..355	CDD:293788	8/34 (24%)
		Arm	361..398	CDD:278915	10/43 (23%)
		armadillo repeat	362..397	CDD:293788	10/38 (26%)
		armadillo repeat	410..435	CDD:293788	6/24 (25%)
		Arm	439..481	CDD:278915	13/84 (15%)
		armadillo repeat	443..481	CDD:293788	12/79 (15%)
		armadillo repeat	490..525	CDD:293788	9/34 (26%)
		Arm	597..636	CDD:278915	6/38 (16%)
		armadillo repeat	600..636	CDD:293788	5/35 (14%)
		armadillo repeat	641..675	CDD:293788
odad2	NP_001072494.1	armadillo repeat	465..490	CDD:293788	6/28 (21%)
		ARM	499..602	CDD:237987	29/104 (28%)
		armadillo repeat	500..532	CDD:293788	9/31 (29%)
		armadillo repeat	539..573	CDD:293788	8/35 (23%)
		armadillo repeat	583..626	CDD:293788	12/51 (24%)
		armadillo repeat	634..670	CDD:293788	13/36 (36%)
		ARM	635..749	CDD:237987	30/118 (25%)
		armadillo repeat	675..707	CDD:293788	7/31 (23%)
		ARM	717..830	CDD:237987	27/115 (23%)
		armadillo repeat	719..750	CDD:293788	9/30 (30%)
		armadillo repeat	767..791	CDD:293788	6/23 (26%)
		armadillo repeat	799..835	CDD:293788	6/35 (17%)
		armadillo repeat	840..872	CDD:293788	2/31 (6%)
		ARM	843..957	CDD:237987	21/119 (18%)
		HEAT_2	851..956	CDD:290374	21/110 (19%)
		armadillo repeat	882..917	CDD:293788	10/38 (26%)
		ARM	924..1040	CDD:237987	20/125 (16%)
		armadillo repeat	924..956	CDD:293788	5/31 (16%)
		HEAT_2	932..1034	CDD:290374	14/111 (13%)
		armadillo repeat	1007..1040	CDD:293788	5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940