DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and Armc3

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_036018461.1	Gene:	Armc3 / 70882	MGIID:	1918132	Length:	885	Species:	Mus musculus

Alignment Length:	637	Identity:	130/637 - (20%)
Similarity:	227/637 - (35%)	Gaps:	173/637 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSTQFDP------QQPTAVQRLSEPSQ-MLKHAVVNLINYQDDAE------LATRAIPELIKLLN 169
            |...|||      :..|.|..|..|.: :|..|...:..:....|      |...|:..|.|||.
Mouse    13 PKDVFDPITIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLT 77

  Fly   170 DEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQ 234
            .||: .|.:.|||:..:....:....::...:::.:::..:|...::...:.|...|.|:|....
Mouse    78 HEDK-TVRRNAMMIFGILASNSDVKKLLRELEVMNSVIAQLSPEEEVVIHEFASLCLANMSVEYT 141

  Fly   235 GLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNV 299
            |.:.||:.||:..|::||||....|...:|..::||:  ||           .|...||.:.|.:
Mouse   142 GKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLV--QD-----------FQCRTTLQELNAI 193

  Fly   300 ----KFLAIVTDCLQILAYG-------NQESKLIILASGGPNELVRIMRS--------------- 338
                :.|......:|:||..       ::|::.::..:.|.:.|.:|:.:
Mouse   194 PPILELLRSEYPIIQLLALKTLGVITCDKEARTMLKENQGLDHLTKILETKELNDLHVEALSVIA 258

  Fly   339 -----YDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRL------VQNCLWT 392
                 .|...|:..|..:.||||...|:....:.....:|:|....:...|.      |:.||.|
Mouse   259 NCLEDMDTMVLMQQTGSLKKVLSFAESSTIPDIQKNAAKAIAKAAYDPENRKVFHEQEVEKCLVT 323

  Fly   393 LRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVR 457
            |.......||:...:|:                   :.:..||:|....|      ..|:..:|:
Mouse   324 LLGSDSDGTKIAASQAI-------------------SALCENLSCKEFFN------TQGIPQIVQ 363

  Fly   458 TIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLI 522
            .:  ..|.||:.|.|..||.:||:.
Mouse   364 LL--RSDNEEVREAAALALANLTTS---------------------------------------- 386

  Fly   523 RNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTV 587
                 .|||.....|..||..|:.:|                      |:..||.     :....
Mouse   387 -----SPANANAAAEADAIDPLINIL----------------------SSKRDGA-----IANAA 419

  Fly   588 GALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGP 652
            ..|..:|.:...||:|:...::...:..|.:....:|..||..:...|.|.|....:...|...|
Mouse   420 TVLTNMATQEPLRAIIQNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVEARTQLRNCGGLVP 484

  Fly   653 LTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTN----SLLREDN 700
            |..||||:|:.|..:|:..:...:.|:|      :::||..    ::|.|.|
Mouse   485 LVGLLHSKNDEVRRHASWAVMVCAGDEP------MAVELCRLGALNILEEIN 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	41/173 (24%)
		armadillo repeat	161..186	CDD:293788	10/24 (42%)
		armadillo repeat	193..231	CDD:293788	4/37 (11%)
		armadillo repeat	238..270	CDD:293788	11/31 (35%)
		armadillo repeat	278..314	CDD:293788	7/39 (18%)
		armadillo repeat	320..355	CDD:293788	7/54 (13%)
		Arm	361..398	CDD:278915	8/42 (19%)
		armadillo repeat	362..397	CDD:293788	8/40 (20%)
		armadillo repeat	410..435	CDD:293788	0/24 (0%)
		Arm	439..481	CDD:278915	11/41 (27%)
		armadillo repeat	443..481	CDD:293788	10/37 (27%)
		armadillo repeat	490..525	CDD:293788	0/34 (0%)
		Arm	597..636	CDD:278915	7/38 (18%)
		armadillo repeat	600..636	CDD:293788	7/35 (20%)
		armadillo repeat	641..675	CDD:293788	10/33 (30%)
Armc3	XP_036018461.1	armadillo repeat	22..52	CDD:293788	6/29 (21%)
		PLN03200	<32..>182	CDD:215629	38/163 (23%)
		armadillo repeat	60..96	CDD:293788	12/36 (33%)
		armadillo repeat	104..136	CDD:293788	3/31 (10%)
		Arm	143..178	CDD:395413	12/34 (35%)
		armadillo repeat	143..177	CDD:293788	11/33 (33%)
		armadillo repeat	184..218	CDD:293788	7/33 (21%)
		armadillo repeat	225..259	CDD:293788	3/33 (9%)
		armadillo repeat	319..343	CDD:293788	7/42 (17%)
		armadillo repeat	350..385	CDD:293788	11/42 (26%)
		SRP1	<358..>504	CDD:227396	43/219 (20%)
		armadillo repeat	391..425	CDD:293788	9/60 (15%)
		ARM	469..504	CDD:214547	12/34 (35%)
		armadillo repeat	473..503	CDD:293788	10/29 (34%)
		EDR1	<754..871	CDD:405130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940