DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and arvcfb

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_009299795.1	Gene:	arvcfb / 564669	ZFINID:	ZDB-GENE-060526-60	Length:	1048	Species:	Danio rerio

Alignment Length:	847	Identity:	188/847 - (22%)
Similarity:	319/847 - (37%)	Gaps:	212/847 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TMSHNNQYNPPDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQ----------VPSLSGKEDEE 64
            |.|:||..:..:..|....:..||   .:.| ||...:.|::::          :|: .|...|.
Zfish   230 TRSYNNYSDSYNDTPDTQFRHYTL---HDGY-GDMPDNYGSLSRGVNYRPYRPYMPT-GGYRPEN 289

  Fly    65 MEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLEE-----GIEIPST-QFD 123
            ....|:..| |.|   :..|.||...:..:...|||..|....|..||:     |.|.... ..:
Zfish   290 SYTLPIRKD-DYG---HVAQPQVPMGSSTVDLNRSQPERFQPEPYGLEDDRRSLGPEDEEPYDLE 350

  Fly   124 PQQPTAVQRLSEPSQMLKHAVVN---LINYQD--DAELATRAIPEL-----IKLLNDEDQVVVSQ 178
            |...|| .|.:.|.:.::..:.|   :..|:|  :|||.....|.:     ..|...|...:.|.
Zfish   351 PDYSTA-NRRTLPGRTIREPLRNGPRVRGYEDPIEAELIDERHPYIHGMYPAPLAQPERGSMASL 414

  Fly   179 AAM------MVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLL 237
            ..|      .:..:.|....|..  :.|:::|.|...|   :.::|..||.  |.:|.:....:.
Zfish   415 DRMGGRRSPSIDSIRKDPRWRDP--DLPEVIAMLGHPI---DPVKSNAAAY--LQHLCYENDKIK 472

  Fly   238 A-IFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQD-GSKMAVRLAGGLQKMVTLLQR-NNV 299
            . :.:..|||.||.||..|...|...|...|.|:...:| .:|:|::...|:..::.||:: |::
Zfish   473 KDVRQLKGIPVLVSLLDHPKAEVHRKACGALRNISYGKDHDNKVAIKSCDGIPALIRLLRKTNDM 537

  Fly   300 KFLAIVTDCL-----------QILAYGNQ--ESKLIILASGGPNELVRIMRSYDYEKLLWTTSRV 351
            :...::|..|           .|:.:|.|  .:::||..||..:|.....:..|.|   |||  |
Zfish   538 EVRELITGTLWNLSSYEPLKMVIINHGLQTMTNEVIIPHSGWEHEPNEDSKPRDAE---WTT--V 597

  Fly   352 LKVLSVCSSNKPA--------------IVDAGGMQALAMHLG--NMSPRLVQNCLWTLRNLSDAA 400
            .|..|.|..|..:              :||| .:.||...:|  :|..:.|:||:..:||||...
Zfish   598 FKNTSGCLRNVSSDGAEARRRLRECEGLVDA-LLHALQSAVGKKDMDNKSVENCVCIMRNLSYHV 661

  Fly   401 TK-VEGLEALLQ-SLVQVLGSTDV-----NVVTCAAGILSNLTCNNQRNKATVCQVGG------- 451
            .| |.|.|.... |.:|..||...     :...|..|..:.....||.::..:.|..|
Zfish   662 HKEVPGAEKFQDPSALQAPGSAGTQRKKKDDAGCFGGKKAKEEWFNQAHQVCLEQYEGRKNGEHD 726

  Fly   452 -------------------------VDALVRTIINAGDREEITEPAVCALRHLTS-RHVDSELAQ 490
                                     |..|..:::.........|.|..||::|:: :...|...:
Zfish   727 KNYDTLDLPKRTEPTKGFELLYQPEVVRLYLSLLTESQNYNTLEAAAGALQNLSAGQWTWSNYIR 791

  Fly   491 NAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDT 555
            ..||...||.::|:||...|. .:::||...:|||::...|...:..: |:..||
Zfish   792 ATVRKEKGLPILVELLRSDSD-KVVRAVAIALRNLSIDRRNKDLIGSY-AMRDLV---------- 844

  Fly   556 ERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALH-ILARESHN-RALIRQQSVIPIFV----- 613
                 |...:|.|:|:...:    |:.|...:..:| |:...|.| |:||..|::..:..
Zfish   845 -----SNLPSGQQRPAKNLE----EDTVVAILNTIHEIITDSSENARSLITAQAIDKLVAINRTS 900

  Fly   614 ----------RLL-----FNEIEN-----------IQRVAAGV-----LCELAADKEGAEIIEQ- 646
                      .:|     :.|:.|           .|.:|||.     .|:...|.....::|:
Zfish   901 QSARETKAASHVLQTVWSYKELRNALTKDGWNKTHFQPIAAGTPKGSKSCKPGYDDTTLPLMEKS 965

  Fly   647 ---EGATG----PLTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSL-----LRED 699
               .|.:|    |:.:|   ..:|.:|..       ..||...||   |.::::.|     |:.|
Zfish   966 QGHRGCSGGDMIPMDEL---GPDGYSTID-------QRDKDSKYK---SSDISSDLQEREPLKND 1017

  Fly   700 NN 701
            .|
Zfish  1018 TN 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	43/190 (23%)
		armadillo repeat	161..186	CDD:293788	5/35 (14%)
		armadillo repeat	193..231	CDD:293788	10/37 (27%)
		armadillo repeat	238..270	CDD:293788	11/32 (34%)
		armadillo repeat	278..314	CDD:293788	9/47 (19%)
		armadillo repeat	320..355	CDD:293788	12/34 (35%)
		Arm	361..398	CDD:278915	14/52 (27%)
		armadillo repeat	362..397	CDD:293788	12/50 (24%)
		armadillo repeat	410..435	CDD:293788	6/30 (20%)
		Arm	439..481	CDD:278915	11/73 (15%)
		armadillo repeat	443..481	CDD:293788	9/69 (13%)
		armadillo repeat	490..525	CDD:293788	11/34 (32%)
		Arm	597..636	CDD:278915	14/75 (19%)
		armadillo repeat	600..636	CDD:293788	12/71 (17%)
		armadillo repeat	641..675	CDD:293788	7/41 (17%)
arvcfb	XP_009299795.1	ARM	434..552	CDD:237987	31/124 (25%)
		armadillo repeat	439..464	CDD:293788	8/29 (28%)
		armadillo repeat	472..508	CDD:293788	12/35 (34%)
		armadillo repeat	515..550	CDD:293788	8/34 (24%)
		armadillo repeat	557..608	CDD:293788	17/55 (31%)
		ARM	745..849	CDD:237987	26/120 (22%)
		armadillo repeat	745..781	CDD:293788	7/35 (20%)
		HEAT_2	757..>825	CDD:290374	17/68 (25%)
		armadillo repeat	791..825	CDD:293788	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940