DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and Ankar

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_038940485.1	Gene:	Ankar / 501138	RGDID:	1561071	Length:	1445	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	171/841 - (20%)
Similarity:	303/841 - (36%)	Gaps:	211/841 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYMPAQNRTMSHNNQYNPPDLPPMVSAKEQTLMW--QQNSYLGDSGIHSGAVTQVPSLSGKEDE 63
            :|..|.:|......|           :||:   :|  ..|::..|||........|....||...
  Rat   388 ISTSPVENALDDFKN-----------NAKK---IWACAANTFTEDSGYKEFYSVPVMEFYGKSYY 438

  Fly    64 EMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQR--VRAAMFPET------LEEGIEIPST 120
                 .:.|:|:..:.|.:.......:|:.::..|.:|  :..|...|.      |::.::..|.
  Rat   439 -----VIYFELEIFYQQLYKTQWWGAINEIVNNLRLKRLPLTEAQLHEQFKKKFGLKKAMKCKSI 498

  Fly   121 QFDPQQPTAVQR-LSEPSQML-KHAVVNLINYQDDAELAT-------RAIPELIKLLNDEDQVVV 176
            .|..:  :||:| ||...... :....:.||..|:|..|.       ..:|.:.:|.|....|..
  Rat   499 PFGLK--SAVERGLSAVFHTFSRKTSSSTINVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQ 561

  Fly   177 SQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLEST------KA-------------- 221
            .:..|...:.||.:..:.  .|.|..:....:|.|    ||:|      ||
  Rat   562 RRFIMFTQESSKMDMKKE--RNGPTPLHLAAQACS----LEATICLLCFKADYTLTEKRGWMPIH 620

  Fly   222 -----------------------AVGTLHNLSHHRQGLLAIFKSGGIPALVKLLS---------S 254
                                   |..|..|   ....||....||.:..:..|.|         :
  Rat   621 FAAFYDNICIIIALCRKDPSLLEAEATAEN---QCTPLLLAATSGALDTIQYLFSLGANWRKTDT 682

  Fly   255 PVESVLFYAITTLHNLLLHQDGSKMAVRL----AGGLQKMVTLLQRNNVKFLAIVTDCLQILAYG 315
            ...:::..::.|.|..:|     |..:.|    ....:.:|.:||..:.|...:....|:::...
  Rat   683 KGNNIIHLSVLTFHTEVL-----KYIIELHIPELPVWKTLVEMLQCESFKRRMMAVMSLEVICLA 742

  Fly   316 NQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGN 380
            |.|....||.:|....||.:::.... ||......:|..:|:..|...|:|:|||:.||...|.:
  Rat   743 NDEYWQNILDAGTIPALVNLLKCPKI-KLQCKIVGLLSNISIHVSVVHALVEAGGIPALISLLAS 806

  Fly   381 MSPRLVQNCLWTLRNLS-----DAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQ 440
            ..|.|...|...|.:::     |...|..|:.||:..|.....:..|||:.|    :..|...|:
  Rat   807 DEPELHSRCAVILYDIAKCENKDVIAKYNGIPALINLLSLNKENVLVNVMNC----IRVLCMGNE 867

  Fly   441 RNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLTSRHV-----DSELAQNAVRLNYGLS 500
            .|:..:....|:..|::.:.:..|          .|:.::|..:     |::..|:|:.:...:.
  Rat   868 GNQKAMRDYNGIHYLIQFLSSDSD----------VLKAVSSATIAEVGRDNKQVQDAIAMEGAIP 922

  Fly   501 VIVKLLHPPSRWPLIKAVIGLIRNLA-LCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIA- 563
            .:|.|.........:|..:. :.:|| ..|:......|......|::|| :|||...:::.:||
  Rat   923 PLVALFKGKQLSVQVKGAMA-VESLANRNPSIQKAFLERKLTKDLLKLL-KAFQIDVKEQGAIAL 985

  Fly   564 -----TTGSQQ------------------PSA---YADG-------------------------- 576
                 .|..||                  |||   |..|
  Rat   986 WALAGQTLKQQKYMAEQIGYNFIINMLLSPSAKMQYVGGEAVIALSKDSRKHQYQICEGNGIAPL 1050

  Fly   577 ---VRMEEIVEGT-------VGALHILARESHN---RALIRQQSVIPIFVRLLFNEIE-NIQ-RV 626
               :|:.:|.|||       ||::.|....:.|   :..:.:::..|:.::||.:... ||: .|
  Rat  1051 IRLLRISKIAEGTLLSVIRAVGSICIGVAHTSNPMSQQCVVEENAFPVLIQLLRSHPSINIKVEV 1115

  Fly   627 AAGVLC-ELAADKEGAEIIEQEG-ATGPLTDLLHSRNEGVATYA--AAVLFRMSEDKPQDY 683
            |..:.| .|..|....|:.|.|| ....:..||||:::.:...|  |..||..: ::.|.|
  Rat  1116 AFSLACIVLGNDSLQKELQENEGFEYSDVLYLLHSKDKEICLRAGYALTLFAFN-NRFQQY 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	38/226 (17%)
		armadillo repeat	161..186	CDD:293788	5/24 (21%)
		armadillo repeat	193..231	CDD:293788	12/80 (15%)
		armadillo repeat	238..270	CDD:293788	6/40 (15%)
		armadillo repeat	278..314	CDD:293788	7/39 (18%)
		armadillo repeat	320..355	CDD:293788	8/34 (24%)
		Arm	361..398	CDD:278915	12/41 (29%)
		armadillo repeat	362..397	CDD:293788	12/34 (35%)
		armadillo repeat	410..435	CDD:293788	5/24 (21%)
		Arm	439..481	CDD:278915	6/41 (15%)
		armadillo repeat	443..481	CDD:293788	4/37 (11%)
		armadillo repeat	490..525	CDD:293788	5/34 (15%)
		Arm	597..636	CDD:278915	10/44 (23%)
		armadillo repeat	600..636	CDD:293788	9/38 (24%)
		armadillo repeat	641..675	CDD:293788	12/36 (33%)
Ankar	XP_038940485.1	PHA02874	<521..>648	CDD:165205	22/132 (17%)
		ANK repeat	537..579	CDD:293786	7/41 (17%)
		ANK repeat	581..612	CDD:293786	9/34 (26%)
		Ank_2	586..681	CDD:403870	16/101 (16%)
		ANK repeat	614..648	CDD:293786	1/33 (3%)
		ANK repeat	650..681	CDD:293786	7/33 (21%)
		armadillo repeat	715..739	CDD:293788	5/23 (22%)
		PLN03200	<717..>1130	CDD:215629	92/429 (21%)
		armadillo repeat	750..781	CDD:293788	8/31 (26%)
		armadillo repeat	788..823	CDD:293788	12/34 (35%)
		armadillo repeat	828..862	CDD:293788	10/37 (27%)
		armadillo repeat	870..901	CDD:293788	5/40 (13%)
		armadillo repeat	1038..1076	CDD:293788	7/37 (19%)
		armadillo repeat	1087..1122	CDD:293788	7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840