DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and ARVCF

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006724306.1	Gene:	ARVCF / 421	HGNCID:	728	Length:	1004	Species:	Homo sapiens

Alignment Length:	667	Identity:	151/667 - (22%)
Similarity:	267/667 - (40%)	Gaps:	152/667 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQ---TRSQR-------VRAAMFPETLEEGIEI 117
            |..:.:|...:.||   ::...|  |:...:|..   |.::|       :....:.:|.::|.|:
Human   252 ERFQAEPYGLEDDT---RSLAAD--DEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGEL 311

  Fly   118 PSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATR-------AIPELIKLL-NDEDQV 174
            ...:  |..|.....|::|.:....::..|:......:.|.:       .:||::.:| :..|.|
Human   312 ADER--PAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPV 374

  Fly   175 VVSQAAMMVHQLSKKEASRHAI---MNSPQMVAAL--VRAISNSNDLESTKAAVGTLHNLSHHR- 233
            ..:.||.:.|...:.|..:..:   ...|.:||.|  .||       |..:.|.|.|.|||:.|
Human   375 KANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRA-------EVRRRACGALRNLSYGRD 432

  Fly   234 -QGLLAIFKSGGIPALVKLLSSPVESVLFYAIT-TLHNLLLHQDGSKMAVRLAGGLQKMVTLLQR 296
             ....||...||:||||:||.:..::.:...:| ||.||..::.            .|||
Human   433 TDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEP------------LKMV----- 480

  Fly   297 NNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSN 361
                   |:...||.|.:     ::|:..||...|.....:..|.|   |||  |.|..|.|..|
Human   481 -------IIDHGLQTLTH-----EVIVPHSGWEREPNEDSKPRDAE---WTT--VFKNTSGCLRN 528

  Fly   362 KPA--------------IVDAGGMQALAMHLG--NMSPRLVQNCLWTLRNLSDAATK-VEGLEAL 409
            ..:              :||| .:.||...:|  :...:.|:||:..:||||....| |.|.:..
Human   529 VSSDGAEARRRLRECEGLVDA-LLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRY 592

  Fly   410 LQSLVQVLGST---------DVNVVTCAAGILSNLTCNNQ--------RN-------KATVCQVG 450
            .::....|||.         |   .:|..|..:.....:|        ||       |.|....|
Human   593 QEAEPGPLGSAVGSQRRRRDD---ASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKG 654

  Fly   451 -------GVDALVRTIINAGDREEITEPAVCALRHLTSRH-VDSELAQNAVRLNYGLSVIVKLLH 507
                   .|..|..:::.........|.|..||::|::.: :.:...:..||...||.|:|:||.
Human   655 FELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQ 719

  Fly   508 PPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSA 572
            ..:. .:::||...:|||:|...|...:..: |:..|||.:..|             ....:|.|
Human   720 SETD-KVVRAVAIALRNLSLDRRNKDLIGSY-AMAELVRNVRNA-------------QAPPRPGA 769

  Fly   573 YADGVRMEEIVEGTVGALHILARES--HNRALIRQQSVIPIFVRLLFNEIENIQ--RVAAGVLCE 633
            ..:    |:.|...:..:|.:..:|  :.|:|::.:.| |..|.|:.:. ::::  :.|:.||..
Human   770 CLE----EDTVVAVLNTIHEIVSDSLDNARSLLQARGV-PALVALVASS-QSVREAKAASHVLQT 828

  Fly   634 LAADKEGAEIIEQEGAT 650
            :.:.||....::::|.|
Human   829 VWSYKELRGTLQKDGWT 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	46/179 (26%)
		armadillo repeat	161..186	CDD:293788	8/25 (32%)
		armadillo repeat	193..231	CDD:293788	12/42 (29%)
		armadillo repeat	238..270	CDD:293788	13/32 (41%)
		armadillo repeat	278..314	CDD:293788	7/35 (20%)
		armadillo repeat	320..355	CDD:293788	11/34 (32%)
		Arm	361..398	CDD:278915	13/52 (25%)
		armadillo repeat	362..397	CDD:293788	11/50 (22%)
		armadillo repeat	410..435	CDD:293788	6/33 (18%)
		Arm	439..481	CDD:278915	13/63 (21%)
		armadillo repeat	443..481	CDD:293788	10/44 (23%)
		armadillo repeat	490..525	CDD:293788	11/34 (32%)
		Arm	597..636	CDD:278915	10/42 (24%)
		armadillo repeat	600..636	CDD:293788	9/37 (24%)
		armadillo repeat	641..675	CDD:293788	2/10 (20%)
ARVCF	XP_006724306.1	ARM	355..473	CDD:237987	38/124 (31%)
		HEAT_2	360..462	CDD:290374	33/108 (31%)
		armadillo repeat	360..385	CDD:293788	7/24 (29%)
		armadillo repeat	393..429	CDD:293788	12/42 (29%)
		armadillo repeat	436..471	CDD:293788	13/34 (38%)
		ARM	437..579	CDD:237987	47/176 (27%)
		armadillo repeat	478..529	CDD:293788	20/72 (28%)
		ARM	656..756	CDD:237987	24/101 (24%)
		armadillo repeat	656..692	CDD:293788	7/35 (20%)
		armadillo repeat	702..736	CDD:293788	11/34 (32%)
		armadillo repeat	743..788	CDD:293788	10/62 (16%)
		armadillo repeat	794..826	CDD:293788	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940