DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and armc3

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001001246.1	Gene:	armc3 / 407950	XenbaseID:	XB-GENE-971492	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	144/718 - (20%)
Similarity:	276/718 - (38%)	Gaps:	147/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSTQFDP------QQPTAVQRLSEP-SQMLKHAVVNLINYQDDAE------LATRAIPELIKLLN 169
            |...|||      :..|||..|..| .::|..:...|..:....|      |...|:..|.||::
Frog    13 PKDVFDPLPIESKKAATAVLMLQSPEEEILAKSCDALYKFAKKGEENKLALLELGAVDPLSKLIS 77

  Fly   170 DEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQ 234
            .||::|...|.|:...::.....| .::....::.:|:..::...::...:.|...|..::....
Frog    78 HEDKIVRRNATMVCGIMASHYDVR-KLLRKLDIIPSLIARLTPEEEVVIHEFATLCLAYMAAEYT 141

  Fly   235 GLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNN- 298
            ....|.:..|:..|:||||||...|.......:: ||..:..|:.||.....:..::.||:...
Frog   142 SKTQIHELNGLEPLIKLLSSPDPDVKKNCAECIY-LLAQEFQSRSAVWELNAIPPLLELLKSEYP 205

  Fly   299 -VKFLAIVT-DCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSN 361
             ::.|.:.| .||.    ...|::.|.:.:....:|::::.:.::..|...|   |.|::.|..:
Frog   206 VIQQLTLRTLGCLS----SEVEARHIFIENQVLEQLLKVLETKEFHDLHVDT---LLVIANCLED 263

  Fly   362 KPA---IVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEG--------LEALLQSLVQ 415
            ..|   :..:||::.: :.....:| |.:..:...:.:|.||...|.        :|.:|.|::.
Frog   264 VEALHILQQSGGLKRI-LEFAETTP-LPEAQMNAAKAISKAAQNDENRKFFHEQEVERILVSMLD 326

  Fly   416 VLGSTDVNVVTC--------------------------------------AAGILSNLTCNNQRN 442
            . .:.:|....|                                      ||.:|:|||.|...|
Frog   327 T-DNDEVKAAACLAIAAMGENLESKNVFNKQGIPQIITLLTRESAEVRESAAFVLANLTTNCPAN 390

  Fly   443 KATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRL---NYGL-SVIV 503
            .:.|.:..|||||:..:  :..|:.:...|...|.::.        ||..:||   .:|| ..::
Frog   391 ASAVAEADGVDALINLL--SDKRDGVIMNACTVLINMA--------AQEPLRLILETHGLVHALI 445

  Fly   504 KLLHPPSRWPLIKAVIGLIRNLALCPAN-HAPLREHGAIHHLVRLLMRAFQDTERQRS-SIATTG 566
            :.||..:...|.||.: .:.::| |.|: ...||..|.:..||:||.....:..|... ::|...
Frog   446 EPLHSSNNMVLSKAAL-TVASIA-CDADIRTDLRNAGGLPPLVKLLQCDHNEVRRSACWAVAVCA 508

  Fly   567 SQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVL 631
            |.:.:|.       |:.:  :|||.:|...:.:|:  |:.:.....:..|.:....::....|.|
Frog   509 SDELTAV-------ELYK--LGALDLLQELNLSRS--RRNNFSEWALNKLLDNNLPLKYSQKGYL 562

  Fly   632 CELAADKEG----------------AEIIEQEGATGPLTDLLHSRNEGVATYAAAVLFRMSEDKP 680
            ......::|                .|:.:||........|:::::..:|..|.|         |
Frog   563 SYSNLIEDGFYDCGRIKPDAKLLPLEELSKQELNQNRAVILINAKSPDLAPAAVA---------P 618

  Fly   681 QDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGPEEAYEGLYGQGPPSVHSSHGGRAFH 745
            ...:|:.|:...:|..|..:...|.|.....|:                |......||||..|..
Frog   619 PAEEKQESVGARSSYSRNASREKAGAPAEEKPE----------------QAVVRTPSSHGRSASK 667

  Fly   746 QQG 748
            ::|
Frog   668 EKG 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	36/172 (21%)
		armadillo repeat	161..186	CDD:293788	8/24 (33%)
		armadillo repeat	193..231	CDD:293788	4/37 (11%)
		armadillo repeat	238..270	CDD:293788	10/31 (32%)
		armadillo repeat	278..314	CDD:293788	8/38 (21%)
		armadillo repeat	320..355	CDD:293788	5/34 (15%)
		Arm	361..398	CDD:278915	5/39 (13%)
		armadillo repeat	362..397	CDD:293788	5/37 (14%)
		armadillo repeat	410..435	CDD:293788	7/62 (11%)
		Arm	439..481	CDD:278915	10/41 (24%)
		armadillo repeat	443..481	CDD:293788	9/37 (24%)
		armadillo repeat	490..525	CDD:293788	10/38 (26%)
		Arm	597..636	CDD:278915	5/38 (13%)
		armadillo repeat	600..636	CDD:293788	5/35 (14%)
		armadillo repeat	641..675	CDD:293788	7/33 (21%)
armc3	NP_001001246.1	armadillo repeat	62..94	CDD:293788	10/31 (32%)
		armadillo repeat	104..136	CDD:293788	3/31 (10%)
		armadillo repeat	144..179	CDD:293788	12/35 (34%)
		PLN03200	155..>405	CDD:215629	55/260 (21%)
		armadillo repeat	184..218	CDD:293788	6/33 (18%)
		HEAT repeat	276..301	CDD:293787	2/26 (8%)
		HEAT repeat	317..345	CDD:293787	5/28 (18%)
		armadillo repeat	352..383	CDD:293788	3/30 (10%)
		Arm	387..426	CDD:366143	10/40 (25%)
		armadillo repeat	391..427	CDD:293788	9/45 (20%)
		HEAT repeat	435..466	CDD:293787	7/31 (23%)
		ARM	469..504	CDD:214547	9/34 (26%)
		armadillo repeat	473..503	CDD:293788	8/29 (28%)
		EDR1	<712..849	CDD:373038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030