DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arm and jup

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_989380.1	Gene:	jup / 395011	XenbaseID:	XB-GENE-489397	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	461/740 - (62%)
Similarity:	571/740 - (77%)	Gaps:	21/740 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGKE--DEEMEGDPLMFDLDTGFPQNFT 83
            ||..:|....:...||: :|..||||:||..|..|||:||.  :::....|..:.:.|   ..:|
Frog     2 DLVDVVEVPIKVTEWQK-TYTYDSGINSGINTASPSLNGKMVIEDDSHAYPGSYTVKT---TTYT 62

  Fly    84 QDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLI 148
            |.|..||:.|::.||:|||||||:|||:|:...:.:||.:.|| |.||:|:|||||||.|:::||
Frog    63 QQQTPDMDAQINMTRAQRVRAAMYPETVEDHSYLLTTQIEGQQ-TNVQKLAEPSQMLKSAIIHLI 126

  Fly   149 NYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNS 213
            ||||||||||||||||.|||||||.:||::|:|:|:|||||||||.|:|.|||:|||:||.:.::
Frog   127 NYQDDAELATRAIPELTKLLNDEDPMVVNKASMIVNQLSKKEASRKALMQSPQIVAAVVRTMQHT 191

  Fly   214 NDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSK 278
            :|:::.:.....||||||||:|||:|||||||||||::|||||||||||||||||||||:|:|:|
Frog   192 SDMDTARCTTSILHNLSHHREGLLSIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAK 256

  Fly   279 MAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEK 343
            ||||||.||||||.||.:||.|||||.|||||:||||||||||||||:|||..||:|||:|:|||
Frog   257 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYNYEK 321

  Fly   344 LLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEA 408
            |||||||||||||||.|||||||:|||||||..||.:.|||||||||||||||||.|||.|||:.
Frog   322 LLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLDN 386

  Fly   409 LLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAV 473
            :|:.||..|.|.||||:|||.|.||||||||.|||..|.|..||::|:.||:.|.|:::|.||||
Frog   387 VLKILVNQLSSDDVNVLTCATGTLSNLTCNNGRNKTLVTQSNGVESLIHTILRASDKDDIAEPAV 451

  Fly   474 CALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREH 538
            ||||||||||.|:|:|||:|||:||:..|||||:||.:|||:||.|||||||||||||||||.:.
Frog   452 CALRHLTSRHQDAEVAQNSVRLHYGIPAIVKLLNPPYQWPLVKATIGLIRNLALCPANHAPLYDA 516

  Fly   539 GAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALI 603
            |.|..||:||::|.||.:|.    |.:|:|||  |.|||:|||||||..||||||||:..||..|
Frog   517 GVIPRLVQLLVKAHQDAQRH----AASGAQQP--YTDGVKMEEIVEGCTGALHILARDPVNRMDI 575

  Fly   604 RQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYA 668
            .:.:.||:||:||::.:|||||||||||||||.|||.|:.|:.|||:.||.:||||||||:||||
Frog   576 YKLNTIPLFVQLLYSPVENIQRVAAGVLCELAQDKEAADTIDAEGASAPLMELLHSRNEGIATYA 640

  Fly   669 AAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGPE-EAYEGLYGQGP 732
            ||||||:||||..||:||:|:||||::.|:|...|..|. .|.| |.|....| |.|..:|.:..
Frog   641 AAVLFRISEDKNADYRKRVSVELTNAIFRQDPAAWEAAQ-SMIP-LNDPYPDEMENYRAMYPEDI 703

  Fly   733 PSVHSSHGGR---AFHQQGYDTLPI 754
            |.  ...||.   .:...||...|:
Frog   704 PL--EPMGGDMDVEYAMDGYSDHPV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	120/163 (74%)
		armadillo repeat	161..186	CDD:293788	16/24 (67%)
		armadillo repeat	193..231	CDD:293788	16/37 (43%)
		armadillo repeat	238..270	CDD:293788	28/31 (90%)
		armadillo repeat	278..314	CDD:293788	28/35 (80%)
		armadillo repeat	320..355	CDD:293788	28/34 (82%)
		Arm	361..398	CDD:278915	30/36 (83%)
		armadillo repeat	362..397	CDD:293788	28/34 (82%)
		armadillo repeat	410..435	CDD:293788	15/24 (63%)
		Arm	439..481	CDD:278915	24/41 (59%)
		armadillo repeat	443..481	CDD:293788	21/37 (57%)
		armadillo repeat	490..525	CDD:293788	24/34 (71%)
		Arm	597..636	CDD:278915	23/38 (61%)
		armadillo repeat	600..636	CDD:293788	22/35 (63%)
		armadillo repeat	641..675	CDD:293788	24/33 (73%)
jup	NP_989380.1	armadillo repeat	139..164	CDD:293788	16/24 (67%)
		armadillo repeat	172..209	CDD:293788	15/36 (42%)
		armadillo repeat	217..248	CDD:293788	28/30 (93%)
		ARM	217..248	CDD:214547	28/30 (93%)
		armadillo repeat	256..292	CDD:293788	28/35 (80%)
		armadillo repeat	300..333	CDD:293788	26/32 (81%)
		ARM	336..376	CDD:214547	32/39 (82%)
		armadillo repeat	340..375	CDD:293788	28/34 (82%)
		PLN03200	<384..>682	CDD:215629	191/304 (63%)
		armadillo repeat	388..413	CDD:293788	15/24 (63%)
		armadillo repeat	421..459	CDD:293788	21/37 (57%)
		armadillo repeat	468..503	CDD:293788	24/34 (71%)
		armadillo repeat	519..565	CDD:293788	29/51 (57%)
		armadillo repeat	572..608	CDD:293788	22/35 (63%)
		armadillo repeat	613..647	CDD:293788	24/33 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163964at33208
OrthoFinder	1	1.000	-	-		FOG0002078
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1754
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010