DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arm and gudu

DIOPT Version :9

Sequence 1:NP_001259149.1 Gene:arm / 31151 FlyBaseID:FBgn0000117 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_609111.1 Gene:gudu / 34014 FlyBaseID:FBgn0031905 Length:669 Species:Drosophila melanogaster


Alignment Length:613 Identity:128/613 - (20%)
Similarity:225/613 - (36%) Gaps:168/613 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 IPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNS---PQMVAALVRAIS---------NS 213
            ||.::.:||...:.:.:.||..:..:.|...:|..:...   |::|..:...:|         :.
  Fly   153 IPLIVDILNSSMKDLKTMAAETLANVCKVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRDQLSP 217

  Fly   214 NDLES---TKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSS-------PV---------ESV 259
            :||||   |:|....|..|:..:..:..:.|||.:|.:.:||.|       |:         |..
  Fly   218 DDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRKCSSEPK 282

  Fly   260 LFYAITT------------LHNLLLHQDGS----KMA--------VRLAGGLQKMVTLLQRNNVK 300
            ...||||            ..|..|..:||    |.|        ||.||||:.:||:::..||:
  Fly   283 FQLAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVREAGGLEPLVTIIKDKNVR 347

  Fly   301 -------------FLAIVTDC-LQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRV 351
                         ::..|||. :::|......:.|:.|.:...:|::               :.|
  Fly   348 ENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVL---------------TNV 397

  Fly   352 LKVLSVC---SSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSL 413
            ...:|.|   .||:..:..|||:.|:...|.:....|::|....|:..::....:..||      
  Fly   398 TGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRILE------ 456

  Fly   414 VQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRH 478
                   |::.|.....:|.|.|...|.:.|.        |:...:.||.|..|:....|.|   
  Fly   457 -------DLDAVRLIWSLLKNPTTRVQAHAAY--------AICPCVRNANDSAELVRSLVGA--- 503

  Fly   479 LTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHH 543
                                :.::|.||...... ::.||...|..:|....|.|.|.:...|:.
  Fly   504 --------------------MELVVGLLKSKDIM-VLSAVCAAIATIAQDQTNLAILTDLKVIYK 547

  Fly   544 LVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSV 608
            |..|:    |.|:                  |.:||.  :...|.|.....  ::...|.|.::|
  Fly   548 LADLV----QTTD------------------DLLRMN--LAAAVAACACFG--NNTEELGRLRTV 586

  Fly   609 IPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVLF 673
            .|| |..:.::...:.|..|..|.:|:.|.:....:.|.|....|.:.:.|.|:.:...||..|.
  Fly   587 TPI-VTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQSGVVPFLLECIGSTNKELQLAAAGCLR 650

  Fly   674 RMSEDKPQDYKKRLSIELTNSLLREDNN 701
            .:.|         |::.....||:.|::
  Fly   651 NIRE---------LALRAEEYLLKIDDD 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
armNP_001259149.1 Adaptin_N <150..>314 CDD:331138 52/221 (24%)
armadillo repeat 161..186 CDD:293788 6/24 (25%)
armadillo repeat 193..231 CDD:293788 12/52 (23%)
armadillo repeat 238..270 CDD:293788 13/59 (22%)
armadillo repeat 278..314 CDD:293788 16/57 (28%)
armadillo repeat 320..355 CDD:293788 4/34 (12%)
Arm 361..398 CDD:278915 9/36 (25%)
armadillo repeat 362..397 CDD:293788 8/34 (24%)
armadillo repeat 410..435 CDD:293788 3/24 (13%)
Arm 439..481 CDD:278915 9/41 (22%)
armadillo repeat 443..481 CDD:293788 8/37 (22%)
armadillo repeat 490..525 CDD:293788 6/34 (18%)
Arm 597..636 CDD:278915 10/38 (26%)
armadillo repeat 600..636 CDD:293788 10/35 (29%)
armadillo repeat 641..675 CDD:293788 8/33 (24%)
guduNP_609111.1 armadillo repeat 105..134 CDD:293788
armadillo repeat 144..180 CDD:293788 6/26 (23%)
Arm_3 214..557 CDD:330530 88/424 (21%)
armadillo repeat 245..275 CDD:293788 8/29 (28%)
armadillo repeat 286..318 CDD:293788 8/31 (26%)
armadillo repeat 328..362 CDD:293788 10/33 (30%)
armadillo repeat 411..447 CDD:293788 8/35 (23%)
armadillo repeat 453..484 CDD:293788 10/51 (20%)
armadillo repeat 494..526 CDD:293788 8/55 (15%)
ARM 614..652 CDD:214547 9/37 (24%)
armadillo repeat 619..652 CDD:293788 8/32 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464371
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2332
SonicParanoid 00.000 Not matched by this tool.
32.870

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