DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and ctnnb1

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_005157888.1	Gene:	ctnnb1 / 30265	ZFINID:	ZDB-GENE-980526-362	Length:	789	Species:	Danio rerio

Alignment Length:	839	Identity:	554/839 - (66%)
Similarity:	642/839 - (76%)	Gaps:	82/839 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGK---EDEEMEGDPLMFDLDTGFPQN 81
            ||....||      .|||.||| ||||||||.|..||||||   ||:::: :.::::.:.||.|:
Zfish    16 PDRKAAVS------HWQQQSYL-DSGIHSGATTTAPSLSGKGNPEDDDVD-NQVLYEWEQGFNQS 72

  Fly    82 FTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVN 146
            |.|:||.|::.|.:.||:||||||||||||:||::|||||||...||.||||:||||||||||||
Zfish    73 FNQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVN 137

  Fly   147 LINYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAIS 211
            ||||||||||||||||||.|||||||||||::||:||||||||||||||||.|||||:|:||.:.
Zfish   138 LINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQ 202

  Fly   212 NSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDG 276
            |:||:|:.:...||||||||||:||||||||||||||||:|.|||:|||||||||||||||||:|
Zfish   203 NTNDVETARCTSGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEG 267

  Fly   277 SKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDY 341
            :||||||||||||||.||.:.|||||||.||||||||||||||||||||||||..||.|||:|.|
Zfish   268 AKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTY 332

  Fly   342 EKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATK---- 402
            |||||||||||||||||||||||||:|||||||.:||.:.|.|||||||||||||||||||
Zfish   333 EKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQTSL 397

  Fly   403 -----VEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINA 462
                 .||:|.||.:|||:|||.|:|||||||||||||||||.:||..||||||::|||||::.|
Zfish   398 AEVDVQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRA 462

  Fly   463 GDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLAL 527
            ||||:|||||:||||||||||.|:|:|||||||:|||.|:||||||||.||||||.:||||||||
Zfish   463 GDREDITEPAICALRHLTSRHQDAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLAL 527

  Fly   528 CPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHI 592
            ||||||||||.|||..||:||:||.|||:| |:|:.  |:||  .:.:||||||||||..|||||
Zfish   528 CPANHAPLREQGAIPRLVQLLVRAHQDTQR-RTSMG--GTQQ--QFVEGVRMEEIVEGCTGALHI 587

  Fly   593 LARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLL 657
            |||:.|||.:||..:.||:||:||::.||||||||||||||||.|||.||.||.||||.|||:||
Zfish   588 LARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELL 652

  Fly   658 HSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIW-ANADLGMGPDLQ-DMLGP 720
            |||||||||||||||||||||||||||||||:|||:||.|.:...| ...|||:....| :.||
Zfish   653 HSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMTWNETGDLGLDIGAQGEPLG- 716

  Fly   721 EEAYEGLYGQGPPSVHSSHGGRAFHQQGY--DTLPIDSMQGLEISSPVGGGGAGGAPGNGGAVGG 783
                   |.|..||.      |:||..||  |.:.:|.|...|:        ||..||..
Zfish   717 -------YRQDDPSY------RSFHSGGYGQDAMGMDPMMEHEM--------AGHHPGPD----- 755

  Fly   784 ASGGGGNIGAIPPSGAPTSPYSMDMDVGEIDAGALNFDLDAMPTPPNDNNNLAAWYDTD 842
                      .|..|.|...::.|:             :|.:  ||.|:|.| ||:|||
Zfish   756 ----------YPVDGLPDLGHTQDL-------------IDGL--PPGDSNQL-AWFDTD 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	134/163 (82%)
		armadillo repeat	161..186	CDD:293788	20/24 (83%)
		armadillo repeat	193..231	CDD:293788	23/37 (62%)
		armadillo repeat	238..270	CDD:293788	28/31 (90%)
		armadillo repeat	278..314	CDD:293788	30/35 (86%)
		armadillo repeat	320..355	CDD:293788	29/34 (85%)
		Arm	361..398	CDD:278915	29/36 (81%)
		armadillo repeat	362..397	CDD:293788	27/34 (79%)
		armadillo repeat	410..435	CDD:293788	19/24 (79%)
		Arm	439..481	CDD:278915	30/41 (73%)
		armadillo repeat	443..481	CDD:293788	28/37 (76%)
		armadillo repeat	490..525	CDD:293788	28/34 (82%)
		Arm	597..636	CDD:278915	26/38 (68%)
		armadillo repeat	600..636	CDD:293788	24/35 (69%)
		armadillo repeat	641..675	CDD:293788	29/33 (88%)
ctnnb1	XP_005157888.1	ARM	<151..221	CDD:237987	51/69 (74%)
		armadillo repeat	152..177	CDD:293788	20/24 (83%)
		armadillo repeat	187..220	CDD:293788	18/32 (56%)
		ARM	228..347	CDD:237987	103/118 (87%)
		armadillo repeat	229..261	CDD:293788	28/31 (90%)
		armadillo repeat	269..305	CDD:293788	30/35 (86%)
		armadillo repeat	311..346	CDD:293788	29/34 (85%)
		ARM	349..389	CDD:214547	32/39 (82%)
		armadillo repeat	353..389	CDD:293788	28/35 (80%)
		ARM	407..526	CDD:237987	92/118 (78%)
		armadillo repeat	410..435	CDD:293788	19/24 (79%)
		armadillo repeat	443..481	CDD:293788	28/37 (76%)
		armadillo repeat	490..525	CDD:293788	28/34 (82%)
		ARM	492..631	CDD:237987	102/143 (71%)
		armadillo repeat	532..590	CDD:293788	40/62 (65%)
		armadillo repeat	595..629	CDD:293788	22/33 (67%)
		ARM	597..>676	CDD:237987	62/78 (79%)
		armadillo repeat	637..670	CDD:293788	28/32 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1564
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1434
Inparanoid	1	1.050	1015	1.000	Inparanoid score	I277
OMA	1	1.010	-	-		QHG45241
OrthoDB	1	1.010	-	-		D163964at33208
OrthoFinder	1	1.000	-	-		FOG0002078
OrthoInspector	1	1.000	-	-		otm26525
orthoMCL	1	0.900	-	-		OOG6_103992
Panther	1	1.100	-	-	LDO	PTHR45976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X1754
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870