DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and vac8

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_595238.1	Gene:	vac8 / 2541010	PomBaseID:	SPBC354.14c	Length:	550	Species:	Schizosaccharomyces pombe

Alignment Length:	727	Identity:	157/727 - (21%)
Similarity:	255/727 - (35%)	Gaps:	226/727 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PSLSGKEDEEMEGDPLMFDLDTGFPQNFTQDQ----------VDDMNQQLSQTRSQRVRAAMFPE 109
            |.|:.:|.|.: .|.|.| |:.....||..::          .|:::       .||..|..|.|
pombe    18 PLLADREREAV-ADLLSF-LEDRNEVNFYSEEPLRALTILAYSDNLD-------LQRSAALAFAE 73

  Fly   110 TLEEGI-EIPSTQFDP-----QQPTA-VQRLSEPSQMLKHAVVNLINYQDDAELATRAIPELIKL 167
            ..|:.: |:.....:|     |.|.| :||.:  |..|.:..||..|.....:|  ..:..||:.
pombe    74 ITEKDVREVDRETIEPVLFLLQSPDAEIQRAA--SVALGNLAVNAENKALVVKL--NGLDLLIRQ 134

  Fly   168 LNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHH 232
            :......|...|...:..|:..:.::..|.:|..: ..|.| ::.|.|:...:.|.|.|.|::|.
pombe   135 MMSPHVEVQCNAVGCITNLATLDENKSKIAHSGAL-GPLTR-LAKSKDIRVQRNATGALLNMTHS 197

  Fly   233 RQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGG----LQKMVTL 293
            .:....:..:|.||.||.||.|....|.:|..|::.|:.:.....|   |||..    ::.::.|
pombe   198 YENRQQLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRK---RLAQSEPKLVRSLIQL 259

  Fly   294 LQRNNVKFLAIVTDCLQILAYGNQES----KLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKV 354
            :..::.|     ..|...||..|..|    ::.|:.|.....|:|::|| .|..|:..:...::.
pombe   260 MDTSSPK-----VQCQAALALRNLASDERYQIEIVQSNALPSLLRLLRS-SYLPLILASVACIRN 318

  Fly   355 LSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGS 419
            :|:...|:..|:|||                                       .|:.||.:|..
pombe   319 ISIHPLNESPIIDAG---------------------------------------FLRPLVDLLSC 344

  Fly   420 TDVNVVTC-AAGILSNLTCNNQRNKATVCQVGGVDALVRTIINA--GDREEITE-PAVCALRHLT 480
            |:...:.| |...|.||..:::|||..:.:...:..|...|::|  ..:.|:|. .||.||
pombe   345 TENEEIQCHAVSTLRNLAASSERNKRAIIEANAIQKLRCLILDAPVSVQSEMTACLAVLAL---- 405

  Fly   481 SRHVDSELAQNAVRLNYGL-SVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHL 544
            |....|.|      ||:|: :|::                              ||.:..:|
pombe   406 SDEFKSYL------LNFGICNVLI------------------------------PLTDSMSI--- 431

  Fly   545 VRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVI 609
                       |.|.:|.|..|:.. |...|..|..|..:...|.:|
pombe   432 -----------EVQGNSAAALGNLS-SNVDDYSRFIECWDSPAGGIH------------------ 466

  Fly   610 PIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVLFR 674
            ...||.|.:|......:||..:.:|.           |.....||..:.|
pombe   467 GYLVRFLSSEDSTFAHIAAWTIVQLL-----------EAGVPRLTAFIQS--------------- 505

  Fly   675 MSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGPEEAYEGLYGQGPPSVHSSH 739
             |:|         .|||.|.::..|.|   |.:                ||.  |:|...:.|
pombe   506 -SDD---------IIELLNDIVARDAN---NGE----------------YED--GEGDVILLS-- 537

  Fly   740 GGRAFHQQGYDT 751
             |||.|....||
pombe   538 -GRALHLIEQDT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	37/167 (22%)
		armadillo repeat	161..186	CDD:293788	4/24 (17%)
		armadillo repeat	193..231	CDD:293788	10/37 (27%)
		armadillo repeat	238..270	CDD:293788	11/31 (35%)
		armadillo repeat	278..314	CDD:293788	8/39 (21%)
		armadillo repeat	320..355	CDD:293788	8/34 (24%)
		Arm	361..398	CDD:278915	5/36 (14%)
		armadillo repeat	362..397	CDD:293788	4/34 (12%)
		armadillo repeat	410..435	CDD:293788	8/25 (32%)
		Arm	439..481	CDD:278915	12/44 (27%)
		armadillo repeat	443..481	CDD:293788	10/40 (25%)
		armadillo repeat	490..525	CDD:293788	4/35 (11%)
		Arm	597..636	CDD:278915	7/38 (18%)
		armadillo repeat	600..636	CDD:293788	7/35 (20%)
		armadillo repeat	641..675	CDD:293788	4/33 (12%)
vac8	NP_595238.1	HEAT repeat	17..37	CDD:293787	8/20 (40%)
		HEAT repeat	48..76	CDD:293787	6/34 (18%)
		ARM	82..195	CDD:237987	27/118 (23%)
		armadillo repeat	119..155	CDD:293788	6/37 (16%)
		armadillo repeat	160..194	CDD:293788	9/35 (26%)
		ARM	162..280	CDD:237987	33/127 (26%)
		armadillo repeat	201..235	CDD:293788	11/33 (33%)
		armadillo repeat	244..278	CDD:293788	8/38 (21%)
		armadillo repeat	286..361	CDD:293788	22/114 (19%)
		ARM	307..404	CDD:237987	27/135 (20%)
		armadillo repeat	369..405	CDD:293788	8/35 (23%)
		Arm	406..446	CDD:278915	15/90 (17%)
		armadillo repeat	410..444	CDD:293788	14/83 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940