DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and bar-1

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_509206.1	Gene:	bar-1 / 180982	WormBaseID:	WBGene00000238	Length:	811	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	179/715 - (25%)
Similarity:	315/715 - (44%)	Gaps:	108/715 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DSGIHSGAVTQVPSLSGKEDEEMEGDPLM----------FDLDTGFPQNFTQDQVDDMNQQLSQT 97
            |:.:...:.|.....|...|..|...|..          .:.|:||             |.::.:
Worm    13 DTNLSEASFTMEQHTSSYSDIHMGSTPCTGHRKVDMWRNHNFDSGF-------------QTMNHS 64

  Fly    98 RSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELAT-RAI 161
            .:..:.:::.|.:...|:. ....::| .||.       |...|.....:...|.|.:..| |||
Worm    65 EAPSIISSLHPSSHLSGMS-SMADYEP-IPTL-------SDQQKQKFDGITQNQADGQYNTVRAI 120

  Fly   162 PELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTK------ 220
            |||..|:.|:|..||.:|.:::..::|.|.......|..::|..  |.|....||...|
Worm   121 PELTMLMKDQDNEVVHKAVILMQNIAKMECDPMRRQNEARIVDP--RVIFTLRDLLRDKVEFPNI 183

  Fly   221 --AAVGTLHNLSHHRQGLLAIFKSGG-----IPALVKLLSSPVESVLFYAITTLHNLLLHQDGSK 278
              ..:||..::.:.::|:..:.::..     ||.|::.:.:...|:..|||.|:|::|..:....
Worm   184 IRCTLGTFFHICNRQEGIDLVTRAIAEQPDIIPNLIRHIGTYPSSIYKYAILTMHSILSDKQRGG 248

  Fly   279 MAVRLAGGLQKMVT-----LLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRS 338
            .:|.:| ..|..:|     |....:.|.|.::.|.:::|...|.|.|:..:..|||.:|:.:::.
Worm   249 QSVIIA-RQQDAITHVTPWLEAEKSEKLLPVIVDLIRVLCEKNTEQKIKFVKMGGPQKLLMLLQH 312

  Fly   339 YDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKV 403
            ..||.|||.|:::||..|  :.:.|.:|..||.|.||..|.:.||||||:.|.||||:||..:|:
Worm   313 RVYENLLWRTTQLLKTFS--NFDAPNLVAFGGRQILANLLSHGSPRLVQSTLETLRNISDVPSKI 375

  Fly   404 EGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINA----GD 464
            :. :.||:||::::.|.:..:...:|.|:|||..||:.||..:|...||..|||.:..|    ||
Worm   376 KE-DLLLKSLLELVNSRNTTIRLYSAQIMSNLVANNRHNKEFMCGNNGVVILVRALTIATKEMGD 439

  Fly   465 --------REEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGL 521
                    .|:..|..:|.||||...|..|:..|..|..:..| .:.|||  ..|..|:|..:.|
Worm   440 LRDKEAQQMEDYIESLICTLRHLCVGHPMSDKVQAFVFRDPAL-FLHKLL--TMRPVLLKHTLSL 501

  Fly   522 I-----RNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEE 581
            :     ::..|.|.....:.:.|.:..|:.:|..|......|.|             .:|||:::
Worm   502 LLKVVSQHALLAPFRSCRIGDKGFVEQLIHILRVACTQLNVQES-------------IEGVRVKD 553

  Fly   582 IVEGTVGALHILARESH--NRALIRQQS----------VIPIFVRLLFNEIENIQRVAAGVLCEL 634
            |:...:..|..:.|:..  |..:...|:          .:||||....|..||.:..|..::..|
Worm   554 IIHLCIQILRWITRDQDILNEVVFFLQTPENSRMGDGHTLPIFVLQKANVEENTKSSALALIYNL 618

  Fly   635 AADKEGAEIIEQEGATGPLTDLLHSRNE---GVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLL 696
            ...::.|.:::::.....:...:..:::   .:|:.|..:|..|.|.:.   |.|.::...||.|
Worm   619 MHHEQMANVLDRDDVLVKMLQNVQMQSQTHPELASLANNILKMMYEKRE---KTRNTLPRYNSYL 680

Fly 697 696
Worm 681 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	46/182 (25%)
		armadillo repeat	161..186	CDD:293788	10/24 (42%)
		armadillo repeat	193..231	CDD:293788	9/45 (20%)
		armadillo repeat	238..270	CDD:293788	9/36 (25%)
		armadillo repeat	278..314	CDD:293788	9/40 (23%)
		armadillo repeat	320..355	CDD:293788	13/34 (38%)
		Arm	361..398	CDD:278915	19/36 (53%)
		armadillo repeat	362..397	CDD:293788	19/34 (56%)
		armadillo repeat	410..435	CDD:293788	7/24 (29%)
		Arm	439..481	CDD:278915	19/53 (36%)
		armadillo repeat	443..481	CDD:293788	17/49 (35%)
		armadillo repeat	490..525	CDD:293788	10/39 (26%)
		Arm	597..636	CDD:278915	11/50 (22%)
		armadillo repeat	600..636	CDD:293788	10/45 (22%)
		armadillo repeat	641..675	CDD:293788	4/36 (11%)
bar-1	NP_509206.1	armadillo repeat	120..145	CDD:293788	10/24 (42%)
		armadillo repeat	155..195	CDD:293788	9/41 (22%)
		armadillo repeat	201..240	CDD:293788	9/38 (24%)
		armadillo repeat	294..331	CDD:293788	14/38 (37%)
		ARM	296..408	CDD:237987	45/114 (39%)
		armadillo repeat	337..368	CDD:293788	17/30 (57%)
		Extensin_2	739..796	CDD:252669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2582
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002078
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45976
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.820