DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and jac-1

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001294123.1	Gene:	jac-1 / 178451	WormBaseID:	WBGene00002175	Length:	1256	Species:	Caenorhabditis elegans

Alignment Length:	957	Identity:	196/957 - (20%)
Similarity:	323/957 - (33%)	Gaps:	310/957 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YMPAQNRTMSHNNQYNPPDLPPMVSAKEQT--LMW----QQNSYL------GDSGIHSGAVTQVP 55
            ::||  |.:|.:.|  ||..|.||...:..  |.|    |...|:      ||...|:.....:.
Worm   416 HVPA--RKVSESVQ--PPGQPQMVEVGDDVVKLEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 476

  Fly    56 SLSGKEDEEMEGDPLMFDLDTGFPQNFTQD-----QVDDMNQQLSQT----------RSQRVRAA 105
            . :|.:.|             |..:|.|.:     .||::..|.|:|          .:..:|.|
Worm   477 Q-NGIQVE-------------GLHRNSTYEFCVISIVDNIASQPSETSDIIHLRPTCNTSALRPA 527

  Fly   106 MFPETLE--EGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINY--------QDDAELATRA 160
              |..||  |.:|:...:.      .:..|...||:      .::.|        |||.......
Worm   528 --PNILEAPEFLEVDGDKI------TICWLPAQSQL------PVMGYDVEFRDLQQDDRWYKVND 578

  Fly   161 IPELI------KLLNDEDQVVVSQAAMMVHQLS--------------KKEASRHA--IMNSPQM- 202
            .|...      .|:.|.|.    |..::.|..|              :...:|.:  .|.||.:
Worm   579 QPVFACKMTVGDLIMDHDY----QFRVLAHNASGCSQPSPPSDFVHIEPSTNRFSSDTMESPHLG 639

  Fly   203 ---VAALVRA-------------ISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKL 251
               |...|.|             :..|..|.....:...|...:::.|     ::...:..:::.
Worm   640 HHDVVKYVEAERFGAVPLLQEEMVRESPPLPERDDSPPPLRRANNNVQ-----WRDPSLKEVIEY 699

  Fly   252 LSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYG- 315
            |||..:.....|...|.:|....:..|...|..||:.|::.||:.:..:.......||:.|::|
Worm   700 LSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGK 764

  Fly   316 -NQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAG----GMQALA 375
             |..:||.::.:.|...:..::|:.....:....:..|..||.....||.|:::.    ..|.:|
Worm   765 ENDANKLAVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMLKPVILESATEILSQQVIA 829

  Fly   376 --MHLGNMSP------RLVQNCLWTLRNLS----DAATKVEGLEALLQSLVQVL------GSTDV 422
              :.:|...|      .|.:|....|||:|    .|..::..:..|:::||..|      ...|.
Worm   830 PVLAVGTSDPTRHFGSTLFKNSTGVLRNVSAASQQARRRLRDIPNLIEALVHFLTHAIQKSQVDS 894

  Fly   423 NVVTCAAGILSNLTC-------------------------------------------NNQRNKA 444
            ..|..|..:|.||:.                                           .|.:|..
Worm   895 PTVENAVCLLRNLSYRIQEVVDPNYDPAAAHSSSSKNMKHVASPKPEKKKKDKEKKKDKNPKNIV 959

  Fly   445 T---VCQVGGVDALVRTIINAGDREEITEPAVCALRHLTS-RHVDSELAQNAVRLNYGLSVIVKL 505
            |   |.....|..|...::......|..|.:..|:::|.: :...|...:.|||:..||.|:|:|
Worm   960 TGPSVLWQPHVVKLYLKLLQDSSNIETLEASAGAIQNLAACQFPPSAEVRAAVRVEKGLPVLVEL 1024

  Fly   506 LHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLV---RLLMRAFQDTERQRSSIATTGS 567
            :..|..: ::.||...:||||:.|.|    ||      |:   :..:|.|.|      .:...||
Worm  1025 IRLPEDF-VVCAVATALRNLAIDPRN----RE------LIVSGKYALRDFLD------KLPEPGS 1072

  Fly   568 QQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLC 632
            .:.||.:|         .|:||:                                     .|:|.
Worm  1073 PRRSAISD---------QTIGAV-------------------------------------LGILF 1091

  Fly   633 ELAADKEG--AEIIEQEGATGPLTDLLHSRNEG-------VATYAAAVLFRMSEDKP-QDYKKRL 687
            |:......  .::.|.:|     ||.|.:.:..       |..||:.||:.|.:.|. .|..||
Worm  1092 EIVRSSAAYTKDVHELKG-----TDKLRALSRSYPTYSHRVCKYASQVLYVMWQHKELHDGFKR- 1150

  Fly   688 SIELTNSLLREDNNIWANADLGMGPDLQDMLGPEEAYEGLYGQGPPSVH------SSHGG----- 741
                  |.|:|.:.....|..|....|...:..:       |:..||:|      ||.||
Worm  1151 ------SGLKEADFYSGTARRGDSSTLARPISSQ-------GRERPSMHQLDETLSSGGGYGTME 1202

  Fly   742 ---RA-----------FHQQGYDTLPIDS--MQGLEISSPVGGGGAG 772
               ||           ..|:.||.:|.|.  ...::..||.||||.|
Worm  1203 SNNRAGTLRPASATSQTIQRRYDQVPRDGPVYSSVQKPSPRGGGGGG 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	38/210 (18%)
		armadillo repeat	161..186	CDD:293788	6/30 (20%)
		armadillo repeat	193..231	CDD:293788	10/56 (18%)
		armadillo repeat	238..270	CDD:293788	5/31 (16%)
		armadillo repeat	278..314	CDD:293788	10/35 (29%)
		armadillo repeat	320..355	CDD:293788	5/34 (15%)
		Arm	361..398	CDD:278915	13/52 (25%)
		armadillo repeat	362..397	CDD:293788	12/46 (26%)
		armadillo repeat	410..435	CDD:293788	7/30 (23%)
		Arm	439..481	CDD:278915	10/44 (23%)
		armadillo repeat	443..481	CDD:293788	8/40 (20%)
		armadillo repeat	490..525	CDD:293788	12/34 (35%)
		Arm	597..636	CDD:278915	3/38 (8%)
		armadillo repeat	600..636	CDD:293788	3/35 (9%)
		armadillo repeat	641..675	CDD:293788	10/40 (25%)
jac-1	NP_001294123.1	FN3	205..294	CDD:238020
		FN3	313..403	CDD:238020
		FN3	428..513	CDD:238020	22/98 (22%)
		FN3	528..619	CDD:238020	19/106 (18%)
		ARM	688..807	CDD:237987	24/118 (20%)
		armadillo repeat	693..718	CDD:293788	5/24 (21%)
		armadillo repeat	726..762	CDD:293788	10/35 (29%)
		armadillo repeat	770..805	CDD:293788	5/34 (15%)
		armadillo repeat	819..858	CDD:293788	8/38 (21%)
		ARM	849..>918	CDD:237987	16/68 (24%)
		armadillo repeat	876..907	CDD:293788	7/30 (23%)
		armadillo repeat	911..999	CDD:293788	10/87 (11%)
		ARM	964..1065	CDD:237987	30/111 (27%)
		armadillo repeat	1009..1043	CDD:293788	12/34 (35%)
		armadillo repeat	1051..1093	CDD:293788	15/99 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940