DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arm and CTNND2

DIOPT Version :9

Sequence 1:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_005248308.1	Gene:	CTNND2 / 1501	HGNCID:	2516	Length:	1250	Species:	Homo sapiens

Alignment Length:	747	Identity:	155/747 - (20%)
Similarity:	252/747 - (33%)	Gaps:	242/747 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PPMVSAKEQTLMWQQNSYLGD------------SGIHSGAVTQVP---SLSGKEDEEMEGDPLMF 72
            |..::|..:.....|:.:||.            ..|:...|.|.|   |||     :.:||||.
Human   388 PGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLS-----QSQGDPLP- 446

  Fly    73 DLDTGFPQNFTQDQ---VDDMNQQL--SQTRSQRVRAAMFPET----------------LE--EG 114
            ...||..:..|...   ||.:..|.  ||...|...||.|...                |:  ..
Human   447 PAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPS 511

  Fly   115 IEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATR--AIPELIKLLNDEDQVVVS 177
            :|.|.::..|..|........||       ::.|. :|..|...|  .:||:|::|..:...|.|
Human   512 VESPYSKSGPALPPEGTLARSPS-------IDSIQ-KDPREFGWRDPELPEVIQMLQHQFPSVQS 568

  Fly   178 QAAMMVHQLS------KKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHR--- 233
            .||..:..|.      |.|..|   ....|::..|:    :....|..::|.|.|.||.:.:
Human   569 NAAAYLQHLCFGDNKIKAEIRR---QGGIQLLVDLL----DHRMTEVHRSACGALRNLVYGKAND 626

  Fly   234 QGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNN 298
            ...:|:...|||||||:||....:..:...:|.:...|...|..||
Human   627 DNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKM------------------- 672

  Fly   299 VKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKP 363
                .|:.|.|.:|.     :.:||..||..|..::     |..|:...:|:||:..:.|..|
Human   673 ----PIIQDALAVLT-----NAVIIPHSGWENSPLQ-----DDRKIQLHSSQVLRNATGCLRN-- 721

  Fly   364 AIVDAGGMQA-------------------LAMHLGNMSPRLVQNCLWTLRNLSD--AATKVEGLE 407
              |.:.|.:|                   .|:....:..:.|:||:..|||||.  ||...:|
Human   722 --VSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQG-- 782

  Fly   408 ALLQSLVQVLGSTDVNVVTCAA-----GILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREE 467
                   |.:|:.:::.:.|..     ...|......::.|.:..|..||          |...:
Human   783 -------QHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGV----------GPLPD 830

  Fly   468 ITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVI---VKLLHPPSRWPLIKAVIGLIRNLALCP 529
            ..||                  ...:::.:..|::   :.||...|....::...|.::|||
Human   831 CAEP------------------PKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLA--- 874

  Fly   530 ANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILA 594
                                               .||.:..|        |.|.|...||..|.
Human   875 -----------------------------------AGSWKGWA--------EDVAGMAYALRSLP 896

  Fly   595 RES--------HNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATG 651
            ..:        :.||.:|::..:||.|.||..:.:.:....|..|..:|.|....|:|.:..
Human   897 EGAPCLPQWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYA--- 958

  Fly   652 PLTDLLH-----SRNEGVATYAAAVLFRMSED 678
             :.||:|     :.:...|:.|      ||:|
Human   959 -MRDLVHRLPGGNNSNNTASKA------MSDD 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	42/174 (24%)
		armadillo repeat	161..186	CDD:293788	8/24 (33%)
		armadillo repeat	193..231	CDD:293788	9/37 (24%)
		armadillo repeat	238..270	CDD:293788	11/31 (35%)
		armadillo repeat	278..314	CDD:293788	6/35 (17%)
		armadillo repeat	320..355	CDD:293788	10/34 (29%)
		Arm	361..398	CDD:278915	12/55 (22%)
		armadillo repeat	362..397	CDD:293788	10/53 (19%)
		armadillo repeat	410..435	CDD:293788	4/29 (14%)
		Arm	439..481	CDD:278915	7/41 (17%)
		armadillo repeat	443..481	CDD:293788	7/37 (19%)
		armadillo repeat	490..525	CDD:293788	5/37 (14%)
		Arm	597..636	CDD:278915	10/46 (22%)
		armadillo repeat	600..636	CDD:293788	10/35 (29%)
		armadillo repeat	641..675	CDD:293788	7/38 (18%)
CTNND2	XP_005248308.1	ARM	544..666	CDD:237987	34/128 (27%)
		armadillo repeat	552..577	CDD:293788	8/24 (33%)
		armadillo repeat	585..621	CDD:293788	11/42 (26%)
		armadillo repeat	629..664	CDD:293788	11/34 (32%)
		armadillo repeat	671..722	CDD:293788	18/87 (21%)
		Arm	834..875	CDD:278915	9/96 (9%)
		armadillo repeat	838..875	CDD:293788	8/74 (11%)
		armadillo repeat	910..944	CDD:293788	10/33 (30%)
		ARM	911..1043	CDD:237987	21/83 (25%)
		armadillo repeat	951..997	CDD:293788	10/43 (23%)
		armadillo repeat	1003..1038	CDD:293788
		CAF20	<1054..1113	CDD:293657
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940