DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arm and CTNNB1

DIOPT Version :9

Sequence 1:NP_001259149.1 Gene:arm / 31151 FlyBaseID:FBgn0000117 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001091679.1 Gene:CTNNB1 / 1499 HGNCID:2514 Length:781 Species:Homo sapiens


Alignment Length:831 Identity:556/831 - (66%)
Similarity:644/831 - (77%) Gaps:74/831 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 PDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGK---EDEEMEGDPLMFDLDTGFPQN 81
            ||....||      .|||.||| ||||||||.|..||||||   |:|:::...::::.:.||.|:
Human    16 PDRKAAVS------HWQQQSYL-DSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQS 73

  Fly    82 FTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVN 146
            |||:||.|::.|.:.||:||||||||||||:||::|||||||...||.||||:||||||||||||
Human    74 FTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVN 138

  Fly   147 LINYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAIS 211
            ||||||||||||||||||.|||||||||||::||:||||||||||||||||.|||||:|:||.:.
Human   139 LINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQ 203

  Fly   212 NSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDG 276
            |:||:|:.:...||||||||||:||||||||||||||||:|.|||:|||||||||||||||||:|
Human   204 NTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEG 268

  Fly   277 SKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDY 341
            :||||||||||||||.||.:.|||||||.||||||||||||||||||||||||..||.|||:|.|
Human   269 AKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTY 333

  Fly   342 EKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGL 406
            |||||||||||||||||||||||||:|||||||.:||.:.|.|||||||||||||||||||.||:
Human   334 EKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGM 398

  Fly   407 EALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEP 471
            |.||.:|||:|||.|:|||||||||||||||||.:||..||||||::|||||::.|||||:||||
Human   399 EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEP 463

  Fly   472 AVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLR 536
            |:||||||||||.::|:|||||||:|||.|:||||||||.||||||.:|||||||||||||||||
Human   464 AICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLR 528

  Fly   537 EHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRA 601
            |.|||..||:||:||.|||:| |:|:.  |:||  .:.:||||||||||..||||||||:.|||.
Human   529 EQGAIPRLVQLLVRAHQDTQR-RTSMG--GTQQ--QFVEGVRMEEIVEGCTGALHILARDVHNRI 588

  Fly   602 LIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVAT 666
            :||..:.||:||:||::.||||||||||||||||.|||.||.||.||||.|||:|||||||||||
Human   589 VIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVAT 653

  Fly   667 YAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIW-ANADLGMGPDLQ-DMLGPEEAYEGLYG 729
            ||||||||||||||||||||||:|||:||.|.:...| ..||||:....| :.||        |.
Human   654 YAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLG--------YR 710

  Fly   730 QGPPSVHSSHGGRAFHQQGY--DTLPIDSMQGLEISSPVGGGGAGGAPGNGGAVGGASGGGGNIG 792
            |..||.      |:||..||  |.|.:|.|...|:                        ||.:.|
Human   711 QDDPSY------RSFHSGGYGQDALGMDPMMEHEM------------------------GGHHPG 745

  Fly   793 A-IPPSGAPTSPYSMDMDVGEIDAGALNFDLDAMPTPPNDNNNLAAWYDTD 842
            | .|..|.|...::.|:             :|.:  ||.|:|.| ||:|||
Human   746 ADYPVDGLPDLGHAQDL-------------MDGL--PPGDSNQL-AWFDTD 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
armNP_001259149.1 Adaptin_N <150..>314 CDD:331138 134/163 (82%)
armadillo repeat 161..186 CDD:293788 20/24 (83%)
armadillo repeat 193..231 CDD:293788 23/37 (62%)
armadillo repeat 238..270 CDD:293788 28/31 (90%)
armadillo repeat 278..314 CDD:293788 30/35 (86%)
armadillo repeat 320..355 CDD:293788 29/34 (85%)
Arm 361..398 CDD:278915 29/36 (81%)
armadillo repeat 362..397 CDD:293788 27/34 (79%)
armadillo repeat 410..435 CDD:293788 19/24 (79%)
Arm 439..481 CDD:278915 30/41 (73%)
armadillo repeat 443..481 CDD:293788 28/37 (76%)
armadillo repeat 490..525 CDD:293788 28/34 (82%)
Arm 597..636 CDD:278915 26/38 (68%)
armadillo repeat 600..636 CDD:293788 24/35 (69%)
armadillo repeat 641..675 CDD:293788 29/33 (88%)
CTNNB1NP_001091679.1 Interaction with VCL. /evidence=ECO:0000250 2..23 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..57 15/22 (68%)
SRP1 142..>431 CDD:227396 239/288 (83%)
ARM 1 151..191 35/39 (90%)
armadillo repeat 153..178 CDD:293788 20/24 (83%)
Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462 156..178 17/21 (81%)
armadillo repeat 188..221 CDD:293788 18/32 (56%)
ARM 2 193..234 26/40 (65%)
armadillo repeat 230..262 CDD:293788 28/31 (90%)
ARM 230..262 CDD:214547 28/31 (90%)
ARM 3 235..276 35/40 (88%)
armadillo repeat 270..306 CDD:293788 30/35 (86%)
ARM 4 277..318 35/40 (88%)
armadillo repeat 312..347 CDD:293788 29/34 (85%)
ARM 5 319..360 35/40 (88%)
ARM 350..390 CDD:214547 32/39 (82%)
armadillo repeat 354..389 CDD:293788 27/34 (79%)
ARM 6 361..389 21/27 (78%)
ARM 7 400..441 30/40 (75%)
armadillo repeat 402..427 CDD:293788 19/24 (79%)
Arm 431..473 CDD:395413 30/41 (73%)
armadillo repeat 435..473 CDD:293788 28/37 (76%)
ARM 8 442..484 30/41 (73%)
armadillo repeat 482..517 CDD:293788 28/34 (82%)
ARM 9 489..530 35/40 (88%)
armadillo repeat 524..582 CDD:293788 40/62 (65%)
ARM 10 531..571 25/44 (57%)
Arm 583..622 CDD:395413 25/38 (66%)
armadillo repeat 587..621 CDD:293788 22/33 (67%)
ARM 11 594..636 30/41 (73%)
armadillo repeat 629..662 CDD:293788 28/32 (88%)
ARM 12 637..666 26/28 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..781 35/130 (27%)
Interaction with SCRIB. /evidence=ECO:0000250 772..781 7/10 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 292 1.000 Domainoid score I1527
eggNOG 1 0.900 - - E1_COG0572
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1434
Inparanoid 1 1.050 1022 1.000 Inparanoid score I279
Isobase 1 0.950 - 0 Normalized mean entropy S2582
OMA 1 1.010 - - QHG45241
OrthoDB 1 1.010 - - D163964at33208
OrthoFinder 1 1.000 - - FOG0002078
OrthoInspector 1 1.000 - - oto91554
orthoMCL 1 0.900 - - OOG6_103992
Panther 1 1.100 - - LDO PTHR45976
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2332
SonicParanoid 1 1.000 - - X1754
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.860

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