Protein Alignment trr and SETDB1

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Alignment Length: 1337
• Identity: 230/1337 - (17%)
• Similarity: 360/1337 - (26%)
• Gaps: 613/1337 - (45%)

  Fly  1259 PTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGAL----KDLTG----------PLPAGAMVQLA 1309
            |....|........|::.|...|.|:.|.::.|.:    :||||          |.|..
Human   397 PMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTA------ 455

  Fly  1310 GMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKL 1374
              ||...:                              ..:|.|       |....|.::...:|
Human   456 --PPAPPF------------------------------PPAPPL-------SPQAGDSESLESQL 481

  Fly  1375 LTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLS 1439
            ....:|:         ..::..|..|| ..||..||.|     .|.|.:..|||
Human   482 AQSRKQV---------AKKSTSFRPGS-VGSGHSSPTS-----PALSENVSGGK----------- 520

  Fly  1440 RHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMS 1504
                                  |||...|        |..:|.:|...:||...:|.|..:
Human   521 ----------------------PGINQTY--------RSPLGSTASAPAPSALPAPPAPPV---- 551

  Fly  1505 SIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLN 1569
                      |...:||.|.|...|                        |.:.:|...|.:.
Human   552 ----------FHGMLERAPAEPSYR------------------------APMEKLFYLPHVC--- 579

  Fly  1570 GNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVI 1634
             :..|..|:.|:                                        .|..|:.||.
Human   580 -SYTCLSRVRPM----------------------------------------RNEQYRGKNP--- 600

  Fly  1635 LALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSH 1699
            |.:|                ||:                               ||:|
Human   601 LLVP----------------LLY-------------------------------DFRR------- 611

  Fly  1700 GHLRKILNGRRKLCRSCG-NVVHATGLRVPRHSVPALEEQL----------------PRLAQLMD 1747
                  :..||::.|..| :|::.|...:...::..:|..|                |.:
Human   612 ------MTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYV----- 665

  Fly  1748 MLPRKSVP-PPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCAS--- 1808
            ::.||..| .||.|..|..       .||:                       |.|.| |.:
Human   666 LVDRKFQPYKPFYYILDIT-------YGKE-----------------------DVPLS-CVNEID 699

  Fly  1809 STAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGT 1873
            :|.|.::...:|         .:||....|....:.:|.|...|.....|..:..:|...|.|.|
Human   700 TTPPPQVAYSKE---------RIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACT 755

  Fly  1874 GAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYET 1938
            ..|.:|      ..||.|.:...:|:                                ..||||
Human   756 PGGQIN------PNSGYQYKRLEECL--------------------------------PTGVYE- 781

  Fly  1939 VSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRC-NSLYHLPCAIREECVFYKNK--SVHCS 2000
                                  |::   ..||..:.| |.|......:|.:....:||  .:.|.
Human   782 ----------------------CNK---RCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCL 821

  Fly  2001 VHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLR 2065
                  ..|..|:......|..|....||.|                               .|.
Human   822 ------DDIAKGSFVCIYAGKILTDDFADKE-------------------------------GLE 849

  Fly  2066 VGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFR-I 2129
            :|:..|.|:..:  ..:|.|..       ||:                     ::|.|..:.. :
Human   850 MGDEYFANLDHI--ESVENFKE-------GYE---------------------SDAPCSSDSSGV 884

  Fly  2130 QVQD-----AGDKEPEREFRGS-----------SPSAVWQQILQ--------------------- 2157
            .::|     :|.::||.....|           |.|:||:....
Human   885 DLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSH 949

  Fly  2158 ---------------PI----------TRLRKVHKWLQL----------------FPQHISGEDL 2181
                           |:          |...||..||..                |..:..||..
Human   950 PPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGR 1014

  Fly  2182 FGLTEPAIVRILESLPGIE--------------------TLTDYRFKYGRNPLLEFPLAINPSGA 2226
            .|.:.....:...|..||:                    .:|:....||.|     |..:.|.|.
Human  1015 AGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYN-----PSPVKPEGL 1074

  Fly  2227 ARTEPK-----QRQLL---------VWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHS 2277
            .|...|     .|:|:         |.....:..:.|...|.|...:...:.........|.:.|
Human  1075 RRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISS 1139

  Fly  2278 KSS----QYKK-----MKQEWRNNVYLARSKIQGLGLYAARDIE-KHTMIIEYIGEVIRTEVSEI 2332
            .|.    :.||     ||::      :|....:|..|.:...|. |.|    .:..|.:.|.:.:
Human  1140 GSEGDDFEDKKNMTGPMKRQ------VAVKSTRGFALKSTHGIAIKST----NMASVDKGESAPV 1194

  Fly  2333 RE--KQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVD-RDVR---IIIF 2391
            |:  :|:.......|        ::||.|.|.|.||:||||:||...:.|.|| .|:|   :..|
Human  1195 RKNTRQFYDGEESCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFF 1251

  Fly  2392 AKRKIYRGEELSYDYKFDIED-ESHKIPCACGAPNCR 2427
            |.::|..|.||::||.:::.. |..::.|.|||..||
Human  1252 ASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECR 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	15/106 (14%)
		FYRN	2067..2118	CDD:461787	7/50 (14%)
		FYRC	2126..2215	CDD:197781	26/187 (14%)
		SET_KMT2C_2D	2278..2430	CDD:380948	49/167 (29%)
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147
		DUF5604	193..250	CDD:408109
		Tudor_SETDB1_rpt1	260..341	CDD:410453
		Tudor_SETDB1_rpt2	348..401	CDD:410548	1/3 (33%)
		MBD	598..673	CDD:128673	20/142 (14%)
		SET_SETDB1	675..>876	CDD:380915	59/371 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		48/330 (15%)
		SET	<1203..1292	CDD:394802	34/94 (36%)