back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and KMT2B

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	2624	Identity:	471/2624 - (17%)
Similarity:	714/2624 - (27%)	Gaps:	1172/2624 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 KQEAVVKDSTGTPTSEERAEEIG-TPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTP 779
            |||..:.|.......||..::.| ..|:|..|...|.|   .:.:.| ::.....|..|.:|..|
Human   356 KQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPA---AEKEEA-KLPPPPLTPPAPSPPPP 416

  Fly   780 NPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAP 844
            .|..:.:|                                          ..||.......|..|
Human   417 LPPPSTSP------------------------------------------PPPLCPPPPPPVSPP 439

  Fly   845 SMGK-----VRSLEDQLARPVI----------PPVPTATQAAGSSSSSGSVATS--TTTTTVASG 892
            .:..     .:..:::...||:          ||:..:.:|...::.:|...||  |.|.:.|:|
Human   440 PLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATG 504

  Fly   893 G---SSQQVATASATAL--------PV----SAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQ 942
            |   .|..||..|.|.|        ||    |:..|.||                    .:..::
Human   505 GPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTP--------------------RRFMDE 549

  Fly   943 APPPPP---------------PPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAK 992
            .||.||               ||..|:...:..|.: .|:|...  .|.:..|..|.:..|....
Human   550 DPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPR-APTPPST--PVPLPEKRRSILREPTFRW 611

  Fly   993 TLVTEATSKPAELLPPPPYEM---ATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDES 1054
            |.:|.....|....||||...   |.|..|...:.:...|..|.|..:|.....:: |...|...
Human   612 TSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLT-PPPLGAPE 675

  Fly  1055 LPEQAEPPLH---SEQGATAAG---------------------VAPH-----SGGPLVSAQWTN- 1089
            .||...||..   :|....|.|                     |:||     |.||...||...
Human   676 APEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQP 740

  Fly  1090 -NHLEGGVATTKIPFKPGEPQKRKLPMHPQL-------------------DEK------------ 1122
             ..|:..:....:|  |.:||.:..|...|:                   :||
Human   741 LQALQTQLLPQALP--PPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQL 803

  Fly  1123 -QIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQ 1186
             :|.||.:..::.|:|.:|.||        :..:|..||:.   ::..|::::.: .|:.:.:..
Human   804 FKIDQQQQQKVAASMPLSPGGQ--------MEEVAGAVKQI---SDRGPVRSEDE-SVEAKRERP 856

  Fly  1187 ATMQGHLSGQMSGQISGHAA---GQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPV 1248
            :..:..:.|.....:..|||   ||..|.:...|.   .::..|.:.:|.|......:|:
Human   857 SGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVP---RLSALPLRDRQDLATEDTSSAS----- 913

  Fly  1249 TGQGAVPIPVPTMESKAGDQRKRR-KREVQKPRRTNLNAGQAGGALKDLTGPLPA--GAMVQLA- 1309
                         |:::...|.|| |.|...|...:...|..|.........||:  |..:::|
Human   914 -------------ETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMAR 965

  Fly  1310 -GMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKR---VRKFSKVE-EDHDA 1369
             |...|...:|...|     ..:.......||          |..||:   .||..|:| ...:.
Human   966 CGHCRGCLRVQDCGS-----CVNCLDKPKFGG----------PNTKKQCCVYRKCDKIEARKMER 1015

  Fly  1370 FTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSR 1434
            ..:|..|.::.:.|                ..::.|...||........||   |||.:.:..:.
Human  1016 LAKKGRTIVKTLLP----------------WDSDESPEASPGPPGPRRGAG---AGGPREEVVAH 1061

  Fly  1435 GWP------LSR-----------HLEGLEDCDGTVLG----------RYGRVNLPGIPSLYDSER 1472
            ..|      |.|           ..:..||.|.:..|          |...:.||. |......|
Human  1062 PGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPE-PEEQSRPR 1125

  Fly  1473 FGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNP----RERLVRHIGA 1533
            ....:.::...||.|....|.:||     |.:|..|.:      |..:::|    |.|    :..
Human  1126 KPTLQPVLQLKARRRLDKDALAPG-----PFASFPNGW------TGKQKSPDGVHRVR----VDF 1175

  Fly  1534 VKDCNLETVDLVESEGVAAWATLPRLTRYPG---LILLNGNSR----------CHGRMSPVAL-- 1583
            .:||:||.|.|:....|        ||..||   ::.|...|:          |.....|..|
Human  1176 KEDCDLENVWLMGGLSV--------LTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEE 1232

  Fly  1584 PEDPLTMRFPV-----SPLLRSCG------EELRKTQQMELGMGP--LGNNNNNNYQQKNQNVIL 1635
            .|.||......     ......||      :.|.:.::......|  ||.:......:|.::.|.
Human  1233 AERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWIC 1297

  Fly  1636 ----------ALPA-------SASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMN-- 1681
                      |.|.       |...::......|....:..|..| :..||   |..|.:.|.
Human  1298 SACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICT-RCYED---NDYESKMMQCA 1358

  Fly  1682 -------------QDDEKHV---------------------DFKRPLSQVSHGHLRKILNGRRK- 1711
                         .|::..:                     .::..||....|.||::|.|...
Human  1359 QCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSS 1423

  Fly  1712 -------LCRSC---GNVVH--ATGLRVPRH--------SVPALEEQLPRLAQLMDMLPRKSVPP 1756
                   ||..|   |..:|  ..||:....        ||.:..|.:  :..||........|
Human  1424 KVVGPLLLCTQCGPDGKQLHPGPCGLQAVSQRFEDGHYKSVHSFMEDM--VGILMRHSEEGETP- 1485

  Fly  1757 PFVYFCDRACFARFKWNGKDGQAEAASL-LLQPAGG-----------SAVKSSNGDSPGSFCASS 1809
                  ||..         .||.:...| ||:.|.|           .:.:..||..|.:....|
Human  1486 ------DRRA---------GGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPS 1535

  Fly  1810 TAPAEMVV----KQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAG 1870
               .:.|.    :||||..:...|  ||:|                                 :.
Human  1536 ---LDHVYAQWRQQEPETPESGQP--PGDP---------------------------------SA 1562

  Fly  1871 AGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGV 1935
            |..|..|         .:...|||.|||..|.:.||..:....|||....::|.|:|||:||..|
Human  1563 AFQGKDP---------AAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEV 1618

  Fly  1936 YETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCS 2000
            :|...|:|.|...|:..|....|..|.:||||:.|..|.|.|.:|..||....|:|..:|.|.|.
Human  1619 FEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQ 1683

  Fly  2001 VHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDE---NRQVATVMHYSELSN 2062
            .|...                 |.|....|. ....|.|||:||.:.   .|:..|.:....::.
Human  1684 KHTDL-----------------LDGKEIVNP-DGFDVLRRVYVDFEGINFKRKFLTGLEPDAINV 1730

  Fly  2063 LLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAE------- 2120
            |  :|::...::|.|    .:.......::||||:.||.||......|||.|.|.|.|
Human  1731 L--IGSIRIDSLGTL----SDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPR 1789

  Fly  2121 ----------------------------------------------------------------- 2120

Human  1790 EEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPP 1854

  Fly  2121 ------AGCK------------------------------------------------------- 2124
                  :|.:
Human  1855 PAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPL 1919

  Fly  2125 -------------------------------------------------------PEF------- 2127
                                                                   |:|
Human  1920 APRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVS 1984

  Fly  2128 ----------------------------------------------------------------- 2127

Human  1985 GLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAP 2049

  Fly  2128 -------RIQVQD------------------------------------AGDK------------ 2137
                   ||:..|                                    |||:
Human  2050 SATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIV 2114

  Fly  2138 ----------------------------------------------------------------- 2137

Human  2115 DFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGP 2179

  Fly  2138 ----------------------------------------------------------------- 2137

Human  2180 APEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLP 2244

  Fly  2138 -------------------------EPERE---------FRGSSPSA------------------ 2150
                                     .|.|:         |.|.||.|
Human  2245 VVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASED 2309

  Fly  2151 ----------------------------------------------------------------- 2150

Human  2310 TPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPP 2374

  Fly  2151 -----------------------------------------------------------VWQQIL 2156
                                                                       .|:.::
Human  2375 DLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLI 2439

  Fly  2157 QPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAI 2221
            :.:...|...:...|....:||..|.|:...|::.:.|.|||.:....|:|:|.:....:....:
Human  2440 EKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPL 2504

  Fly  2222 NPSGAARTEPKQRQLL-----VWRKPHTQRTAG-SCSTQR---MANSAAIAGEVACPYSKQFVHS 2277
            ||.||||.|...|:..     .....|.....| :|..:.   ...|...|..:..|.:.:|.|.
Human  2505 NPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHL 2569

  Fly  2278 KSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNR 2342
            |.:..:.:      .||  ||.|.|.||:..|:|:...|:|||.|.|||:.:::.|||.|:.|..
Human  2570 KKTSKEAV------GVY--RSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGI 2626

  Fly  2343 GIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYK 2407
            |.||||:|:..|||||:.|..||:|||||.|||.:.::.|:....|:|||.|:|.|||||:||||
Human  2627 GCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYK 2691

  Fly  2408 FDIEDESHKIPCACGAPNCRKWMN 2431
            |.|||.|:|:||.|||..||:::|
Human  2692 FPIEDASNKLPCNCGAKRCRRFLN 2715

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.