DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and SETD1A

DIOPT Version :10

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens


Alignment Length:2343 Identity:437/2343 - (18%)
Similarity:701/2343 - (29%) Gaps:900/2343 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 VNAKK---LSEVTQTTAKVSIGNKTISVPLLK-----------PLMSASGAATAGGATIVESKQL 355
            ||..|   :.::......|...|:..|:|:.|           ||...:.|...........|.:
Human    49 VNDSKYIPVEDLQDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDM 113

  Fly   356 LQPGGQVTTVMSAAQQSGGQQVHPHVHSH---AHHNFTKLIKRGPKNSGTIVSFSGLQIKPANTK 417
            .:..|:|..|...        :||....|   |...||.  .||.|.:          :|..:..
Human   114 CRKYGEVEEVEIL--------LHPRTRKHLGLARVLFTS--TRGAKET----------VKNLHLT 158

  Fly   418 IVATKVVSKKMLQLQQHQQ-QIQQQQQLQQLQVTSGGGLAP---PTGSIVTITTTNPSQTYAMVQ 478
            .|...::         |.| .|:.||:::..::...|...|   |||....      |:.:   |
Human   159 SVMGNII---------HAQLDIKGQQRMKYYELIVNGSYTPQTVPTGGKAL------SEKF---Q 205

  Fly   479 DSATVGPAAH-----SEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDK 538
            .|......|.     |.|.|..|...||                 .|.|...|        |..:
Human   206 GSGAATETAESRRRSSSDTAAYPAGTTA-----------------VGTPGNGT--------PCSQ 245

  Fly   539 NT------LNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNASDLA-TTSTVSVS 596
            :|      .:.|.||..|..|               |..|||.|...::..:.|.| ::||.|.|
Human   246 DTSFSSSRQDTPSSFGQFTPQ---------------SSQGTPYTSRGSTPYSQDSAYSSSTTSTS 295

  Fly   597 AGTICINSPMMGTRPIISIQN----KNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQD 657
                     ....|...|.|:    ::.|...:.||.:    ..|..||           |....
Human   296 ---------FKPRRSENSYQDAFSRRHFSASSASTTAS----TAIAATT-----------AATAS 336

  Fly   658 SSADKAGSSANSGSATSGASMQLKLTTANTPT--------KLSVSLAPDVVKLEEVGSESKAKLL 714
            |||..:..|::|.|::|.:|.|.:.:.||.|.        :...|..|                 
Human   337 SSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPP----------------- 384

  Fly   715 VKQEAVVKDSTGTPTSEERAEEI---------GTPEKRLNANATMTAINQVQNQ----------- 759
              :.|..::..|.|.:|..||..         ..|.:..:.:....|......:           
Human   385 --RRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGG 447

  Fly   760 --SANQIQMATSTSTASNPSTPNP---TVNATPMNNQRSAAED--NALLKQ------LLQNNSSS 811
              |..:.::.||...||...:.:|   |.|.:....|.|:.:.  ..|||:      .|.:::..
Human   448 GPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512

  Fly   812 HSLNQISI-----TSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAA 871
            ...|...:     |.:.|.|.|...|.:.                          ||.|...:  
Human   513 EEENSSMVLGARDTGSEVPSGSGHGPCTP--------------------------PPAPANFE-- 549

  Fly   872 GSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSA---VAITTPGVGGEAKLEQKSDQPAA 933
             ..:.:||.....|..:..:.|.:|        |.|.|:   :.|:....||       |..||.
Human   550 -DVAPTGSGEPGATRESPKANGQNQ--------ASPCSSGDDMEISDDDRGG-------SPPPAP 598

  Fly   934 IMQNQSQNQAPPPPPPPQQQQQQQL----HQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTL 994
            ....|.....|||||||.......|    |||..|.| |..               .||      
Human   599 TPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLP-PRP---------------DGP------ 641

  Fly   995 VTEATSKPAELLPPPP-----YEMATAPISNVTISISTKQAA-----PKELQMKPKAVAMSLPME 1049
                  .|.|..||||     |:...      ::.:..:..|     |...||:.:.:.....:.
Human   642 ------PPPEYPPPPPPPPHIYDFVN------SLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLR 694

  Fly  1050 QGDESLPEQAEPPLHS-----------EQGATAAGVAPHSGGPLVSAQWTNN--HLEGGVATTKI 1101
            ||...:...|.||..:           ::.|.....|.::.|......::..  ||...:|...:
Human   695 QGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPL 759

  Fly  1102 PFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKV------QLISAIATYVK 1160
            |......::.:||.         :::||:....:|||.    ||..:|      ::.|.:...:.
Human   760 PSSSVSGEEARLPP---------REEAELAEGKTLPTA----GTVGRVLAMLVQEMKSIMQRDLN 811

  Fly  1161 KSGVPN---------------EAQPIQNQSQGQVQMQAQMQATMQ--GHL-------SGQMSGQI 1201
            :..|.|               :|:|.||.::.|.:.:.:.:..::  |.|       ||..:| |
Human   812 RKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTG-I 875

  Fly  1202 SGHAAG-------QIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVP 1259
            ...|.|       ::|:   .:|:.:     .|.:..:...:.:|:.:|               |
Human   876 EAFAFGSGLRGALRLPS---FKVKRK-----EPSEISEASEEKRPRPST---------------P 917

  Fly  1260 TMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASG 1324
            ..|.:...::::...|..:|                             ...||.....:|...|
Human   918 AEEDEDDPEQEKEAGEPGRP-----------------------------GTKPPKRDEERGKTQG 953

  Fly  1325 ---TGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHD----AFTEKLLTHIRQMQ 1382
               ....:.|.|:       .||..:||    :|......:.|||.|    ..|.|..|.:...:
Human   954 KHRKSFALDSEGE-------EASQESSS----EKDEEDDEEDEEDEDREEAVDTTKKETEVSDGE 1007

  Fly  1383 PLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLED 1447
            ..:.........:....|.|:::.....:|.||::|:.|||:........|..            
Human  1008 DEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSES------------ 1060

  Fly  1448 CDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTR-----SPSPAESPGAEKML--PMSS 1505
                              |..|.|.......|...|...|     :|:|.|.|..|::.  |::.
Human  1061 ------------------SSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107

  Fly  1506 IQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAA-WATLPRLTRYPGLILLN 1569
            :.    :||.|......|.|.           :..:..|...|..|. .|..||....|.     
Human  1108 LP----EQEASPARPAGPTEE-----------SPPSAPLRPPEPPAGPPAPAPRPDERPS----- 1152

  Fly  1570 GNSRCHGRMSPVALPEDPLTMRFPVS-----------------PLLRSCGEELRKTQQMELGMGP 1617
                     ||:.|...|...|..||                 |..:..|...||        .|
Human  1153 ---------SPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK--------AP 1200

  Fly  1618 LG-NNNNNNYQQKNQNVILALPASAS-----------------ENIAGVLRDLANLLHLA----- 1659
            .| .....|....:.:::.:.|...|                 |...|...|||.|..||     
Human  1201 RGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265

  Fly  1660 ---PALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVH 1721
               |||..  :||....:..|           :.:||...:||     ||            :.|
Human  1266 RGLPALPA--VEDSEATETSD-----------EAERPRPLLSH-----IL------------LEH 1300

  Fly  1722 ATGLRV-PRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLL 1785
            ...|.| |....|||.             |.:.||.|...|...|          |...||..::
Human  1301 NYALAVKPTPPAPALR-------------PPEPVPAPAALFSSPA----------DEVLEAPEVV 1342

  Fly  1786 LQPAGGSAVKS-----SNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCI 1845
            :..|.....:.     ..|:..|              ::|.|:|:|::.....:.....|.|:..
Human  1343 VAEAEEPKPQQLQQQREEGEEEG--------------EEEGEEEEEESSDSSSSSDGEGALRRRS 1393

  Fly  1846 VKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQAD 1910
            ::..:.........|                |.....:|..:...|:                  
Human  1394 LRSHARRRRPPPPPP----------------PPPPRAYEPRSEFEQM------------------ 1424

  Fly  1911 GPSRLLNFDVDKWVHLNCALWSNGV-YETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSR 1974
                .:.:|:          |::|: .|.:|...:.::..||                       
Human  1425 ----TILYDI----------WNSGLDSEDMSYLRLTYERLLQ----------------------- 1452

  Fly  1975 CNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHR 2039
                                                      .|:||                  
Human  1453 ------------------------------------------QTSGA------------------ 1457

  Fly  2040 RVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWC 2104
                                          .:||....:.|.:....||..              
Human  1458 ------------------------------DWLNDTHWVHHTITNLTTPKR-------------- 1478

  Fly  2105 VRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWL 2169
            .|||                       ||.    |.....||:.|..:    .||::..| .|:|
Human  1479 KRRP-----------------------QDG----PREHQTGSARSEGY----YPISKKEK-DKYL 1511

  Fly  2170 QLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQR 2234
            .:.|  :|...|.|:......|:|..                               .|:|  ||
Human  1512 DVCP--VSARQLEGVDTQGTNRVLSE-------------------------------RRSE--QR 1541

  Fly  2235 QLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSK 2299
            :||                ..:..||.:..::.          |.:|.|..|::.|    ..||:
Human  1542 RLL----------------SAIGTSAIMDSDLL----------KLNQLKFRKKKLR----FGRSR 1576

  Fly  2300 IQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMFRLDEDRVVDATLSGGL 2363
            |...||:|...|....|:|||:|:.||..|:::|||:|..:..| .|:||:|.|.::|||..|.|
Human  1577 IHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNL 1641

  Fly  2364 ARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRK 2428
            ||:|||.|.|||..:::.::...:|:|::|:.|...||::|||||.:||  :||||.||..:||.
Human  1642 ARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLED--NKIPCLCGTESCRG 1704

  Fly  2429 WMN 2431
            .:|
Human  1705 SLN 1707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 3/17 (18%)
PRK13914 <623..>851 CDD:237555 48/273 (18%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 7/104 (7%)
FYRN 2067..2118 CDD:461787 8/50 (16%)
FYRC 2126..2215 CDD:197781 17/88 (19%)
SET_KMT2C_2D 2278..2430 CDD:380948 65/152 (43%)
SETD1ANP_055527.1 Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068 60..89 5/28 (18%)
RRM_Set1A 92..186 CDD:409964 23/122 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308 37/171 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486 19/123 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655 47/220 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 79/489 (16%)
PRK12323 <1070..>1130 CDD:481241 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 8/41 (20%)
HCFC1-binding motif (HBM) 1299..1303 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 24/162 (15%)
Interaction with CFP1 1415..1450 7/66 (11%)
N-SET 1425..1562 CDD:463344 44/366 (12%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 30/278 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 11/67 (16%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 2/4 (50%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1537..1542 3/6 (50%)
SET_SETD1 1556..1703 CDD:380946 63/162 (39%)

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