DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trr and SET1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_011987.1	Gene:	SET1 / 856519	SGDID:	S000001161	Length:	1080	Species:	Saccharomyces cerevisiae

Alignment Length:	330	Identity:	103/330 - (31%)
Similarity:	154/330 - (46%)	Gaps:	74/330 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2172 FPQHISGEDL-FGLTEPAIVRILESL---------PGIETLTDYRFKYGRNPLLE---------- 2216
            :.|.:|..|| ..:.:...:.||:.|         |......:|:....|..:||
Yeast   755 YSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIE 819

  Fly  2217 -----FPLAINPSGAARTEPKQR---QLLVWRKPHTQR-----------------TAGSCSTQRM 2256
                 |...:.|..:.:.|..::   :|.:...||.:|                 |...|..:..
Yeast   820 LNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREES 884

  Fly  2257 AN---SAAIAGEVA---------------CPYSKQFVHSKS-----SQYKKMKQEWRNNVYLARS 2298
            :|   |.::..||:               ....|..:.::|     :|..|.|:.    |..|||
Yeast   885 SNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKP----VMFARS 945

  Fly  2299 KIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMFRLDEDRVVDATLSGG 2362
            .|...||||...|....|||||:||.||..|:|:|||:|.....| .|:||:||:.|:|||..||
Yeast   946 AIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGG 1010

  Fly  2363 LARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIE-DESHKIPCACGAPNC 2426
            :||:|||.|:|||..:|::|....||:|:|.|.|...|||:|||||:.| |:..::||.||||||
Yeast  1011 IARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNC 1075

  Fly  2427 RKWMN 2431
            :.::|
Yeast  1076 KGFLN 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781	10/52 (19%)
		SET	<2266..2431	CDD:225491	78/186 (42%)
		SET	2291..2413	CDD:214614	63/123 (51%)
		PostSET	2415..2431	CDD:214703	8/15 (53%)
SET1	NP_011987.1	RRM_scSet1p_like	246..360	CDD:409743
		SET_assoc	422..486	CDD:403081
		SET	612..1080	CDD:225491	102/328 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940