DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trr and SET4

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_012430.1	Gene:	SET4 / 853339	SGDID:	S000003641	Length:	560	Species:	Saccharomyces cerevisiae

Alignment Length:	403	Identity:	88/403 - (21%)
Similarity:	151/403 - (37%)	Gaps:	118/403 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2107 RPNRRCRYICSIAEAGCKPEFRIQVQDA-----------GDKEP-EREF---RGSSPSAVWQQIL 2156
            :|...|  ||..:::  |.|..||....           ...:| :|:|   |..|.:.|....:
Yeast   158 KPKNGC--ICGSSDS--KDELFIQCNKCKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQV 218

  Fly  2157 QPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIV--------RILESLPGIETLTDYRFKYGRNP 2213
            :|:           :||:.:..|.||..:  :||        :..:|:..||.....|..:...|
Yeast   219 KPM-----------IFPRKMGDERLFQFS--SIVTTSASNTNQHQQSVNNIEEQPKKRQLHYTAP 270

  Fly  2214 LLEFPLAINPSGAARTEPKQRQLLV---WRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFV 2275
            ..|      .|.:.|.:.:|.:|:|   :.||.....:.|..|:   ..|....|....|.|.|:
Yeast   271 TTE------NSNSIRKKLRQEKLVVSSHFLKPLLNEVSSSNDTE---FKAITISEYKDKYVKMFI 326

  Fly  2276 HSKSSQYKKMKQEWRN----NVYLARSKIQ-GLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREK 2335
            .:.......:...|.:    ::.:.:|..: ..|::||....|..:|.||:|::       ..:|
Yeast   327 DNHYDDDWVVCSNWESSRSADIEVRKSSNERDFGVFAADSCVKGELIQEYLGKI-------DFQK 384

  Fly  2336 QYESKNRGIY----------MFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEV-------- 2382
            .|::.....|          :|.......:|:..:|||.|||..||.||  .|:|.|
Yeast   385 NYQTDPNNDYRLMGTTKPKVLFHPHWPLYIDSRETGGLTRYIRRSCEPN--VELVTVRPLDEKPR 447

  Fly  2383 -DRDVRI--IIFAKRKIYRGEELSYDYKFDIEDESHKI--------------------------- 2417
             |.|.|:  ::.|.|.|.:|||:|.::::|:.:...:|
Yeast   448 GDNDCRVKFVLRAIRDIRKGEEISVEWQWDLRNPIWEIINASKDLDSLPDPDKFWLMGSIKTILT 512

  Fly  2418 --PCACG--APNC 2426
              .||||  ..||
Yeast   513 NCDCACGYLGHNC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589	4/10 (40%)
		FYRC	2126..2215	CDD:197781	22/111 (20%)
		SET	<2266..2431	CDD:225491	49/218 (22%)
		SET	2291..2413	CDD:214614	38/147 (26%)
		PostSET	2415..2431	CDD:214703	7/43 (16%)
SET4	NP_012430.1	SET	16..526	CDD:225491	88/403 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940