DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and Setdb1

DIOPT Version :10

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_061365.3 Gene:Setdb1 / 84505 MGIID:1934229 Length:1308 Species:Mus musculus


Alignment Length:1527 Identity:291/1527 - (19%)
Similarity:486/1527 - (31%) Gaps:533/1527 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1110 KRKLPMHPQLDEKQIQQQA---EIPIS----TSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNE 1167
            |..|..|....|.:..:..   |||..    .|:.:...|..||...:|..|:|. ::||     
Mouse   102 KLGLQYHDSSSEDEASRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAA-LRKS----- 160

  Fly  1168 AQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQ 1232
            ||.:| :....|..::..|...:|.| ||:||::|  ..|.:...|.          :..:::.:
Mouse   161 AQDVQ-KFMDAVNKKSSSQDLHKGTL-GQVSGELS--KDGDLIVSMR----------ILGKKRTK 211

  Fly  1233 QLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLT 1297
            ..|    :...|.:...|.|                   :|.:|:..     |.|::        
Mouse   212 TWH----KGTLIAIQTVGLG-------------------KKYKVKFD-----NKGKS-------- 240

  Fly  1298 GPLPAGAMVQLAGMPPGTQYIQGAASGTGHVIT--STGQGVTL-GGVGASTGASSSPMLKKRVRK 1359
              |.:|..:.....||..:...|:     .|:.  ..|..|.| .|:.|.|     |.:|.::|.
Mouse   241 --LLSGNHIAYDYHPPADKLFVGS-----RVVAKYKDGNQVWLYAGIVAET-----PNVKNKLRF 293

  Fly  1360 FSKVEEDHDAF-TEKLLTHIRQMQPL----QVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASA 1419
            ....::.:.:: |:..|..|  .:||    :.:|....|:|   |....|:....|..:..:   
Mouse   294 LIFFDDGYASYVTQSELYPI--CRPLKKTWEDIEDSSCRDF---IEEYITAYPNRPMVLLKS--- 350

  Fly  1420 GSSSAGGGKLKGGSRG-WPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGS 1483
                  |..:|....| |..||    :|:.||:::    |:      ...|.:|   ...:..||
Mouse   351 ------GQLIKTEWEGTWWKSR----VEEVDGSLV----RI------LFLDDKR---CEWIYRGS 392

  Fly  1484 ARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESE 1548
            .|           .|.|..|.:......:::....:...|....||..|.|..   .|.||. ..
Mouse   393 TR-----------LEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQ---YTQDLT-GT 442

  Fly  1549 GVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSP-----------LLRSCG 1602
            |:......|                    :.|:| |..||.:. |:||           |.:|..
Mouse   443 GIQFKPMEP--------------------LQPIA-PPAPLPIP-PLSPQAADTESLESQLAQSRK 485

  Fly  1603 EELRKTQQMELGMGPLGNNN-----------------NNNYQQKNQNVILALPASASENI----- 1645
            :..:|:.....|....|:::                 |..|:....:| .:.||||:..:     
Mouse   486 QVAKKSTSFRPGSVGSGHSSPTSSTLSENVSAGKLGINQTYRSPLASV-TSTPASAAPPVPPVPP 549

  Fly  1646 -----------AGVLRDLA--NLLHLAPA-------------------LTCKIIEDKIGNKLEDQ 1678
                       .|.|...|  .:|..|||                   .||.   .:|.....:|
Mouse   550 GPPTPPGPPAPPGPLAPPAFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCL---SRIRPMRNEQ 611

  Fly  1679 FMNQDD---EKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCG-NVVHATGLRVPRHSVPALEEQL 1739
            :..::.   ....||:|             :..||::.|..| :|::.|...:...::..:|..|
Mouse   612 YRGKNPLLVPLLYDFRR-------------MTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYL 663

  Fly  1740 ----------------PRLAQLMDMLPRKSVP-PPFVYFCDRACFARFKWNGKDGQAEAASLLLQ 1787
                            |.:     ::.||..| .||.|..|..       .||:           
Mouse   664 FETGCDFLFLEMFCLDPYV-----LVDRKFQPFKPFYYILDIT-------YGKE----------- 705

  Fly  1788 PAGGSAVKSSNGDSPGSFCAS---STAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCF 1849
                        |.|.| |.:   :|.|.::...:|         .:||....|....:.:|.|.
Mouse   706 ------------DVPLS-CVNEIDTTPPPQVAYSKE---------RIPGKGVFINTGPEFLVGCD 748

  Fly  1850 SADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCV-----FCNQRGDGQA 1909
            ..|.....|..:..:|...|.|.|..|.||      ..||.|.:...:|:     .||:|.:.. 
Mouse   749 CKDGCRDKSKCACHQLTIQATACTPGGQVN------PNSGYQYKRLEECLPTGVYECNKRCNCD- 806

  Fly  1910 DGPSRLLNFDVDKWVHLNCAL-------W--------SNGVYETV-SGALMNFQTALQAGLSQA- 1957
              |:...|..|...:.:...|       |        :.|.:..: :|.::....|.:.||... 
Mouse   807 --PNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGD 869

  Fly  1958 ---CSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATT 2019
               .:..|.  .:::.||....|  .:|.:.....|..|::.                       
Mouse   870 EYFANLDHI--ESVENFKEGYES--DVPTSSDSSGVDMKDQE----------------------- 907

  Fly  2020 GAGLGGS---------------VADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLL----- 2064
             .|..||               ..|.:.|:..|.|.....|....|     ..:|||.:.     
Mouse   908 -DGNSGSEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQ-----KENELSEMTSKDSR 966

  Fly  2065 -------RVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAG 2122
                   .|...:.::||...|...|  .||.      .||:.:..|           .|::|.|
Mouse   967 PPDLGPPHVPIPSSVSVGGCNPPSSE--ETPK------NKVASWLSC-----------NSVSEGG 1012

  Fly  2123 -----CKPEFR-----------------------IQVQDAGD-KEPEREFRGSSPSAVWQQILQP 2158
                 .:..|:                       :..:|.|| |:|::|              .|
Mouse  1013 FADSDSRSSFKTSEGGDGRAGGGRGEAERASTSGLSFKDEGDNKQPKKE--------------DP 1063

  Fly  2159 ITRLRKVHKWLQLFPQHISGEDLFGLTEP----------AIVRILESLPGIETLTDYRFKYGRNP 2213
            ..|.:        .|....|....|...|          :.:.:|:| ..:.|.|.      .||
Mouse  1064 ENRNK--------MPVVTEGSQNHGHNPPMKSEGLRRSASKMSVLQS-QRVVTSTQ------SNP 1113

  Fly  2214 --LLEFPLAINPSGAARTEPKQRQLLVWRKP---HTQRTAGSCSTQRMANSAAIAGEVACPYSKQ 2273
              :|....:....|.:.|.         |||   ||..||......:..:|.:...:        
Mouse  1114 DDILTLSSSTESEGESGTS---------RKPTAGHTSATAVDSDDIQTISSGSDGDD-------- 1161

  Fly  2274 FVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIE-KHTMIIEYIGEVIRTEVSEIRE--K 2335
            |...|:......:|       :|....:|..|.:...|. |.|    .:..|.:.|.:.:|:  :
Mouse  1162 FEDKKNLSGPTKRQ-------VAVKSTRGFALKSTHGIAIKST----NMASVDKGESAPVRKNTR 1215

  Fly  2336 QYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVD-RDVR---IIIFAKRKI 2396
            |:.......|        ::||.|.|.|.||:||||:||...:.|.|| .|:|   :..||.::|
Mouse  1216 QFYDGEESCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRI 1272

  Fly  2397 YRGEELSYDYKFDIED-ESHKIPCACGAPNCR 2427
            ..|.||::||.:::.. |..::.|.|||..||
Mouse  1273 RAGTELTWDYNYEVGSVEGKELLCCCGAIECR 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
PRK13914 <623..>851 CDD:237555
ePHD2_KMT2C_like 1898..2002 CDD:277136 21/128 (16%)
FYRN 2067..2118 CDD:461787 9/50 (18%)
FYRC 2126..2215 CDD:197781 19/124 (15%)
SET_KMT2C_2D 2278..2430 CDD:380948 46/158 (29%)
Setdb1NP_061365.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..148 4/20 (20%)
DUF5604 193..250 CDD:408109 13/106 (12%)
Tudor_SETDB1_rpt1 260..341 CDD:410453 21/95 (22%)
Tudor_SETDB1_rpt2 348..401 CDD:410548 17/89 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..424 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..571 8/39 (21%)
MBD 615..690 CDD:128673 14/92 (15%)
SET_SETDB1 692..>912 CDD:380915 52/296 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..1175 61/384 (16%)
SET <1219..1308 CDD:394802 34/94 (36%)
Blue background indicates that the domain is not in the aligned region.

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