DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and SDG29

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_200155.2	Gene:	SDG29 / 835424	AraportID:	AT5G53430	Length:	1043	Species:	Arabidopsis thaliana

Alignment Length:	1306	Identity:	268/1306 - (20%)
Similarity:	433/1306 - (33%)	Gaps:	435/1306 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1276 VQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGG 1340
            |:|.|:.|||.|.:||   |...||                          :::...|.|:..|.
plant    23 VRKKRKVNLNGGGSGG---DYYYPL--------------------------NLLGEIGAGIVPGK 58

  Fly  1341 VGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPL--------QVLEPHLN----R 1393
            .|.|...........:|....:.||:.:..:.:|::.    .||        |||....|    .
plant    59 NGFSVSLCKQVSCSPKVEVVEEEEEEEEIKSTRLVSR----PPLVKTSRGRVQVLPSRFNDSVIE 119

  Fly  1394 NFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGR 1458
            |:.   ..|::||......:...|....      |:|..      |.|...::..:.....|
plant   120 NWR---KDNKSSGEEREEEIEEEACRKE------KVKVS------SNHSLKIKQQETKFTPR--- 166

  Fly  1459 VNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNP 1523
                       :.::..|..|.|           |....:|...:....|.| :.:...:::..|
plant   167 -----------NYKYSSSSALCG-----------EIDDEDKCEEIVRYGNSF-EMKKQRYVDDEP 208

  Fly  1524 RERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPV--ALPED 1586
            |.:                    .|||......     |.| .|:.|.|   ||..|.  |:..|
plant   209 RPK--------------------KEGVYGPEDF-----YSG-DLVWGKS---GRNEPFWPAIVID 244

  Fly  1587 PLTMRFPVSP--LLRSC--------------GEELRKTQQMELGM--------------GPLGNN 1621
            |:|.    :|  :||||              .|..|....:..||              ..|...
plant   245 PMTQ----APELVLRSCIPDAACVMFFGHSGTENERDYAWVRRGMIFPFVDYVERLQEQSELRGC 305

  Fly  1622 NNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPA------LTCKIIEDKIGNK--LEDQ 1678
            |..::|...:..:||        ..|....|...:|:|..      ...:.:|:..|:.  |:..
plant   306 NPRDFQMALEEALLA--------DQGFTEKLMQDIHMAAGNQTFDDSVYRWVEEAAGSSQYLDHV 362

  Fly  1679 FMNQDDEKHVDFKRPLSQVSHG---------HLRKILNGRRKLCRSCGNVV---HATGL--RVPR 1729
            ..:||.:|   ::.|.:.|..|         .::.::.|.:.||:.|..:.   |..|:  |:..
plant   363 APSQDMKK---YRNPRACVGCGMVLSFKMAQKMKALIPGDQLLCQPCSKLTKPKHVCGICKRIWN 424

  Fly  1730 HSVPALEEQ--------LPRLAQLMDMLPRKSVPP--PFVYFCDRACFARFKWNGKDGQAEAASL 1784
            |    |:.|        ...:....|.:..|....  ...|:|. .|..:|.:...|.:
plant   425 H----LDSQSWVRCDGCKVWIHSACDQISHKHFKDLGETDYYCP-TCRTKFDFELSDSE------ 478

  Fly  1785 LLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCF 1849
              :|...|.:..:|        |....|.:::|         ....|.|  ...|:....:.||.
plant   479 --KPDSKSKLGKNN--------APMVLPDKVIV---------VCSGVEG--IYFPSLHLVVCKCG 522

  Fly  1850 SADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWET----ETSGLQLEDTRQCV---FCNQRGDG 1907
            |  |.....|.|..|      ..||:...|   |.|    ::|.|.||:....:   ..|.....
plant   523 S--CGPERKALSEWE------RHTGSKAKN---WRTSVKVKSSKLPLEEWMMKLAEFHANATAAK 576

  Fly  1908 QADGPS------RLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACH---- 1962
            ....||      |||:|..:|:..:| ..|:                      ::.|:.|.
plant   577 PPKRPSIKQRKQRLLSFLREKYEPVN-VKWT----------------------TERCAVCRWVED 618

  Fly  1963 -QPGATIKCFKSRCNSLYHLPC--------------------AIREECVFYKNKSVHCSVHGHAH 2006
             .....|.|  :||....|..|                    .|:.||..       |.|.
plant   619 WDYNKIIIC--NRCQIAVHQECYGTRNVRDFTSWVCKACETPEIKRECCL-------CPVK---- 670

  Fly  2007 AGITMGAGAGATTGAGLGGSVADNELSSLVVH-------RRVFVDRDENRQVATVMHYSELSNLL 2064
                             ||::...::.:|.||       ..|....:|..:.|.        .:|
plant   671 -----------------GGALKPTDVETLWVHVTCAWFQPEVCFASEEKMEPAL--------GIL 710

  Fly  2065 RVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYY--WCVRRPNRRCRYICSIAEAGCKPEF 2127
            .:.:..|:.: .::..|:....|.      ..|.|.||  .|..|...|....|
plant   711 SIPSSNFVKI-CVICKQIHGSCTQ------CCKCSTYYHAMCASRAGYRMELHC----------- 757

  Fly  2128 RIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRI 2192
                         .|..|                 |::.|.:.....|.:       ..|..|.|
plant   758 -------------LEKNG-----------------RQITKMVSYCSYHRA-------PNPDTVLI 785

  Fly  2193 LESLPGI---ETLTDYRFKYGRNPLL-----------EFPLAINPSGAARTEPKQRQLLVWRK-- 2241
            :::..|:   ::|...:.|.|...:|           |..:.|:|..:||....:|.:...::
plant   786 IQTPSGVFSAKSLVQNKKKSGTRLILANREEIEESAAEDTIPIDPFSSARCRLYKRTVNSKKRTK 850

  Fly  2242 ----PHTQRTAG-----SCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLAR 2297
                ||  .|.|     |.:.|.:.....:|.|   |.|......:....::.:.|   .|...|
plant   851 EEGIPH--YTGGLRHHPSAAIQTLNAFRHVAEE---PKSFSSFRERLHHLQRTEME---RVCFGR 907

  Fly  2298 SKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGG 2362
            |.|.|.||:|.|:|::..|::||.||.:|..::::||.:|..:.:..|:|::.|:.|||||..|.
plant   908 SGIHGWGLFARRNIQEGEMVLEYRGEQVRGIIADLREARYRREGKDCYLFKISEEVVVDATEKGN 972

  Fly  2363 LARYINHSCNPNCVTEIVEV-DRDVRIIIFAKRKIYRGEELSYDYKFD-IEDESHKIPCACGAPN 2425
            :||.|||||.|||...|:.| |.:.||::.||..:...|||:|||.|| .|.:..|:||.|.:||
plant   973 IARLINHSCMPNCYARIMSVGDDESRIVLIAKTTVASCEELTYDYLFDPDEPDEFKVPCLCKSPN 1037

  Fly  2426 CRKWMN 2431
            |||:||
plant  1038 CRKFMN 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	22/137 (16%)
		FYRN	2068..2118	CDD:283589	11/51 (22%)
		FYRC	2126..2215	CDD:197781	12/91 (13%)
		SET	<2266..2431	CDD:225491	66/166 (40%)
		SET	2291..2413	CDD:214614	54/123 (44%)
		PostSET	2415..2431	CDD:214703	9/15 (60%)
SDG29	NP_200155.2	PWWP	221..324	CDD:295359	26/123 (21%)
		PHD_TCF19_like	415..466	CDD:276992	9/55 (16%)
		PHD_ATX3_4_5_like	609..655	CDD:276970	8/47 (17%)
		ePHD_ATX3_4_5_like	664..775	CDD:277133	27/194 (14%)
		SET	901..1024	CDD:214614	54/125 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1076
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910