DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and setbp1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_005165732.1	Gene:	setbp1 / 796785	ZFINID:	ZDB-GENE-060526-72	Length:	1438	Species:	Danio rerio

Alignment Length:	1560	Identity:	296/1560 - (18%)
Similarity:	484/1560 - (31%)	Gaps:	502/1560 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 IKPAN-------TKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTT 468
            ||.||       .||..||...|....|:.:                    :.||.   :.||..
Zfish    88 IKEANFSEGSLKLKIQTTKRAKKPPKNLENY--------------------ICPPE---IRITIK 129

  Fly   469 NPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKS--QESTGGPEEFTN---- 527
            .|.:..:..|  |....|...|:..| |||.|  .|...|:|.|:::  .|:|...:..:|
Zfish   130 QPGEQKSAKQ--AKNAKAGKEEEKGP-PRKRT--YERPSKLLGKTENVMMENTKPKQSKSNDILH 189

  Fly   528 ------INSV---------VIKPLDKNTLNC------PPSFNIFKQQQHSQAAQSQSISAVGSGA 571
                  :::|         ..:|..|....|      |.....|.:.|..:.|...|.|..||..
Zfish   190 LDWTKKLDTVGEVGSQEQNRTEPETKKESACTNKGPLPEPSTPFLKTQVKKVADGLSGSHFGSTM 254

  Fly   572 GTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKM 636
            .:|.|..:|   ||.:.|..:.|..:.....|.. .|.:.:......||     |....::.|
Zfish   255 SSPSTDLLA---ASSVNTVMSPSTDSSLFSFNKD-RGLQQVTEQVFGNI-----KRKYGRKDP-- 308

  Fly   637 ITTTTLSSQAALQMHHAL-----IQDSSADKAGSSANSGSATSGASMQL------KLTTANTPTK 690
             |.|.:.....||....:     .|||:.:|...|.:..:........:      ..||....|.
Zfish   309 -TKTPVMHNLDLQWVKKMDRDTENQDSAKEKQPYSQDKSAFEEEPEKPINRLDDDNKTTTGCGTH 372

  Fly   691 LSVSLAPDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQ 755
            .:          ||..|:.:....|.::::|.:          |:.:...||..|.:...|.:..
Zfish   373 YT----------EESRSKKRRNRKVTEDSMVSN----------AQTVQQDEKTDNTDQGCTKLKV 417

  Fly   756 VQNQSAN-------QIQMA------TSTSTA---SNPSTPNPTVNATPM-------NNQRSAAED 797
            .:....|       .:|.:      |.|..|   .|.....|...|..|       ..::|..:|
Zfish   418 TKKTDVNAPKQFGFNLQQSKEDIAGTVTDDAEMFQNRPRKTPAGRARSMIDVDKQTEGRQSKVKD 482

  Fly   798 NAL-LKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVI 861
            ..| ||.  ||:|....|||    |..:....::.|::....:.....|:..:..::.:..||..
Zfish   483 RWLYLKS--QNSSPHKDLNQ----SLSIEEPPSAFPITPSSPLYTNTNSLTVITPVKKKRGRPKK 541

  Fly   862 PP---VPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAK 923
            .|   |.|..:...:|..|.....|:.|:.......|:.|..|...:.|...:.:
Zfish   542 QPLLTVETIHEGTATSPVSPIAHDSSNTSKRKKHNMSKLVQLAFHKSPPAQQLQL---------- 596

  Fly   924 LEQKSDQPAAI------------MQN---------QSQNQAPPPPPPPQQQQQQQLHQPQQLQPS 967
              :||||...:            |||         .|.|.||.|..|              :..:
Zfish   597 --KKSDQEGVLKKRTPTKIKEVKMQNIINELLSTSSSGNLAPKPNVP--------------VSNA 645

  Fly   968 PHQVKQTVQI-------VSKETSFISGPVAAKTLVTEATSKPAE--------LLPPPPYEMATAP 1017
            ...|..|::.       |||..:...|....:....:.:|:..|        ||...|:|....|
Zfish   646 MSTVASTIEARFGKQINVSKRGTIYIGKKRGRKPRADLSSQQDEHKASDKHSLLNSSPFENPLVP 710

  Fly  1018 ISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLH------SEQGATAAGVAP 1076
            .||   |.:|...:|:.:.      :.|.....|..:.|...:...|      :.|..:|.....
Zfish   711 SSN---SSTTGMPSPRVMH------SFSSHSAPGGAAHPVTTDTSQHDLKTMPNLQPISALPTKT 766

  Fly  1077 HSGGPLVSAQW----------TNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIP 1131
            |.|  |:|:.|          :.:||....:..::...         |:.....|:.|...:.|.
Zfish   767 HKG--LLSSNWKLSPPRLMANSPSHLSEVASIKEVTLS---------PVSESHSEETIPSDSGIG 820

  Fly  1132 ISTSLPTTPTGQGTPDK----VQLISAIATYVKKSGVPNEAQ-----------PIQN-------- 1173
            ...:..:..|.:|...:    ..|.|..||........::|.           .::|
Zfish   821 TDNNSTSDQTEKGPASRRRYSFDLCSFDATEAAIIDAKSKAARGHYQKHVTAVSVENFFAQENLK 885

  Fly  1174 -----------QSQGQVQMQAQMQATMQGHLSGQMSGQ-ISGHAAGQIPAQMHLQVQHQLHMAVH 1226
                       |||..:|..|.::..:......::|.: ...:.....|:...|...|...|..:
Zfish   886 KQKHRRKRKALQSQDDLQFMADLEELVSKFQVFRISHRNYKFYHENSYPSIFRLNFDHYYPMPYY 950

  Fly  1227 P---------QQQQQQLHQNQPQNATIPL-----------PVTGQG-----AVP---IPVPTMES 1263
            |         ...:.:..:.:|..:..|:           ||.|..     |:|   :|:.|
Zfish   951 PYDPLHYLRRSSDKSKRRRGRPAKSDEPISKMPFIQGFGCPVPGGNYYAPYAMPYTSMPLAT--- 1012

  Fly  1264 KAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPL-------PAGAMVQLAGMPPGTQYIQGA 1321
                              :.:|.|..|    ....||       |..:.:....:|| .::..||
Zfish  1013 ------------------SMINMGYYG----QYPSPLYLSHALGPTASPLMRPPVPP-PKFHPGA 1054

  Fly  1322 AS----GTGHVITSTGQGVTLGGVGASTGASSSPM----LKKRVRKFS-KVEEDHDAFTEKLLTH 1377
            :|    .:.|.:.:....::...:..|...|||.:    |.||..|.. |.:||.         :
Zfish  1055 SSCLSASSRHRVKNMPHEMSSSRMSDSHHPSSSCLGSVCLHKRKHKHKYKHKEDQ---------Y 1110

  Fly  1378 IRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMS---SAASAGSSSAGGGKLKGGSRGWPLS 1439
            |::.:.|..|                .||..|||.:|   ......|.|    |||...||
Zfish  1111 IQEREDLGGL----------------FSGTQSPAFLSLLNERLEKNSLS----KLKDKQRG---- 1151

  Fly  1440 RHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMS 1504
            :|   ..|........|..|:.....||.||:....:||                         .
Zfish  1152 KH---STDTSPKASRNYFEVDTLSSLSLSDSQHCKRTRG-------------------------E 1188

  Fly  1505 SIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLN 1569
            ::.|      |.....|.|.|||    .|.:|   :.:||                 :.|..|..
Zfish  1189 TLNN------FLNICTRQPHERL----RASQD---QPLDL-----------------FKGQHLGG 1223

  Fly  1570 GNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVI 1634
            .:|..|.|...:   ||..|.:.......:.|.||  :.:||              ||   .:..
Zfish  1224 DDSSIHIRRHSL---EDFTTYKEGSMASFQGCSEE--RAEQM--------------YQ---CSTA 1266

  Fly  1635 LALPASAS------ENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRP 1693
            :|.|:|..      |.:..|..|:......:..||.|                    |::|
Zfish  1267 VAEPSSYKRRPKLVEEVEEVQCDMRKKCAFSKILTTK--------------------KNLD---- 1307

  Fly  1694 LSQVSHGHLRKILNGRR--KLCRSCGNVVHATGLRVPRHSVPALEE----QLPRLAQLMDMLPRK 1752
                   |:.|||..:|  :..::..|:|.....| ||..:.:|||    |:|.|.:.:| ||.|
Zfish  1308 -------HVNKILKVKRLQRQAKTGNNMVKRRRGR-PRKQLLSLEEGLLGQMPVLEKCVD-LPGK 1363

Fly 1753 1752
Zfish 1364 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
setbp1	XP_005165732.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930