DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and setd1b

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_001072649.1 Gene:setd1b / 780106 XenbaseID:XB-GENE-5842344 Length:1956 Species:Xenopus tropicalis


Alignment Length:2253 Identity:466/2253 - (20%)
Similarity:734/2253 - (32%) Gaps:796/2253 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   458 PTGSIVTITTTNPSQTYAMVQD-----SATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQ- 516
            |.||.:..:.| .::|..:|:.     ...:||:.......|.... ||||.:.|...| |.|| 
 Frog   221 PVGSDLDASPT-VNETPQVVESVKRTKETAIGPSVTPNSSTPFSHD-TAYSSSRQGTPN-SYSQF 282

  Fly   517 --ESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNI-----FKQQQH--------SQAAQSQSISA 566
              :|.|.|.. ..:.:...:....::....|:|:.     ||.::|        ::......:.:
 Frog   283 TPQSQGTPHT-PRLGTPFSQDSSYSSRQTTPAFHYGQDSGFKPRRHENKFTDAYNRRPGHHYVHS 346

  Fly   567 VGSGAGTPVTF--TMASGNASDLATTSTVSVSAGTI-CINSPMMGTRPIISIQNKNISLVLSKTT 628
            .||..||..||  |........:..|..:|.|:|.. ...||..|            :.|..:|.
 Frog   347 SGSYRGTEHTFNVTRPQPEPVQVPRTPPLSHSSGNYKSAFSPYQG------------NTVFPQTD 399

  Fly   629 MAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSV 693
            .:|.           .|.:..|.:......::|     :.|.:..:.||::||      |.|.. 
 Frog   400 ESQY-----------PQTSRDMEYRRTGPQTSD-----SYSDAGCNSASLELK------PVKEK- 441

  Fly   694 SLAPDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTP--EKRLNANATMTAINQV 756
               |:.....|..|.::.|....|         ||   ||.|..|||  |..|..|:..|.|..:
 Frog   442 ---PEEPPPPEPDSTTEQKASFSQ---------TP---ERCETPGTPTLEAELQHNSLDTRIAML 491

  Fly   757 --------------QNQSANQIQM----ATSTSTASNP----------------STPNPT----V 783
                          || |.|:|:|    .:|:|:..:|                |.|:.|    :
 Frog   492 LKEQRTQLHLIAGDQN-SDNEIRMEGSPISSSSSQLSPIPPYSSGSRYQDVTPSSRPSSTGLEDI 555

  Fly   784 NATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGS-------ASASAPLSARKVINV 841
            :.||:.:.....|.......|.||:.|:..::||:.:.....|       |....|.|.:  ::.
 Frog   556 SPTPLPDSDDDDEPIPGTASLCQNSRSASPIDQINQSGRKTESLDKKELVAGDETPTSEK--MDE 618

  Fly   842 RAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATAL 906
            ..||.|:...:.|....|  .|:.:|..|..|||...||                          
 Frog   619 GHPSSGEDMEISDDEVTP--SPITSAECAITSSSVISSV-------------------------- 655

  Fly   907 PVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQV 971
                :.|..||.                      ...||||||     |.....|..|.|.|...
 Frog   656 ----IPIPPPGF----------------------PPLPPPPPP-----QPGFPMPPPLPPPPPPT 689

  Fly   972 KQTVQIVSKETSFISGPVAAKTLVTEATSKPAELL-PPPPYE---MATAPISNV--------TIS 1024
            ..:|.:...       |:.|...|     .|..:| .||||.   :....:.||        |:|
 Frog   690 HPSVTVPPP-------PLPAPPGV-----PPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMS 742

  Fly  1025 ISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTN 1089
                      .||:.:.::.   |.||      |...|.|...|.              |.|:.|
 Frog   743 ----------FQMQTQMLSR---MMQG------QGSYPYHHFMGG--------------SMQFGN 774

  Fly  1090 NHLEGGVATTKIPFKP---------GEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGT 1145
            .|          |::|         |:|    .|..|:.|             .|:|  |.|   
 Frog   775 QH----------PYRPFAISAHLTRGQP----WPPFPKFD-------------PSVP--PPG--- 807

  Fly  1146 PDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQ-MQAQMQATMQGHLSGQMSGQISGHAAGQI 1209
                        |..|...|::|     ...|.:| :..:::|.|:..|:.:|...::..|..:.
 Frog   808 ------------YEHKKEDPHKA-----TVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEW 855

  Fly  1210 PAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKR 1274
                              ..::::|.:   |:.|             ||.:.|||..|::|.:: 
 Frog   856 ------------------WDKKERLAK---QSLT-------------PVKSGESKEEDKQKTKE- 885

  Fly  1275 EVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITS------TG 1333
                                                                |:.:|      .|
 Frog   886 ----------------------------------------------------HITSSLLESWNKG 898

  Fly  1334 QGVTLGGVGAS---TGASSSPMLK---------------KRVRKFSKV-EEDHDAFTEKLLTHI- 1378
            :|:...|:|..   .||...|..|               ||:|....| :||.::..::.::.. 
 Frog   899 EGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSVDDEDEESERDRDISSTA 963

  Fly  1379 ------------RQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGK--L 1429
                        .:.:|.:.|:..............|||.....:|.......||.||...|  |
 Frog   964 SDLSKKDADAVNNRRRPARPLDSEGEEEVESEGDDGETSDKEDSSSEKEDQDDGSVSALSSKKQL 1028

  Fly  1430 KGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAES 1494
            .|...|        ..||.|....|:...:    :....|:.....||..:..|..:...|..||
 Frog  1029 YGDKEG--------DDEDDDTQSSGKEEDL----VSEEEDTTSVASSRAEMDSSDESEESSEYES 1081

  Fly  1495 PG----------AEKMLPMSSIQNDFYD--QEFSTHMERNP---RERLVRHIGAVKDCNLETVDL 1544
            ..          .|:.|.....|::..|  ||:....:|..   ||.|.......|..::|..|.
 Frog  1082 SSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDREEDFFRENLSECSSLPKAGDVELEDE 1146

  Fly  1545 VE--SEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALP-----------EDPLTMRFPVSP 1596
            ::  .|.||...|...|               |.|...:.:|           .|.:...|.| |
 Frog  1147 MQKVEEDVARQTTQETL---------------HLRKKNLDVPLVESKECKQDTLDKVEKLFAV-P 1195

  Fly  1597 LLRSCGEELRKTQQMELGMGPLGNNNNNNY-QQKNQNVIL----ALPASASENIAGVLRDLANLL 1656
            :.....:|..|        .|...|....| :.:.:.|.|    |.||:....|...|.......
 Frog  1196 MQEEVFKEHEK--------APSPMNEEEEYIELQLEPVPLVPEGAAPAAQEPVIIRPLTPTGAFG 1252

  Fly  1657 HLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVH 1721
            ...|.|  |:.|.|:...| .||..:|:|.:.  :.|              ||.....|...|..
 Frog  1253 ETGPVL--KLEEPKLQVNL-TQFATEDEELYP--RTP--------------GRDTAAHSDTEVTF 1298

  Fly  1722 ATGLRVPRHSVPAL-----EEQ--LPRLAQ-----LMDMLPRKSVPPPFVYFCDRACFARFKWNG 1774
            ..||:|...|:|.|     ||:  ||....     :..||..:.:|               :..|
 Frog  1299 QPGLKVAPSSLPFLPSHNKEEECLLPPEKHAGHLTVTKMLSEEDLP---------------RTPG 1348

  Fly  1775 KD--------GQAEAASLLL------QPAGGSAVKSSNGDSPGS-FCASSTAPA--EMVVKQEPE 1822
            :|        |::::...:.      .|..||::..::...||| |...|.:|.  ...:.:.|.
 Frog  1349 RDIVVKSSHLGKSQSTETVPATPGSDAPLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPG 1413

  Fly  1823 DEDEKTPSVPGNPTNIPAQ---RKCIV-----KCF---SADCFTTDSAPS---------GL-ELD 1866
            .:...||:.|.:.:..|..   :|..|     |.|   ::...|.:|.||         || .:|
 Frog  1414 RDFNFTPTFPESNSIFPCHPSGKKPSVDEPDEKSFKEPTSASLTMNSVPSPIPFASPPRGLPHMD 1478

  Fly  1867 GTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFC--------------------NQRGDGQADG 1911
                ...||..:.::......|...|.:..:|.|.                    .::|| ::..
 Frog  1479 ----IRLGADDLESSDTPAYLSDKLLSEESECEFTKVHLTSTDESAPSPPLPPAEKRKGD-RSKK 1538

  Fly  1912 PSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQ----AGLSQACSACHQPGATIKCFK 1972
            |.....|:.:|            .|||.|...|: :.||.    .|...|.|....|.|....|:
 Frog  1539 PLSAHEFETEK------------NYETSSAVAMS-EGALGKQMFIGQPDAVSGIKDPAAVPLDFR 1590

  Fly  1973 --SRCNSLYHLPC---------------AIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTG 2020
              |...:..|.|.               .::||....|:|....|.|.:.:...:          
 Frog  1591 NDSLSENTVHEPIIQKVPLKELENQWNEVLKEEEDITKHKKSRNSRHNNRYDEFS---------- 1645

  Fly  2021 AGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAF 2085
                 :|...|.|.   .|.:|..|.|..:                  ||.|             
 Frog  1646 -----TVPSPEFSP---PRAMFKPRSEFEE------------------MTIL------------- 1671

  Fly  2086 HTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAG-----DKEPEREFRG 2145
                  |.|        |.....:...:|:|...:       |:..||.|     |         
 Frog  1672 ------YDI--------WNGGIDDEDIKYMCITYD-------RLLQQDNGMDWLND--------- 1706

  Fly  2146 SSPSAVWQQILQPIT-----RLRKVHKWLQLFPQHISG----EDLFGLTEPAIVRIL-------E 2194
                .:|  :..|.|     :.:|....|:   :|::|    |..:.:.:...::.|       |
 Frog  1707 ----TLW--VYHPSTSVYSPKKKKRDDGLR---EHVTGCARSEGYYKIDKKDKLKYLINNRSLTE 1762

  Fly  2195 SLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRMANS 2259
            .|| |:|       .|:: :...|.|...:|:.| ..:||:||       ....|||.:..:   
 Frog  1763 ELP-IDT-------QGKS-IPAQPQASTRAGSER-RSEQRRLL-------SSFTGSCDSDLL--- 1807

  Fly  2260 AAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEV 2324
                              |.:|.|..|::.|    ..:|.|...||:|...|....|:|||:|:.
 Frog  1808 ------------------KFNQLKFRKKKLR----FCKSHIHDWGLFAMEPIIADEMVIEYVGQN 1850

  Fly  2325 IRTEVSEIREKQYESKNRG-IYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRI 2388
            ||..::::|||:||.:..| .||||:|.|.::|||..|..||:|||||||||..:::.|:...:|
 Frog  1851 IRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKI 1915

  Fly  2389 IIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            :|::|:.|...||::|||||.|||.  ||||.|||.|||..:|
 Frog  1916 VIYSKQYINVNEEITYDYKFPIEDV--KIPCLCGAENCRGTLN 1956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 28/144 (19%)
FYRN 2068..2118 CDD:283589 8/49 (16%)
FYRC 2126..2215 CDD:197781 20/109 (18%)
SET <2266..2431 CDD:225491 70/165 (42%)
SET 2291..2413 CDD:214614 54/122 (44%)
PostSET 2415..2431 CDD:214703 10/15 (67%)
setd1bNP_001072649.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
RRM_Set1B 119..211 CDD:240993
RRM <127..304 CDD:223796 21/86 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..478 64/305 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..637 30/139 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..696 13/60 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..1148 44/233 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1341..1386 7/59 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1464 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1512..1553 6/53 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1627..1655 7/45 (16%)
N-SET 1669..1807 CDD:288597 38/206 (18%)
SET <1732..1956 CDD:225491 91/267 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1766..1790 7/32 (22%)
SET 1817..1939 CDD:214614 54/125 (43%)
PostSET 1940..1956 CDD:214703 10/17 (59%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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