DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and setdb1b

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_005158070.2	Gene:	setdb1b / 768131	ZFINID:	ZDB-GENE-061013-224	Length:	1242	Species:	Danio rerio

Alignment Length:	1620	Identity:	299/1620 - (18%)
Similarity:	484/1620 - (29%)	Gaps:	608/1620 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1028 KQAAPKELQMKPKAVAMS----LPMEQG-DESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQW 1087
            :..|.|:.:...:|..::    :.::.| :..:..:.||.|..|.|.:...:          .:|
Zfish     7 RSQAQKQRRRNDRASHLNSVQCMEVDAGLNSGMEMELEPELEEELGVSLDEL----------RKW 61

  Fly  1088 TNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPT----------- 1141
            ....::...|.          ||||..:. ||.|...|::.|:....:|.:..:
Zfish    62 IEEQVDSSEAV----------QKRKADLE-QLQEWVEQREKEVADIDALCSNASESVVQCEALVK 115

  Fly  1142 -------------------GQGTPDKVQLI------SAIA-----------TYVKKSGVPNEAQP 1170
                               |:..|.:|..|      ..||           |..|...:...:..
Zfish   116 EVYSNMGLVYRESSSDDEGGKANPSEVIEIDDDDDDDVIAVGCLVPPKKSLTQAKDPALKEASAA 180

  Fly  1171 IQNQSQGQVQMQAQ-MQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQL 1234
            :|..|| |||..|| :..|.|   ||..:...:|...||.|            :|| |.......
Zfish   181 LQRTSQ-QVQNLAQTVNRTAQ---SGVTTPVKTGGPPGQGP------------LAV-PAVFMSSA 228

  Fly  1235 HQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALK----- 1294
            .:|.|   |.|.|...|.::.|.:..:         .:||.....|.|.:...|.|..||
Zfish   229 PRNTP---TQPNPNIKQDSIKINMTLL---------GKKRTKTWHRGTLVAIKQVGNNLKYKVRF 281

  Fly  1295 -DLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVIT--STGQGVTL-GGVGASTGASSS----- 1350
             :....|.:|..|.....|...:...||     .|:.  ..|..|.| .||.|....|.:
Zfish   282 ENKGKSLLSGNHVAFEYHPTLERLFVGA-----RVVARYKDGNQVWLYAGVVAEMPNSKNRMRFL 341

  Fly  1351 -------------PMLKKRVRKFSKVEED-HDA----FTEKLLTHIRQ-----MQPLQV------ 1386
                         |.|....|...|..|| .||    |.|:.:|....     ::|.|:
Zfish   342 IFFDDGYASYVGLPELYPICRPLKKTWEDIEDASCRDFIEEYITSYPNRPMVLLKPGQIIKTEWE 406

  Fly  1387 -----------------------------------LEPHLNRNFHFL----------------IG 1400
                                               |||..|...:..                :|
Zfish   407 GTWWKSRVEEVDGSLVKMLFLDDKRSEWIYRGSTRLEPMFNLKMNTANSQEKKMAGQQRQRPNMG 471

  Fly  1401 SNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIP 1465
            :..|.|   |....::.::.::|.|||....|:...|::....|                 |..|
Zfish   472 ALRTKG---PVVQYTSDNSAAASTGGGAATPGTPTRPVAPQPAG-----------------PPQP 516

  Fly  1466 SLYDSERFGGSRGLVGGSARTRSPS-----PAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRE 1525
            |                  ||.|||     ..:|.|...:.|...:.:|...:.....::.|...
Zfish   517 S------------------RTESPSFKSQMAKKSTGQLALQPRQGMPSDLQPKPIINALQTNTSR 563

  Fly  1526 RLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDP--- 1587
            ..:...|.|.                   ||..:|..|..:....::..:.|     :|::|
Zfish   564 LFLLQSGPVH-------------------TLTPITPAPQTVQTAISTYTNER-----VPQEPSYQ 604

  Fly  1588 ------LTMRFPVSPLLRSCGEELRKTQ-QMELGMGPL------------GNNNNNNYQQKNQNV 1633
                  ..:....||   .|.:.:|.|: .:..|..||            |....|  ::.:.:|
Zfish   605 APNDRLFYLTHNCSP---ECLKRIRPTRPNLHRGRNPLLTPLLYEFRRMTGRRRLN--RKMSFHV 664

  Fly  1634 ILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLE----DQFMNQDDEKHVDFKRPL 1694
            |...|...|      ||::..:........|..|      .||    |.::..|  :....:||.
Zfish   665 IYKSPCGLS------LRNMTEIQRYLFQTQCDFI------FLEMFCLDPYVLVD--RRFQPQRPF 715

  Fly  1695 SQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFV 1759
            .     .:|.|.:||..:..||.|.:..|    |..||...:|::|.....:      :....|:
Zfish   716 Y-----FIRDITSGREDIPLSCVNEIDNT----PPPSVAYSKERIPEDGVYI------NTSADFL 765

  Fly  1760 YFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDE 1824
            ..||.....|.|     .:.....|.||         :.|.:||.
Zfish   766 VGCDCTDGCRDK-----SKCSCHQLTLQ---------ATGCTPGG-------------------- 796

  Fly  1825 DEKTPSVPGN--------PTNI-PAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNN 1880
             :..|:...:        ||.| ...::|  :|....| |......||:             |..
Zfish   797 -QINPNAGYHYKRLDECLPTGIYECNKRC--RCNMQMC-TNRLVQHGLQ-------------VRL 844

  Fly  1881 TVWETETSGLQ---LEDTRQ----CVFCNQ-RGDGQAD------GPSRLLNFDVDKWVHLNCALW 1931
            .:::|:..|..   |:|..:    |::..: ..|..||      |.....|.|     |:
Zfish   845 QLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLD-----HI----- 899

  Fly  1932 SNGVYETVSGALMNFQTALQAGLSQA-CSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNK 1995
                 |:|.    ||:...:   |:| ||.....|..:...|        ||.:.|
Zfish   900 -----ESVE----NFKEGYE---SEAHCSDSEGSGVDMSRVK--------LPASSR--------- 935

  Fly  1996 SVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSEL 2060
                  ||.::   .|.....:|||.....|..:::...         |.|.|..      .|:.
Zfish   936 ------HGKSN---KMEERNSSTTGKSQDDSSEESDDEK---------DDDSNED------DSDS 976

  Fly  2061 SNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKP 2125
            |      :.||:.         :.::|...::       |.|...|:..            |.|.
Zfish   977 S------DDTFVK---------DTYYTTSSVW-------RSYTTRRQAK------------GLKE 1007

  Fly  2126 EFR-----IQVQDAGDKEPER--EFRGSSPSAVW--QQILQPITRLRKVHKWLQLFPQHISGEDL 2181
            |.:     :.|....|::|..  |..|.|..|.|  .|......:..||...::
Zfish  1008 ESQDSKDGMSVSAGEDRKPPHMPEETGKSKVASWLTNQSSTSANQSVKVEGGIK----------- 1061

  Fly  2182 FGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQR 2246
               ||...|..|.....::|::                  :.|...:...|:.|.:|.|:...:.
Zfish  1062 ---TEKKDVMTLSDSDDVQTIS------------------SGSDDNKEREKKTQAVVKRQVAVKS 1105

  Fly  2247 TAG----SCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYA 2307
            |.|    |.|....:......|..:.|                              ..|.|...
Zfish  1106 TRGIALKSHSMMVKSGGGGAGGGGSGP------------------------------SHGHGGGG 1140

  Fly  2308 ARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCN 2372
            ..:..|:|.:. :.||          |..|                ::||.|.|.|.||:||||:
Zfish  1141 GDNGPKNTRLF-FDGE----------ESCY----------------IIDAKLEGNLGRYLNHSCS 1178

  Fly  2373 PNCVTEIVEVD-RDVR---IIIFAKRKIYRGEELSYDYKFDIED-ESHKIPCACGAPNCR 2427
            ||...:.|.|| .|:|   :..||.::|..|.||::||.:::.. |..::.|.||:..||
Zfish  1179 PNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGSTECR 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	21/111 (19%)
		FYRN	2068..2118	CDD:283589	6/49 (12%)
		FYRC	2126..2215	CDD:197781	17/97 (18%)
		SET	<2266..2431	CDD:225491	41/167 (25%)
		SET	2291..2413	CDD:214614	34/126 (27%)
		PostSET	2415..2431	CDD:214703	5/13 (38%)
setdb1b	XP_005158070.2	TUDOR	305..364	CDD:295375	13/63 (21%)
		TUDOR	395..446	CDD:197660	5/50 (10%)
		HMT_MBD	638..699	CDD:238689	14/74 (19%)
		Pre-SET	721..834	CDD:282838	31/160 (19%)
		SET	842..>905	CDD:214614	15/81 (19%)
		SET	<1142..1219	CDD:214614	32/103 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930