back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Kmt2b

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001277502.1	Gene:	Kmt2b / 75410	MGIID:	109565	Length:	2722	Species:	Mus musculus

Alignment Length:	2700	Identity:	479/2700 - (17%)
Similarity:	725/2700 - (26%)	Gaps:	1238/2700 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 QDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKAKLLVKQEAV 720
            ||:...|.|.....||.......                      ||||...|.:.:...|:|
Mouse   337 QDAPQRKDGDEPERGSCRKKQEQ----------------------KLEEEEEEEEKEGEEKEE-- 377

  Fly   721 VKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNA 785
             ||.......:|..||            |..|:.:.:...|.:.:.|...|....|..|:|....
Mouse   378 -KDDNEDNNKQEEEEE------------TERAVAEEEAMLAKEKEEAKLPSPPLTPPVPSPPPPL 429

  Fly   786 TPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPSMGKVR 850
            .|.:                              ||....::....|:|....::  .|......
Mouse   430 PPPS------------------------------TSPPPPASPLPPPVSPPPPLS--PPPYPAPE 462

  Fly   851 SLED-----------QLARPVIPPVPTATQAAGSSSSSGSVA--TSTTTTTVASGGSSQQVATAS 902
            ..|:           :..||.:.|...|.:.|..|...|:::  .:.:|||.:....|..|...|
Mouse   463 KQEESPPLVPATCSRKRGRPPLTPSQRAEREAARSGPEGTLSPTPNPSTTTGSPLEDSPTVVPKS 527

  Fly   903 ATAL--------PV----SAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPP------- 948
            .|.|        ||    |:..|.||                    .:..::.||.||
Mouse   528 TTFLKNIRQFIMPVVSARSSRVIKTP--------------------RRFMDEDPPKPPKVEASIV 572

  Fly   949 -------PPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELL 1006
                   ||..|:...:..|.:: |:|...  .|.:..|..|.:..|....|.:|.      ||.
Mouse   573 RPPVATSPPAPQEPVPVSSPPRV-PTPPST--PVPLPEKRRSILREPTFRWTSLTR------ELP 628

  Fly  1007 PPPPY-------EMATAPISNVTISISTKQAAPKELQMKPKAVAMSLP----MEQGDESLPEQAE 1060
            ||||.       ..|.|..|...:.:...|..|.|..:|.....::.|    :|..:..||...:
Mouse   629 PPPPAPPPAPSPPPAPATPSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGALETPEPELPPADD 693

  Fly  1061 PPLHSEQGATA-------------------AGVAPHSGGPLVSAQWTNNHLEG----------GV 1096
            .|...|..|..                   ..|.|| |.|.:|        ||          .:
Mouse   694 SPAEPEPRAVGRTNHLSLPRFVPVVTSPVKVEVPPH-GAPALS--------EGQQLQLQQPPQAL 749

  Fly  1097 ATTKIP--FKPGEPQKRKLPMHPQ--------------------LDEK-------------QIQQ 1126
            .|..:|  ..|.:||.:. |..||                    ::||             :|.|
Mouse   750 QTQLLPQALPPQQPQAQP-PPSPQHTPPLEKARVASLGSLPLSGVEEKMFSLLKRAKVQLFKIDQ 813

  Fly  1127 QAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQG 1191
            |.:..::.|:|.:|.       ||...|:.| ||           |...:|.|:.:.:.....:.
Mouse   814 QQQQKVAASMPLSPA-------VQTEEAVGT-VK-----------QTPDRGCVRSEDESMEAKRD 859

  Fly  1192 HLSGQMSGQISGHAAGQIPAQMHLQVQHQL-HMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVP 1255
            ..||..|           |.| ..:::|.. |.||...|.:..:.::.|:.:.:||......|..
Mouse   860 RASGPES-----------PLQ-GPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATE 912

  Fly  1256 IPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMP----PGTQ 1316
            ......|:::...|.:|:: |:       :||..|.:       .|.|:...||..|    |...
Mouse   913 DTSSASETESVPSRSQREK-VE-------SAGPGGDS-------EPTGSTGALAHTPRRSLPSHH 962

  Fly  1317 YIQGAASGTGHV-----ITSTGQGVT------LGGVGASTGASSSPMLKKR---VRKFSKVE-ED 1366
            ..:...:..||.     :...|..|.      .||          |..||:   .||..|:| ..
Mouse   963 GKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGG----------PNTKKQCCVYRKCDKIEARK 1017

  Fly  1367 HDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKG 1431
            .:...:|..|.::.:.|                ..::.|...||........||   |||.:.:.
Mouse  1018 MERLAKKGRTIVKTLLP----------------WDSDESPEASPGPPGPRRGAG---AGGSREEV 1063

  Fly  1432 GSRGWP-------LSR-----------HLEGLEDCDGTVLG-------RYGRVN-LPGI-PSLYD 1469
            |:...|       |.|           ..:..||.|.:..|       |..|.: ||.: |....
Mouse  1064 GATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQS 1128

  Fly  1470 SERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNP----RERLVRH 1530
            ..|....:.::...||.|....|.:||     |.:|..|.:      |..:::|    |.|
Mouse  1129 RPRKPTLQPVLQLKARRRLDKDALAPG-----PFASFPNGW------TGKQKSPDGVHRVR---- 1178

  Fly  1531 IGAVKDCNLETVDLVESEGVAAWATLPRLTRYPG---LILLNGNSR----------CHGRMSPVA 1582
            :...:||:||.|.|:....|        ||..||   ::.|...|:          |.....|..
Mouse  1179 VDFKEDCDLENVWLMGGLSV--------LTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFC 1235

  Fly  1583 LPEDPLTMRFPVSPLLRS------------CG------EELRKTQQMELGMGP--LGNNNNNNYQ 1627
            |.|....     ||..|.            ||      :.|.:.::......|  ||.:......
Mouse  1236 LEEAERP-----SPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRAT 1295

  Fly  1628 QKNQNVIL----------ALPA-------SASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKL 1675
            ::.::.|.          |.|.       |...::.....:|....:..|..| :..||   |..
Mouse  1296 RRRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICT-RCYED---NDY 1356

  Fly  1676 EDQFMN---------------QDDEKHV---------------------DFKRPLSQVSHGHLRK 1704
            |.:.|.               .|::..:                     .::..||....|.||:
Mouse  1357 ESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQPRWREALSGALQGGLRQ 1421

  Fly  1705 ILNGRRK--------LCRSCGN----------VVHATGLR-------------------VPRHSV 1732
            :|.|...        ||..||.          .:.|.|.|                   :.|||.
Mouse  1422 VLQGLLSSKVAGPLLLCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFMEDVVAILMRHSE 1486

  Fly  1733 PALEEQLP--RLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVK 1795
               |.:.|  |....|..|..|.:...|.:|           :..|.:....|..|
Mouse  1487 ---EGETPERRAGSQMKGLLLKLLESAFCWF-----------DAHDPKYWRRSTRL--------- 1528

  Fly  1796 SSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAP 1860
             .||..|.:....|........:|: |.|..::...||:|              ||...:.|.|.
Mouse  1529 -PNGVLPNAVLPPSLDHVYAQWRQQ-ESETPESGQPPGDP--------------SAAFQSKDPAA 1577

  Fly  1861 SGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVH 1925
            ..                            .|:|.|||..|.:.||..:....|||....::|.|
Mouse  1578 FS----------------------------HLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTH 1614

  Fly  1926 LNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECV 1990
            :|||:||..|:|...|:|.|...|:..|....|..|.:||||:.|..|.|.|.:|..||....|:
Mouse  1615 VNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCI 1679

  Fly  1991 FYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDE---NRQVA 2052
            |..:|.|.|..|      ..:..|....|..|..            |.|||:||.:.   .|:..
Mouse  1680 FQDDKKVFCQKH------TDLLDGKEIVTPDGFD------------VLRRVYVDFEGINFKRKFL 1726

  Fly  2053 TVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICS 2117
            |.:. .::.|:| :|::...::|.|    .:.......::||||:.||.||......|||.|.|.
Mouse  1727 TGLE-PDVINVL-IGSIRINSLGTL----SDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCR 1785

  Fly  2118 IAE-------------------------------------------------------------- 2120
            |.|
Mouse  1786 ILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSEPPNHDDLPDTDSLIPGDPVHHSPIQNLDPPL 1850

  Fly  2121 ---------------AGCK---------------------------------------------- 2124
                           :|.:
Mouse  1851 RTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFPAPP 1915

  Fly  2125 ----------------------------------------------------------------P 2125
                                                                            |
Mouse  1916 RRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDLAPSPLPPSEDLGP 1980

  Fly  2126 EF--------------------------------------------------------------- 2127
            :|
Mouse  1981 DFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGGPGDSSEEEASPTTHYVHFPVT 2045

  Fly  2128 ----------------RIQVQD------------------------------------AGDK--- 2137
                            ||:..|                                    |||:
Mouse  2046 VVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVGRGGVLGAAGDRAQP 2110

  Fly  2138 ----------------------------------------------------------------- 2137

Mouse  2111 PEDLPSEIVDFVLKNLGGPGEGAAGPREDSLPSAPPLANGSQPPQSLSTSPADPTRTFAWLPGAP 2175

  Fly  2138 ----------------------------------------------------------------- 2137

Mouse  2176 GVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVAPPVKQPPLPPIIPPTAPTSWTLP 2240

  Fly  2138 ------------------------------------EPERE---------FRGSSP--------- 2148
                                                .|.|:         |.|.||
Mouse  2241 PGPLLSVLPVVGVGVVRPAPPPPPPPLTLVFSSGPPSPPRQAIRVKRVSTFSGRSPPVPPPNKTP 2305

  Fly  2149 ----------------------------------------------------------------- 2148

Mouse  2306 RLDEDGESLEDAHHVPGISGSGFSRVRMKTPTVRGVLDLNNPGEQPEEESPGRPQDRCPLLPLAE 2370

  Fly  2149 ----------------------------------------------------------------- 2148

Mouse  2371 APSQALDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRVGPHLRFEISSDDGFSVEA 2435

  Fly  2149 ---SAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYG 2210
               ...|:.:::.:...|...:...|....:||..|.|:...|::.:.|.|||.:....|:|:|.
Mouse  2436 ESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYH 2500

  Fly  2211 RNPLLEFPLAINPSGAARTEPKQRQLL-----VWRKPHTQRTAG-SCSTQR---MANSAAIAGEV 2266
            :....:....:||.||||.|...|:..     .....|.....| :|..:.   ...|...|..:
Mouse  2501 QQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSL 2565

  Fly  2267 ACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSE 2331
            ..|.:.:|.|.|.:..:.:      .||  ||.|.|.||:..|:|:...|:|||.|.|||:.:::
Mouse  2566 ELPMAMRFRHLKKTSKEAV------GVY--RSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTD 2622

  Fly  2332 IREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKI 2396
            .|||.|:.|..|.||||:|:..|||||:.|..||:|||||.|||.:.::.|:....|:|||.|:|
Mouse  2623 KREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRI 2687

  Fly  2397 YRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            .|||||:|||||.|||.|:|:||.|||..||:::|
Mouse  2688 LRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2722

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.