back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and NSD2

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens

Alignment Length:	1564	Identity:	298/1564 - (19%)
Similarity:	487/1564 - (31%)	Gaps:	526/1564 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1023 ISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQW 1087
            :..|.|| :|..:|...|.:.|            :||...|.|..|.|.:..........:|...
Human     1 MEFSIKQ-SPLSVQSVVKCIKM------------KQAPEILGSANGKTPSCEVNRECSVFLSKAQ 52

  Fly  1088 TNNHLEGGV-----ATTKIPFKPGEPQK----RKLPMHPQLDEKQI--QQQAEIPISTSLPTTPT 1141
            .::.|:.||     ....:||.|.:..|    |.....|...:.::  :.|....|.|...|||.
Human    53 LSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPI 117

  Fly  1142 GQGTPD-KVQLISAIATYVKKSGVP---------NEAQPIQNQSQGQ-------------VQMQA 1183
            ..|:|: |:::..   ||:  :|.|         :.|...|::..||             ::..:
Human   118 KNGSPEIKLKITK---TYM--NGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS 177

  Fly  1184 QMQATMQGHLSGQMSGQISGHAAGQIPAQM-----------HL---------------------- 1215
            .::   ||.:...:..:||..:..:|||:.           ||
Human   178 LLE---QGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCM 239

  Fly  1216 -QVQHQLHMAVHPQQQQQQLHQ-------NQPQNATI----PLPVTGQGAVPIPVPTMESKAGDQ 1268
             .....||.....:.|::...|       :.|:.|.|    .:...|:|       ..|....:.
Human   240 VSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEG-------QFEKLCQES 297

  Fly  1269 RKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTG 1333
            .|:...:.:|.:           .||.::|.|.|             |:
Human   298 AKQAPTKAEKIK-----------LLKPISGKLRA-------------QW---------------- 322

  Fly  1334 QGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFT-----EKLLTHIRQMQPLQVLEPHLNR 1393
               .:|.|.|...||.|            |||....||     ::|               |||.
Human   323 ---EMGIVQAEEAASMS------------VEERKAKFTFLYVGDQL---------------HLNP 357

  Fly  1394 NFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGR 1458
            .    :.........|...|:.::.....:|...|              ...|:|
Human   358 Q----VAKEAGIAAESLGEMAESSGVSEEAAENPK--------------SVREEC---------- 394

  Fly  1459 VNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAES----PGAEKMLPMSSIQNDFYDQEFSTHM 1519
                 ||              :....|.:..|.||:    |...|..|..:.:.|
Human   395 -----IP--------------MKRRRRAKLCSSAETLESHPDIGKSTPQKTAEAD---------- 430

  Fly  1520 ERNPRERLVRHIGAVKDCNLETVDLVES-EGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVAL 1583
               ||    |.:|:.......||.:..| :|.||...|....::
Human   431 ---PR----RGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKH--------------------- 467

  Fly  1584 PEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASE---NI 1645
             .|.:....|     .:.|||:.:..:.:..:  |.......|   |....|..|..|.|   |:
Human   468 -RDEVVAEHP-----DASGEEIEELLRSQWSL--LSEKQRARY---NTKFALVAPVQAEEDSGNV 521

  Fly  1646 AGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRR 1710
            .|..|:     |      .|.|:|.           .:|.:..|..|...:.....|||......
Human   522 NGKKRN-----H------TKRIQDP-----------TEDAEAEDTPRKRLRTDKHSLRKRDTITD 564

  Fly  1711 KLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGK 1775
            |..|:              .|..|:|    ..:.|......|::        ..||....|.|..
Human   565 KTART--------------SSYKAME----AASSLKSQAATKNL--------SDACKPLKKRNRA 603

  Fly  1776 DGQAEAASLLLQPAGGSAVKSSN--GDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNI 1838
            ...|.:|....:.:..||..:.|  .||||.      .|:|...:...|.:.|.:.|...:...:
Human   604 STAASSALGFSKSSSPSASLTENEVSDSPGD------EPSESPYESADETQTEVSVSSKKSERGV 662

  Fly  1839 PAQRKCIVKCFSADCFTTDSAPSGLELDG-TAGA------GTGAGPVNNTVWETETSGLQLEDTR 1896
            .|:::.:       |...:...|.|..:| ..||      |....|..........||:     .
Human   663 TAKKEYV-------CQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGI-----H 715

  Fly  1897 QCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCA-LWSNGVYETVSGALMNFQTALQAGLSQACSA 1960
            .|..|.   :.:.| ..|.:.....|:.|..|. .:...|:|:     ..|:..|     .:|.:
Human   716 SCFVCK---ESKTD-VKRCVVTQCGKFYHEACVKKYPLTVFES-----RGFRCPL-----HSCVS 766

  Fly  1961 CH---------QPGATIKCFKSRCNSLYHL-PCAIREECVFYKNKSVHCSVH--------GHAHA 2007
            ||         ..|..::|.  ||...||. ...:...|....:.|:.|:.|        .|||.
Human   767 CHASNPSNPRPSKGKMMRCV--RCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHV 829

  Fly  2008 GITMGAGAGATTGAGLGGSVADNELSSLVVHRRVF-VDRDENR------QVATVMHYSELSNLLR 2065
            .::.      ......|||:...|......|.... ::..:..      :....:|:.::. .::
Human   830 NVSW------CFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDII-WVK 887

  Fly  2066 VGNMTFL------------NVGQLLPHQLEAFHTPHYIYPIGYKVSR-YYWC------------- 2104
            :||..:.            |: |.:.|::..|       |:.:..|: |||.
Human   888 LGNYRWWPAEVCHPKNVPPNI-QKMKHEIGEF-------PVFFFGSKDYYWTHQARVFPYMEGDR 944

  Fly  2105 ------VRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLR 2163
                  ||...|..:.....|||..: |.::|.:....:|.||:      ...::.|     ::.
Human   945 GSRYQGVRGIGRVFKNALQEAEARFR-EIKLQREARETQESERK------PPPYKHI-----KVN 997

  Fly  2164 KVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAAR 2228
            |.:..:|::...||                 .:|          |....|..|     ||.| ..
Human   998 KPYGKVQIYTADIS-----------------EIP----------KCNCKPTDE-----NPCG-FD 1029

  Fly  2229 TEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNV 2293
            :|...|.|:....|........|..|             |...:|:..:|
Human  1030 SECLNRMLMFECHPQVCPAGEFCQNQ-------------CFTKRQYPETK--------------- 1066

  Fly  2294 YLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQ-YESKNRGIYMFRLDEDRVVDA 2357
             :.::..:|.||.|.|||.|...:.||:||:|..|....|.|. :|:.....||..:|:||::||
Human  1067 -IIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDA 1130

  Fly  2358 TLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACG 2422
            ...|..:|::||||.|||.|....|:.|.|:.:||...|..|.||:::|..|... :.|..|.||
Human  1131 GPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG-NEKTVCRCG 1194

  Fly  2423 APNC 2426
            |.||
Human  1195 ASNC 1198

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.