DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Setdb1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_006232975.1	Gene:	Setdb1 / 689883	RGDID:	1308370	Length:	1322	Species:	Rattus norvegicus

Alignment Length:	1524	Identity:	288/1524 - (18%)
Similarity:	475/1524 - (31%)	Gaps:	533/1524 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1110 KRKLPMHPQLDEKQIQQQA---EIPIS----TSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNE 1167
            |..|..|....:.:..|..   |||..    .|:.:...|..||...:|..|:|. ::||
  Rat   122 KLGLQYHDSSSDDEASQPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAA-LRKS----- 180

  Fly  1168 AQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQ 1232
            ||.:| :....|..::..|...:|.| ||:||::|  ..|.:...|.          :..:::.:
  Rat   181 AQDVQ-KFMDAVNKKSSSQDLHKGTL-GQVSGELS--KDGDLIVSMR----------ILGKKRTK 231

  Fly  1233 QLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLT 1297
            ..|    :...|.:...|.|                   :|.:|:..     |.|::
  Rat   232 TWH----KGTLIAIQTVGLG-------------------KKYKVKFD-----NKGKS-------- 260

  Fly  1298 GPLPAGAMVQLAGMPPGTQYIQGAASGTGHVIT--STGQGVTL-GGVGASTGASSSPMLKKRVRK 1359
              |.:|..:.....||..:...|:     .|:.  ..|..|.| .|:.|.|     |.:|.::|.
  Rat   261 --LLSGNHIAYDYHPPADKLFVGS-----RVVAKYKDGNQVWLYAGIVAET-----PNVKNKLRF 313

  Fly  1360 FSKVEEDHDAF-TEKLLTHIRQMQPL----QVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASA 1419
            ....::.:.:: |:..|..|  .:||    :.:|....|:|   |....|:....|..:..:
  Rat   314 LIFFDDGYASYVTQSELYPI--CRPLKKTWEDIEDSSCRDF---IEEYITAYPNRPMVLLKS--- 370

  Fly  1420 GSSSAGGGKLKGGSRG-WPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGS 1483
                  |..:|....| |..||    :|:.||:::    |:      ...|.:|   ...:..||
  Rat   371 ------GQLIKTEWEGTWWKSR----VEEVDGSLV----RI------LFLDDKR---CEWIYRGS 412

  Fly  1484 ARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESE 1548
            .|           .|.|..|.:......:::....:...|....||..|.|..   .|.||. |.
  Rat   413 TR-----------LEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQ---YTQDLT-ST 462

  Fly  1549 GVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSP-----------LLRSCG 1602
            |:......|                    :.|: :|..||.| .|:||           |.:|..
  Rat   463 GIQFKPMEP--------------------LQPI-VPPAPLPM-LPLSPQAGDSESLESQLAQSRK 505

  Fly  1603 EELRKTQQMELGMGPLGNNN-----------------NNNYQQKNQNVI---------------- 1634
            :..:|:.....|....|:::                 |..|:..:.:|.
  Rat   506 QVAKKSTSFRPGSVSSGHSSPTSPTLSENVPPGKIGMNQTYRSPSASVTSTPAPAAPSGPPAPPG 570

  Fly  1635 -LALP--------------ASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDD 1684
             ||.|              |.|..:....:..|..|.|:. :.||.   .:|.....:|:..::.
  Rat   571 PLAPPGPPAPPAFHGMLERAPAEPSYRAPMEKLFYLPHVC-SYTCL---SRIRPMRNEQYRGKNP 631

  Fly  1685 ---EKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCG-NVVHATGLRVPRHSVPALEEQL------ 1739
               ....||:|             :..||::.|..| :|::.|...:...::..:|..|
  Rat   632 LLVPLLYDFRR-------------MTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCD 683

  Fly  1740 ----------PRLAQLMDMLPRKSVP-PPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSA 1793
                      |.:     ::.||..| .||.|..|..       .||:
  Rat   684 FLYLEMFCLDPYV-----LVDRKFQPFKPFYYILDIT-------YGKE----------------- 719

  Fly  1794 VKSSNGDSPGSFCAS---STAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFT 1855
                  |.|.| |.:   :|.|.::...:|         .:||....|....:.:|.|...|...
  Rat   720 ------DVPLS-CVNEIDTTPPPQVAYSKE---------RIPGKGVFINTGPEFLVGCDCKDGCR 768

  Fly  1856 TDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDV 1920
            ..|..:..:|...|.|.|..|.:|      .:||.|.:...:|:
  Rat   769 DKSKCACHQLTVQATACTPGGQIN------PSSGYQHKRLEECL--------------------- 806

  Fly  1921 DKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRC-NSLYHLPCA 1984
                       ..||||                       |::   ..||..:.| |.|......
  Rat   807 -----------PTGVYE-----------------------CNK---RCKCDPNMCTNRLVQHGLQ 834

  Fly  1985 IREECVFYKNK--SVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDE 2047
            :|.:....:||  .:.|.      ..|..|:......|..|....||.|  .|.:....|.:.|
  Rat   835 VRLQLFKTQNKGWGIRCL------DDIAKGSFVCIYAGKILTDDFADKE--GLEMGDEYFANLD- 890

  Fly  2048 NRQVATVMHYSE----------LSNLLRVGNMTFLNVGQLLPHQL------------EAFHTPHY 2090
              .:.:|.::.|          .|:.:.:.:....|.|...|.:.            |.|.|.
  Rat   891 --HIESVENFKEGYESDVPSSSDSSGVDMKDQEDGNSGSEDPEESNDDSSDDNFCKDEDFSTS-- 951

  Fly  2091 IYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPER-----------EFR 2144
                  .|.|.| ..||..|           |.|.....:|.....:.|:|           ...
  Rat   952 ------SVWRSY-ATRRQTR-----------GQKESELSEVTSKDSRAPDRGPPHVPITPSGSVG 998

  Fly  2145 GSSPSAVWQQILQPITRLRKVHKWLQL----------------FPQHISGEDLF----GLTEPAI 2189
            |.:|.:..:      |...||..||..                |.....|:...    |..|.|.
  Rat   999 GCNPPSSEE------TPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDGRAGGGRGEAERAS 1057

  Fly  2190 VRIL----------------ESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLV 2238
            ...|                |....:..:|:....:|.||.::......|  |::....|.|.:|
  Rat  1058 TSGLSFKDEGDSKQSKKEDPEDRNKMSVVTEGSQNHGHNPPMKSEGLRRP--ASKISMLQSQRVV 1120

  Fly  2239 W-------------------------RKPHTQRTAGSC--STQRMANSAAIAGEVACPYSKQFVH 2276
            .                         |||.|.:|:.:.  |......|:...|:       .|..
  Rat  1121 TSTQSNPDDILTLSSSTESEGESGTSRKPTTGQTSATAVDSDDIQTISSGSDGD-------DFED 1178

  Fly  2277 SKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIE-KHTMIIEYIGEVIRTEVSEIRE--KQYE 2338
            .|:......:|       :|....:|..|.:...|. |.|    .:..|.:.|.:.:|:  :|:.
  Rat  1179 KKNLSGPTKRQ-------VAVKSTRGFALKSTHGIAIKST----NMASVDKGESAPVRKNTRQFY 1232

  Fly  2339 SKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVD-RDVR---IIIFAKRKIYRG 2399
            ......|        ::||.|.|.|.||:||||:||...:.|.|| .|:|   :..||.::|..|
  Rat  1233 DGEESCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAG 1289

  Fly  2400 EELSYDYKFDIED-ESHKIPCACGAPNCR 2427
            .||::||.:::.. |..::.|.|||..||
  Rat  1290 TELTWDYNYEVGSVEGKELLCCCGAIECR 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	15/106 (14%)
		FYRN	2068..2118	CDD:283589	12/61 (20%)
		FYRC	2126..2215	CDD:197781	21/135 (16%)
		SET	<2266..2431	CDD:225491	47/170 (28%)
		SET	2291..2413	CDD:214614	37/129 (29%)
		PostSET	2415..2431	CDD:214703	6/13 (46%)
Setdb1	XP_006232975.1	YlqD	<44..118	CDD:287979
		TUDOR	277..337	CDD:197660	14/71 (20%)
		TUDOR	368..420	CDD:197660	17/88 (19%)
		MBD	629..704	CDD:128673	14/92 (15%)
		Pre-SET	714..827	CDD:282838	34/216 (16%)
		SET	835..>898	CDD:214614	15/73 (21%)
		SET	<1237..1299	CDD:214614	27/69 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930