back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and NSD1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_071900.2	Gene:	NSD1 / 64324	HGNCID:	14234	Length:	2696	Species:	Homo sapiens

Alignment Length:	2567	Identity:	491/2567 - (19%)
Similarity:	803/2567 - (31%)	Gaps:	828/2567 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 QDVETADGVWDARDQQIIVCNF---GSGTEMGAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAF 162
            ||.|.:    |:|.|..|||..   |..|.:...:....:...|.::...:..: |..||    |
Human    98 QDPEKS----DSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIK-NGFLH----F 153

  Fly   163 TSFTKKEGASSSASSS-----SSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGADSSTSV 222
            .:||..:.|...:...     :...|:..|..............|||:...|.|   |::..::.
Human   154 ENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAM---GSEQDSTP 215

  Fly   223 GNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQ---KSGHTNYNIFNTTATGSQT 284
            .:..|.......|:...|.|   ..|.....|.|:.....|..   ..|.||..|
Human   216 ESRHGAVKSPFLPLAPQTET---QKNKQRNEVDGSNEKAALLPAPFSLGDTNITI---------- 267

  Fly   285 PTTTLLNRVNL----HPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAG 345
              ...||.:||    .|...|..:.|..:|...:.::....:       |..:|...::......
Human   268 --EEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQEL-------PFCQPKKKSTPLKYEV 323

  Fly   346 GATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQ 410
            | .::.:|...:|.........           |.:::|:.   .|:..|.|.....:.:|.
Human   324 G-DLIWAKFKRRPWWPCRICSD-----------PLINTHSK---MKVSNRRPYRQYYVEAFG--- 370

  Fly   411 IKPANTKIVATKVV----------SKKMLQLQQHQQQIQQQQQLQQLQVT---SGGGLAP----P 458
             .|:....||.|.:          ...:|:.:..|::...:.::.|..::   :..|||.    |
Human   371 -DPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVP 434

  Fly   459 TGS--------IVTI----------TTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSEN 505
            .||        .:.:          .|.:|...:.::.:......|..||..|....|..|
Human   435 KGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCA---- 495

  Fly   506 LQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSG 570
                  ||::::|:..|:. |::....|:            |...|.::..:..::..::.: ||
Human   496 ------KSRARKSSDNPKR-TSVKKGHIQ------------FEAHKDERRGKIPENLGLNFI-SG 540

  Fly   571 AGTPVTFTMASGNASDLATTSTVSVSA-GTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKP 634
               .::.|.||...|.:|.:.|.|.:| |:...:|                   ..|.|    ..
Human   541 ---DISDTQASNELSRIANSLTGSNTAPGSFLFSS-------------------CGKNT----AK 579

  Fly   635 KMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDV 699
            |...|:...|...|. ..|||...|.:|                       |.|.:..|  ....
Human   580 KEFETSNGDSLLGLP-EGALISKCSREK-----------------------NKPQRSLV--CGSK 618

  Fly   700 VKLEEVGSESKAKLLVKQEAVVKDSTG-TPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQ 763
            |||..:|:..:.|.        .||.. ..||::.:.::...|....::.::..|....:::.|.
Human   619 VKLCYIGAGDEEKR--------SDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENM 675

  Fly   764 IQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSAS 828
            :.|      ..|.........||   |.|..|:.    |.|:.|:.:.|.:.  ...||..|:.:
Human   676 LSM------QKNEKIKYSRFAAT---NTRVKAKQ----KPLISNSHTDHLMG--CTKSAEPGTET 725

  Fly   829 ASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGG 893
            :...||     :::|.::             |..|....|..|.|...:.|.:.|:..:.:..|.
Human   726 SQVNLS-----DLKASTL-------------VHKPQSDFTNDALSPKFNLSSSISSENSLIKGGA 772

  Fly   894 SSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQP--AAIMQNQSQNQAPPPPPPPQQQQQQ 956
            ::|                         |.|..||.||  .:|.....:|.....||
Human   773 ANQ-------------------------ALLHSKSKQPKFRSIKCKHKENPVMAEPP-------- 804

  Fly   957 QLHQPQQLQPSPHQVK-QTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISN 1020
            .:::...|:......| ..:..:||     ||.|....|:.....|..:     ..::.||.:.:
Human   805 VINEECSLKCCSSDTKGSPLASISK-----SGKVDGLKLLNNMHEKTRD-----SSDIETAVVKH 859

  Fly  1021 VTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSA 1085
            |...:       |||..:      ||..:..|....:.::|.|.|.                .|:
Human   860 VLSEL-------KELSYR------SLGEDVSDSGTSKPSKPLLFSS----------------ASS 895

  Fly  1086 QWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQG-----T 1145
            |   ||         ||.:|.......|.|...:.:.:.::|..:.....:.....|:|     :
Human   896 Q---NH---------IPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNS 948

  Fly  1146 PDKVQ--LISAIATY---VKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHA 1205
            |..|.  |:|..:|:   .|..|..|.|.|  :.|.|...:..::.|::.|.||.:.....||.:
Human   949 PVGVSKVLVSGGSTHNSEKKGDGTQNSANP--SPSGGDSALSGELSASLPGLLSDKRDLPASGKS 1011

  Fly  1206 AGQ-------------------IPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQ 1251
            ...                   ..|||   |::.::......:::::|:|
Human  1012 RSDCVTRRNCGRSKPSSKLRDAFSAQM---VKNTVNRKALKTERKRKLNQ--------------- 1058

  Fly  1252 GAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAG------ 1310
                :|..|:::.....|:|              .|...|..:|.:...|...|..|..
Human  1059 ----LPSVTLDAVLQGDRER--------------GGSLRGGAEDPSKEDPLQIMGHLTSEDGDHF 1105

  Fly  1311 -----------MPPGTQYIQGAA--SGTGHVITS--TGQGVTLGGVGASTGASSSPML------- 1353
                       ..||....:|.:  :|.|..:.|  ..:...|.||...........|
Human  1106 SDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKP 1170

  Fly  1354 KKRVRKFSK----------------VEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSN 1402
            :||:.:|.:                |:|..|.|.|      .:.....:||..|....|
Human  1171 RKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPE------HRTPSASILEEPLTEQNH------ 1223

  Fly  1403 ETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSL 1467
                            |....:.|.:                |..||.:..........||||||
Human  1224 ----------------ADCLDSAGPR----------------LNVCDKSSASIGDMEKEPGIPSL 1256

  Fly  1468 YDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDF---YDQEFSTHMERNPRERLVR 1529
                           :.:...|.||.....:::...|....::   |||.|:...::...:..|.
Human  1257 ---------------TPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVH 1306

  Fly  1530 HIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRM----SPVALPEDPLTM 1590
            .:.:  .|..|:                        :|..|.|....:.    |.::..|:|
Human  1307 KVSS--RCEEES------------------------LLARGRSSAQNKQVDENSLISTKEEP--- 1342

  Fly  1591 RFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANL 1655
                 |:|.      |:...:|   |||..:.......:...:.|::|.:...:....| :...|
Human  1343 -----PVLE------REAPFLE---GPLAQSELGGGHAELPQLTLSVPVAPEVSPRPAL-ESEEL 1392

  Fly  1656 LHLAPA---------LTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRK 1711
            |...|.         .|.|::|   .|.|:..||    .|..|..........|||.   ||..:
Human  1393 LVKTPGNYESKRQRKPTKKLLE---SNDLDPGFM----PKKGDLGLSKKCYEAGHLE---NGITE 1447

  Fly  1712 LCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKD 1776
            .|.:..:.....|                 ..::.|. |||                      :.
Human  1448 SCATSYSKDFGGG-----------------TTKIFDK-PRK----------------------RK 1472

  Fly  1777 GQAEAASLLLQPAGGSAVKSSNGDS----PGSF-----CASSTAPAEMVVKQEPEDEDEKTPSVP 1832
            .|..||:.:      ...|..|.||    |||.     ..::|:|.|.|  :|..:.|      |
Human  1473 RQRHAAAKM------QCKKVKNDDSSKEIPGSEGELMPHRTATSPKETV--EEGVEHD------P 1523

  Fly  1833 GNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQ 1897
            |    :||.:|                     :.|..|.  ||....|.....|..|..|....|
Human  1524 G----MPASKK---------------------MQGERGG--GAALKENVCQNCEKLGELLLCEAQ 1561

  Fly  1898 CVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACH 1962
            |  |..                    .||.|.    |:.|...|..:  ....:.|: ..|..|.
Human  1562 C--CGA--------------------FHLECL----GLTEMPRGKFI--CNECRTGI-HTCFVCK 1597

  Fly  1963 QPGATIK-CFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLG-- 2024
            |.|..:| |....|...||..|..:......:||...||:    |..||..|...|...|..|
Human  1598 QSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSL----HICITCHAANPANVSASKGRL 1658

  Fly  2025 -------------------GS--VADNELSSLVVHRRVFVDR-----DENRQVATVMHYSELSNL 2063
                               ||  :|.|.    ::....|..|     .|:..|:.....||..:|
Human  1659 MRCVRCPVAYHANDFCLAAGSKILASNS----IICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSL 1719

  Fly  2064 L------RVGNMTFLNV----GQLLPHQLEAFHTPHYIYPIGYKVSRYYW-----CVRR--PNR- 2110
            |      ...:...||:    |....:..:|...|||...:..||.||.|     |..|  |:.
Human  1720 LCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNI 1784

  Fly  2111 -RCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQ 2174
             :.|:     :.|   ||.:.            |.||: ..:|       |...:|..:::   .
Human  1785 DKMRH-----DVG---EFPVL------------FFGSN-DYLW-------THQARVFPYME---G 1818

  Fly  2175 HISGEDLFG---------LTEPAIVRI--LESLPGIETLTDYRFKYGRNP--------------- 2213
            .:|.:|..|         ..:.|..|.  |::...:..|.:.| |..:.|
Human  1819 DVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDR-KNDKKPPPYKHIKVNRPIGRV 1882

  Fly  2214 ------LLEFPLA------INPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEV 2266
                  |.|.|..      .||.| ..:|...|.||....|......|.|..|
Human  1883 QIFTADLSEIPRCNCKATDENPCG-IDSECINRMLLYECHPTVCPAGGRCQNQ------------ 1934

  Fly  2267 ACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEV-- 2329
             | :||:       ||.:        |.:.|:..:|.||....||:|...:.||:||:|..|.
Human  1935 -C-FSKR-------QYPE--------VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECR 1982

  Fly  2330 SEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKR 2394
            :.||..| |......||..||:||::||...|..||::||.|.|||.|:...|:.|.|:.:||..
Human  1983 ARIRYAQ-EHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALS 2046

  Fly  2395 KIYRGEELSYDYKFDIEDESHKIPCACGAPNC 2426
            .|..|.||:::|..:..... |..|.||||||
Human  2047 DIKAGTELTFNYNLECLGNG-KTVCKCGAPNC 2077

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.