|
Fly 41 DTATPAEDPTRKKAKTELLLGTGTAAPSLPAKASSTAPQQLLYQRSGQQAKAQVKAASEPQD-VE 104
|....:.:|.:|:.:.:.|:.:...:|...:..::....::|...|..::|.:.:...|.:| |:
Human 2786 DNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNVD 2850
Fly 105 T----ADGVWDARD--------------------------------------QQII-VCNF-GSG 125
| |....|..| |.:| .|.. ||.
Human 2851 TPCSQASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITGST 2915
Fly 126 TEMGAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVIS-IEP 189
..:.::.|.:....|:.| |..|...|.| .||.|:..:|:.. |.|
Human 2916 PVLSSLLANEKSDNSDIR---PSGSPPPPTL-----------------PASPSNHVSSLPPFIAP 2960
Fly 190 SGSGQDHAENSGKS--EDLDYV----------LMPASGADSSTSVGNSTGTGTPAGTPIGATTST 242
.|...|:|.||..: ..:::| |:| ..::|.:|.|||.|| |..|..||
Human 2961 PGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIP-----GQSTVNHSLGTGKPA-TQTGPQTS- 3018
Fly 243 IILNANNGTAGVSGAGTTTI---LTQKSGHTNYNIFNTTATGSQTP--TTTLLNRVNLHPKMKTQ 302
.:||:.:||.....| |.|::......: .:.| ...||::.....:.:.|
Human 3019 -----QSGTSSMSGPQQLMIPQTLAQQNRERPLLL-------EEQPLLLQDLLDQERQEQQQQRQ 3071
Fly 303 LMVNAKKLSEVTQTTAKVSIGNKTISVP---------LLKPLMSASGAATAGGATIVESKQLLQP 358
:....::.|| | :..|:|.|...|..|...::....|..|
Human 3072 MQAMIRQRSE-----------------PFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMP 3119
Fly 359 ----------GGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGT-IVSFSGLQIK 412
|..||...::..|:.|.|..|...|..| ::.:..|.|.|. .|:.|
Human 3120 PMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITH----QISRPNPPNFGPGFVNDS----- 3175
Fly 413 PANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMV 477
|.:|:::.:|:.|||.|:| |.|...
Human 3176 -----------------QRKQYEEWLQETQQLLQMQ-----------------------QKYLEE 3200
Fly 478 QDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLN 542
| :| ||.:. :|..:..:...|...:...:|.....:..|...|:|.|.|::
Human 3201 Q----IG--AHRKS-----KKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQ---- 3250
Fly 543 CPPSFNIFKQQ-QHSQAAQSQSISAVGSGAGTPVTFTMASGNASDL---ATTSTVSVSAGTICIN 603
|.||| :|::..:...|......|..|.|...:......| ||..|:|
Human 3251 ------IRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMS--------- 3300
Fly 604 SPMMGTRPII--SIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSS 666
..|.|:: .:|::..:.|:|..|...:.|.:......|:.|.|.::...||...|
Human 3301 ---QPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIA------ 3356
Fly 667 ANSGSATSGASMQLKLTTANTPTKLSVSLA------PDVVKLEEVGSESKAKLLVKQEAVVKDST 725
||.:.|. ||...:||.| |..|:.::
Human 3357 ------------QLPIKTC-TPAPGTVSNANPQSGPPPRVEFDD--------------------- 3387
Fly 726 GTPTSE-----ERAEEIGTPEKRLNANATMTAINQVQNQSANQ--IQMATSTSTASNPSTPNPTV 783
..|.|| ||.|.:...::| ..:..:.:|..|.|.| ::|.......|..|:...:|
Human 3388 NNPFSESFQERERKERLREQQER----QRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSV 3448
Fly 784 NATPMNN--------------QRSAAEDNALLKQLLQNNSSSHSLNQISITS-------AHVGSA 827
:..|..: |:|......:.:.|.|.|....|:|..|..: ..||..
Human 3449 SQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPP 3513
Fly 828 S--ASAPLSARKVINVRAPSMGKVR---------SLEDQLARP-VIPPVPTATQAAGSSSSSGSV 880
| ..:| .|.|.:|:...|: |.:....|| ..|.:|.|...|.||...|.
Human 3514 SFVPDSP-----SIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQ- 3572
Fly 881 ATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQK------SDQPAAIMQNQS 939
.||.|...:..||:|.:....:..:|... |:.|..:| ::...|.....|
Human 3573 -DSTITHGHSYPGSTQSLIQLYSDIIPEEK---------GKKKRTRKKKRDDDAESTKAPSTPHS 3627
Fly 940 QNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQ-TVQIVSKETSFISGPVAAKTLVTEATSKPA 1003
...|||.|...:......:..|.:| |.|..| :|:.|...|. .:||..|.||..:|
Human 3628 DITAPPTPGISETTSTPAVSTPSEL---PQQADQESVEPVGPSTP----NMAAGQLCTELENK-- 3683
Fly 1004 ELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGD-ESLPEQAEPPLHSEQ 1067
||...:..||........|...| |.|:..|....:.:|:.: ||.|.|.||.|..:.
Human 3684 --LPNSDFSQATPNQQTYANSEVDK------LSMETPAKTEEIKLEKAETESCPGQEEPKLEEQN 3740
Fly 1068 GATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKR-----KLPMHPQLDEKQIQQQ 1127
|:...|.| ...|:.||| ..|...|.|..: :|..|...::|.
Human 3741 GSKVEGNA--VACPVSSAQ-------------SPPHSAGAPAAKGDSGNELLKHLLKNKKS---- 3786
Fly 1128 AEIPISTSLPTTPTG------QGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQ 1186
|:.|...|.| ..|.| |:....||.::|...:.||||
Human 3787 -----SSLLNQKPEGSICSEDDCTKD------------------NKLVEKQNPAEGLQTLGAQMQ 3828
Fly 1187 ATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQ 1251
.|...| || ||.|..
Human 3829 ---------------GGFGCG-----------------------------NQ-------LPKTDG 3842
Fly 1252 GAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQ 1316
|: :.:|:|.:..|:
Human 3843 GS-------------ETKKQRSKRTQR-------------------------------------- 3856
Fly 1317 YIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAF--TEKLLTHIR 1379
||..::|..||| .|.||:..|. :....||::
Human 3857 ----------------------------TGEKAAPRSKKR----KKDEEEKQAMYSSTDTFTHLK 3889
Fly 1380 QMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEG 1444
|...| ||..: .|||:..... |::
Human 3890 QQNNL----------------SNPPT---PPASLPPTPP------------------PMA----- 3912
Fly 1445 LEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGS--ARTRSPSPAESPGAEKMLPMSSIQ 1507
|.....| ...:|...|..|::... .:|..|.|.:.| ..| |
Human 3913 ---CQKMANG------------FATTEELAGKAGVLVSHEVTKTLGPKPFQLP----FRP----Q 3954
Fly 1508 NDFYDQEFS-------------THMERNPRE-RLVRHIG-------AVKDCNLETVDLVESEGVA 1551
:|...:..: |....|..| |:..|.| .|...:.|:|..||
Human 3955 DDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVE----- 4014
Fly 1552 AWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRS----CGEELRKTQQME 1612
::|||.|.|:. .|.|..:..|:.|:|.| ..|..|...:.|
Human 4015 -------VSRYPDLSLVK--------------EEPPEPVPSPIIPILPSTAGKSSESRRNDIKTE 4058
Fly 1613 LG-------MGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDK 1670
.| .||..|...:.. .:|.:.|..:|:|||:.|:...::|||: :
Human 4059 PGTLYFASPFGPSPNGPRSGL----ISVAITLHPTAAENISSVVAAFSDLLHV-----------R 4108
Fly 1671 IGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPAL 1735
|.|..| ..:..|.. .:..||...:...|..|:.|. ||.| |..
Human 4109 IPNSYE--VSSAPDVP------SMGLVSSHRINPGLEYRQHLL-----------LRGP----PPG 4150
Fly 1736 EEQLPRLAQLMDMLPRKSVP-PPFVYFCDRACFARFKWNGKDGQAE-----AASLLLQPAG---- 1790
....|||.... .|.:.:|| || ..||..|..: |.|..|:|..
Human 4151 SANPPRLVSSY-RLKQPNVPFPP-------------TSNGLSGYKDSSHGIAESAALRPQWCCHC 4201
Fly 1791 -----GSAVKSS-------NGDSPGS---------FCA-------SSTAPAEMVVKQEPEDEDEK 1827
||.|:.| |.||..| ||: ||||.| :..:..|.
Human 4202 KVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQA------KNSENKES 4260
Fly 1828 TPSVPGNP-------------TNI-------------------------------------PAQR 1842
.||:|.:| .|| |.:.
Human 4261 IPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDEL 4325
Fly 1843 KCIVKC----------FSADCFTTDSAPSGLE-----LDGTAGAGTGAGPVNNTVWE-TETSGLQ 1891
|..||. |. ||...:....|:: :......||...|..:.:.| .:..|..
Human 4326 KVTVKLKPRLRAVHGGFE-DCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTS 4389
Fly 1892 L------EDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTAL 1950
| :|.|:|.||::.|||..|||:||||.|:|.||||||||||..||||.:|||:|.:.||
Human 4390 LKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELAL 4454
Fly 1951 QAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGA 2015
:.||...|..||:.|||..|.:.||.::||..|||:.:|:|:|:|::.|.:|...
Human 4455 RRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPK---------- 4509
Fly 2016 GATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPH 2080
.:.:.|||...|.|||:|.|||.||:|:::...|..:..|||::.|..:|||||.
Human 4510 ----------GIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQ 4564
Fly 2081 QLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRG 2145
|::|||:|..::|:||:.||.||..|..||||||:|||.|...:|.|.|::.:.|.: :.....
Human 4565 QMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHE--DLVLSD 4627
Fly 2146 SSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYG 2210
.||..||.:||:|:..:||..:.|||||.::.||||||||..|:.||.|||||:|...:|.|:||
Human 4628 ISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYG 4692
Fly 2211 RNPLLEFPLAINPSGAARTEPK-----QRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPY 2270
||||:|.|||:||:|.||:||| :|.:| :|| |..|.||.:...| .:.||:..||
Human 4693 RNPLMELPLAVNPTGCARSEPKMSAHVKRFVL---RPH---TLNSTSTSKSFQS-TVTGELNAPY 4750
Fly 2271 SKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREK 2335
||||||||||||:|||.||::|||||||:|||||||||||||||||:|||||.:||.||:..:||
Human 4751 SKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEK 4815
Fly 2336 QYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGE 2400
.|||:|||:||||:|.|.|:||||:||.||||||||.||||.|:|..:|..:|||.:.|:|.:||
Human 4816 LYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGE 4880
Fly 2401 ELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
||.||||||.||:.|||||.|||.|||||||
Human 4881 ELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN 4911
| 
