DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and KMT2C

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_005250082.1 Gene:KMT2C / 58508 HGNCID:13726 Length:4983 Species:Homo sapiens


Alignment Length:2718 Identity:711/2718 - (26%)
Similarity:1035/2718 - (38%) Gaps:864/2718 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 DTATPAEDPTRKKAKTELLLGTGTAAPSLPAKASSTAPQQLLYQRSGQQAKAQVKAASEPQD-VE 104
            |....:.:|.:|:.:.:.|:.:...:|...:..::....::|...|..::|.:.:...|.:| |:
Human  2803 DNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNVD 2867

  Fly   105 T----ADGVWDARD--------------------------------------QQII-VCNF-GSG 125
            |    |....|..|                                      |.:| .|.. ||.
Human  2868 TPCSQASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITGST 2932

  Fly   126 TEMGAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVIS-IEP 189
            ..:.::.|.:....|:.|   |..|...|.|                 .||.|:..:|:.. |.|
Human  2933 PVLSSLLANEKSDNSDIR---PSGSPPPPTL-----------------PASPSNHVSSLPPFIAP 2977

  Fly   190 SGSGQDHAENSGKS--EDLDYV----------LMPASGADSSTSVGNSTGTGTPAGTPIGATTST 242
            .|...|:|.||..:  ..:::|          |:|     ..::|.:|.|||.|| |..|..|| 
Human  2978 PGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIP-----GQSTVNHSLGTGKPA-TQTGPQTS- 3035

  Fly   243 IILNANNGTAGVSGAGTTTI---LTQKSGHTNYNIFNTTATGSQTP--TTTLLNRVNLHPKMKTQ 302
                 .:||:.:||.....|   |.|::......:       .:.|  ...||::.....:.:.|
Human  3036 -----QSGTSSMSGPQQLMIPQTLAQQNRERPLLL-------EEQPLLLQDLLDQERQEQQQQRQ 3088

  Fly   303 LMVNAKKLSEVTQTTAKVSIGNKTISVP---------LLKPLMSASGAATAGGATIVESKQLLQP 358
            :....::.||                 |         :..|:|.|...|..|...::....|..|
Human  3089 MQAMIRQRSE-----------------PFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMP 3136

  Fly   359 ----------GGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGT-IVSFSGLQIK 412
                      |..||...::..|:.|.|..|...|..|    ::.:..|.|.|. .|:.|     
Human  3137 PMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITH----QISRPNPPNFGPGFVNDS----- 3192

  Fly   413 PANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMV 477
                             |.:|:::.:|:.|||.|:|                       |.|...
Human  3193 -----------------QRKQYEEWLQETQQLLQMQ-----------------------QKYLEE 3217

  Fly   478 QDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLN 542
            |    :|  ||.:.     :|..:..:...|...:...:|.....:..|...|:|.|.|::    
Human  3218 Q----IG--AHRKS-----KKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQ---- 3267

  Fly   543 CPPSFNIFKQQ-QHSQAAQSQSISAVGSGAGTPVTFTMASGNASDL---ATTSTVSVSAGTICIN 603
                  |.||| :|::..:...|......|..|.|...:......|   ||..|:|         
Human  3268 ------IRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMS--------- 3317

  Fly   604 SPMMGTRPII--SIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSS 666
               ..|.|::  .:|::..:.|:|..|...:.|.:......|:.|.|.::...||...|      
Human  3318 ---QPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIA------ 3373

  Fly   667 ANSGSATSGASMQLKLTTANTPTKLSVSLA------PDVVKLEEVGSESKAKLLVKQEAVVKDST 725
                        ||.:.|. ||...:||.|      |..|:.::                     
Human  3374 ------------QLPIKTC-TPAPGTVSNANPQSGPPPRVEFDD--------------------- 3404

  Fly   726 GTPTSE-----ERAEEIGTPEKRLNANATMTAINQVQNQSANQ--IQMATSTSTASNPSTPNPTV 783
            ..|.||     ||.|.:...::|    ..:..:.:|..|.|.|  ::|.......|..|:...:|
Human  3405 NNPFSESFQERERKERLREQQER----QRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSV 3465

  Fly   784 NATPMNN--------------QRSAAEDNALLKQLLQNNSSSHSLNQISITS-------AHVGSA 827
            :..|..:              |:|......:.:.|.|.|....|:|..|..:       ..||..
Human  3466 SQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPP 3530

  Fly   828 S--ASAPLSARKVINVRAPSMGKVR---------SLEDQLARP-VIPPVPTATQAAGSSSSSGSV 880
            |  ..:|     .|.|.:|:...|:         |.:....|| ..|.:|.|...|.||...|. 
Human  3531 SFVPDSP-----SIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQ- 3589

  Fly   881 ATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQK------SDQPAAIMQNQS 939
             .||.|...:..||:|.:....:..:|...         |:.|..:|      ::...|.....|
Human  3590 -DSTITHGHSYPGSTQSLIQLYSDIIPEEK---------GKKKRTRKKKRDDDAESTKAPSTPHS 3644

  Fly   940 QNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQ-TVQIVSKETSFISGPVAAKTLVTEATSKPA 1003
            ...|||.|...:......:..|.:|   |.|..| :|:.|...|.    .:||..|.||..:|  
Human  3645 DITAPPTPGISETTSTPAVSTPSEL---PQQADQESVEPVGPSTP----NMAAGQLCTELENK-- 3700

  Fly  1004 ELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGD-ESLPEQAEPPLHSEQ 1067
              ||...:..||........|...|      |.|:..|....:.:|:.: ||.|.|.||.|..:.
Human  3701 --LPNSDFSQATPNQQTYANSEVDK------LSMETPAKTEEIKLEKAETESCPGQEEPKLEEQN 3757

  Fly  1068 GATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKR-----KLPMHPQLDEKQIQQQ 1127
            |:...|.|  ...|:.|||             ..|...|.|..:     :|..|...::|.    
Human  3758 GSKVEGNA--VACPVSSAQ-------------SPPHSAGAPAAKGDSGNELLKHLLKNKKS---- 3803

  Fly  1128 AEIPISTSLPTTPTG------QGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQ 1186
                 |:.|...|.|      ..|.|                  |:....||.::|...:.||||
Human  3804 -----SSLLNQKPEGSICSEDDCTKD------------------NKLVEKQNPAEGLQTLGAQMQ 3845

  Fly  1187 ATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQ 1251
                           .|...|                             ||       ||.|..
Human  3846 ---------------GGFGCG-----------------------------NQ-------LPKTDG 3859

  Fly  1252 GAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQ 1316
            |:             :.:|:|.:..|:                                      
Human  3860 GS-------------ETKKQRSKRTQR-------------------------------------- 3873

  Fly  1317 YIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAF--TEKLLTHIR 1379
                                        ||..::|..|||    .|.||:..|.  :....||::
Human  3874 ----------------------------TGEKAAPRSKKR----KKDEEEKQAMYSSTDTFTHLK 3906

  Fly  1380 -QMQPLQVLEPHLNRNF-HFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSR--GWPLSR 1440
             |:..|.::||.:..|| |||                        ..|.|:...|:|  |...|.
Human  3907 QQLSLLPLMEPIIGVNFAHFL------------------------PYGSGQFNSGNRLLGTFGSA 3947

  Fly  1441 HLEGLEDCDGTVLGRYGRVNLPGIP------------------SLYDSERFGGSRGLVGGS--AR 1485
            .|||:.|....::.:...::.|..|                  ....:|...|..|::...  .:
Human  3948 TLEGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTK 4012

  Fly  1486 TRSPSPAESPGAEKMLPMSSIQNDFYDQEFS-------------THMERNPRE-RLVRHIG---- 1532
            |..|.|.:.|    ..|    |:|...:..:             |....|..| |:..|.|    
Human  4013 TLGPKPFQLP----FRP----QDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDT 4069

  Fly  1533 ---AVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPV 1594
               .|...:.|:|..||            ::|||.|.|:.              .|.|..:..|:
Human  4070 PDSFVPSSSPESVVGVE------------VSRYPDLSLVK--------------EEPPEPVPSPI 4108

  Fly  1595 SPLLRS----CGEELRKTQQMELG-------MGPLGNNNNNNYQQKNQNVILALPASASENIAGV 1648
            .|:|.|    ..|..|...:.|.|       .||..|...:..    .:|.:.|..:|:|||:.|
Human  4109 IPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGL----ISVAITLHPTAAENISSV 4169

  Fly  1649 LRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLC 1713
            :...::|||:           :|.|..|  ..:..|..      .:..||...:...|..|:.|.
Human  4170 VAAFSDLLHV-----------RIPNSYE--VSSAPDVP------SMGLVSSHRINPGLEYRQHLL 4215

  Fly  1714 RSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVP-PPFVYFCDRACFARFKWNGKDG 1777
                       ||.|    |......|||.... .|.:.:|| ||             ..||..|
Human  4216 -----------LRGP----PPGSANPPRLVSSY-RLKQPNVPFPP-------------TSNGLSG 4251

  Fly  1778 QAE-----AASLLLQPAG---------GSAVKSS-------NGDSPGS---------FCA----- 1807
            ..:     |.|..|:|..         ||.|:.|       |.||..|         ||:     
Human  4252 YKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFI 4316

  Fly  1808 --SSTAPAEMVVKQEPEDEDEKTPSVPGNP-------------TNI------------------- 1838
              ||||.|      :..:..|..||:|.:|             .||                   
Human  4317 LYSSTAQA------KNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPA 4375

  Fly  1839 ------------------PAQRKCIVKC----------FSADCFTTDSAPSGLE-----LDGTAG 1870
                              |.:.|..||.          |. ||...:....|::     :.....
Human  4376 SPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFE-DCRPLNKKWRGMKWKKWSIHIVIP 4439

  Fly  1871 AGTGAGPVNNTVWE-TETSGLQL------EDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNC 1928
            .||...|..:.:.| .:..|..|      :|.|:|.||::.|||..|||:||||.|:|.||||||
Human  4440 KGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNC 4504

  Fly  1929 ALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYK 1993
            ||||..||||.:|||:|.:.||:.||...|..||:.|||..|.:.||.::||..|||:.:|:|:|
Human  4505 ALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFK 4569

  Fly  1994 NKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYS 2058
            :|::.|.:|...                    .:.:.|||...|.|||:|.|||.||:|:::...
Human  4570 DKTMLCPMHKPK--------------------GIHEQELSYFAVFRRVYVQRDEVRQIASIVQRG 4614

  Fly  2059 ELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGC 2123
            |..:..|||::.|..:|||||.|::|||:|..::|:||:.||.||..|..||||||:|||.|...
Human  4615 ERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDG 4679

  Fly  2124 KPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPA 2188
            :|.|.|::.:.|.:  :......||..||.:||:|:..:||..:.|||||.::.||||||||..|
Human  4680 RPVFVIRIVEQGHE--DLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSA 4742

  Fly  2189 IVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPK-----QRQLLVWRKPHTQRTA 2248
            :.||.|||||:|...:|.|:||||||:|.|||:||:|.||:|||     :|.:|   :||   |.
Human  4743 VARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVL---RPH---TL 4801

  Fly  2249 GSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEK 2313
            .|.||.:...| .:.||:..||||||||||||||:|||.||::|||||||:||||||||||||||
Human  4802 NSTSTSKSFQS-TVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEK 4865

  Fly  2314 HTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTE 2378
            |||:|||||.:||.||:..:||.|||:|||:||||:|.|.|:||||:||.||||||||.||||.|
Human  4866 HTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAE 4930

  Fly  2379 IVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            :|..:|..:|||.:.|:|.:||||.||||||.||:.|||||.|||.|||||||
Human  4931 VVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN 4983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 34/153 (22%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 56/103 (54%)
FYRN 2068..2118 CDD:283589 26/49 (53%)
FYRC 2126..2215 CDD:197781 41/88 (47%)
SET <2266..2431 CDD:225491 118/164 (72%)
SET 2291..2413 CDD:214614 85/121 (70%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
KMT2CXP_005250082.1 ePHD1_KMT2C 248..331 CDD:277166
PHD1_KMT2C_like 344..389 CDD:276984
PHD2_KMT2C 391..436 CDD:277069
PHD3_KMT2C 467..518 CDD:276986
PHD4_KMT2C 953..1009 CDD:277071
PHD5_KMT2C_like 1010..1056 CDD:276988
RanBP2-type Zn finger 1085..1107 CDD:275375
PHD6_KMT2C 1087..1137 CDD:277073
HMG-box 1671..1722 CDD:294061
DUF2962 1709..>1792 CDD:288077
SYCE1 <3198..3287 CDD:291886 26/132 (20%)
ePHD2_KMT2C 4474..4578 CDD:277167 56/103 (54%)
FYRN 4624..4674 CDD:283589 26/49 (53%)
FYRC 4680..4761 CDD:283590 36/82 (44%)
SET <4797..4983 CDD:225491 127/189 (67%)
SET 4844..4965 CDD:214614 85/120 (71%)
PostSET 4967..4983 CDD:214703 13/15 (87%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158025
Domainoid 1 1.000 156 1.000 Domainoid score I4184
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - otm40757
orthoMCL 1 0.900 - - OOG6_102575
Panther 1 1.100 - - O PTHR45888
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.730

Return to query results.
Submit another query.