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Protein Alignment trr and kmt2bb

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_002664717.2	Gene:	kmt2bb / 566825	ZFINID:	ZDB-GENE-080521-1	Length:	3772	Species:	Danio rerio

Alignment Length:	1716	Identity:	349/1716 - (20%)
Similarity:	552/1716 - (32%)	Gaps:	616/1716 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 RKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQS 1175
            |...:.|.:.|||:::..:...:.::..:|..|...:.::|      .:..:....||    |.:
Zfish  2278 RVTEVRPAVQEKQVEESPDHGENCTIAHSPCPQSECEALEL------GLSSTNPSTEA----NFT 2332

  Fly  1176 QGQVQMQAQMQATMQ-----------GHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQ 1229
            .|.|..:..:.|..:           |.||..:.      :.|..|::.|    |.|.::.....
Zfish  2333 SGSVFAKPDLGARPKITSYPQNRRPAGGLSRPLP------SPGAAPSKPH----HILTISDLEDT 2387

  Fly  1230 QQQQLH----QNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAG 1290
            ::.:.|    ||....:.:..|..|..|.|||     |:||.....:..:...|.
Zfish  2388 RRPRRHSPHTQNSGTRSHMTSPTLGSPAGPIP-----SRAGGSHHPKSSQTTSPM---------- 2437

  Fly  1291 GALKDLTGPLPAGAMVQL----AGMPPGTQYIQGAAS--GTGHVIT--ST----GQGVTLGGVGA 1343
                     .|.||...|    :..|.|    :.|:|  ||| ::|  ||    .|....||:|:
Zfish  2438 ---------FPLGATENLLTSSSARPVG----RSASSVRGTG-ILTPHSTSGLFSQSTKQGGIGS 2488

  Fly  1344 S--TGAS-SSPM-LKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLE-PHLNRNFHFLIGSNE 1403
            :  |..| :||. |..|.|.|                   ...|:..|| ||     :|:....|
Zfish  2489 TPCTNRSLTSPTHLSTRPRPF-------------------DFNPIDSLELPH-----NFIASPQE 2529

  Fly  1404 ---TSGG---GSPASMSSAASAGSSSAGGGKLKGGSRGWP-LSRHLEGLEDCDGTVLGRYGRVNL 1461
               .:|.   |...||.......|           .|.:| .|.|||    .|.||        .
Zfish  2530 HLSETGALPLGDALSMPKVNHLCS-----------DRDFPYTSIHLE----ADLTV--------A 2571

  Fly  1462 PGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFY--------------- 1511
            |.:.:..:.|....:.|:            |.:..|:.::.....|.||:
Zfish  2572 PELRTELEIEESVVNEGV------------AMNCSAQIVVEGEDNQEDFWEPDDNKSKMSSQRLS 2624

  Fly  1512 ---------------DQEFSTHM----------------ERNPRERLVRHIGAVKDCNLETVDLV 1545
                           |::...:.                :::|..|.:..:..|.|.......|.
Zfish  2625 CTVDPCREDWGNSSSDEDMENYFNFTRTVVTCKAQRDSSKKSPSVRQISQLDGVDDGTESDTSLA 2689

  Fly  1546 ESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDP-----LTMRFPVSPL-----LRS 1600
            .|:..|             :.|.|...:.|..:|  |:|.:.     |.:.|| |||     :..
Zfish  2690 NSDNHA-------------MKLSNQTQKPHKSLS--AVPHEQTASNGLCLTFP-SPLSDISSINC 2738

  Fly  1601 CGEELRK----TQQMELGM-----------GPLGNNNNNNYQQKNQNVILALPASASENIA---- 1646
            |.|.:..    |.|...|:           ||..:...|..:.|:.|...:...:..:::|
Zfish  2739 CFESVPNSEVLTDQDSFGLTQILESSSGVCGPQQDTLINFVESKSSNPTFSTYGNDYQSLAEPET 2803

  Fly  1647 -------GVLRDLANLLHLAPALTCKIIEDKIGNKLEDQ----------FMNQDDEKHVDFKRPL 1694
                   ..|...|:...|.|      ::|...:..|.:          |::..|:..|
Zfish  2804 PLILERCDPLSPNAHFTELVP------VQDSPCDPQESKELYLDPSSGHFVSSVDDATV------ 2856

  Fly  1695 SQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFV 1759
              ..:.||:.          ...|:....|::......|....:|.:.|.|::  |..||..|||
Zfish  2857 --YQNSHLQD----------DSLNLNQVNGIQFSLQQNPVPSTELLKPAPLLE--PSSSVQVPFV 2907

  Fly  1760 YFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMV-VKQEPED 1823
            .|              ..|....::.|.|...||.|            :...|.|.. .|..|..
Zfish  2908 AF--------------PNQTTPTNVSLFPVQTSAGK------------TILPPMESFRTKLNPHP 2946

  Fly  1824 ED-EKTPSVPGN-----PTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAG--AGTGAGPVNN 1880
            |. ...|||||.     |.|||.:.:.::...||         :|:.| ||.|  :||.:.|::.
Zfish  2947 EQRHPAPSVPGGALPYVPANIPQKPESMLSVPSA---------TGVPL-GTYGPISGTVSVPLHP 3001

  Fly  1881 TVWE----------TETSGLQLEDTRQC-----------VFCNQRG-------DGQADGPSRLLN 1917
            |..:          :.::.:..:.:.||           ..|...|       ...|.|.:..:|
Zfish  3002 TYMQPIGSTTVGVVSSSTSVTSQPSAQCQAMPSAIQPASAPCVINGYNTMPMQRDSAPGRTISIN 3066

  Fly  1918 F--------------------------------DVDKWVH------------------------- 1925
            |                                :||...|
Zfish  3067 FSTPRSAVEPQQQLVTQALPGHAILTVKEVGGPNVDPTPHVLLVNRLGQIFVKNPESNTFQLPTP 3131

  Fly  1926 -------------------LNCALWSNGVYETVSGALMNFQ-------------TALQAGLSQAC 1958
                               |:..|.:.|....|:||.:..|             |..|...:...
Zfish  3132 NSPSFSCVTQIASLLQSNALSATLAAAGSLPAVAGATIPTQVSHIVTPLVQTSNTITQLLATNNN 3196

  Fly  1959 SACHQPGATIKCFKSRCNS-----LYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGAT 2018
            .|...|.|.:|  |.|.|:     ....|...:|.....:.||...|              ...:
Zfish  3197 EAAPPPPADVK--KPRRNTKSTGEKVKKPRTKKESSTPRRTKSTSTS--------------GKQS 3245

  Fly  2019 TGAGLGGSVADNELSS--LVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQ 2081
            ||..:..|...|:|.|  .::::.:....|.|:.|:.::..|...|...|| .|...|..:||..
Zfish  3246 TGQVITSSDKFNQLDSAQAIINQAMAGYYDPNKTVSNILPSSSPCNTKPVG-QTQTTVSPVLPET 3309

  Fly  2082 L--------------------------------------------------EAFHTPHYIYPIGY 2096
            |                                                  .|...||....:
Zfish  3310 LLVKPEKKSSPPVTPEVAPRPKQVRMKRVSCLSDRIATKKSKSDFLDMERPSALEEPHKSSSV-- 3372

  Fly  2097 KVSRYYWCVRRP-----------NRRCRYICSIAEAGCKPEFRIQVQDAGDK------------- 2137
            ..|||...::.|           |.........|..|  |..|:.:...|:.
Zfish  3373 SASRYGVRIKTPTVKGILDLDKLNEEPSSDSESARPG--PWDRLSLPRTGESNKPSTWDPANRSG 3435

  Fly  2138 --------------------------------EPEREF----------RGSSPSAVWQQILQPIT 2160
                                            :|...|          ...|....|..:|:.:.
Zfish  3436 LSDLNKYSGMLSCSDDELSPSDGEEHVPLSRDQPHLRFEIASDDGFSIEADSIEVAWSAVLEGVQ 3500

  Fly  2161 RLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSG 2225
            ..|.......|....:||..:.|:...|:|.::|.|.|.:....:.|::.:....:..|.:||||
Zfish  3501 EARAAAGLRLLTMCGMSGARVMGMLHDAVVYLVEQLQGAKRCHRHTFRFHKQASQDDDLPVNPSG 3565

  Fly  2226 AARTE---------------PKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFV 2275
            .||:|               .:.|||     |.|. .......:.:..|...|..:..|.:.:|.
Zfish  3566 CARSEVYLRKSTFDMFNFLASQHRQL-----PDTD-LYDEEEDEVLLKSTRRATSLELPMAMRFR 3624

  Fly  2276 HSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESK 2340
            |        :::..:..|.:.||.|.|.||:..|:||...|:|||.|.|||:.:::.|||.|:.|
Zfish  3625 H--------LERTSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYDGK 3681

  Fly  2341 NRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYD 2405
            ..|.||||:|:..|||||:.|..||:|||||.|||.:.::.|:....|:|||.|||||||||:||
Zfish  3682 GIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYD 3746

  Fly  2406 YKFDIEDESHKIPCACGAPNCRKWMN 2431
            |||.|||.|:|:.|.|||..||:::|
Zfish  3747 YKFPIEDASNKLGCNCGAKRCRRFLN 3772

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.