DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and kmt2ba

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_689347.5 Gene:kmt2ba / 560856 ZFINID:ZDB-GENE-060503-376 Length:2863 Species:Danio rerio


Alignment Length:1930 Identity:379/1930 - (19%)
Similarity:587/1930 - (30%) Gaps:757/1930 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   675 GASMQLKLTTANTPTKLSVSLAPDVVK----LEEVGSESKAKLLVKQEA---------------- 719
            |.|::.|..|...|..::|.:....||    |.|:.:.|.....|..:.                
Zfish  1518 GISLRRKFLTGLEPESVNVMIGSLHVKNLGVLTELSANSGKLYPVGYQCSRWYWSTVDPRRRCRY 1582

  Fly   720 VVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTV- 783
            ..|.|...|::..|     ||...::.....|.::..:.|:......:.|.|.....|||:.|. 
Zfish  1583 TCKVSEVRPSTRCR-----TPSFMVDQGENHTIVHSPKAQNDEDGTDSESFSPGLPLSTPSKTKQ 1642

  Fly   784 -----NATP--MNNQRSA--------AEDNALLKQLLQNNSSSHSLNQIS-------ITSAH-VG 825
                 ..||  .:::|.|        :..|||        |:||.:..||       .|..| ..
Zfish  1643 DSGSGGRTPGYPHSRRPAGGMSRPLPSPGNAL--------STSHHILTISDLDETRRSTRRHSTR 1699

  Fly   826 SASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVA 890
            |.:||.|                          |||...|.|.::.||.:.             .
Zfish  1700 SRNASPP--------------------------PVILSGPMALRSGGSINP-------------R 1725

  Fly   891 SGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQ 955
            |...|..|:...||.   :.::.|:|...|    ...|..|::|:      ..|.||....:...
Zfish  1726 SLSFSPPVSPLGATE---NLMSTTSPRRRG----RPPSLSPSSII------SGPSPPQAALRSPS 1777

  Fly   956 QQL-----HQPQQLQP---SPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPA-----ELLP 1007
            ..|     |.|:..||   |||:..:.||      .|:|.|       .||...|.     :||.
Zfish  1778 SALPSTVHHSPRLQQPFTTSPHKTDKVVQ------DFLSEP-------EEAAGAPVLKSDHDLLS 1829

  Fly  1008 P---PPYEMATAPISNVTISIS------------TKQAAPKELQ---------MKPKAVAMSLPM 1048
            |   |..::|.|.:.|..:...            ..|.|..||:         .|..:....:.|
Zfish  1830 PHFDPDTDVAVASVLNAKLEFDEALLNENVALDCDPQGAEGELEEEACKYNAGRKDLSSIAEMQM 1894

  Fly  1049 EQGDESLPEQ---------AEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFK 1104
            |..||.....         .||...::.|.|   |.|:||        :.:.|:|  |.......
Zfish  1895 ETDDEVADHYLNFSRTVVVCEPAKDTQTGLT---VLPNSG--------SISQLDG--ADNDSESD 1946

  Fly  1105 PGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQ--GTP--DKVQLISAIATYVKKSGVP 1165
            .||         ...|:...:..:......:.|...|||  ||.  |...:.:.||.......|.
Zfish  1947 TGE---------ANADDNTQEVGSSFLSQDTEPLKITGQNKGTTLGDGQLVCTEIANPHTADSVD 2002

  Fly  1166 NEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQ 1230
            ..|:| :.|:..||..:.::.:                     :....:|.|.     |......
Zfish  2003 ENAKP-ETQNIEQVCEEQEVSS---------------------LEDNANLLVD-----AGSDSSN 2040

  Fly  1231 QQQLHQNQPQNATIPLPVTGQGAVPIP---VPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGA 1292
            ||::......|||.|:...|...:...   :...||.||.|      ||               .
Zfish  2041 QQEMSFTDGLNATTPVVYKGSDLIATQEEILAESESSAGSQ------EV---------------F 2084

  Fly  1293 LKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRV 1357
            |.|.:|........::...|..|...:|:                         ..|.|:.|:.|
Zfish  2085 LDDTSGNFICTVDGRVVDSPKNTADPEGS-------------------------RDSVPINKENV 2124

  Fly  1358 ---RKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNET-------SGGGSPAS 1412
               |..|.||                 :|...::....|.||.:..|...       ..|..|.:
Zfish  2125 VLNRALSPVE-----------------KPAAAVKSSATRTFHVVAPSMPAKRRFVTIQPGSQPKT 2172

  Fly  1413 MSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSR 1477
            ...|....:|.             |:|                        :|.           
Zfish  2173 FQMAMPVATSI-------------PIS------------------------VPI----------- 2189

  Fly  1478 GLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETV 1542
                 :..:.||:.:.:|...:..|...:.|.|                     ||:..      
Zfish  2190 -----NVVSTSPTFSVAPHGTQFTPSPVVINGF---------------------GAIPK------ 2222

  Fly  1543 DLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRK 1607
            :.::...:|.....|:                  :..|..:|..|.|   |...|:...|:.|.|
Zfish  2223 EALKGRRIAIRIATPK------------------QSLPHCVPGTPPT---PQVLLVNRAGQILVK 2266

  Fly  1608 TQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIG 1672
                        |..||.||         :|::.|                 |:.|         
Zfish  2267 ------------NPQNNTYQ---------IPSANS-----------------PSYT--------- 2284

  Fly  1673 NKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEE 1737
                                .:||::     :|::|        .||:.....:|....||.|:.
Zfish  2285 --------------------QISQIA-----RIIHG--------SNVLQRPVPKVTVMPVPQLQA 2316

  Fly  1738 QLPRL--AQLMDMLPRKSVPPPFVYFCDR--ACFARFKWNG------------KDGQAEAASLLL 1786
            .|.|.  |:::.........||......|  ..|...:.:|            :.||.|.|.:::
Zfish  2317 CLSRTSPARIISYSSNSGAAPPTQVLIRRIPQSFPGGQLSGVSPPLEKAGSISEGGQKELAQVII 2381

  Fly  1787 QPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKT----PSVPGNP--------TNIP 1839
            ..|..|..:.:|        |::.:|:.:..:..||.:...|    |::..|.        .:..
Zfish  2382 DKAMASHREVAN--------ATTASPSLLGKRLSPESKKSSTLRTQPNILANSRSQVRIKRVSSV 2438

  Fly  1840 AQRKCIVKCFSADCFTTDSAPSG--------------------LELDGTAGAGTGAGPVNNTVWE 1884
            .:|..:.:| ..| |....|||.                    |:.||:      ..|.|:....
Zfish  2439 TERIGVKRC-KTD-FLDQMAPSSQDDHSRSNRVRIKAPSVKEVLDFDGS------FDPKNDDSKV 2495

  Fly  1885 TETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNF---DVDKWVHLNCALWSNGVYETVSGALMNF 1946
            .|...:    |.:........|.|..|.|.:|:.   |...|...  |.||:. .|:.|      
Zfish  2496 AEHERI----TPKEPIATHANDSQDGGKSHILSSKLGDSSDWAPY--AGWSSD-EESPS------ 2547

  Fly  1947 QTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITM 2011
                             ||.     :.:|.|||.                               
Zfish  2548 -----------------PGK-----QEKCASLYQ------------------------------- 2559

  Fly  2012 GAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQ 2076
                                                                             
Zfish  2560 ----------------------------------------------------------------- 2559

  Fly  2077 LLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPER 2141
                       ||.|                                   |:|..:|....|.: 
Zfish  2560 -----------PHLI-----------------------------------FQITSEDGFSVEAD- 2577

  Fly  2142 EFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYR 2206
                 |....|:.::..:...|...:..||....|:|..:.|:...|::.:||.|.|......:|
Zfish  2578 -----SMDVAWKAVMDGVQEARIGCRMEQLPFNSINGARVLGVLHDAVLFLLEQLQGASLCQKHR 2637

  Fly  2207 FKYGRNPLLEFPLAINPSGAARTE---------------PKQRQLLVWRKPHTQRTAGSCSTQRM 2256
            |::.::.:.|..|..||:|.||.|               .:.|||     |.: |.........|
Zfish  2638 FRFHQHEIPEEELPENPNGCARAEVYVRKSTFDMFNFLASQHRQL-----PES-RPCDDDEDDIM 2696

  Fly  2257 ANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYI 2321
            ..|:..|.....|.:.:|.|.:.:..:.:      .||  ||.|.|.||:..|:||...|:|||.
Zfish  2697 LKSSRRATSTELPVAMRFRHLEKTSKEAV------GVY--RSAIHGRGLFCKRNIEAGEMVIEYA 2753

  Fly  2322 GEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDV 2386
            |.|||..:::.|||.|:||..|.||||:|:..|||||:.|..||:|||||:|||.:.::.|:...
Zfish  2754 GNVIRAVLTDKREKYYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCDPNCYSRVINVEGQK 2818

  Fly  2387 RIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            .|:|||.|||||||||:|||||.|||..:|:.|.|||..||:::|
Zfish  2819 HIVIFALRKIYRGEELTYDYKFPIEDADNKLHCNCGARRCRRFLN 2863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 18/106 (17%)
FYRN 2068..2118 CDD:283589 3/49 (6%)
FYRC 2126..2215 CDD:197781 19/88 (22%)
SET <2266..2431 CDD:225491 79/164 (48%)
SET 2291..2413 CDD:214614 68/121 (56%)
PostSET 2415..2431 CDD:214703 7/15 (47%)
kmt2baXP_689347.5 zf-CXXC 780..823 CDD:251032
PHD_SF 1016..1062 CDD:304600
PHD_SF 1064..1112 CDD:304600
PHD_SF 1149..1206 CDD:304600
Bromo_ALL-1 1187..1334 CDD:99925
PHD_SF 1389..1492 CDD:304600
FYRN 1540..1586 CDD:283589 6/45 (13%)
FYRC 2561..2646 CDD:295414 21/125 (17%)
SET <2677..2863 CDD:225491 87/199 (44%)
SET 2725..2845 CDD:214614 68/127 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D738155at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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