DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and kmt2ca

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_005162602.1 Gene:kmt2ca / 560793 ZFINID:ZDB-GENE-080520-3 Length:4958 Species:Danio rerio


Alignment Length:2629 Identity:656/2629 - (24%)
Similarity:975/2629 - (37%) Gaps:802/2629 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 KAASEPQDVETADGVWDARDQQIIVCNFGSGTEMGAIKAEDADKQSEYRISTPRNSQSNPLL-HR 158
            ||.||.::..               |..||.  ...::.|..     ..|..|..:.||.:| |.
Zfish  2840 KALSEKRNAR---------------CEGGSA--QSTLEGEQG-----LNILKPEKTLSNEVLDHS 2882

  Fly   159 NTAFTSFTKKEGASSS------ASSSSSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGAD 217
            .:..|..|:.:|.::|      |||.||...|     ||..:|..|::..:..|..:::.....|
Zfish  2883 QSEITIKTEIQGLATSVDDHRPASSKSSQNDV-----SGLFEDSCEDAHCAPTLSSLMVKEKLED 2942

  Fly   218 SSTSVGNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGS 282
                                 |.|..|::|..|.                            ..|
Zfish  2943 ---------------------TRSESIISAIQGD----------------------------PNS 2958

  Fly   283 QTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGA 347
            ||         ||...|.   ||..:..|:..:..:.|::|::..|            |.|.|  
Zfish  2959 QT---------NLDSNMS---MVMLQGQSQEHRIKSGVTMGHRVDS------------ALTQG-- 2997

  Fly   348 TIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKL-----IKRGPKNSGTIVSFS 407
            |::.:..::..|.|...:.......|         .|.|.|...:     :...|:|...|.| .
Zfish  2998 TLLSNSNMMHSGNQQVPLQGFGPSQG---------QHIHLNMPAVGTQQPVLINPQNQQGIFS-P 3052

  Fly   408 GLQIKPANTKIVATKVVSKKMLQLQQHQ----------------QQIQQQQQLQQLQVTSGGGLA 456
            |:.::..:.           |.|.||::                |:.|:|||.:.:|        
Zfish  3053 GIPVQQGSL-----------MQQSQQNRPLLLEEQPLLLQDLLDQERQEQQQQRDMQ-------- 3098

  Fly   457 PPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGG 521
                :::...:::|  .:..:...|...|                        :.|:|.....| 
Zfish  3099 ----AMIRQRSSDP--FFPNIDFDAITDP------------------------IMKAKMVALKG- 3132

  Fly   522 PEEFTNINSVVIKPLDKNTLNCPPS-FNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNAS 585
                  ||.|::    :|::..||. .|..:|...|.|..:.:.|.         .|....|...
Zfish  3133 ------INKVMV----QNSMGMPPMVMNRMQQVPASHAPDTPAFSQ---------PFFGPDGKLP 3178

  Fly   586 DLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQM 650
            ......|           .|..|...:...|.|.....|.:|                 |..|||
Zfish  3179 PQIARPT-----------PPNFGPGFVNESQKKQYEEWLQET-----------------QQLLQM 3215

  Fly   651 HHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKAKLLV 715
            ....::    |:.|:...|..|.|......|......|.:       |..:|:.|         .
Zfish  3216 QQKFLE----DQIGAHRKSKKALSAKQRTAKKAGREFPEE-------DAEQLKNV---------T 3260

  Fly   716 KQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPN 780
            :|::||         :::.|:|...:|..........:.|.|.|...|..|.....|.  |....
Zfish  3261 EQQSVV---------QKQLEQIRKQQKEHAELIEEYRVKQQQQQQRLQTGMMGPMKTM--PVMQG 3314

  Fly   781 PTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPS 845
            ......|:....:.....::|.  :|:..........|:...|.|:   :.|:|..::.....|.
Zfish  3315 QPPGMMPVGPPMAQPMMGSMLP--MQHPHFGKPSRMPSMPGWHPGT---TGPISGPRMPPHLPPQ 3374

  Fly   846 MGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSA 910
            |......:...|:|..|..|     .|....||:||...      .||:|        ::.|...
Zfish  3375 MALPNPAQPLQAQPPAPIAP-----GGKPGQSGTVAGGN------GGGAS--------SSAPHVK 3420

  Fly   911 VAITTPGVGG-------EAKLEQKSDQPAAIMQ-----------------------NQSQNQAPP 945
            .....|...|       |...||:..|...:||                       |...:.|..
Zfish  3421 FDDNNPFSEGFQERERRERLREQQEKQRVQLMQEVERQRALQRLELEQQSLGLGPDNNGDSLAQM 3485

  Fly   946 P------------PPPPQQQQQQQLHQPQQLQP-SPHQVKQTVQIVSKETSFISGPVAAKTLVTE 997
            |            .|.|||||       |||.| .|.|.......|.:.::|:.|          
Zfish  3486 PFYNSDLSQEFMQTPRPQQQQ-------QQLGPLFPQQGNVPCDFVGQGSAFMQG---------- 3533

  Fly   998 ATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPP 1062
                 .|..|.|         .|.:..   .:..|   ..:||.     ||..|..:  .:..||
Zfish  3534 -----GEHRPIP---------GNGSFG---PEMGP---NFQPKN-----PMMPGFSA--GRPRPP 3571

  Fly  1063 LHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIP----------------FKPGEPQKR 1111
               ..|.|.   .||.||...|:...|       :||.:|                ..|.|..|:
Zfish  3572 ---GFGGTR---MPHHGGGEPSSFGMN-------STTPLPPNFPGSGQSLIQLYSNIIPEEKGKK 3623

  Fly  1112 KLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQ 1176
            |     :..:|:....|:   |...|:||....|......:|      ..|..|..:..|...  
Zfish  3624 K-----RSRKKKRDDDAD---SVKTPSTPHSDITAPLTPCVS------DTSSTPTRSVAIMGD-- 3672

  Fly  1177 GQVQMQAQMQATMQ-----GHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQ 1236
                     |.|.:     |.::|..|.::....:|..|.:....|..:....:....:.::|..
Zfish  3673 ---------QDTSEFSNPLGSMTGLPSSELEISLSGSTPLRRQTSVSSEAEHGLLHDIKLEKLES 3728

  Fly  1237 NQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQA------GGALKD 1295
            :..|.|....|| |..|         .:.|..:.....|:....||:.:..|:      ...||.
Zfish  3729 SVCQKAEGEAPV-GHSA---------EETGIIKTEEVNEIISHNRTSQSPAQSTKGEPGNELLKH 3783

  Fly  1296 L-----TGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGA------------ 1343
            |     |.|.|:..::............:|.....|::...:..  ::.|:.:            
Zfish  3784 LLKNKNTPPPPSAPLMHQMSNESLRSEDEGLNDSKGYLRQDSTD--SMSGINSRLTDLEPSLPEQ 3846

  Fly  1344 -----------STGASSSPMLKKRVRKFSKVEEDHDAF---TEKLLTHIR-QMQPLQVLEPHLNR 1393
                       ..|....|   .|.:|..|.|::..|.   |:.|:|.:: |:..|.::||.:..
Zfish  3847 CKKKQRNKRTPKNGVDKPP---SRWKKRKKDEDERQAIYTNTDTLMTQLKQQLSMLPLMEPLIGV 3908

  Fly  1394 NF-HFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYG 1457
            || ||                        ...|.|:|.|.:|                 :.|.:|
Zfish  3909 NFAHF------------------------PPYGSGQLNGENR-----------------LSGSFG 3932

  Fly  1458 RVNLPGIPSLYDSERFGGSRGLVGGSARTRSP--SPAESPGAEKMLPMSSIQNDFYDQEFSTHME 1520
            ..:|.|:...|..        |:.......:|  .||..|.....:....:.|.|...|   .:.
Zfish  3933 SASLDGVSDYYSQ--------LIYKQNNLSNPPTPPASLPPTPPPVARQKLLNGFATAE---ELA 3986

  Fly  1521 RNPRERLVRHIG--------AVKDCNL--------ETVDLVESEGVAAWATLPRLTRYPGLILLN 1569
            |.....:.:.:|        ..:|..|        :|||:     .|:..|.|...:..    |.
Zfish  3987 RKAEVMVSKSLGQKQLTASFKAEDDLLGHTITQGPKTVDV-----PASLPTPPHNNQED----LR 4042

  Fly  1570 GNSRCHGRMSPVAL-----PEDPLTMRF-------------------PVSPLLRSCGEELRKTQQ 1610
            |...|..|.:|.:.     ||..:.|..                   ||.|:|...|.|.|:   
Zfish  4043 GQEHCIDRDTPDSFVPSSSPESVVGMEISRYPDLSRVKEEPPSPAVSPVIPILDCKGSEARR--- 4104

  Fly  1611 MELGMGPLGNNNNNNYQQKNQ-------NVILALPASASENIAGVLRDLANLLHLAPALTCKIIE 1668
            .|:...|..|...:.:.|.:.       .|.:.|...|:.||.||:..|||:|.::         
Zfish  4105 WEVKTEPPSNFFASQFGQLSTCLRTDLVPVSITLNPVAAMNIQGVVSALANMLCVS--------- 4160

  Fly  1669 DKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCG-----NVVHATGLRVP 1728
                                                 :.|..::.||.|     ::...:||:||
Zfish  4161 -------------------------------------IPGNYEVTRSPGPEHRSSIDMLSGLKVP 4188

  Fly  1729 R-----HSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQP 1788
            .     |..|.:....|              |.|...|.|.....|..:    ||...:||..:|
Zfish  4189 HPTSLFHQQPGMRLHRP--------------PLPHQTFSDGTAMVRRDY----GQMHGSSLGSKP 4235

  Fly  1789 AG---------GSAVKSSNGDSPGS------------FCASS--------------------TAP 1812
            ..         |:.|:.|..:.|.:            ||:::                    ..|
Zfish  4236 QWCSHCRVVVLGNGVRKSTKELPMNKLGHGGAVESLVFCSNNCLVLYSASMQSKLLDGKPNFPPP 4300

  Fly  1813 AEMVVKQEP-----------EDED-----EKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPS 1861
            :|...||.|           .|.|     :..|.....||.|.:......:....|| ..|:...
Zfish  4301 SESGDKQNPTKVLHQYNNNISDLDVHCLAQLQPKQSPPPTPIISFPSITSEMLRGDC-KPDTLKV 4364

  Fly  1862 GLELDGTAGAGTGAGP----VNNTVW-----------------------ETETSGL--------- 1890
            .::|.....|....|.    ::...|                       |.|...|         
Zfish  4365 TVKLKPRPRAVHNGGDEPRYLSGKRWKALRWRRWSVQIIVPKGNYHLPVEEEIDALLKKLGTSLR 4429

  Fly  1891 ---QLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQA 1952
               ..:|.|:|.||::.|||..|||:||||.|:|.||||||||||..||||.:|||:|.:.||:.
Zfish  4430 PEPMPKDMRRCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRR 4494

  Fly  1953 GLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGA 2017
            |||..|:.|.|.|||..|.:.||.:.||..||::.:|.|:|:|::.|  |.|...|.::      
Zfish  4495 GLSVRCAYCQQTGATSGCHRLRCTNAYHFTCALKAQCTFFKDKTMLC--HLHRPRGTSL------ 4551

  Fly  2018 TTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQL 2082
             .|.||.|:  ::||....|.|||:|.|||:||:|:::...|..:..|||::....||||||.|:
Zfish  4552 -IGGGLLGT--EHELRCFAVFRRVYVQRDESRQIASIIQRGEREHTFRVGSLVLHAVGQLLPQQM 4613

  Fly  2083 EAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSS 2147
            .|||:...|:|:||:.||.||.:|..||||.|:|||.|....|||.|:|.:.|  ..:....|||
Zfish  4614 LAFHSMTAIFPVGYEASRIYWSMRHGNRRCHYVCSINENDGSPEFVIRVVEQG--YDDLILTGSS 4676

  Fly  2148 PSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRN 2212
            |..||.::|:|:...|....:|:|||.::.||||||||..|:.||:|||||:|....|.|:||||
Zfish  4677 PKGVWDKVLEPVAERRNETGFLRLFPVYLKGEDLFGLTVSAVTRIVESLPGVEACERYTFRYGRN 4741

  Fly  2213 PLLEFPLAINPSGAARTEPK-----QRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSK 2272
            ||::.||||||||.||:|||     :|.:|   :||| .|:.|.:.|...|.|.|.   ..||||
Zfish  4742 PLMQLPLAINPSGCARSEPKACTHIKRFVL---RPHT-LTSTSKALQSPGNPAEIG---VPPYSK 4799

  Fly  2273 QFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQY 2337
            .||||||:||::|..||::|||||||:||||||||||||||:||:|||||.:||:||:..:||.|
Zfish  4800 HFVHSKSAQYRRMNAEWKSNVYLARSRIQGLGLYAARDIEKYTMVIEYIGTIIRSEVANRKEKMY 4864

  Fly  2338 ESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEEL 2402
            |::|||:||||:|.:.|:|||::||.||||||||.|||:||:|.::|..:|||.:.|:|.|||||
Zfish  4865 EAQNRGVYMFRIDSEHVIDATITGGPARYINHSCAPNCITEVVALERGHKIIISSNRRIQRGEEL 4929

  Fly  2403 SYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            .||||||:||:.|||||.|||.|||||||
Zfish  4930 CYDYKFDLEDDQHKIPCHCGAVNCRKWMN 4958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 21/135 (16%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 56/103 (54%)
FYRN 2068..2118 CDD:283589 25/49 (51%)
FYRC 2126..2215 CDD:197781 42/88 (48%)
SET <2266..2431 CDD:225491 111/164 (68%)
SET 2291..2413 CDD:214614 82/121 (68%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
kmt2caXP_005162602.1 PHD_SF 263..346 CDD:304600
PHD1_KMT2C_like 360..404 CDD:276984
PHD2_KMT2C 406..451 CDD:277069
PHD_SF 484..535 CDD:304600
PHD4_KMT2C 973..1029 CDD:277071
PHD5_KMT2C_like 1030..1076 CDD:276988
PHD_SF 1108..1157 CDD:304600
HMG 1707..1760 CDD:197700
CITED 2586..>2683 CDD:282356
ePHD2_KMT2C 4440..4544 CDD:277167 57/105 (54%)
FYRN 4599..4649 CDD:283589 25/49 (51%)
FYRC 4656..4736 CDD:283590 37/81 (46%)
SET 4819..4940 CDD:214614 82/120 (68%)
SET <4820..4958 CDD:225491 95/137 (69%)
PostSET 4942..4958 CDD:214703 13/15 (87%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593891
Domainoid 1 1.000 155 1.000 Domainoid score I4180
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 638 1.000 Inparanoid score I798
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - otm26107
orthoMCL 1 0.900 - - OOG6_102575
Panther 1 1.100 - - O PTHR45888
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.780

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