DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and KMT2E

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_061152.3	Gene:	KMT2E / 55904	HGNCID:	18541	Length:	1858	Species:	Homo sapiens

Alignment Length:	1573	Identity:	297/1573 - (18%)
Similarity:	473/1573 - (30%)	Gaps:	524/1573 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGAAEKAKPERVASVAAAAFNAVSLQKRSGDDTATPAEDPTRKKAKTELLLGTGTAAPSLPAKAS 74
            |..:...:|:.:..:......:..::..|.:..|......||::.|.|.:|.....
Human   535 LSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFAR--------- 590

  Fly    75 STAPQQLLYQRSGQQAKAQVKAASEPQDVETADGVWDARDQQIIVCNFGSGTEM--GAIKAEDAD 137
                   |.:|..::.:|..:.::...:|:|     :.:|.||:     |..|:  ...|.|:|.
Human   591 -------LEKREKRREQALERISTAKTEVKT-----ECKDTQIV-----SDAEVIQEQAKEENAS 638

  Fly   138 KQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVIS-IEPSGSGQDHAENSG 201
            |.:..:::..:..:            ||::.............|.|:.| |:||
Human   639 KPTPAKVNRTKQRK------------SFSRSRTHIGQQRRRHRTVSMCSDIQPS----------- 680

  Fly   202 KSEDLDYVLMPASGADSSTSVGNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQK 266
             |.|::.       ......:.|:..|..|.                          |.|.|.:.
Human   681 -SPDIEV-------TSQQNDIENTVLTIEPE--------------------------TETALAEI 711

  Fly   267 SGHTNYNIFNTTATGSQTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPL 331
            ...|.....|      :.||.        :||.|..| || :.|||..:.|.|.|.|...
Human   712 ITETEVPALN------KCPTK--------YPKTKKHL-VN-EWLSEKNEKTGKPSDGLSE----- 755

  Fly   332 LKPLMSASGAATAGGATIVESKQLLQPGGQVTT---VMSAAQQS-GGQQVHPHVHSHAHH--NFT 390
             :||                         ::||   |::....| .|....|||:|...|  .||
Human   756 -RPL-------------------------RITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFT 794

  Fly   391 KLI---KRGPKNSGTIVSFSGLQIKPANTKIVATKVVSKKMLQ--LQQHQQQIQQQ-----QQLQ 445
            ...   ||..|.....:|.|                ..|:.|:  |::....|..:     |:..
Human   795 SPFLSEKRRRKEPTENISGS----------------CKKRWLKQALEEENSAILHRFNSPCQERS 843

  Fly   446 QLQVTSGGGLAP----PTGSIVTITT--------------------------TNPSQTYAMVQDS 480
            :....:|...:|    .:.|:..:||                          ..|:.|.....|.
Human   844 RSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDP 908

  Fly   481 ATVGPAAHSEDD-----------------APAPRKITAYSENLQ------KILNKSKSQES---- 518
            :...|.....||                 .|.....|.:.||:.      :|..::.|||.
Human   909 SFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRS 973

  Fly   519 ----TGGPEEFTNINSVVIK---------PLDKNTLN--CP-----------------PS--FNI 549
                |.||...:|:..:.::         |..:..:|  ||                 |:  ...
Human   974 STMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKT 1038

  Fly   550 FKQQQHSQAAQSQSISAVGSGAG------------TPVTFTMASGNASDLATTSTVSVSAG---- 598
            .:...|.:|..:..:.:..||.|            |.|.|::.| |..||..:..:.|..|
Human  1039 LETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNS-NLRDLTPSHQLEVGGGFRIS 1102

  Fly   599 ------------------TIC-------------INSPMM--GTRPIISIQNKNISLVLSKTTMA 630
                              ..|             :|..::  ...|....|.|.:|| |......
Human  1103 ESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNCTPQNPPQKKKVSL-LEYRKRQ 1166

  Fly   631 QQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATS-GASMQL-----------KLT 683
            ::..|..:.|......::..|.:....::.|...||.::|.... .||:.|           :.|
Human  1167 REARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEET 1231

  Fly   684 TANTPTK---LSVSLAPDV-----VKLEEVGSES-KAKLLVKQEAVVKDSTG-------TPT--- 729
            :.|.|.|   .|....|:|     ..:|:|...| :..||:......|||.|       :|:
Human  1232 SNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQ 1296

  Fly   730 SEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQ--- 791
            |...:.....|:  |.|...:.:.:::......:....|:|:...:|.|...|..:.|..::
Human  1297 SSPSSHSNHIPQ--LQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGS 1359

  Fly   792 --------------------------RSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASAS 830
                                      .|.||:...||..||....|:  |..:::..|
Human  1360 PGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSN--NNQALSKNH------- 1415

  Fly   831 APLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASG--- 892
                         |....||:..:||::. :|.|||......|........:||..|.|..|
Human  1416 -------------PPQTHVRNSSEQLSQK-LPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLS 1466

  Fly   893 --GSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQN------------------ 937
              ..|||:.:      |.......:|.||...:..|::..|||  ||
Human  1467 PKPPSQQLGS------PYRPHHSQSPQVGTPQREPQRNFYPAA--QNLPANTQQATSGTLFTQTP 1523

  Fly   938 -------------QSQNQA--PPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISG 987
                         ||.|..  |||||||......|..||.....:.:|:|.:   :|::|.|.||
Human  1524 SGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGS---LSQQTVFTSG 1585

  Fly   988 PVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGD 1052
            |..|....|...:.|...:.|..:    .|..|.||...|..|........|.|..
Human  1586 PNQALPGTTSQQTVPGHHVTPGHF----LPSQNPTIHHQTAAAVVPPPPPPPPAPG--------- 1637

  Fly  1053 ESLPEQAEPPLHSEQGATAAGVAP-H--SGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLP 1114
               |...:.|...:|.:.|..|.| |  :.|..:.:|...:||      ...|..||.......|
Human  1638 ---PHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHL------PPPPPPPGPAPHHHPP 1693

  Fly  1115 MHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQN-QSQGQ 1178
            .||....:.:|.|.:..::::.|..|.   .|....|.|...|        ..||.:.: ..||.
Human  1694 PHPSTGLQGLQAQHQHVVNSAPPPPPP---PPPSSVLASGHHT--------TSAQALHHPPHQGP 1747

  Fly  1179 VQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNAT 1243
            ....:....|:..:.|                     |..|...:...||      ||.......
Human  1748 PLFPSSAHPTVPPYPS---------------------QATHHTTLGPGPQ------HQPSGTGPH 1785

  Fly  1244 IPLPVTG-----QGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAG 1303
            .||||||     ||...||.||.....           ..|....|..|..|   .....|:|..
Human  1786 CPLPVTGPHLQPQGPNSIPTPTASGFC-----------PHPGSVALPHGVQG---PQQASPVPGQ 1836

  Fly  1304 AMVQLAGMPPGTQ 1316
            ..:..|.:||..|
Human  1837 IPIHRAQVPPTFQ 1849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	26/136 (19%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
KMT2E	NP_061152.3	HCFC1-binding motif (HBM). /evidence=ECO:0000269\|PubMed:23629655	63..66
		PHD_MLL5	120..163	CDD:277025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..269
		SET	343..452	CDD:214614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..530
		ARGLU	550..>605	CDD:330370	10/70 (14%)
		ERM	<561..>669	CDD:330563	23/145 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..687		14/87 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..960		10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1068		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1561		86/429 (20%)
		DUF4045	<1310..>1502	CDD:330572	40/220 (18%)
		Med15	1442..>1829	CDD:312941	105/471 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1835		70/327 (21%)
		Atrophin-1	<1741..1846	CDD:331285	29/145 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030