DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and ASH1L

DIOPT Version :10

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens


Alignment Length:2601 Identity:473/2601 - (18%)
Similarity:792/2601 - (30%) Gaps:906/2601 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 KRGPK--NSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQI-----------QQQQQLQ 445
            ::.|.  ::||:||...:::: .|||       .::.|:.:..::.|           |||..::
Human    20 RKSPSAISTGTLVSKREVELE-KNTK-------EEEDLRKRNRERNIEAGKDDGLTDAQQQFSVK 76

  Fly   446 QLQVTSGG-----GL------APPTG--SIV---TITTT-------------------------N 469
            :...:.|.     ||      .||..  :.|   .|.||                         :
Human    77 ETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHPRKALKSGKMTDEKNEHCPSKRD 141

  Fly   470 PSQTYAMVQDSATVGPAA------HSE-DDAPAPRKITAYSENLQKILNKSK-----SQESTGGP 522
            ||:.|....|.|.:...:      ||: ::.|..:|::.....:...:|.:.     |::.....
Human   142 PSKLYKKADDVAAIECQSEEVIRLHSQGENNPLSKKLSPVHSEMADYINATPSTLLGSRDPDLKD 206

  Fly   523 EEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSI--------SAVGSGAGTPVTFTM 579
            ....|..:.|.:.|.:....||||.:...:.:......:..:        :.|||.||.      
Human   207 RALLNGGTSVTEKLAQLIATCPPSKSSKTKPKKLGTGTTAGLVSKDLIRKAGVGSVAGI------ 265

  Fly   580 ASGNASDLATTSTVSVSAGTICINSPMMGTRPI----ISIQNKNISLVLSKTTMA-------QQK 633
               ...||....|:|.:.|.: ...|  |.:|:    :.:.||:....|...|.|       .:|
Human   266 ---IHKDLIKKPTISTAVGLV-TKDP--GKKPVFNAAVGLVNKDSVKKLGTGTTAVFINKNLGKK 324

  Fly   634 PKMITTTTLSS-----QAALQMHHALIQDSSADKAGSSANSGSATSGASMQL----KLTTANTPT 689
            |..|||..|.|     :..:.:...|:...|..|.|.....|........:|    .|...:...
Human   325 PGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGLVNKDLGKKLGSTVGLVAKDCAK 389

  Fly   690 KLSVSLAPDVVKLEEVGSE----------SKAKLLVKQEAV------------------------ 720
            |:..|.|..:|. :::|.:          ||..:.:|.||:                        
Human   390 KIVASSAMGLVN-KDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKASCSTNINNQESQELS 453

  Fly   721 --VKDSTGTPTSEERA---------EEIGTPEKRLNANATM----TAINQVQNQSANQIQMATS- 769
              :|||..:.|.|:..         |:....::.:|....|    |.|.|....|:.:....|| 
Human   454 ESLKDSATSKTFEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSK 518

  Fly   770 ---------------------TSTASNP---------STPNPTVNATPMNNQRSAAEDNALL--- 801
                                 .|||.:|         .:|:|||:..|:.  ||..|.::.|   
Human   519 HEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLT--RSPPETSSQLAPN 581

  Fly   802 -------KQLLQNNSSSHSLNQISITSAH--VGSASASAPLSAR-----------KVINVRAP-- 844
                   .:|::..|.|...||.:..|.|  ||..|....:|..           |..::..|  
Human   582 PLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKEVNDSKTTHIDIPRI 646

  Fly   845 --SMGKVRSLEDQLA-RPVIPPVPTATQ-----------AAGSSSSSGSVATSTTTTTVASGGSS 895
              |:||..||..:.: ..:.|.|...|.           |..:|.....||.|.:|:..:.....
Human   647 SSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKK 711

  Fly   896 QQVATASATALPVSAVAITTPGVGGE----------AKLEQKSDQPAAIMQNQSQNQAPPPP--- 947
            ::......|.:...:...:..|:..|          :.|...:.:||..|:|     ..||.   
Human   712 RKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKN-----IGPPSFVD 771

  Fly   948 --------PPPQQQQQQQL------HQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEA 998
                    |...:.....|      .:|.....:.|::..::.:.|...|.|..|...:     .
Human   772 HDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGR-----P 831

  Fly   999 TSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQ-------MKPKAVAMSLPMEQG----D 1052
            .||....|..||......|.|.|....|.::..|..||       .|........|.::|    .
Human   832 KSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQ 896

  Fly  1053 ESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGG---------------------- 1095
            ...|.:.:||:.|    .|..||..|...|.|.  ::||....                      
Human   897 MRSPVKMKPPVLS----VAPFVATESPSKLESE--SDNHRSSSDFFESEDQLQDPDDLDDSHRPS 955

  Fly  1096 -VATTKIPFKP---------GEPQK---RKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPD 1147
             .:.:.:..:|         |:..|   ||:.....|..|::..|.   :|:|:.::..|     
Human   956 VCSMSDLEMEPDKKITKRNNGQLMKTIIRKINKMKTLKRKKLLNQI---LSSSVESSNKG----- 1012

  Fly  1148 KVQ------LISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQM----QATMQGHLSG------- 1195
            |||      :.|..||:..|.|     |.|....:|.:.:..:.    :..:.|.|||       
Human  1013 KVQSKLHNTVSSLAATFGSKLG-----QQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAV 1072

  Fly  1196 --QMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVT--------G 1250
              |.:.|.:|.|.|||...:                    |..:...:..:|.|:.        |
Human  1073 LEQTAQQAAGSALGQILPPL--------------------LPSSASSSEILPSPICSQSSGTSGG 1117

  Fly  1251 QGAV--------PIPVPTME--------------SKAGDQRKRRKREVQKPRRTNLNAGQAGGAL 1293
            |..|        |..||.:.              .||...|:|.......|        .:...|
Human  1118 QSPVSSDAGFVEPSSVPYLHLHSRQGSMIQTLAMKKASKGRRRLSPPTLLP--------NSPSHL 1174

  Fly  1294 KDLTG-----PLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTG----------------QGVT 1337
            .:||.     |.|.........:|        :.||.|....||.                :.|:
Human  1175 SELTSLKEATPSPISESHSDETIP--------SDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHVS 1231

  Fly  1338 LGGVGASTGASS----------------------SPMLKKRVRKFSKVEEDHD----AFTEKLLT 1376
            |.....||..||                      ....:||.:|:.::....|    |..|:|::
Human  1232 LIPPETSTVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELIS 1296

  Fly  1377 HIRQMQ---------PLQVLEPHLNRNF--------------HFLIGSNETSGGGSPASMSSAAS 1418
            .:.:::         |..:|......||              |::...:.....|.|..|..|.:
Human  1297 RLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMA 1361

  Fly  1419 AGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGS 1483
            .....        .|..:|||.            .|.|....:|..||...:...|  .|..|..
Human  1362 EMPFM--------HSLSFPLSS------------TGFYPSYGMPYSPSPLTAAPIG--LGYYGRY 1404

  Fly  1484 ARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNP------RERLVRHIGAVKDCNLETV 1542
            ..|..| |..||.....||..|..:       :.|:..||      :.:|:|.            
Human  1405 PPTLYP-PPPSPSFTTPLPPPSYMH-------AGHLLLNPAKYHKKKHKLLRQ------------ 1449

  Fly  1543 DLVESEGVAAWATLPR-----LTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCG 1602
                    .|:.|..|     ::.||.:              |   ||.............|...
Human  1450 --------EAFLTTSRTPLLSMSTYPSV--------------P---PEMAYGWMVEHKHRHRHKH 1489

  Fly  1603 EELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKII 1667
            .|.|.::|.::.| ..|::.:                        ||..|...         :..
Human  1490 REHRSSEQPQVSM-DTGSSRS------------------------VLESLKRY---------RFG 1520

  Fly  1668 EDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHL---RKILNGRRKLCRSCGNVVHATGLRVPR 1729
            :|.:|.:.:.:      |||      ...:|..||   :.::|...:.       ||    |.|.
Human  1521 KDAVGERYKHK------EKH------RCHMSCPHLSPSKSLINREEQW-------VH----REPS 1562

  Fly  1730 HSVP-ALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSA 1793
            .|.| ||..|.|......:..|..|:             ..|..|.:...::..:.|...|.||.
Human  1563 ESSPLALGLQTPLQIDCSESSPSLSL-------------GGFTPNSEPASSDEHTNLFTSAIGSC 1614

  Fly  1794 VKS---SNG-----DSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGN-PT-NIPAQRKCIVKC 1848
            ..|   |:|     ||||.|.|..|:...:..|:.....:....::.|: || :.|:||    ..
Human  1615 RVSNPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGSQPTSDKPSQR----PS 1675

  Fly  1849 FSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPS 1913
            .|.:|..|....|......|                  .:|:.....|...    .||...|.  
Human  1676 ESTNCSPTRKRSSSESTSST------------------VNGVPSRSPRLVA----SGDDSVDS-- 1716

  Fly  1914 RLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSL 1978
             ||.           .:..|...|.:..::........|..|.:....|....|:    .:.:||
Human  1717 -LLQ-----------RMVQNEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTL----GKPDSL 1765

  Fly  1979 YHLPCAIREECVFYKNKSV---------HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSS 2034
            . :|....:.|    |.|:         .||.| |....:.               .....:...
Human  1766 L-VPAVTSDSC----NNSISLLSEKLTSSCSPH-HIKRSVV---------------EAMQRQARK 1809

  Fly  2035 LVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQ--------LEAFHTPHYI 2091
            :..:.::...:.....|..::...:|....|.|| .|:......|.:        ::||....::
Human  1810 MCNYDKILATKKNLDHVNKILKAKKLQRQARTGN-NFVKRRPGRPRKCPLQAVVSMQAFQAAQFV 1873

  Fly  2092 YP------------------------------------IGYKVSRYYWCVRRPNRRCRYICSIAE 2120
            .|                                    .|.|  |..|.:....|:.:       
Human  1874 NPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLK--RKGWLLEEQTRKKQ------- 1929

  Fly  2121 AGCKPEFRIQVQDAGDKEPEREF---------------RGSSPSAVWQQILQPITRLRK------ 2164
               ||     :.:..::|..:.|               :.|.|.:..|.:|..|.|.:|      
Human  1930 ---KP-----LPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPK 1986

  Fly  2165 -----------VHK-------WLQLFPQHIS---GEDLFGLTEPAIVRILESLPGIETLTDYRFK 2208
                       |:|       .:||..:.:.   ||..:||. ||.:.::..:.|         |
Human  1987 KKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLF-PAPIHVVFFVSG---------K 2041

  Fly  2209 YGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQ--------------------------RT 2247
            |.|...::|.|..:              ::|:..|.|                          ..
Human  2042 YLRQKRIDFQLPYD--------------ILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYE 2092

  Fly  2248 AGSCSTQRMANSA--------------AIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARS 2298
            |.:|:.::..:..              |......||..:|..:.:..::     ||...:...|:
Human  2093 ATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRH-----EWVQCLERFRA 2152

  Fly  2299 KIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYES--KNRGIYMFRLDEDRVVDATLSG 2361
            :.:|.|:.....::....||||:|||:..:  |.|.:..|.  .:...|...||...|:|:...|
Human  2153 EEKGWGIRTKEPLKAGQFIIEYLGEVVSEQ--EFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMG 2215

  Fly  2362 GLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNC 2426
            ..||:|||||:|||..:...|:...||.::|.:.:..|.||:|||.|...:...:..|.||...|
Human  2216 NEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKC 2280

  Fly  2427 R 2427
            |
Human  2281 R 2281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
PRK13914 <623..>851 CDD:237555 70/350 (20%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 19/112 (17%)
FYRN 2067..2118 CDD:461787 12/94 (13%)
FYRC 2126..2215 CDD:197781 23/130 (18%)
SET_KMT2C_2D 2278..2430 CDD:380948 47/152 (31%)
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143 0/24 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583 13/47 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966 15/93 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281 4/37 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711 32/169 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991 16/96 (17%)
Catalytic domain 2069..2288 53/220 (24%)
AWS 2092..2143 CDD:197795 6/55 (11%)
SET_ASH1L 2146..2286 CDD:380951 45/138 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346
Bromo_ASH1 2443..2548 CDD:99955
PHD_ASH1L 2586..2628 CDD:277023
BAH_polybromo 2665..2799 CDD:240068
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919
Blue background indicates that the domain is not in the aligned region.

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