DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and ASH1L

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens


Alignment Length:2594 Identity:470/2594 - (18%)
Similarity:795/2594 - (30%) Gaps:892/2594 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 KRGPK--NSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQI-----------QQQQQLQ 445
            ::.|.  ::||:||...:::: .|||       .::.|:.:..::.|           |||..::
Human    20 RKSPSAISTGTLVSKREVELE-KNTK-------EEEDLRKRNRERNIEAGKDDGLTDAQQQFSVK 76

  Fly   446 QLQVTSGG-----GL------APPTG--SIV---TITTT-------------------------N 469
            :...:.|.     ||      .||..  :.|   .|.||                         :
Human    77 ETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHPRKALKSGKMTDEKNEHCPSKRD 141

  Fly   470 PSQTYAMVQDSATVGPAA------HSE-DDAPAPRKITAYSENLQKILNKSK-----SQESTGGP 522
            ||:.|....|.|.:...:      ||: ::.|..:|::.....:...:|.:.     |::.....
Human   142 PSKLYKKADDVAAIECQSEEVIRLHSQGENNPLSKKLSPVHSEMADYINATPSTLLGSRDPDLKD 206

  Fly   523 EEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSI--------SAVGSGAGTPVTFTM 579
            ....|..:.|.:.|.:....||||.:...:.:......:..:        :.|||.||.      
Human   207 RALLNGGTSVTEKLAQLIATCPPSKSSKTKPKKLGTGTTAGLVSKDLIRKAGVGSVAGI------ 265

  Fly   580 ASGNASDLATTSTVSVSAGTICINSPMMGTRPI----ISIQNKNISLVLSKTTMA-------QQK 633
               ...||....|:|.:.|.: ...|  |.:|:    :.:.||:....|...|.|       .:|
Human   266 ---IHKDLIKKPTISTAVGLV-TKDP--GKKPVFNAAVGLVNKDSVKKLGTGTTAVFINKNLGKK 324

  Fly   634 PKMITTTTLSS-----QAALQMHHALIQDSSADKAGSSANSGSATSGASMQL----KLTTANTPT 689
            |..|||..|.|     :..:.:...|:...|..|.|.....|........:|    .|...:...
Human   325 PGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGLVNKDLGKKLGSTVGLVAKDCAK 389

  Fly   690 KLSVSLAPDVVKLEEVGSE----------SKAKLLVKQEAV------------------------ 720
            |:..|.|..:|. :::|.:          ||..:.:|.||:                        
Human   390 KIVASSAMGLVN-KDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKASCSTNINNQESQELS 453

  Fly   721 --VKDSTGTPTSEERA---------EEIGTPEKRLNANATM----TAINQVQNQSANQIQMATS- 769
              :|||..:.|.|:..         |:....::.:|....|    |.|.|....|:.:....|| 
Human   454 ESLKDSATSKTFEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSK 518

  Fly   770 ---------------------TSTASNP---------STPNPTVNATPMNNQRSAAEDNALL--- 801
                                 .|||.:|         .:|:|||:..|:.  ||..|.::.|   
Human   519 HEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLT--RSPPETSSQLAPN 581

  Fly   802 -------KQLLQNNSSSHSLNQISITSAH--VGSASASAPLSAR-----------KVINVRAP-- 844
                   .:|::..|.|...||.:..|.|  ||..|....:|..           |..::..|  
Human   582 PLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKEVNDSKTTHIDIPRI 646

  Fly   845 --SMGKVRSLEDQLA-RPVIPPVPTATQ-----------AAGSSSSSGSVATSTTTTTVASGGSS 895
              |:||..||..:.: ..:.|.|...|.           |..:|.....||.|.:|:..:.....
Human   647 SSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKK 711

  Fly   896 QQVATASATALPVSAVAITTPGVGGE----------AKLEQKSDQPAAIMQNQSQNQAPPPP--- 947
            ::......|.:...:...:..|:..|          :.|...:.:||..|:|     ..||.   
Human   712 RKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKN-----IGPPSFVD 771

  Fly   948 --------PPPQQQQQQQL------HQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEA 998
                    |...:.....|      .:|.....:.|::..::.:.|...|.|..|...:     .
Human   772 HDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGR-----P 831

  Fly   999 TSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQ-------MKPKAVAMSLPMEQG----D 1052
            .||....|..||......|.|.|....|.::..|..||       .|........|.::|    .
Human   832 KSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQ 896

  Fly  1053 ESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGG---------------------- 1095
            ...|.:.:||:.|    .|..||..|...|.|.  ::||....                      
Human   897 MRSPVKMKPPVLS----VAPFVATESPSKLESE--SDNHRSSSDFFESEDQLQDPDDLDDSHRPS 955

  Fly  1096 -VATTKIPFKP---------GEPQK---RKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPD 1147
             .:.:.:..:|         |:..|   ||:.....|..|::..|.   :|:|:.::..|     
Human   956 VCSMSDLEMEPDKKITKRNNGQLMKTIIRKINKMKTLKRKKLLNQI---LSSSVESSNKG----- 1012

  Fly  1148 KVQ------LISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQM----QATMQGHLSG------- 1195
            |||      :.|..||:..|.|     |.|....:|.:.:..:.    :..:.|.|||       
Human  1013 KVQSKLHNTVSSLAATFGSKLG-----QQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAV 1072

  Fly  1196 --QMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQ------G 1252
              |.:.|.:|.|.|||...:                    |..:...:..:|.|:..|      |
Human  1073 LEQTAQQAAGSALGQILPPL--------------------LPSSASSSEILPSPICSQSSGTSGG 1117

  Fly  1253 AVP------------IPVPTMESKAGD--------QRKRRKREVQKPRRTNLNAGQAG--GALKD 1295
            ..|            :|...:.|:.|.        :..:.:|.:..|.....:.....  .:||:
Human  1118 QSPVSSDAGFVEPSSVPYLHLHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKE 1182

  Fly  1296 LTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTG----------------QGVTLGGVGAS 1344
            .| |.|.........:|        :.||.|....||.                :.|:|.....|
Human  1183 AT-PSPISESHSDETIP--------SDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHVSLIPPETS 1238

  Fly  1345 TGASS----------------------SPMLKKRVRKFSKVEEDHD----AFTEKLLTHIRQMQ- 1382
            |..||                      ....:||.:|:.::....|    |..|:|::.:.::: 
Human  1239 TVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRI 1303

  Fly  1383 --------PLQVLEPHLNRNF--------------HFLIGSNETSGGGSPASMSSAASAGSSSAG 1425
                    |..:|......||              |::...:.....|.|..|..|.:.....  
Human  1304 THRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFM-- 1366

  Fly  1426 GGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPS 1490
                  .|..:|||.            .|.|....:|..||...:...|  .|..|....|..| 
Human  1367 ------HSLSFPLSS------------TGFYPSYGMPYSPSPLTAAPIG--LGYYGRYPPTLYP- 1410

  Fly  1491 PAESPGAEKMLPMSSIQNDFYDQEFSTHMERNP------RERLVRHIGAVKDCNLETVDLVESEG 1549
            |..||.....||..|..:       :.|:..||      :.:|:|.                   
Human  1411 PPPSPSFTTPLPPPSYMH-------AGHLLLNPAKYHKKKHKLLRQ------------------- 1449

  Fly  1550 VAAWATLPR-----LTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQ 1609
             .|:.|..|     ::.||.:              |   ||.............|....|.|.::
Human  1450 -EAFLTTSRTPLLSMSTYPSV--------------P---PEMAYGWMVEHKHRHRHKHREHRSSE 1496

  Fly  1610 QMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNK 1674
            |.::.| ..|::.:                        ||..|...         :..:|.:|.:
Human  1497 QPQVSM-DTGSSRS------------------------VLESLKRY---------RFGKDAVGER 1527

  Fly  1675 LEDQFMNQDDEKHVDFKRPLSQVSHGHL---RKILNGRRKLCRSCGNVVHATGLRVPRHSVP-AL 1735
            .:.:      |||      ...:|..||   :.::|...:.       ||    |.|..|.| ||
Human  1528 YKHK------EKH------RCHMSCPHLSPSKSLINREEQW-------VH----REPSESSPLAL 1569

  Fly  1736 EEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKS---S 1797
            ..|.|......:..|..|:             ..|..|.:...::..:.|...|.||...|   |
Human  1570 GLQTPLQIDCSESSPSLSL-------------GGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNS 1621

  Fly  1798 NG-----DSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGN-PT-NIPAQRKCIVKCFSADCFT 1855
            :|     ||||.|.|..|:...:..|:.....:....::.|: || :.|:||    ...|.:|..
Human  1622 SGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGSQPTSDKPSQR----PSESTNCSP 1682

  Fly  1856 TDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDV 1920
            |....|......|                  .:|:.....|...    .||...|.   ||.   
Human  1683 TRKRSSSESTSST------------------VNGVPSRSPRLVA----SGDDSVDS---LLQ--- 1719

  Fly  1921 DKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAI 1985
                    .:..|...|.:..::........|..|.:....|....|:    .:.:||. :|...
Human  1720 --------RMVQNEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTL----GKPDSLL-VPAVT 1771

  Fly  1986 REECVFYKNKSV---------HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRV 2041
            .:.|    |.|:         .||.| |....:.               .....:...:..:.::
Human  1772 SDSC----NNSISLLSEKLTSSCSPH-HIKRSVV---------------EAMQRQARKMCNYDKI 1816

  Fly  2042 FVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQ--------LEAFHTPHYIYP----- 2093
            ...:.....|..::...:|....|.|| .|:......|.:        ::||....::.|     
Human  1817 LATKKNLDHVNKILKAKKLQRQARTGN-NFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNRD 1880

  Fly  2094 -------------------------------IGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEF 2127
                                           .|.|  |..|.:....|:.:          ||  
Human  1881 EEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLK--RKGWLLEEQTRKKQ----------KP-- 1931

  Fly  2128 RIQVQDAGDKEPEREF---------------RGSSPSAVWQQILQPITRLRK------------- 2164
               :.:..::|..:.|               :.|.|.:..|.:|..|.|.:|             
Human  1932 ---LPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAG 1993

  Fly  2165 ----VHK-------WLQLFPQHIS---GEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLL 2215
                |:|       .:||..:.:.   ||..:||. ||.:.::..:.|         ||.|...:
Human  1994 LYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLF-PAPIHVVFFVSG---------KYLRQKRI 2048

  Fly  2216 EFPLAINPSGAARTEPKQRQLLVWRKPHTQ--------------------------RTAGSCSTQ 2254
            :|.|..:              ::|:..|.|                          ..|.:|:.:
Human  2049 DFQLPYD--------------ILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCK 2099

  Fly  2255 RMANSA--------------AIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGL 2305
            :..:..              |......||..:|..:.:..::     ||...:...|::.:|.|:
Human  2100 KPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRH-----EWVQCLERFRAEEKGWGI 2159

  Fly  2306 YAARDIEKHTMIIEYIGEVIRTEVSEIREKQYES--KNRGIYMFRLDEDRVVDATLSGGLARYIN 2368
            .....::....||||:|||:..:  |.|.:..|.  .:...|...||...|:|:...|..||:||
Human  2160 RTKEPLKAGQFIIEYLGEVVSEQ--EFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFIN 2222

  Fly  2369 HSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCR 2427
            |||:|||..:...|:...||.::|.:.:..|.||:|||.|...:...:..|.||...||
Human  2223 HSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCR 2281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 19/112 (17%)
FYRN 2068..2118 CDD:283589 11/93 (12%)
FYRC 2126..2215 CDD:197781 23/130 (18%)
SET <2266..2431 CDD:225491 50/164 (30%)
SET 2291..2413 CDD:214614 40/123 (33%)
PostSET 2415..2431 CDD:214703 5/13 (38%)
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143 0/24 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583 13/47 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966 15/93 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231 13/88 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281 4/37 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711 32/169 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991 16/96 (17%)
Catalytic domain 2069..2288 53/220 (24%)
AWS 2092..2143 CDD:197795 6/55 (11%)
SET 2146..2266 CDD:214614 40/121 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346
Bromo_ASH1 2443..2548 CDD:99955
PHD_ASH1L 2586..2628 CDD:277023
BAH_polybromo 2665..2799 CDD:240068
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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