DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and kmt2a

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_005157640.1 Gene:kmt2a / 557048 ZFINID:ZDB-GENE-080521-3 Length:4219 Species:Danio rerio


Alignment Length:2602 Identity:511/2602 - (19%)
Similarity:826/2602 - (31%) Gaps:925/2602 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 LPAKASSTAPQQL-------LYQRSGQQAKAQVKAASEPQDVETADGVWDARDQQIIVCNFGSGT 126
            ||....||.|..:       :|.|:...:......:...:.:.:.||..:...:.:.|   |...
Zfish  2304 LPGPIDSTKPSNVPSTPKPRVYFRNRHPSFPPCHRSPSTRPLPSPDGFNNTGHEIVTV---GDPL 2365

  Fly   127 EMGAIKAEDADKQSEYRIST--PRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTAS------ 183
            ...::::..:.:.|...||.  ||...|:| ....|.::     :..:||||..|||:.      
Zfish  2366 LSSSLRSIGSRRHSTSSISAQQPRQKVSSP-PQGGTVYS-----QTGNSSASFMSSTSKEPLTKD 2424

  Fly   184 -----VISIEPSGSGQDHAENSGKSEDLDYVLMP-ASGADSST---SVGNSTGTGTPAGT----- 234
                 |.|.|.|.|.:.::.|.|....|.:.... ..|:..:|   |.|.|..:..||..     
Zfish  2425 TDKGRVSSGETSFSREPNSINIGAQRRLSFGFTERVDGSKEATKKHSDGESLKSSQPASVSQVSP 2489

  Fly   235 PIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTTLLNRVNLHPKM 299
            |:|....|....|:.|.....|...          |..|.....||...:....:|.:...:|. 
Zfish  2490 PLGTAVLTGHQRASGGIKNEKGKQA----------TKDNDLPAGATFMSSHPLAMLPKDKANPN- 2543

  Fly   300 KTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQPGGQVTT 364
            |...|.:...|.:..:|.:...|.||:.|        ..|....:|.|.:|..|.|...|.::  
Zfish  2544 KEGNMTSMAALKDTVKTGSPQRIYNKSGS--------RKSHDYASGPAAVVAMKPLWSSGAKL-- 2598

  Fly   365 VMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSG---LQIKPANTKIVATKVVSK 426
                     |::.               ||||.:.|..|....|   .:.|.:..|:..::.|||
Zfish  2599 ---------GEED---------------IKRGFQASAGITGSHGTSSTKEKHSKVKMNVSRDVSK 2639

  Fly   427 KMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSED 491
            :..:..|::..:...........|.  |..||..:|....|...|.|     .|.||......:.
Zfish  2640 ERKETPQNRNAVLNSNSKSSNVKTQ--GQVPPPHNISNKATALSSNT-----GSGTVEVNKFDQK 2697

  Fly   492 DAPAPRKI-------TAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNI 549
            :...|.|.       ..::..:..|..|:.|:.|...|:.....:..|  ||            :
Zfish  2698 EVEKPLKSKERFSFEKKHTSAMDAIQPKAGSERSIRPPQVHPKSSKEV--PL------------V 2748

  Fly   550 FKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIIS 614
            .|:.....:..||.:                     |...|..||:|..|....|          
Zfish  2749 GKKHTERLSLMSQKM---------------------DPNRTKAVSISPNTQTYTS---------- 2782

  Fly   615 IQNKNISLVLSKTTMAQQKPK------MITTTTLSSQAALQMHHALIQDS--------------- 658
                        .|.:.|.|:      |:.:.:.||:::....|....||               
Zfish  2783 ------------VTPSNQGPQRRSSRAMVFSPSASSESSESDSHIHPDDSEEHLMDHQCADDGED 2835

  Fly   659 -------SADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAP------------------D 698
                   |.||.....:.|||.| |..:....:|...:.:...|.|                  :
Zfish  2836 NNLEDEGSVDKHHEEDSDGSAGS-AKRRYPRRSARARSNMFFGLTPFYGVRSYGEEDIPFYRSGE 2899

  Fly   699 VVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEE----IGTPEKRLNANATMTAINQVQNQ 759
            :...:..||..::   .:.:....|...|.:|.:..|:    ||:.:.....|.|.|.|      
Zfish  2900 ISMKKRTGSSKRS---AEGQVDGADDMSTSSSADSGEDEEGGIGSNKDTYYYNFTRTII------ 2955

  Fly   760 SANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNAL-----LKQLLQNNSSSHSLNQISI 819
                           |||:..|::          |..|..|     :.:.|::.:..|..:...:
Zfish  2956 ---------------NPSSGLPSI----------AGIDQCLGRGSQIHRFLRDQAKEHEDDSDEV 2995

  Fly   820 TSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATST 884
            ::|               ..|:....:|::..::|                  .|.|..|::||:
Zfish  2996 STA---------------TKNLELQQIGQLDGVDD------------------GSESDISISTSS 3027

  Fly   885 TTTTVASG---GSSQQVATASATA---LPVSAVAITTPGVGGEAKLEQKSD-QPAAIMQNQSQNQ 942
            |||...|.   ||:::....|.|.   :.....|:.|.....:::..||.: .|...::.|.|: 
Zfish  3028 TTTATTSSTQKGSTKRKGRESRTEKSNVDSGKEAVNTTSNSRDSRKNQKDNCLPLGSVKTQGQD- 3091

  Fly   943 APPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLP 1007
                                   |...|:..|..::..::.            ...:.....:||
Zfish  3092 -----------------------PLETQLSLTTDLLKSDSD------------NNNSDDCGNILP 3121

  Fly  1008 PPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQG-------DESLPEQAEPPLHS 1065
                    :.|....::..:.||..::.: .|.|...||....|       |....:..:|..::
Zfish  3122 --------SDIMEFVLNTPSMQALGQQAE-APSAEQFSLDESYGVDVNQRKDMLFEDFTQPLANA 3177

  Fly  1066 EQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEI 1130
            |.|                        |.||:||     ....:...||:             |:
Zfish  3178 ESG------------------------ESGVSTT-----IAVEESYGLPL-------------EL 3200

  Fly  1131 PISTSLPTT-----------PTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQ 1184
            |...|:.||           |....|.::..|  |:||...::|                   ..
Zfish  3201 PSDLSVLTTRSPTVSNQNHGPLISETSERTML--ALATEESEAG-------------------KS 3244

  Fly  1185 MQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVT 1249
            .:.|..|......|.| .|.|..|:| :.|:..:|.:..:|....                  :|
Zfish  3245 KKKTRTGSTVSSKSPQ-EGCADSQVP-EGHMTPEHFIPPSVDGDH------------------IT 3289

  Fly  1250 GQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMP-- 1312
            ..|..|:      .:.|:|...|...                     |..||:...:.|....  
Zfish  3290 SPGVAPV------GETGNQDMTRTSS---------------------TPVLPSSPTLPLQNQKFI 3327

  Fly  1313 PGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTH 1377
            |.|....|.|..|...:.:....:..|                               .|||:..
Zfish  3328 PATTVTSGPAPITSSAVQAAASQLKPG-------------------------------PEKLIVL 3361

  Fly  1378 IRQMQPLQVLE--PH--LNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGW-P 1437
            .:.:|||.||:  |:  :|.|...|.|   .|||     :|::.|.         ...||:|. |
Zfish  3362 NQHLQPLYVLQTVPNGVMNPNAPVLTG---LSGG-----ISTSQSI---------FPAGSKGLVP 3409

  Fly  1438 LSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGG-------------------- 1482
            :|.|.: :....||....:    .|.|||.        :.||:.|                    
Zfish  3410 VSHHPQ-IHAFTGTTQTGF----QPVIPST--------TSGLLIGVTSHDPQIGVTEAGHRHDHA 3461

  Fly  1483 -------SARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLE 1540
                   ||.|.:|:|:       |:|             |.|    .::||:..:.:.|     
Zfish  3462 PNVAMVSSASTITPAPS-------MIP-------------SGH----GKKRLISRLQSPK----- 3497

  Fly  1541 TVDLVESEGVAAWATLPRLTRY---PGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCG 1602
                  |:..|...|.|.|...   |.:.|:|        :||     ..:....|.        
Zfish  3498 ------SKKQARPKTQPTLAPSDVGPNMTLIN--------LSP-----SQIAAGIPA-------- 3535

  Fly  1603 EELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKII 1667
                :|..||||                  .|.|.|.....||  :.|....:::|.|.:..:.:
Zfish  3536 ----QTGLMELG------------------TITATPHRKIPNI--IKRPKQGVMYLEPTILPQPM 3576

  Fly  1668 EDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSV 1732
              .|....:...:..|...|:             |...::| ....:|..|||          ||
Zfish  3577 --PISTTTQPGILGHDSSTHL-------------LPCTVSG-LNTSQSVLNVV----------SV 3615

  Fly  1733 PALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSS 1797
            |:                  |.|..|:                              |||:|..|
Zfish  3616 PS------------------SAPGNFL------------------------------GGSSVSLS 3632

  Fly  1798 NGDSPGSFCASST----APAEMVVKQEPEDED-EKTPSV--PGNP-----TNIPAQRKCIVKCFS 1850
               :||  ..|||    :.:.:::|..|.:.. .:.|.|  ||.|     || |||    ....|
Zfish  3633 ---APG--LISSTEITGSLSNLLIKANPHNLSLSEQPMVLHPGTPMMSHLTN-PAQ----TSIAS 3687

  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRL 1915
            :.|....:....:             |||..|.:..|..||                  ...||:
Zfish  3688 SICVFPPNQSITV-------------PVNQQVEKEGTVHLQ------------------HAVSRV 3721

  Fly  1916 LNFDVDKWVHLN------CALWSNGVYETVS-GALMNFQTALQAGLSQACSACHQP--------- 1964
            |   .||.:..|      .||..|.:.:.:: |.:::..|.     |...|...:|         
Zfish  3722 L---ADKTLDPNVSSAGQVALAPNPISQELNKGHVVSVLTQ-----SSRTSPISRPQHQHQASKL 3778

  Fly  1965 --GATIKCF-KSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGS 2026
              ||:...| |.:..:....||         .:||     .|..|.|:........|:...|...
Zfish  3779 PAGASSVAFGKGKHKAKRPRPC---------PDKS-----SGKKHKGLHSDTPTVDTSAIQLSYI 3829

  Fly  2027 VADNELS--------------------------SLVVHRRVFVDRDENRQVATVMHYSELSNLLR 2065
            ..|.|||                          |..:.|:.....||....|.:....:     .
Zfish  3830 KGDQELSSPEPMDTGQSNETGSKKRDSTTMTTNSSALKRKTVDAVDEKPSTAGLPSKGD-----G 3889

  Fly  2066 VGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQ 2130
            .||..|                                .|..|::|                   
Zfish  3890 TGNKAF--------------------------------SVDTPDQR------------------- 3903

  Fly  2131 VQDAG-----DKEPER------------EFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISG 2178
              |:|     |.:|::            :.|..|....|:.:...:...|...:...|....::|
Zfish  3904 --DSGRDSSLDHKPKKGLIFEICSDDGFQIRCESIEEAWKSLTDKVQEARSNARLKALSFDGVNG 3966

  Fly  2179 EDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLV----- 2238
            ..:.|:...|:|.:||.|.|.....:|||::.:....:: |.:||.|:||.|...|:.::     
Zfish  3967 LKMLGVVHDAVVFLLEQLYGARHCRNYRFRFHKPEETDY-LPVNPHGSARAEVYHRKSVLDMFNF 4030

  Fly  2239 ----WRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSK 2299
                .|:|...........:....||..|.....|..::|        :::|:..|:.|.:.||.
Zfish  4031 LASKHRQPPVYNPQEEDEEEMQQKSARRATSTDLPLPEKF--------RQLKKASRDAVGVYRSA 4087

  Fly  2300 IQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLA 2364
            |.|.||:..::||...|:|||.|.|||:.:::.|||.|:.|..|.||||:|:..|||||:.|..|
Zfish  4088 IHGRGLFCRKNIEPGEMVIEYSGNVIRSVLTDKREKYYDDKGIGCYMFRIDDYEVVDATIHGNSA 4152

  Fly  2365 RYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKW 2429
            |:|||||.|||.:.:|.||....|:|||.||||:||||:|||||.||:..:|:||.|||..|||:
Zfish  4153 RFINHSCEPNCYSRVVNVDGQKHIVIFATRKIYKGEELTYDYKFPIEEPGNKLPCNCGAKKCRKF 4217

  Fly  2430 MN 2431
            :|
Zfish  4218 LN 4219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 31/144 (22%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 22/122 (18%)
FYRN 2068..2118 CDD:283589 5/49 (10%)
FYRC 2126..2215 CDD:197781 20/105 (19%)
SET <2266..2431 CDD:225491 79/164 (48%)
SET 2291..2413 CDD:214614 66/121 (55%)
PostSET 2415..2431 CDD:214703 9/15 (60%)
kmt2aXP_005157640.1 zf-CXXC 1312..1359 CDD:251032
PHD1_KMT2A 1627..1673 CDD:277063
PHD2_KMT2A 1675..1724 CDD:277065
PHD3_KMT2A 1762..1818 CDD:277067
Bromo_ALL-1 1841..1971 CDD:99925
ePHD_KMT2A 2066..2178 CDD:277163
FYRN 2220..2266 CDD:283589
FYRC 3919..4002 CDD:197781 16/82 (20%)
SET <4060..4219 CDD:225491 79/166 (48%)
SET 4081..4201 CDD:214614 66/119 (55%)
PostSET 4203..4219 CDD:214703 9/15 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D738155at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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