Protein Alignment trr and kmt2a

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: XP_005157640.1
• Gene: kmt2a / 557048
• ZFINID: ZDB-GENE-080521-3
• Length: 4219
• Species: Danio rerio
• Alignment Length: 2602
• Identity: 511/2602 - (19%)
• Similarity: 826/2602 - (31%)
• Gaps: 925/2602 - (35%)

  Fly    69 LPAKASSTAPQQL-------LYQRSGQQAKAQVKAASEPQDVETADGVWDARDQQIIVCNFGSGT 126
            ||....||.|..:       :|.|:...:......:...:.:.:.||..:...:.:.|   |...
Zfish  2304 LPGPIDSTKPSNVPSTPKPRVYFRNRHPSFPPCHRSPSTRPLPSPDGFNNTGHEIVTV---GDPL 2365

  Fly   127 EMGAIKAEDADKQSEYRIST--PRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTAS------ 183
            ...::::..:.:.|...||.  ||...|:| ....|.::     :..:||||..|||:.
Zfish  2366 LSSSLRSIGSRRHSTSSISAQQPRQKVSSP-PQGGTVYS-----QTGNSSASFMSSTSKEPLTKD 2424

  Fly   184 -----VISIEPSGSGQDHAENSGKSEDLDYVLMP-ASGADSST---SVGNSTGTGTPAGT----- 234
                 |.|.|.|.|.:.::.|.|....|.:.... ..|:..:|   |.|.|..:..||..
Zfish  2425 TDKGRVSSGETSFSREPNSINIGAQRRLSFGFTERVDGSKEATKKHSDGESLKSSQPASVSQVSP 2489

  Fly   235 PIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTTLLNRVNLHPKM 299
            |:|....|....|:.|.....|...          |..|.....||...:....:|.:...:|.
Zfish  2490 PLGTAVLTGHQRASGGIKNEKGKQA----------TKDNDLPAGATFMSSHPLAMLPKDKANPN- 2543

  Fly   300 KTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQPGGQVTT 364
            |...|.:...|.:..:|.:...|.||:.|        ..|....:|.|.:|..|.|...|.::
Zfish  2544 KEGNMTSMAALKDTVKTGSPQRIYNKSGS--------RKSHDYASGPAAVVAMKPLWSSGAKL-- 2598

  Fly   365 VMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSG---LQIKPANTKIVATKVVSK 426
                     |::.               ||||.:.|..|....|   .:.|.:..|:..::.|||
Zfish  2599 ---------GEED---------------IKRGFQASAGITGSHGTSSTKEKHSKVKMNVSRDVSK 2639

  Fly   427 KMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSED 491
            :..:..|::..:...........|.  |..||..:|....|...|.|     .|.||......:.
Zfish  2640 ERKETPQNRNAVLNSNSKSSNVKTQ--GQVPPPHNISNKATALSSNT-----GSGTVEVNKFDQK 2697

  Fly   492 DAPAPRKI-------TAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNI 549
            :...|.|.       ..::..:..|..|:.|:.|...|:.....:..|  ||            :
Zfish  2698 EVEKPLKSKERFSFEKKHTSAMDAIQPKAGSERSIRPPQVHPKSSKEV--PL------------V 2748

  Fly   550 FKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIIS 614
            .|:.....:..||.:                     |...|..||:|..|....|
Zfish  2749 GKKHTERLSLMSQKM---------------------DPNRTKAVSISPNTQTYTS---------- 2782

  Fly   615 IQNKNISLVLSKTTMAQQKPK------MITTTTLSSQAALQMHHALIQDS--------------- 658
                        .|.:.|.|:      |:.:.:.||:::....|....||
Zfish  2783 ------------VTPSNQGPQRRSSRAMVFSPSASSESSESDSHIHPDDSEEHLMDHQCADDGED 2835

  Fly   659 -------SADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAP------------------D 698
                   |.||.....:.|||.| |..:....:|...:.:...|.|                  :
Zfish  2836 NNLEDEGSVDKHHEEDSDGSAGS-AKRRYPRRSARARSNMFFGLTPFYGVRSYGEEDIPFYRSGE 2899

  Fly   699 VVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEE----IGTPEKRLNANATMTAINQVQNQ 759
            :...:..||..::   .:.:....|...|.:|.:..|:    ||:.:.....|.|.|.|
Zfish  2900 ISMKKRTGSSKRS---AEGQVDGADDMSTSSSADSGEDEEGGIGSNKDTYYYNFTRTII------ 2955

  Fly   760 SANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNAL-----LKQLLQNNSSSHSLNQISI 819
                           |||:..|::          |..|..|     :.:.|::.:..|..:...:
Zfish  2956 ---------------NPSSGLPSI----------AGIDQCLGRGSQIHRFLRDQAKEHEDDSDEV 2995

  Fly   820 TSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATST 884
            ::|               ..|:....:|::..::|                  .|.|..|::||:
Zfish  2996 STA---------------TKNLELQQIGQLDGVDD------------------GSESDISISTSS 3027

  Fly   885 TTTTVASG---GSSQQVATASATA---LPVSAVAITTPGVGGEAKLEQKSD-QPAAIMQNQSQNQ 942
            |||...|.   ||:::....|.|.   :.....|:.|.....:::..||.: .|...::.|.|:
Zfish  3028 TTTATTSSTQKGSTKRKGRESRTEKSNVDSGKEAVNTTSNSRDSRKNQKDNCLPLGSVKTQGQD- 3091

  Fly   943 APPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLP 1007
                                   |...|:..|..::..::.            ...:.....:||
Zfish  3092 -----------------------PLETQLSLTTDLLKSDSD------------NNNSDDCGNILP 3121

  Fly  1008 PPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQG-------DESLPEQAEPPLHS 1065
                    :.|....::..:.||..::.: .|.|...||....|       |....:..:|..::
Zfish  3122 --------SDIMEFVLNTPSMQALGQQAE-APSAEQFSLDESYGVDVNQRKDMLFEDFTQPLANA 3177

  Fly  1066 EQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEI 1130
            |.|                        |.||:||     ....:...||:             |:
Zfish  3178 ESG------------------------ESGVSTT-----IAVEESYGLPL-------------EL 3200

  Fly  1131 PISTSLPTT-----------PTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQ 1184
            |...|:.||           |....|.::..|  |:||...::|                   ..
Zfish  3201 PSDLSVLTTRSPTVSNQNHGPLISETSERTML--ALATEESEAG-------------------KS 3244

  Fly  1185 MQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVT 1249
            .:.|..|......|.| .|.|..|:| :.|:..:|.:..:|....                  :|
Zfish  3245 KKKTRTGSTVSSKSPQ-EGCADSQVP-EGHMTPEHFIPPSVDGDH------------------IT 3289

  Fly  1250 GQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMP-- 1312
            ..|..|:      .:.|:|...|...                     |..||:...:.|....
Zfish  3290 SPGVAPV------GETGNQDMTRTSS---------------------TPVLPSSPTLPLQNQKFI 3327

  Fly  1313 PGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTH 1377
            |.|....|.|..|...:.:....:..|                               .|||:..
Zfish  3328 PATTVTSGPAPITSSAVQAAASQLKPG-------------------------------PEKLIVL 3361

  Fly  1378 IRQMQPLQVLE--PH--LNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGW-P 1437
            .:.:|||.||:  |:  :|.|...|.|   .|||     :|::.|.         ...||:|. |
Zfish  3362 NQHLQPLYVLQTVPNGVMNPNAPVLTG---LSGG-----ISTSQSI---------FPAGSKGLVP 3409

  Fly  1438 LSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGG-------------------- 1482
            :|.|.: :....||....:    .|.|||.        :.||:.|
Zfish  3410 VSHHPQ-IHAFTGTTQTGF----QPVIPST--------TSGLLIGVTSHDPQIGVTEAGHRHDHA 3461

  Fly  1483 -------SARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLE 1540
                   ||.|.:|:|:       |:|             |.|    .::||:..:.:.|
Zfish  3462 PNVAMVSSASTITPAPS-------MIP-------------SGH----GKKRLISRLQSPK----- 3497

  Fly  1541 TVDLVESEGVAAWATLPRLTRY---PGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCG 1602
                  |:..|...|.|.|...   |.:.|:|        :||     ..:....|.
Zfish  3498 ------SKKQARPKTQPTLAPSDVGPNMTLIN--------LSP-----SQIAAGIPA-------- 3535

  Fly  1603 EELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKII 1667
                :|..||||                  .|.|.|.....||  :.|....:::|.|.:..:.:
Zfish  3536 ----QTGLMELG------------------TITATPHRKIPNI--IKRPKQGVMYLEPTILPQPM 3576

  Fly  1668 EDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSV 1732
              .|....:...:..|...|:             |...::| ....:|..|||          ||
Zfish  3577 --PISTTTQPGILGHDSSTHL-------------LPCTVSG-LNTSQSVLNVV----------SV 3615

  Fly  1733 PALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSS 1797
            |:                  |.|..|:                              |||:|..|
Zfish  3616 PS------------------SAPGNFL------------------------------GGSSVSLS 3632

  Fly  1798 NGDSPGSFCASST----APAEMVVKQEPEDED-EKTPSV--PGNP-----TNIPAQRKCIVKCFS 1850
               :||  ..|||    :.:.:::|..|.:.. .:.|.|  ||.|     || |||    ....|
Zfish  3633 ---APG--LISSTEITGSLSNLLIKANPHNLSLSEQPMVLHPGTPMMSHLTN-PAQ----TSIAS 3687

  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRL 1915
            :.|....:....:             |||..|.:..|..||                  ...||:
Zfish  3688 SICVFPPNQSITV-------------PVNQQVEKEGTVHLQ------------------HAVSRV 3721

  Fly  1916 LNFDVDKWVHLN------CALWSNGVYETVS-GALMNFQTALQAGLSQACSACHQP--------- 1964
            |   .||.:..|      .||..|.:.:.:: |.:::..|.     |...|...:|
Zfish  3722 L---ADKTLDPNVSSAGQVALAPNPISQELNKGHVVSVLTQ-----SSRTSPISRPQHQHQASKL 3778

  Fly  1965 --GATIKCF-KSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGS 2026
              ||:...| |.:..:....||         .:||     .|..|.|:........|:...|...
Zfish  3779 PAGASSVAFGKGKHKAKRPRPC---------PDKS-----SGKKHKGLHSDTPTVDTSAIQLSYI 3829

  Fly  2027 VADNELS--------------------------SLVVHRRVFVDRDENRQVATVMHYSELSNLLR 2065
            ..|.|||                          |..:.|:.....||....|.:....:     .
Zfish  3830 KGDQELSSPEPMDTGQSNETGSKKRDSTTMTTNSSALKRKTVDAVDEKPSTAGLPSKGD-----G 3889

  Fly  2066 VGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQ 2130
            .||..|                                .|..|::|
Zfish  3890 TGNKAF--------------------------------SVDTPDQR------------------- 3903

  Fly  2131 VQDAG-----DKEPER------------EFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISG 2178
              |:|     |.:|::            :.|..|....|:.:...:...|...:...|....::|
Zfish  3904 --DSGRDSSLDHKPKKGLIFEICSDDGFQIRCESIEEAWKSLTDKVQEARSNARLKALSFDGVNG 3966

  Fly  2179 EDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLV----- 2238
            ..:.|:...|:|.:||.|.|.....:|||::.:....:: |.:||.|:||.|...|:.::
Zfish  3967 LKMLGVVHDAVVFLLEQLYGARHCRNYRFRFHKPEETDY-LPVNPHGSARAEVYHRKSVLDMFNF 4030

  Fly  2239 ----WRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSK 2299
                .|:|...........:....||..|.....|..::|        :::|:..|:.|.:.||.
Zfish  4031 LASKHRQPPVYNPQEEDEEEMQQKSARRATSTDLPLPEKF--------RQLKKASRDAVGVYRSA 4087

  Fly  2300 IQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLA 2364
            |.|.||:..::||...|:|||.|.|||:.:::.|||.|:.|..|.||||:|:..|||||:.|..|
Zfish  4088 IHGRGLFCRKNIEPGEMVIEYSGNVIRSVLTDKREKYYDDKGIGCYMFRIDDYEVVDATIHGNSA 4152

  Fly  2365 RYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKW 2429
            |:|||||.|||.:.:|.||....|:|||.||||:||||:|||||.||:..:|:||.|||..|||:
Zfish  4153 RFINHSCEPNCYSRVVNVDGQKHIVIFATRKIYKGEELTYDYKFPIEEPGNKLPCNCGAKKCRKF 4217

  Fly  2430 MN 2431
            :|
Zfish  4218 LN 4219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	31/144 (22%)
		PRK13914	<623..>851	CDD:237555	44/282 (16%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136	22/122 (18%)
		FYRN	2067..2118	CDD:461787	6/50 (12%)
		FYRC	2126..2215	CDD:197781	20/105 (19%)
		SET_KMT2C_2D	2278..2430	CDD:380948	77/151 (51%)
kmt2a	XP_005157640.1	zf-CXXC	1312..1359	CDD:366873
		PHD1_KMT2A	1627..1673	CDD:277063
		PHD2_KMT2A	1675..1724	CDD:277065
		PHD3_KMT2A	1762..1818	CDD:277067
		Bromo_ALL-1	1841..1971	CDD:99925
		ePHD_KMT2A	2066..2178	CDD:277163
		FYRN	2219..2266	CDD:461787
		Atrophin-1	3221..>3709	CDD:460830	146/793 (18%)
		FYRC	3919..4002	CDD:197781	16/82 (20%)
		SET_KMT2A	4066..4219	CDD:380983	78/160 (49%)