DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and setd1a

DIOPT Version :10

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_021329647.2 Gene:setd1a / 556535 ZFINID:ZDB-GENE-080521-4 Length:2253 Species:Danio rerio


Alignment Length:2679 Identity:526/2679 - (19%)
Similarity:849/2679 - (31%) Gaps:902/2679 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 TPAEDPTRKKAKTELLLGTGTAAPSLPAK--ASSTAPQQLLYQRSGQQAKAQVKAAS-EPQDVET 105
            ||...||..||.||..      .|.:|.:  .||...::|...:....|.|.:.:.| .|..|:|
Zfish   186 TPQTVPTGGKALTEKF------QPPVPTQPDTSSDIRRRLSTDQMAAPAAATLNSGSTTPCSVDT 244

  Fly   106 ADGVWDARDQQIIVCNFGSGTEMGAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEG 170
            ..|     ||                           |:.||.:|...|          :|....
Zfish   245 GFG-----DQ---------------------------RLDTPPSSMGGP----------YTPGSS 267

  Fly   171 ASSSASSSSSTASVISIEPSGSGQDHAENSGKSEDLDYV---LMPASGADSSTSVGNSTG----- 227
            |||....:..|....:.....||...|.:.|.|....:.   ::|:|.. ||::|.:|:|     
Zfish   268 ASSQGGGTPYTPRSGTPFSQDSGYSVARHGGYSSTQSFPQQDMLPSSSC-SSSAVSSSSGFKPPR 331

  Fly   228 ------------------TGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNI 274
                              .|.||..|.                             :.....|..
Zfish   332 FHDDLHAPPPQDVFQRGRPGFPASAPF-----------------------------RPNEPPYPY 367

  Fly   275 FNTTATGSQTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSAS 339
            .:...:|...|         |||.:..|.  ....||:..:...: ..|::...        ..|
Zfish   368 PSAGGSGMHMP---------LHPPVPPQF--EQPPLSDRERERDR-ERGHRDRE--------RDS 412

  Fly   340 GAATAGGATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRG----PKNS 400
            |....||.  :.|::...|..|.|...|.::..       |.| |:||...:..:.|    ..:|
Zfish   413 GGGRYGGG--ISSRRSTYPYQQETNSSSTSKTY-------HAH-HSHHADRREDRDGRGYRRDSS 467

  Fly   401 GTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTI 465
            |   |.||...:..|                  |.......         ||||     ||....
Zfish   468 G---SRSGDHSRHRN------------------HHHSHNHH---------SGGG-----GSSRRR 497

  Fly   466 TTT------------NPSQ-TYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQE 517
            ::.            |||. .|....:|      :|...::.:|...|:                
Zfish   498 SSRDREWERDRDGEFNPSDPRYGSHSNS------SHHSSNSLSPPSATS---------------- 540

  Fly   518 STGGPEEFTNINSVVIKPLD-KNTLNCPPSFNIFKQQQ-------------------HSQ----- 557
            |.||   |:  :|..:.|.| .::....|| :.|:.||                   ||.     
Zfish   541 SFGG---FS--SSKDLSPYDTPSSSRLEPS-SAFRPQQGAGERAFGMGGSMDNDYRGHSHHTPLA 599

  Fly   558 ---------------AAQSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMM 607
                           ||.::::|::..|..:|:        ..:..|......|...:...:|..
Zfish   600 PPPPPPPLPPASVIAAAVAETLSSLDFGQDSPI--------REEQWTKPKRHPSTPPLPPRTPPT 656

  Fly   608 GTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAAL-----QMHHALIQDSSADKAGSSA 667
            .:.|..||.:.:.|  .|.|::....|        ||.|:|     |...:...||:.:......
Zfish   657 SSPPHASIPSSSTS--PSSTSLPHHLP--------SSTASLSPPPPQRDSSPEPDSTNESLPFMH 711

  Fly   668 NSGSATSGASMQLKLTTANTPTKLSVSLAPDV-VKLEEVGSESKAKLLVKQEAVVKDSTGTPTSE 731
            :|.|..|...|.||...|    |.|...:.|. .:.:||....|::........:::..|...|.
Zfish   712 HSSSLDSRIEMLLKEQKA----KFSFLASDDEDDEKDEVRERGKSENSKDGGNKLREHGGERPSH 772

  Fly   732 ERAEEIGTPEKRLN---------------------------ANATMTAINQVQNQSANQI----Q 765
            :|..|:...::|..                           |::|.|..:.|......||    :
Zfish   773 KRQGEMEAGQQRRRGEKDGRRSRGKRQVSGVGEGRKTPPEVASSTPTVHSLVSESLQGQIPPPQE 837

  Fly   766 MATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASAS 830
            ..|::.|...|.|| ||.|.....:.||:.||..:         |....|.|:..::|..::|:|
Zfish   838 EHTTSDTHRAPHTP-PTYNGEAQPSPRSSGEDMEI---------SDEDDNTITTATSHPAASSSS 892

  Fly   831 APLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSS 895
            :|.::.:.:            |..|...|...|.|..:|...                       
Zfish   893 SPAASSQTV------------LPSQTTDPSASPAPDTSQHFS----------------------- 922

  Fly   896 QQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQ 960
               ||.....:|.....:..|.:.|.:.                  |.||||..|......:|| 
Zfish   923 ---ATMPPPPIPSYPPHLPPPPLPGFSL------------------QPPPPPGIPPPLPHMELH- 965

  Fly   961 PQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPIS---NVT 1022
            |:...|.||.:......:...:.:..|                   .|..::|.|..:|   .:.
Zfish   966 PEYPPPLPHHMYDYASSMELMSQYCGG-------------------APMSFQMQTHMLSRLHQMR 1011

  Fly  1023 ISISTKQAAPKELQMKPKAV--AMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSA 1085
            ::.|...|||      |..|  |...|......|:|....||.|           ||.  |.:..
Zfish  1012 MASSNSTAAP------PAEVPPASEYPPSYHLHSIPPPHAPPHH-----------PHH--PYMDQ 1057

  Fly  1086 QWTNNHLEGGVAT----------TKIPFKPGEPQKRKLPMH-----------PQLDEKQIQQQAE 1129
                   :|.||:          ..:|:...:|...:||.|           |.|..:|.  .:.
Zfish  1058 -------DGNVASHYDQDHRYIPPPLPYAYPDPHAAQLPHHHTIPPPHTPWPPHLLPQQF--PSH 1113

  Fly  1130 IPISTSLPTTPTGQGTPDKV--QLISAIATYVKKSGVPNEAQPIQNQSQGQVQ-----MQAQMQA 1187
            .|        |.|.|....|  :|..|....:...|        .|..:..||     :..:|:.
Zfish  1114 YP--------PPGFGAVPGVDGELYGAAGDQMAIMG--------HNPCEAVVQQVLAALIEEMKN 1162

  Fly  1188 TMQGHLSGQMSGQISGHAAGQI------------PAQMHLQVQHQLHMAVHPQQQQQQ------- 1233
            .||..|:.:|   :...|.|..            |.|..::     .:||..::::::       
Zfish  1163 IMQRDLNRKM---VENVAFGTFDEWWDRKERKAKPFQTAMR-----GVAVVREEEKKEEKTTTTM 1219

  Fly  1234 LHQNQPQNATIPL-------PVTG---QGAVPIPVPTMESK------AGDQRKRRK-----REVQ 1277
            ...|:|:...:.|       .:.|   :||:.:|...::.|      .||:.||.:     .|..
Zfish  1220 TTSNRPREPLMSLVDWAKSGGMEGFSLRGALRLPSFKVKRKEPQELVEGDELKRARPSTPPDEED 1284

  Fly  1278 KPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVG 1342
            :......:|..|.|..::.          ::|.        :|||.............:...|..
Zfish  1285 EDSYQGKSADAAAGRTEER----------RVAE--------RGAARRRSRAKARKPYELDSEGEE 1331

  Fly  1343 ASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGG 1407
            .|.|:||    :|......||:|..|   |.|..                       .|::.|..
Zfish  1332 TSDGSSS----EKEDEDSDKVDESED---EALSA-----------------------DSDDESVS 1366

  Fly  1408 GSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNL----------- 1461
            .|.:..||::||.|||:.....:.|.:    :...|.|:..|.:.:.....|:.           
Zfish  1367 SSSSESSSSSSASSSSSDEEDEEEGEQ----AAESESLDTMDESTMDSVAAVDTEKDERDKASLD 1427

  Fly  1462 -PGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPM----------SSIQNDFYDQEF 1515
             |.:.:..|.:.          ..::.:|.|..||......|:          .::.....:.|.
Zfish  1428 QPSVTTPEDKQE----------EEKSATPVPPSSPYPRPSSPILLLPPLKKRRKTVSFSMEESEV 1482

  Fly  1516 STHME----RNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHG 1576
            ...::    .:|....|.....|.    .:|..|.:...||    |..:..|..:||...|| ..
Zfish  1483 KPSVQSSTASSPSPSPVSQASDVP----PSVSPVSTPTPAA----PSASSKPVPMLLPFASR-PS 1538

  Fly  1577 RMSPVALPEDPLTMRFPVSPLLRSC-GEELRKTQQMELGMGPLGNNNN---NNYQQKNQNVILAL 1637
            ..|.:..|..|..: ..|.|.:||. .:|.:|:.      ||..:...   .|..::.::.....
Zfish  1539 ESSALTSPASPSAI-LTVPPPVRSLRPDEPKKSP------GPPPSPQTPPPKNSTKRGKDSPRTP 1596

  Fly  1638 PASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHL 1702
            ||.....:..:..|.|:::.:|       .||.:                     ||.....|..
Zfish  1597 PAPVCLTVQNLPLDHASMVKMA-------YEDPV---------------------PLPTTQKGRA 1633

  Fly  1703 RKILNGR-RKLCRSCGNVVHATGLRVPRHSVPAL------EEQLPRLAQLMD------MLPRKSV 1754
            |    || |.|.:|..          ..|..|||      ||:|.:..:|.:      :|...|.
Zfish  1634 R----GRPRTLSQSAS----------ASHLHPALEEEDEDEEELEQRLKLREQLGVSSLLQLASA 1684

  Fly  1755 PPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTA-----PAE 1814
            |.|     |.:..|..... .|.:|:..|...: ....|.:....:..|.|.|....     |..
Zfish  1685 PKP-----DLSVLADVALK-MDPEADIDSEETE-TSDEAEEHKLEEEEGDFFAPHPRQPLLDPEG 1742

  Fly  1815 MVVKQEPEDEDEKTPSVPGNPTNI-PAQRKCIVKCFSADCFTTDSAPSGL-----ELDGTAGAGT 1873
            :.|.|  |....|||:    |.:| |.|:|  .|..|......|....|:     |:.|.|.|..
Zfish  1743 LFVMQ--EHNYSKTPA----PQHITPPQKK--TKQDSTVLLPADLNQHGVQEAPEEVIGEALAAR 1799

  Fly  1874 GAGPV----------NNTVWETETSGLQLEDTR-----QCVFCNQRGDGQADGPSRLLNFDVDKW 1923
            ...|.          .....||:|..|.....|     :.|...:||.|:....||     .|| 
Zfish  1800 AEAPELYGDLDLLCDGREAAETQTKTLSSPYKRTGSISKEVELEERGKGKNKKRSR-----KDK- 1858

  Fly  1924 VHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREE 1988
                    .|...:|                     :..|....:|..|.|         .:.| 
Zfish  1859 --------ENEELQT---------------------SKKQKEKQVKKQKKR---------KLEE- 1884

  Fly  1989 CVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVAT 2053
              |.::..|.....|.                  |..|.:|:..|...:.|.:..:::|      
Zfish  1885 --FEEDVDVEQLESGE------------------LSSSTSDSGDSDFGLERSLEFEKEE------ 1923

  Fly  2054 VMHYSELSNLLRVGNMTFLNVGQLLPH-QLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICS 2117
                      :|.....||....|.|. |....|||..: ||           .||:.:.|    
Zfish  1924 ----------VRKSERLFLQEAGLTPSTQRRPKHTPESL-PI-----------PRPSYKNR---- 1962

  Fly  2118 IAEAGCKPEFR-----IQVQDAG-DKEPEREFRGSSPSAVWQQILQP---ITRLRKVHKWLQLFP 2173
                   .||.     ..:.::| |:|..|..:     :.::::||.   ...|...| |:.   
Zfish  1963 -------SEFEQMTILYDIWNSGLDQEDMRLLK-----STYEKLLQDDHGTDWLNDTH-WVP--- 2011

  Fly  2174 QHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTE------PK 2232
                                      .|:|:......:....:..|..:.:|.||:|      .|
Zfish  2012 --------------------------HTITNIPNPRRKKKTADGQLREHVTGCARSEGYYAISRK 2050

  Fly  2233 QRQL-LVWRKPHTQR------TAGS--CSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQE 2288
            ::.: |...:|.|.|      ||||  ..::|.:....:...:..|........|.:|.|..|::
Zfish  2051 EKDVYLELDQPVTLREIGDYDTAGSNRVLSERRSEQRRLLSAIGTPAVMDSDLLKLNQLKFRKKK 2115

  Fly  2289 WRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMFRLDED 2352
            .|    ..||:|...||:|...|....|:|||:|:.||..|::.|||:|..:..| .|:||:|.|
Zfish  2116 LR----FGRSRIHEWGLFAMEPIAADEMVIEYVGQSIRQMVADNREKRYAQEGIGSSYLFRVDHD 2176

  Fly  2353 RVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKI 2417
            .::|||..|.|||:|||.|.|||..:::.::...:|:|::|:.|...||::|||||.||:  :||
Zfish  2177 TIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVNEEITYDYKFPIEE--NKI 2239

  Fly  2418 PCACGAPNCRKWMN 2431
            ||.||..:||..:|
Zfish  2240 PCLCGTESCRGTLN 2253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 25/161 (16%)
PRK13914 <623..>851 CDD:237555 53/264 (20%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 17/103 (17%)
FYRN 2067..2118 CDD:461787 13/51 (25%)
FYRC 2126..2215 CDD:197781 13/97 (13%)
SET_KMT2C_2D 2278..2430 CDD:380948 65/152 (43%)
setd1aXP_021329647.2 None

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