DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and nsd1a

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_683890.4	Gene:	nsd1a / 556086	ZFINID:	ZDB-GENE-080519-3	Length:	2055	Species:	Danio rerio

Alignment Length:	2106	Identity:	412/2106 - (19%)
Similarity:	651/2106 - (30%)	Gaps:	759/2106 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 GTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNN 790
            |...||.|    |.|:   ::.|....|.....||....|     |:|.:...|...::|....|
Zfish     9 GRDGSECR----GDPQ---DSRALDVRIGSCGQQSTKADQ-----SSAMHFLNPGYKLSAPFAYN 61

  Fly   791 QRSAAEDNALLKQL-----LQNNSSS-------HSLNQISITSAHVGSASASAPLSARKVINVRA 843
            ||.:..:.:.|::|     :.|::..       |..|::.:.|...|:...   :......|
Zfish    62 QRESTSNYSPLRRLQDLTTMVNHADGGLQDKDFHGRNKLLMHSPIGGNEFG---IGLYNTTN--- 120

  Fly   844 PSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQ-------QVATA 901
             |.|.. :::| |.:....||.:.:....|..|:|.:  ...:|...||.|..       :|||.
Zfish   121 -SQGNT-AIQD-LDKNGFSPVSSDSLEHFSPISNGFL--HFDSTLFDSGDSKDNDEDVKGEVATF 180

  Fly   902 SATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPP----------------- 949
            ..|:.......:        ||.|.:|.......::.|:|.|...||.
Zfish   181 KDTSKKCQKRNV--------AKTETQSSHRLDANKHSSKNTAKSDPPASPFHVPFTMMEDFDSMD 237

  Fly   950 ---------PQQQQ-------QQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEA 998
                     |..:.       .::.|.|.....:|....:..|::|.:.| |...|.||
Zfish   238 DYSDSDCDLPSTENCASIFNLSKRAHSPSDSHSNPSSSPKKKQLLSVKYS-IGDVVWAK------ 295

  Fly   999 TSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAM--------------SLPME 1049
                ....|..|..:.|.|    .|.:.||...|.....:...|.|              :.|.|
Zfish   296 ----FNRRPWWPCHVTTDP----QIDVHTKMKDPSRRPCRLYFVRMFGEIVDQAWVPAKATFPFE 352

  Fly  1050 QGDE---------------------------------------SLPEQ--AEPPLH--------- 1064
            .||:                                       ||.:|  :||||.
Zfish   353 GGDQFEKLPVLRRRGRQKEKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLTLIQDVCVPI 417

  Fly  1065 SEQGATAAGVAPHSGGPLVSAQWT-----NNHLEGGV-ATTKIPFKPGEPQKRKLPMHPQLDEKQ 1123
            :|..|       |...|......|     ::.|..|: |:.|...|||...|:|      ..:|.
Zfish   418 TEDKA-------HKKNPACPKSTTLSTPSSSLLSNGLNASVKNRLKPGTASKKK------ATKKM 469

  Fly  1124 IQQQAEIPISTSLPTTPT---GQGTP--DKVQLISAIAT------YVKKSGVPNEAQPIQNQSQG 1177
            ||.|     |..|..||:   .:..|  ||    .:|||      |.....||
Zfish   470 IQSQ-----SIKLSETPSLFKSKSNPSSDK----PSIATDPLDSPYSDIDSVP------------ 513

  Fly  1178 QVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNA 1242
            ::....::..::|..|..::|.:.:             :||
Zfish   514 RILCSKRIDESLQVELEKELSTKTT-------------KVQ------------------------ 541

  Fly  1243 TIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGP-------- 1299
              ....|.:.:|..|....:.|.   .|..|.:...|:...|.|  ....||:.:.|
Zfish   542 --ACKKTSKNSVDKPGKKTDVKC---LKNSKLKKSTPKDKTLKA--TSSRLKESSSPGSSDGSFA 599

  Fly  1300 -----LPA--GAMVQ------------LAGMP----PGTQYIQGAASGTGHVITSTGQGVTLGGV 1341
                 |||  |.:|:            |:..|    |.:::    :|.|.|.::.....|.....
Zfish   600 MHSHYLPASSGLIVRALAAGEETKEKDLSHEPNSHSPSSEH----SSQTNHELSKQNWEVKNNSE 660

  Fly  1342 GA--STGASSSP-------MLKKRVRK---------------FSKVEEDHDAFTEKLLTHI--RQ 1380
            .:  |..||.||       .:|||.:|               .|||..: ..|::...:.|  ..
Zfish   661 SSEESVDASDSPPNPTSIKRIKKRPQKNGIHKDPPPKSHEESESKVNNE-SMFSDTSSSSIPSPS 724

  Fly  1381 MQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGL 1445
            :.|:...:.....:|..|: ..|.|.|.||....|                   .:..|..|..|
Zfish   725 ISPMDAFQDIKELSFRSLV-KEECSSGESPLRADS-------------------NYKFSTFLMLL 769

  Fly  1446 EDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSP-SPA----ESPGAEKMLPMSS 1505
            :|                   |:||..       ..|...|..| ||:    |.|   .::|:.
Zfish   770 KD-------------------LHDSRE-------KEGKPLTLPPTSPSSLIKEEP---SLIPVG- 804

  Fly  1506 IQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNG 1570
                          |..|.|.|         |..|         .|..::||..|..|     |.
Zfish   805 --------------EEPPNEVL---------CEKE---------FAEQSSLPGKTSTP-----NN 832

  Fly  1571 NSRCHGRMSPVALPED--PLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNV 1633
            :.:...::......|.  |..:...||||.:.              :.|:|    .:...|:..:
Zfish   833 SKQSKAKLKSTVKKESQKPDVVIDSVSPLKKP--------------ISPVG----LDVLDKSLPL 879

  Fly  1634 ILALPASASENIAGVLRDL---ANLLHLAPALTCKIIEDKIGNKLE----------DQFMNQDDE 1685
            :..||.|:  :::..:.|:   ..:..:||....|..|.::|..::          |:..:...|
Zfish   880 LGDLPKSS--DVSAAVTDVCAKGTISKVAPKKRWKTFESELGKSIKPKSDQVDSTLDEVKSVSTE 942

  Fly  1686 KHVDFKRPLSQVSHG------------HLRK--------------ILNGRRKL------CR--SC 1716
            .:..||..|.:.:|.            .|||              |...::|.      |:  ||
Zfish   943 PNGVFKDGLQESAHSDVPNKKDASENKRLRKPSKRLIECGEEYEQIFPSKKKTKKSTESCKTGSC 1007

  Fly  1717 ---------------GNVVHATGLRVPRHSVPALEEQLP-------------------------- 1740
                           .:.|.::....|...|.| |||.|
Zfish  1008 ISNTTPEQPASDQITLDAVSSSSAEKPLDHVVA-EEQKPPADVLVPPSAPKSPSCATSLETEPCE 1071

  Fly  1741 -RLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSN------ 1798
             :.|.|....|||||....                 |...|..|:.:...|.|....:|
Zfish  1072 KKSAPLERKRPRKSVHKVL-----------------DCAIEGESVKIPKKGESRQHKTNPEESGV 1119

  Fly  1799 ---------GDSPGSFCA------------SSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQR 1842
                     |..|.|.||            |...|....|.|.|.:.::.:||.|    .|..:.
Zfish  1120 RDLEKQEEAGPPPSSPCAVSAQSEGELRTSSPIQPDVPSVSQIPVEGEQSSPSKP----QINNED 1180

  Fly  1843 KCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRG-- 1905
            ..|.:.|:|.  ..|||.|  ..|..:|..:|......:|  ....|..|:: ..|..|.:.|
Zfish  1181 SLISEGFAAG--LNDSAFS--SRDSLSGDLSGLSTNKRSV--ERGGGASLKE-NVCQVCEKTGEL 1238

  Fly  1906 ---DGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGAT 1967
               :||..|.           .||.|.    |:.||..|..:..:..:..   ..|..|.:|...
Zfish  1239 LLCEGQCCGA-----------FHLQCI----GLTETPKGRFICQECKMGV---HTCFVCKKPDKE 1285

  Fly  1968 I-KCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNE 2031
            : :|....|...||:.|.::......:|:...||:|......||.....|.:.|
Zfish  1286 VRRCMIPVCGKFYHMDCILKYSPTVAQNRGFRCSIHVCLSCYITNPNNPGISKG----------- 1339

  Fly  2032 LSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGY 2096
                    |:      .|.|...:.|......:..|::...|...|.|:        |:....|.
Zfish  1340 --------RL------TRCVRCPVAYHANDYCMAAGSVPLANNSFLCPN--------HFTPRKGC 1382

  Fly  2097 KVSRYY---WCV---------------RRPNRRC--------RYICSIAEAGCKPEFRIQVQDAG 2135
            |...:.   ||.               ...:|.|        .:.|:...||.||.::
Zfish  1383 KNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYK------- 1440

  Fly  2136 DKEPEREFRGSSPSAVW----------QQILQP------ITRLRKVHKWLQLFPQHISGEDLFGL 2184
                         ..:|          .::.||      |:|::  |: :..||.|..|...:..
Zfish  1441 -------------DILWVKVGRYRWWPAEVTQPKSVPENISRMK--HE-VGEFPVHFFGSKDYVW 1489

  Fly  2185 TEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAAR-----TEPKQRQLLVWRK--- 2241
            |..|     ...|.:|...:.:.|.|:.....:..|:| ..|.|     .|.:.|||...||
Zfish  1490 TYQA-----RCFPYMEGDANNKEKMGKGADAVYKKALN-EAADRFRELLKEKEMRQLQEDRKNDK 1548

  Fly  2242 ---PH----TQRTAGS-------------CSTQRM-ANSAAIAGEV------------ACPYSKQ 2273
               |:    ..:..|.             |:.:.. .|...|..|.            .||..::
Zfish  1549 KPPPYKHIKVNKQIGKVLIITADLSEIPRCNCKATDENPCGIDSECINRMLLYECHSQVCPAGER 1613

  Fly  2274 FVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYE 2338
                  .|.:...:.....|.:.|:..:|.||.:..||:|...:.||:||||..|  |.|.:...
Zfish  1614 ------CQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEE--ECRSRIKN 1670

  Fly  2339 SKNRGI---YMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGE 2400
            :::..|   ||..||:||::||...|..:|::||||.|||.|:...|:.|.|:.:||...|.:|.
Zfish  1671 AQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGV 1735

  Fly  2401 ELSYDYKFDIEDESHKIPCACGAPNC 2426
            ||:::|..:..... |..|.||||||
Zfish  1736 ELTFNYNLECLGNG-KTVCKCGAPNC 1760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	24/109 (22%)
		FYRN	2068..2118	CDD:283589	11/75 (15%)
		FYRC	2126..2215	CDD:197781	16/104 (15%)
		SET	<2266..2431	CDD:225491	57/176 (32%)
		SET	2291..2413	CDD:214614	46/124 (37%)
		PostSET	2415..2431	CDD:214703	8/12 (67%)
nsd1a	XP_683890.4	PWWP	285..382	CDD:295359	19/111 (17%)
		TNG2	<1108..1270	CDD:227367	41/187 (22%)
		PHD1_NSD1_2	1228..1270	CDD:277118	13/56 (23%)
		PHD_SF	1275..1321	CDD:304600	11/45 (24%)
		PHD3_NSD1	1322..1375	CDD:277123	12/85 (14%)
		PHD4_NSD1	1392..1431	CDD:277126	5/38 (13%)
		WHSC1_related	1437..1531	CDD:99899	21/122 (17%)
		AWS	1574..1624	CDD:197795	7/55 (13%)
		SET	1626..1748	CDD:214614	46/123 (37%)
		PHD5_NSD1	1802..1844	CDD:277129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840