DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and NSD3

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_075447.1 Gene:NSD3 / 54904 HGNCID:12767 Length:1437 Species:Homo sapiens


Alignment Length:1689 Identity:304/1689 - (17%)
Similarity:492/1689 - (29%) Gaps:710/1689 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   925 EQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPV 989
            |..:.:|..|::..|    ||.||||               ||   |.|||  :.|:|    |..
Human   115 EIPNTRPHEILEKPS----PPQPPPP---------------PS---VPQTV--IPKKT----GSP 151

  Fly   990 AAKTLVTEATSKPAELLPPPPYEMATAP--ISNVTISIST--KQAAPKELQMKPKAVAMSLPMEQ 1050
            ..|..:|:......||     :|.:...  ::.|..|..|  |..:.||.:.|......|...|:
Human   152 EIKLKITKTIQNGREL-----FESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEER 211

  Fly  1051 GDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPM 1115
            ....:| :.||   .||.      .|:.....||.                  ||.|        
Human   212 KSHKIP-KLEP---EEQN------RPNERVDTVSE------------------KPRE-------- 240

  Fly  1116 HPQLDEKQIQQQAEI-PISTSLPTTPTGQGTPDKV-QLI-SAIATY------------------V 1159
                 |..::::|.: ||.:|:|||....|...:| .|: |.:.||                  :
Human   241 -----EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300

  Fly  1160 KKSGVPN-EAQPIQNQSQGQVQMQAQMQATMQGH-----LSGQMSGQISGHAAGQ---IPAQMHL 1215
            ...|... ..|...||.: :..:..:.....:||     |..:.:.|.|.|:..|   .|.....
Human   301 NTRGAREYHVQFFSNQPE-RAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRE 364

  Fly  1216 QVQHQLHMAVHPQQ-----QQQQLHQ-------NQPQNA-------------------------T 1243
            :.|..:.:| |.::     :::::.|       .||:.|                         |
Human   365 RAQWDIGIA-HAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNT 428

  Fly  1244 IPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLP--AGAM- 1305
            .| ..|..|.|...:.:.|.:...||:....|.::|....: |.:...|.|.|...:.  .|:: 
Human   429 QP-EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKI-AWKTAAARKSLPASITMHKGSLD 491

  Fly  1306 VQLAGMPPGTQYIQ----GAASGTG-----HVITSTGQG----VTLGG----------------- 1340
            :|...|.|..:..|    ..|:|.|     .|.::.|.|    :::.|                 
Human   492 LQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPT 556

  Fly  1341 --------VGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQ----PLQVLEPHLNR 1393
                    ...|||:......::.:|..|:.|:..:...:|   .|::.|    |...::..|.:
Human   557 QSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKK---KIKKEQVETVPQATVKTGLQK 618

  Fly  1394 NFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGR 1458
                  |::|.|....|....|.||.                           |.:.|       
Human   619 ------GASEISDSCKPLKKRSRAST---------------------------DVEMT------- 643

  Fly  1459 VNLPGIPSLYDSERFGGSRGL----VGGSARTRSPSPAESPGAEKMLPMSSIQNDFYD-QEFSTH 1518
                  .|.|.......||||    ||...:..|||             ::...|..| |...:.
Human   644 ------SSAYRDTSDSDSRGLSDLQVGFGKQVDSPS-------------ATADADVSDVQSMDSS 689

  Fly  1519 MERNPRERLVRHIGAVKDCNLETV-DLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVA 1582
            :.|       |..|..|.   :|| .:.||.|.:                               
Human   690 LSR-------RGTGMSKK---DTVCQICESSGDS------------------------------- 713

  Fly  1583 LPEDPLTMRFPVSPLLRSCGEELRKTQQME-LGMGPLGNNNNNNYQQKNQNVILALPASASENIA 1646
                           |..|..|..|...:| ||:..|.::.           .:.:.....::  
Human   714 ---------------LIPCEGECCKHFHLECLGLASLPDSK-----------FICMECKTGQH-- 750

  Fly  1647 GVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRK 1711
                         |..:||:                   ...|.||                   
Human   751 -------------PCFSCKV-------------------SGKDVKR------------------- 764

  Fly  1712 LCR--SCGNVVH-------------ATGLRVPRH--SVPALEEQLPRLAQLMDMLPRKSVPPPFV 1759
             |.  :||...|             :.|.|.|:|  |..::|:.:.:.::...|   :.:..|..
Human   765 -CSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMM---RCLRCPVA 825

  Fly  1760 YFCDRACFARFKWNGKDGQAEAASLLLQP----AGGSAVKSSNGDSPG-SFC------------- 1806
            |....||.|            |.|:|:..    ....:.:|||..:.. .||             
Human   826 YHSGDACIA------------AGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHS 878

  Fly  1807 ----ASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDG 1867
                :|....:..::.:....|..|.|.:|.:..   :::||                       
Human   879 DPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSA---SKKKC----------------------- 917

  Fly  1868 TAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWS 1932
                                               ::|       .|||                
Human   918 -----------------------------------EKG-------GRLL---------------- 924

  Fly  1933 NGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSV 1997
                                    .|.:|                    |.:...||:       
Human   925 ------------------------CCESC--------------------PASFHPECL------- 938

  Fly  1998 HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSN 2062
                      .|.|..|.........|..                            :||.::. 
Human   939 ----------SIEMPEGCWNCNDCKAGKK----------------------------LHYKQIV- 964

  Fly  2063 LLRVGNMTF------------LNVGQLLPHQLEAFHTPHYIYPIGYKVSR-YYWCVRRPNRRCRY 2114
            .:::||..:            ||: |.|.|.|..|       |:.:..|. |||.  ...|...|
Human   965 WVKLGNYRWWPAEICNPRSVPLNI-QGLKHDLGDF-------PVFFFGSHDYYWV--HQGRVFPY 1019

  Fly  2115 I---CSIAE--AGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFP- 2173
            :   .|.||  ......|:..:::|..:..|.:.:..|..|:            ::.|..:..| 
Human  1020 VEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL------------EIEKNSRKPPP 1072

  Fly  2174 -QHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLL 2237
             :||....:.|..:..:..:.| :|.....               |...||.| ..:|...|.|.
Human  1073 YKHIKANKVIGKVQIQVADLSE-IPRCNCK---------------PADENPCG-LESECLNRMLQ 1120

  Fly  2238 VWRKPHT----QRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARS 2298
            ....|..    .|....|.|:|:...|.|                      :|.|.|        
Human  1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEI----------------------IKTERR-------- 1155

  Fly  2299 KIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQ-YESKNRGIYMFRLDEDRVVDATLSGG 2362
               |.||...|.|:|...:.||:||:|..|...:|.|: :|:.....||..:.:||::||...|.
Human  1156 ---GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGN 1217

  Fly  2363 LARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNC 2426
            .:|::||||||||.|:...|:.|||:.:||...|..|.||:::|..|..... :..|.|||.||
Human  1218 YSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNG-RTECHCGADNC 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 9/103 (9%)
FYRN 2068..2118 CDD:283589 15/65 (23%)
FYRC 2126..2215 CDD:197781 12/90 (13%)
SET <2266..2431 CDD:225491 53/162 (33%)
SET 2291..2413 CDD:214614 44/122 (36%)
PostSET 2415..2431 CDD:214703 6/12 (50%)
NSD3NP_075447.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..157 19/63 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..252 21/111 (19%)
PWWP domain; Pfam PF00855 264..324 10/60 (17%)
MSH6_like 267..383 CDD:99898 20/117 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..365 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..465 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..696 36/224 (16%)
TNG2 <602..746 CDD:227367 43/269 (16%)
PHD type zinc finger motif 697..738 14/89 (16%)
PHD1_NSD3 703..746 CDD:277119 12/99 (12%)
PHD type zinc finger motif 745..795 12/103 (12%)
PHD2_NSD3 751..797 CDD:277122 13/84 (15%)
PHD3_NSD3 798..850 CDD:277125 11/66 (17%)
PHD type zinc finger motif 858..945 20/231 (9%)
PHD4_NSD3 917..952 CDD:277128 13/176 (7%)
PWWP domain; Pfam PF00855 954..1013 17/97 (18%)
WHSC1_related 958..1051 CDD:99899 23/103 (22%)
AWS 1094..1144 CDD:197795 14/66 (21%)
SET 1145..1268 CDD:214614 49/155 (32%)
SET domain 1149..1255 43/138 (31%)
PHD type zinc finger motif 1317..1364
PHD5_NSD3 1323..1365 CDD:277131
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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