DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and PHF20

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_057520.2	Gene:	PHF20 / 51230	HGNCID:	16098	Length:	1012	Species:	Homo sapiens

Alignment Length:	858	Identity:	156/858 - (18%)
Similarity:	233/858 - (27%)	Gaps:	370/858 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 DDAPAPRKITAYSENLQKILNKSKSQE-STGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQ 554
            |...:..|...||||..|.|::.:|.. ||.|..|..:.:.||...:|.:.|.     :.....:
Human   304 DKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQ-----DTLSSTK 363

  Fly   555 HSQAAQSQSISAVG--SGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMG--------T 609
            .|:..|.:|....|  |.|.|..:|...||              |..:.:|.|.||        |
Human   364 ESEEGQLKSALEAGQVSSALTCHSFGDGSG--------------AAGLELNCPSMGENTMKTEPT 414

  Fly   610 RPIISIQNKNISLVLSKTTMAQQ-----------------KPKMITTTTLSSQAALQMHH----- 652
            .|::.:|  .||.|....|..:.                 :.|::.......:|.|..:|
Human   415 SPLVELQ--EISTVEVTNTFKKTDDFGSSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYFH 477

  Fly   653 ----ALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKAKL 713
                :|..:.|..|........||:...|.:       |.|:..||.:....|.:|...|.|.|.
Human   478 GMEKSLEPEESPGKRHVQTRGPSASDKPSQE-------TLTRKRVSASSPTTKDKEKNKEKKFKE 535

  Fly   714 LV------KQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTST 772
            .|      |::...|.....|.|||.::                                    |
Human   536 FVRVKPKKKKKKKKKTKPECPCSEEISD------------------------------------T 564

  Fly   773 ASNPSTP------------NPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVG 825
            :..||.|            .|.|:.:|               ||....|..|.
Human   565 SQEPSPPKAFAVTRCGSSHKPGVHMSP---------------QLHGPESGHHK------------ 602

  Fly   826 SASASAPLSARKVINVRAPSMGKVRSL-EDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTV 889
                                 |||::| ||.|                |.|||.|...|..
Human   603 ---------------------GKVKALEEDNL----------------SESSSESFLWSDD---- 626

  Fly   890 ASGGSSQQVATASATALPVSAVAITTPGVGGE----------AKLEQKSD-----------QPAA 933
             ..|....|.|.....|.           |.:          .::::::|           |...
Human   627 -EYGQDVDVTTNPDEELD-----------GDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGV 679

  Fly   934 IMQNQSQN----------QAPPPPPPPQQQ------------------QQQQLHQPQQLQPSPHQ 970
            .|....:|          |.||...|..:.                  ::...||..:...:.||
Human   680 CMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQ 744

  Fly   971 VKQTVQIV---------------SKE-------------------TSFISGPVAAKTLVTEATS- 1000
            :...||.|               |:|                   :.|.:.||.......||.|
Human   745 LLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSY 809

  Fly  1001 --------KPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPK----AVAMSLPMEQGDE 1053
                    ||..|..|.|.            |:.......:....||:    ||...|.:|....
Human   810 RTLNGAVEKPRPLALPLPR------------SVEESYITSEHCYQKPRAYYPAVEQKLVVETRGS 862

  Fly  1054 SLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQ 1118
            :| :.|..||| |.|..:  ::|..|.||     ..:..:|....     |||.|:
Human   863 AL-DDAVNPLH-ENGDDS--LSPRLGWPL-----DQDRSKGDSDP-----KPGSPK--------- 904

  Fly  1119 LDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEA---QPIQNQSQGQVQ 1180
                                                :..||.|..:|.||   :.:....:|.:.
Human   905 ------------------------------------VKEYVSKKALPEEAPARKLLDRGGEGLLS 933

  Fly  1181 MQAQMQATMQGHL 1193
            .|.|.|..:..|:
Human   934 SQHQWQFNLLTHV 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
PHF20	NP_057520.2	MBT	3..68	CDD:302657
		TUDOR	90..135	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..336		11/31 (35%)
		DUF3776	176..259	CDD:289391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..611		37/220 (17%)
		PHD_PHF20	654..697	CDD:277104	4/42 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..912		17/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030