DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Kmt2c

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_038964891.1 Gene:Kmt2c / 502710 RGDID:1587205 Length:5003 Species:Rattus norvegicus


Alignment Length:2824 Identity:725/2824 - (25%)
Similarity:1071/2824 - (37%) Gaps:859/2824 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 NIPKVTTSLGAAEKAKPERVASVA--------AAAFNAVSLQKRSGDDTATPAEDPTRKKAKTEL 58
            |:.:|..|  ..|:..|...:|:.        :..|:...|      .|:||.|.|      .:.
  Rat  2645 NLEQVPPS--QPEQGHPAHQSSIVMRPLTHPLSGEFSEAPL------STSTPTETP------PDN 2695

  Fly    59 LLGTGTAAPSLPAKASSTAPQQLLYQRSGQQAKAQVKAASEPQDVETADG--VWDARDQQIIVCN 121
            |...|.::..|..|..|..|              .||..    ||:..:|  |.|..|:.:.  |
  Rat  2696 LEIAGQSSDGLEEKLDSDDP--------------SVKEL----DVKDLEGVEVKDLDDEDLE--N 2740

  Fly   122 FGSGTEMGAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAF--TSFTKKE---GASSSASSSSST 181
            ....||.|  |.:|.|.......:.|....    |.|:..|  .::|..|   |...|..:....
  Rat  2741 LNLDTEDG--KGDDLDTLDNLETNDPNLDD----LLRSDEFDIIAYTDPELDLGDKKSMFNEELD 2799

  Fly   182 ASV----------ISIEPSGSGQ------------DHAENSGKSEDLDYVLMPASGADSSTSVGN 224
            .:|          :|:||....|            ...::||.||.....|.|.|..:..:.:.|
  Rat  2800 LNVPIDDKLDNQCVSVEPKIRDQGDKTMVLEDKDLPQKKSSGISEIKTEALSPHSKEEPESDIKN 2864

  Fly   225 ------------STGTG----TPAGTPIGATTSTIIL----NANNGTAGVSGAGTTTILTQKSGH 269
                        |..:|    :..|.|...||...:|    |..|...||.....:|.|..:   
  Rat  2865 CDDSRGDAEIACSQASGQTSHSDRGKPSLLTTDQEMLEKRNNRENAAPGVCAIQESTPLPAQ--- 2926

  Fly   270 TNYNIFNTTATGSQTPTTTLLNRVNLHPKMKTQLMVNAK-KLSEVTQTTAKVSIGNKTISVPLLK 333
               ::.|:......||             :.:.|:.|.| ..|::          ..::|.|...
  Rat  2927 ---DVMNSCDITGSTP-------------VLSSLLSNEKCDSSDI----------RPSVSSPPTL 2965

  Fly   334 PLMSASGAATAGGATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPK 398
            |:     :.:..|:::..:  |:.||..:...|::     ...|.|.|    :|.|::       
  Rat  2966 PI-----SPSTHGSSLPPT--LIPPGPLLDNTMNS-----NVTVVPRV----NHAFSQ------- 3007

  Fly   399 NSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIV 463
                     |:.:.|.                      .:|.|..:..|      |...||..  
  Rat  3008 ---------GVPVNPG----------------------FLQGQSSVNHL------GTGKPTNQ-- 3033

  Fly   464 TITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEE---- 524
            |:..||.|.|..|......:.|...::.....|..:......||.:|::.:.::......:    
  Rat  3034 TVPLTNQSSTSGMPGPQQLMMPQTLAQQSRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIR 3098

  Fly   525 ------FTNIN------------SVVIKPLDK----NTLNCPPSFNIFKQQQHSQAAQSQSISAV 567
                  |.||:            .|.:|.::|    |:|..||      ...........|::.|
  Rat  3099 QRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNSLGMPP------MVMSRFPFMGPSMAGV 3157

  Fly   568 GSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQ 632
            .:..|..:   |....|.|.:.|..:|..      |.|..|...:...|.|.....|.:|     
  Rat  3158 QTSEGQTL---MPQAVAQDGSITHQISRP------NPPNFGPGFVNDSQRKQYEEWLQET----- 3208

  Fly   633 KPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAP 697
                        |..|||....::    ::.|:...|..|.|......|......|.:       
  Rat  3209 ------------QQLLQMQQKYLE----EQIGAHRKSKKALSAKQRTAKKAGREFPEE------- 3250

  Fly   698 DVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSAN 762
            |..:|:.| :|.::.:..:.|.:.|.      .:|.||.|  .:.|:..........|.|.|...
  Rat  3251 DAEQLKHV-TEQQSMVQKQLEQIRKQ------QKEHAELI--EDYRIKQQQQQQQQQQQQQQQQQ 3306

  Fly   763 QIQMATSTSTASNPST-PNPTV--NATPMNNQRSAAEDN-ALLKQLLQNNSSSHSLNQISITSAH 823
            |.|..........|.. |.|.:  .|:|:    :.::.| .::.|.||:...:      ::.|.|
  Rat  3307 QQQQCALAPPILMPGVQPQPPLVPGASPL----TMSQPNFPMVSQQLQHQQHT------AVISGH 3361

  Fly   824 VGSA---------SASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGS 879
            ...|         |:|||  |...:|   ||.              |.| |||            
  Rat  3362 TSPARMPGLPGWQSSSAP--AHLPLN---PSR--------------IQP-PTA------------ 3394

  Fly   880 VATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQP-AAIMQNQSQNQA 943
                             |::..:.|..| .||:...|..|...::|...:.| :...|.:.:.: 
  Rat  3395 -----------------QLSLKTCTPAP-GAVSSANPQNGPPPRVEFDDNNPFSESFQERERKE- 3440

  Fly   944 PPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTE----ATSKPAE 1004
                   :.::||:..:.|.:|....|.....::..::...:...:|.:|.|::    |:.:|.:
  Rat  3441 -------RLREQQERQRVQLMQEVDRQRALQQRMEMEQHGLMGAELANRTPVSQMPFYASDRPCD 3498

  Fly  1005 LLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGA 1069
            .|.|                       |:.||..|:      ..:|....||:|.     .:||:
  Rat  3499 FLQP-----------------------PRPLQQSPQ------HQQQIGPVLPQQT-----VQQGS 3529

  Fly  1070 TAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKP----GEPQKRKLPM-HPQLDEKQIQQQAE 1129
            .       :..|..:...||...:.| .|..:|..|    |.|....:.. |..|.....||...
  Rat  3530 V-------NSPPNQTFMQTNERRQVG-PTPFVPDSPSASGGSPNFHSVKQGHGNLSGSSFQQSPL 3586

  Fly  1130 IPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVP--------NEAQPIQNQSQGQVQMQAQMQ 1186
            .|     |.||...|.|.           |..|.||        .:.|.....||..:|:.:.:.
  Rat  3587 RP-----PFTPILPGKPP-----------VANSSVPCGQDPAVTAQGQNFSGSSQSLIQLYSDII 3635

  Fly  1187 ATMQGHLSGQMSGQISGHA-AGQIPAQMH----------LQVQHQLHMAVHPQQQQQQLHQNQPQ 1240
            ...:|........:....| :.:.|:..|          |...........|.:..||..|...:
  Rat  3636 PEEKGKKKRTRKKKKDDDAESSKAPSTPHSDCTAPPTPGLSETTSAPAVSTPSELPQQRQQEAVE 3700

  Fly  1241 NATIPLP--VTGQGAV------------------PIPV------PTME-SKAGDQRKRRKREVQ- 1277
            ...:|.|  .|||..:                  ..||      |:.| |...::||....|:| 
  Rat  3701 PVRVPTPNVATGQPCIESENKLPSSEFIKETSSQQTPVSSEADKPSGEASNKSEERKLETAEIQP 3765

  Fly  1278 --------------------------------KPRRTNLNAGQAGG-ALKDLTGPLPAGAMVQLA 1309
                                            .|.||.:..|..|. .||.|.....|.::  |.
  Rat  3766 CPSQEDTKVEEKTGSKIKDTAAGPVSSIQCPSNPARTPVTKGDTGNELLKHLLKNKKASSL--LT 3828

  Fly  1310 GMPPGTQYIQGAASGTGHVI--TSTGQGV-TLG-------GVGAS-------------------- 1344
            ..|.||.....:::..|.::  .:..:|: |||       |.|.|                    
  Rat  3829 QKPEGTLSSDESSTQDGKLVEKQNPAEGLQTLGAQMQGGFGGGNSQLPKTDGGSETKKQRSKRTQ 3893

  Fly  1345 -TGASSSPMLKKRVRKFSKVEEDHDAF--TEKLLTHIR-QMQPLQVLEPHLNRNF-HFLIGSNET 1404
             ||..::|..|||    .|.||:..|.  :....||:: |:..|.::||.:..|| |||      
  Rat  3894 RTGEKAAPRSKKR----KKDEEEKQAVCSSSDSFTHLKQQLSLLPLMEPIIGVNFAHFL------ 3948

  Fly  1405 SGGGSPASMSSAASAGSSSAGGGKLKGGSR--GWPLSRHLEGLEDCDGTVLGRYGRVNLPGIP-- 1465
                              ..|.|:...|:|  |...|..|||:.|....::.:...::.|..|  
  Rat  3949 ------------------PYGSGQFNSGTRLLGTFGSAALEGVSDYYSQLIYKQNNLSNPPTPPA 3995

  Fly  1466 ----------------SLYDSERFGGSRGLVGGSARTRS--PSPAESPGAEKMLPMSSIQNDFYD 1512
                            ....:|...|..|::.....||:  |.|.:.|    ..|    |:|...
  Rat  3996 SLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTRALGPKPFQLP----FRP----QDDLLA 4052

  Fly  1513 QEFS-------------THMERNPRE-RLVRHIG-------AVKDCNLETVDLVESEGVAAWATL 1556
            :..:             |....|..| |:..|.|       .|...:.|:|..||          
  Rat  4053 RAIAQGPKTVDVPASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPESVVGVE---------- 4107

  Fly  1557 PRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSC----GEELRKTQQMELG--- 1614
              :.:||.|.|:.              .|.|..:..|:.|:|.|.    .|..|...:.|.|   
  Rat  4108 --VNKYPDLSLVK--------------EEPPEPVPSPIIPILPSISGRDSESRRNDIKTEPGTLF 4156

  Fly  1615 -MGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQ 1678
             ..|.|::.|.. :....:|.:.|..:|:|||:.|:...::|||:           :|.|..|  
  Rat  4157 FTSPFGSSPNGP-RSGLISVAITLHPTAAENISSVVAAFSDLLHV-----------RIPNSYE-- 4207

  Fly  1679 FMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLA 1743
            ..:..|..      .:..||...:...|..|:.|.           ||.|    |......||||
  Rat  4208 VSSAPDVP------SMGLVSSHRINPGLEYRQHLL-----------LRGP----PPGSANPPRLA 4251

  Fly  1744 QLMDMLPRKSVP-PPFVYFCDRACFARFKWNG----KD---GQAEAASLLLQPAG---------G 1791
            ... .|.:.:|| ||             ..||    ||   |.||..|  |:|..         |
  Rat  4252 TSY-RLKQPNVPFPP-------------ASNGLSGCKDSSHGIAEGTS--LRPQWCCHCKVVILG 4300

  Fly  1792 SAVKSSNGD----SPGS------------FCA-------SSTAPAEMVVKQEPEDEDEKTPSVPG 1833
            |.|:.|..|    :.||            ||:       |:||.|::      .|..|..||:|.
  Rat  4301 SGVRKSFKDLTFANKGSRESTRRTEKDIVFCSNNCYILHSTTAQAKI------SDNKEPLPSLPQ 4359

  Fly  1834 NPTNIPAQRKCIVKCF---SADCFTTD-------------------------------------- 1857
            :|...|:      |.|   |.:..|.|                                      
  Rat  4360 SPMKEPS------KAFHQYSNNISTLDVHCLPQFQEKVSPPASPPITFPPAFEAAKVESKPDELK 4418

  Fly  1858 ----------SAPSGLE------------------LDGTAGAGTGAGPVNNTVWE-TETSGLQL- 1892
                      :.|.|||                  :......||...|..:.:.| .:..|..| 
  Rat  4419 VTVKLKPRLRTVPVGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLK 4483

  Fly  1893 -----EDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQA 1952
                 :|.|:|.||::.|||..|||:||||.|:|.||||||||||..||||.:|||:|.:.||:.
  Rat  4484 PDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRR 4548

  Fly  1953 GLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGA 2017
            ||...|..||:.|||..|.:.||.::||..||.:.:|:|:|:|::.|.:|...            
  Rat  4549 GLQMKCVFCHKTGATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPK------------ 4601

  Fly  2018 TTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQL 2082
                    .:.:.|||...|.|||:|.|||.||:|:::...|..:..|||::.|..:|||||.|:
  Rat  4602 --------GIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHAIGQLLPQQM 4658

  Fly  2083 EAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSS 2147
            :|||:...::|:||:.||.||..|..||||||:|||.|...:|.|.|::.:.|.:  :.....||
  Rat  4659 QAFHSSKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHE--DLVLSDSS 4721

  Fly  2148 PSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRN 2212
            |..||.:||:|:..:||..:.|||||.::.||||||||..|:.||.|||||:|...:|.|:||||
  Rat  4722 PKDVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRN 4786

  Fly  2213 PLLEFPLAINPSGAARTEPK-----QRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSK 2272
            ||:|.|||:||:|.||.|||     :|.:|   :||   |..|.||.:...| .:.||:..||||
  Rat  4787 PLMELPLAVNPTGCARAEPKMSAHVKRFVL---RPH---TLNSTSTSKSFQS-TVTGELNAPYSK 4844

  Fly  2273 QFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQY 2337
            ||||||||||::||.||::|||||||:|||||||||||||||||:|||||.:||.||:..:||.|
  Rat  4845 QFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLY 4909

  Fly  2338 ESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEEL 2402
            ||:|||:||||:|.|.|:||||:||.||||||||.||||.|:|..:|..:|||.:.|:|.:||||
  Rat  4910 ESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSNRRIQKGEEL 4974

  Fly  2403 SYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            .||||||.||:.|||||.|||.|||||||
  Rat  4975 CYDYKFDFEDDQHKIPCHCGAVNCRKWMN 5003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 33/178 (19%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 55/103 (53%)
FYRN 2068..2118 CDD:283589 25/49 (51%)
FYRC 2126..2215 CDD:197781 42/88 (48%)
SET <2266..2431 CDD:225491 117/164 (71%)
SET 2291..2413 CDD:214614 85/121 (70%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
Kmt2cXP_038964891.1 ePHD1_KMT2C 247..330 CDD:277166
PHD1_KMT2C_like 343..388 CDD:276984
PHD2_KMT2C 390..435 CDD:277069
PHD3_KMT2C 466..517 CDD:276986
PHD_SF 948..1004 CDD:419867
PHD5_KMT2C_like 1005..1051 CDD:276988
RanBP2-type Zn finger 1080..1102 CDD:275375
PHD6_KMT2C 1082..1132 CDD:277073
HMG 1659..1712 CDD:197700
PHA03247 <1901..2381 CDD:223021
Atrophin-1 <2439..>2692 CDD:397323 12/54 (22%)
MDN1 <2694..2955 CDD:227596 62/305 (20%)
Myosin_tail_1 <3202..>3284 CDD:396244 22/118 (19%)
PHA03247 <3314..3677 CDD:223021 89/488 (18%)
ePHD2_KMT2C 4494..4598 CDD:277167 55/103 (53%)
FYRN 4643..4694 CDD:399155 26/50 (52%)
FYRC 4700..4784 CDD:399156 38/85 (45%)
SET_KMT2C_2D 4850..5002 CDD:380948 107/151 (71%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102575
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.900

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