DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and NSD

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster

Alignment Length:	1629	Identity:	316/1629 - (19%)
Similarity:	482/1629 - (29%)	Gaps:	640/1629 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 EIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSG---VPNEAQP------IQNQSQGQVQMQAQ 1184
            |||       ..|...||  |:|:.       |.|   |.|.|||      :::|.|..||.|.|
  Fly    51 EIP-------RDTNNSTP--VRLLD-------KPGQNPVQNGAQPAAEESELESQRQTPVQKQQQ 99

  Fly  1185 MQATMQG------HLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNAT 1243
            .:.:|..      :|...:|.:..|:|                                   ||.
  Fly   100 QRVSMVNRKRDLINLQSALSPKYIGYA-----------------------------------NAN 129

  Fly  1244 IPLPVTGQGAVPIPVPTMESKAGDQ-RKRRKREVQKPRRTNLNAGQ---------------AGGA 1292
            .|.|:              |.:.|. |..|:|..|.....|.:||:               .||.
  Fly   130 SPTPL--------------SDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGG 180

  Fly  1293 LKDLTGPLPAGAMVQLAGMPPGTQYI--QGAAS--GTGHVITSTGQGVTLGGVGASTGASSSPML 1353
                 |...|..::....|.|..:.:  .||:|  .||....|...|:             .|::
  Fly   181 -----GDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGI-------------RPIV 227

  Fly  1354 KKRVRKFSK--------------------------------VEEDHDAFTEKLLT---------- 1376
            :|.|::..|                                |:...:|.|::..|
  Fly   228 RKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETE 292

  Fly  1377 ---------HIRQMQPLQV---------------LEP-HLNRN-----FHFLIGSNETSGGGSPA 1411
                     ||:|...:::               .|| .|.::     |...:.|:......||.
  Fly   293 AEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPP 357

  Fly  1412 SMSSAASAGS----SSAGGGKLKGGS----RGWPLSRHLEG-----------------LEDCDGT 1451
            .:||.|.|.|    ||......||.|    .|||  .:..|                 ..|..|.
  Fly   358 DLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWP--TYQVGDLFWGKVFSYCFWPCMVCPDPLGQ 420

  Fly  1452 VLGRYGRVNLPGIP---SLYDSE-------RFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSI 1506
            ::|     |:|..|   ||.::.       ||....|      |.....|      |.:|..:.:
  Fly   421 IVG-----NMPSHPQRSSLDNANVPIQVHVRFFADNG------RRNWIKP------ENLLTFAGL 468

  Fly  1507 QNDFYDQEFSTHMERNPRERLVRHI-----------GAVKDCNLET----VDLVES-----EGVA 1551
            : .|.|......::..|:....|.:           .|:::....|    .|.:|.     |.|
  Fly   469 K-AFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENV- 531

  Fly  1552 AWATLPR----LTRY-------PGLILLNGNSRCHGRMSPVAL------PEDPLTMRFPVSPLLR 1599
              .||.|    .|:|       .|..|.:.....|.:.....|      .|.|.:..|  || ::
  Fly   532 --VTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAF--SP-VK 591

  Fly  1600 SCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTC 1664
            |..|  ::.::.:|..|...:..:|:...........:.:||.||     .:...||...
  Fly   592 SKNE--KRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYEN-----PEFRQLLSAV----- 644

  Fly  1665 KIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSH-GHLRKILNGRRKLCR--SCGNVVHATGLR 1726
                      :|...||:.||| |: |..||.||: ..|::|  ..|:|.|  :.|.:....|..
  Fly   645 ----------MEYVMMNRSDEK-VE-KVLLSVVSNIWSLKQI--QLRELERDLASGEIEEPLGSS 695

  Fly  1727 -VPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAG 1790
             |.|.|.....::|..  :||.|:.|:|:.|                            ::.|
  Fly   696 VVGRGSGVGTIKRLSN--RLMTMMVRRSMTP----------------------------VVTP-- 728

  Fly  1791 GSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFT 1855
                              ||.||               ||.|....:.|.:.|
  Fly   729 ------------------STTPA---------------PSEPDRRLSEPPKTK------------ 748

  Fly  1856 TDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLED-------TRQ--CVFCNQRGDGQADG 1911
                                .|||..:.|.....|||:.       :|:  |.:|.|.|
  Fly   749 --------------------KPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAG------ 787

  Fly  1912 PSRLLNFD--VDKWVHLNCALWSNGVYETVSGALM----------------------NFQTA--- 1949
             |.|:...  ...|:|.:|      :...|:||.|                      :..||
  Fly   788 -SDLVRCSRTCSSWLHADC------LERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAK 845

  Fly  1950 -------------LQAGLSQACSACHQ------PGATIK---------------CFKSRCNSLYH 1980
                         ...|..:.|..|||      |....|               |.:..|...:|
  Fly   846 EVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFH 910

  Fly  1981 LPCAIREECVFY-----KNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRR 2040
            ..|     |.::     ...|..|..| ..|..:       :...:|....:..::|:..|
  Fly   911 TSC-----CKYWPQASSSKHSARCPRH-VCHTCV-------SDDPSGKFQQLGSSKLAKCV---- 958

  Fly  2041 VFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPH------YIYPIGYKVS 2099
                    |..||   |.:||..:..|.........:.|....|....|      ||...|.::.
  Fly   959 --------RCPAT---YHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELV 1012

  Fly  2100 RYYWCVRRPNRRCR---------YICSIAEAGCKP--------EFRIQVQDAGDKEPEREFRGSS 2147
            ....|....:..||         |||...|:|..|        :|             ..||.
  Fly  1013 CCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKF-------------NNFRW-- 1062

  Fly  2148 PSAVWQQILQPITR-----LRKV---------------HKWL---------------------QL 2171
                |..|:.|.|.     |:|.               |.|:                     ||
  Fly  1063 ----WPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQL 1123

  Fly  2172 FPQHISGEDLFGLTEPAI-----VRILESLPGIETLTDYRFKYGRN---PLLEFPLAINPSGAAR 2228
            |..:.:|.:......|.|     .:.:|...|.:.......|...|   |.|.|...:.......
  Fly  1124 FRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCN 1188

  Fly  2229 TEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNV 2293
            ..|...        |.......|..:.:.|      |....|.|.....::..:::.|......|
  Fly  1189 CLPVDE--------HPCGPEAGCLNRMLFN------ECNPEYCKAGSLCENRMFEQRKSPRLEVV 1239

  Fly  2294 YLARSKIQGLGLYAARDIEKHTMIIEYIGEVI-RTEVSEIREKQYESKNRGIYMFRLDEDRVVDA 2357
            |:..   :|.||.....|.....:|||:|||| ..|.....|::...::...|...:::|.::||
  Fly  1240 YMNE---RGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDA 1301

  Fly  2358 TLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACG 2422
            ...|.|||::||||.|||.|:...|:...|:.|||.:.|....||:::|.:|....:.|..|.||
  Fly  1302 GPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCG 1366

  Fly  2423 APNC 2426
            |..|
  Fly  1367 AKRC 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	29/169 (17%)
		FYRN	2068..2118	CDD:283589	12/64 (19%)
		FYRC	2126..2215	CDD:197781	22/137 (16%)
		SET	<2266..2431	CDD:225491	50/162 (31%)
		SET	2291..2413	CDD:214614	41/122 (34%)
		PostSET	2415..2431	CDD:214703	6/12 (50%)
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	22/136 (16%)
		PHD2_NSD	867..932	CDD:277040	13/69 (19%)
		PHD3_NSD	933..988	CDD:277041	12/76 (16%)
		PHD4_NSD	1001..1041	CDD:277042	9/39 (23%)
		WHSC1_related	1047..1141	CDD:99899	17/112 (15%)
		AWS	1183..1233	CDD:197795	7/63 (11%)
		SET	1234..1354	CDD:214614	40/122 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940