DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and KMT2A

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens


Alignment Length:2520 Identity:508/2520 - (20%)
Similarity:811/2520 - (32%) Gaps:868/2520 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 STPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVISIEPSGSGQDHAENSGKS-----E 204
            ||..:.::..:.|..|:||        .||:..|.:||.:|| .||.....|::.||..     .
Human  2121 STVEHDENRTIAHSPTSFT--------ESSSKESQNTAEIIS-PPSPDRPPHSQTSGSCYYHVIS 2176

  Fly   205 DLDYVLMPASGADSSTSVG----NSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQ 265
            .:..:..| |.:.:..|.|    .|.|:.||....| .|....:|::...:.|.....|:::..|
Human  2177 KVPRIRTP-SYSPTQRSPGCRPLPSAGSPTPTTHEI-VTVGDPLLSSGLRSIGSRRHSTSSLSPQ 2239

  Fly   266 KS----------GHT--NYNIFNTTATGSQTPTTTLLNRVN--LHP-KMKTQLMVNAKKLSEVTQ 315
            :|          |:|  ..|:.:.:.||:.|...:....|:  |.| ...|.|..|....|.:.:
Human  2240 RSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQR 2304

  Fly   316 TTAKVSIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPH 380
            |.  |::|||...:    ...|:|....:..:.:|.....|:  |:.|.|:|:....|.      
Human  2305 TV--VTVGNKNSHL----DGSSSSEMKQSSASDLVSKSSSLK--GEKTKVLSSKSSEGS------ 2355

  Fly   381 VHSHAHHNFTKLIKRGPKNSGTI-----VSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQ 440
            .|:.|:....||   .|:...|.     ||..|...:|::....:.:.:|...|.|:..:....|
Human  2356 AHNVAYPGIPKL---APQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQ 2417

  Fly   441 QQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSEN 505
            .                          |:.:|       ||...|   .||......|::..| |
Human  2418 H--------------------------TDSTQ-------SANSSP---DEDTEVKTLKLSGMS-N 2445

  Fly   506 LQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSG 570
            ...|:|:.....|....:              |...:|..:|    :::||    |:|....|. 
Human  2446 RSSIINEHMGSSSRDRRQ--------------KGKKSCKETF----KEKHS----SKSFLEPGQ- 2487

  Fly   571 AGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPK 635
                    :.:|...:|.......|      :....||.||..::                    
Human  2488 --------VTTGEEGNLKPEFMDEV------LTPEYMGQRPCNNV-------------------- 2518

  Fly   636 MITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVV 700
                                   |:||.|.        .|.||                  |.|.
Human  2519 -----------------------SSDKIGD--------KGLSM------------------PGVP 2534

  Fly   701 KLEEVGSESKAK-LLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQI 764
            |...:..|..|| |...::..||.:.             ||.|..|.:.:..|:.:....|..||
Human  2535 KAPPMQVEGSAKELQAPRKRTVKVTL-------------TPLKMENESQSKNALKESSPASPLQI 2586

  Fly   765 QMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHV----- 824
            :..:.|...|....|.....|.|..|..|.            .:|.|::...:.:...::     
Human  2587 ESTSPTEPISASENPGDGPVAQPSPNNTSC------------QDSQSNNYQNLPVQDRNLMLPDG 2639

  Fly   825 ------GSASASAP-LSARKVINV---RAPSMGKVRSL--EDQLARPVIPPVPTAT-QAAGSSSS 876
                  ||.....| .|||...|:   ..|..| |||.  ||      ||...::| :..|..|:
Human  2640 PKPQEDGSFKRRYPRRSARARSNMFFGLTPLYG-VRSYGEED------IPFYSSSTGKKRGKRSA 2697

  Fly   877 SGSV------ATS--------TTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQK 927
            .|.|      :||        ..|.||.|.|..:::|:.:.                  .:.|::
Human  2698 EGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNL------------------FREEEQ 2744

  Fly   928 SDQP----------------AAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTV- 975
            .|.|                :.....:..:|.|.........:..::.:|:......|..|.:| 
Human  2745 CDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVG 2809

  Fly   976 ----------QIVSKETSFISGPVAAKTLVTEA-----TSKPAE--LLPPPPYEMATAPISNVTI 1023
                      ..||:..:.....:.|:....|:     ||.|::  ||.....|:..:...| ..
Human  2810 HKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDN-NN 2873

  Fly  1024 SISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWT 1088
            |.......|.::.   ..|..:.|..|.....||.:.    ||......|:...|          
Human  2874 SDDCGNILPSDIM---DFVLKNTPSMQALGESPESSS----SELLNLGEGLGLDS---------- 2921

  Fly  1089 NNHLEGGVATTKIPFKPGEPQKRKLPMHPQLD---------EKQIQQQAEIP-----ISTSLPTT 1139
            |...:.|:.         |...::||....:|         |:|.:...|:|     ::|..||.
Human  2922 NREKDMGLF---------EVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTV 2977

  Fly  1140 PTGQGTPDKVQLIS----AIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQ 1200
            |:  ..|.::.:||    ...|..:||...:|:.|        ..:...:..|.:||::....  
Human  2978 PS--QNPSRLAVISDSGEKRVTITEKSVASSESDP--------ALLSPGVDPTPEGHMTPDHF-- 3030

  Fly  1201 ISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLH---QNQPQNATIP-LPVTGQGAVPIPVPTM 1261
            |.||....             |::..|....:|.|   |:..:|::.| |.|.....|||     
Human  3031 IQGHMDAD-------------HISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPI----- 3077

  Fly  1262 ESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTG 1326
                       :.:...|..|:                            .||...|..||..| 
Human  3078 -----------QNQKYVPNSTD----------------------------SPGPSQISNAAVQT- 3102

  Fly  1327 HVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHL 1391
                                  :.|.||..              ||||:...:.||||.||:...
Human  3103 ----------------------TPPHLKPA--------------TEKLIVVNQNMQPLYVLQTLP 3131

  Fly  1392 NRNFHFLIGSNE-----TSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGT 1451
            |       |..:     :|...:|:.|.:..|......||..|..|..                 
Human  3132 N-------GVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLN----------------- 3172

  Fly  1452 VLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFS 1516
                      |.:|:                   ::|..|:.|.|   :||||..|         
Human  3173 ----------PSLPT-------------------SQSLFPSASKG---LLPMSHHQ--------- 3196

  Fly  1517 THMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYP--GL-----------ILL 1568
             |:...|                          .|..::.|.....|  ||           :|:
Human  3197 -HLHSFP--------------------------AATQSSFPPNISNPPSGLLIGVQPPPDPQLLV 3234

  Fly  1569 NGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNV 1633
            :.:|:.....:.||.|...|..| |:|.|      :.||.:::                      
Human  3235 SESSQRTDLSTTVATPSSGLKKR-PISRL------QTRKNKKL---------------------- 3270

  Fly  1634 ILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVS 1698
               .|:|...||             ||:       |.:.|.                        
Human  3271 ---APSSTPSNI-------------APS-------DVVSNM------------------------ 3288

  Fly  1699 HGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQL--MDMLPRKSVP------ 1755
                               .:::.|..::|.|         |.|..|  ::....::||      
Human  3289 -------------------TLINFTPSQLPNH---------PSLLDLGSLNTSSHRTVPNIIKRS 3325

  Fly  1756 -PPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKS-------------SNGDSPGSFC 1806
             ...:||                  |.|.||.|..||:|..:             ::|...|...
Human  3326 KSSIMYF------------------EPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLAS 3372

  Fly  1807 ASSTAPAEMVVKQEPEDEDEKTPSVPGNPT----------NIPAQRKCIVKCFSADCFTTDSAPS 1861
            :||..   .||..:.......:.||||:.|          :|.:....::|.........|..  
Human  3373 SSSVL---NVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQP-- 3432

  Fly  1862 GLELDGTAG----AGTGAGPVNNTVW---------ETETSGL-------------QLEDTRQC-- 1898
             :.|..::|    .||...|....:.         .|:|:|:             ||:...|.  
Human  3433 -VALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLA 3496

  Fly  1899 ----VFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLS---- 1955
                :..:||....|.|| ::.||........:..|..|   :.:|.|:....|:.....|    
Human  3497 SKTGIHSSQRDLDSASGP-QVSNFTQTVDAPNSMGLEQN---KALSSAVQASPTSPGGSPSSPSS 3557

  Fly  1956 -QACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATT 2019
             |..::...||.|....|::   .:.||.   ::....|:|..|... ..:.|.|........|:
Human  3558 GQRSASPSVPGPTKPKPKTK---RFQLPL---DKGNGKKHKVSHLRT-SSSEAHIPDQETTSLTS 3615

  Fly  2020 GAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLL------ 2078
            |.|..|:.|                  |.:..|:|...|:.......|.:..|...|:.      
Human  3616 GTGTPGAEA------------------EQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANE 3662

  Fly  2079 -----PHQLEA----FHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPE----FRIQ 2130
                 |..:|.    |.:|..:           |..:...|:    .||.|.  ||:    |.|.
Human  3663 QESAEPKTVEEEESNFSSPLML-----------WLQQEQKRK----ESITEK--KPKKGLVFEIS 3710

  Fly  2131 VQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILES 2195
            ..|.      .:....|....|:.:...:...|...:..||....::|..:.|:...|:|.::|.
Human  3711 SDDG------FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQ 3769

  Fly  2196 LPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLV---------WRKPHTQRTAGSC 2251
            |.|.:...:|:|::.:......| .:||.|:||.|...|:...         .|:|.........
Human  3770 LSGAKHCRNYKFRFHKPEEANEP-PLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEE 3833

  Fly  2252 STQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTM 2316
            ..:....||..|..:..|...:|.|.|.:..:.:      .||  ||.|.|.||:..|:|:...|
Human  3834 EEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAV------GVY--RSPIHGRGLFCKRNIDAGEM 3890

  Fly  2317 IIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVE 2381
            :|||.|.|||:..::.|||.|:||..|.||||:|:..|||||:.|..||:|||||.|||.:.::.
Human  3891 VIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVIN 3955

  Fly  2382 VDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            :|....|:|||.|||||||||:|||||.|||.|:|:||.|||..|||::|
Human  3956 IDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 4005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 36/159 (23%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 23/114 (20%)
FYRN 2068..2118 CDD:283589 8/64 (13%)
FYRC 2126..2215 CDD:197781 17/92 (18%)
SET <2266..2431 CDD:225491 82/164 (50%)
SET 2291..2413 CDD:214614 67/121 (55%)
PostSET 2415..2431 CDD:214703 9/15 (60%)
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:251032
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163
FYRN 2061..2107 CDD:283589
FYRC 3705..3788 CDD:197781 17/88 (19%)
SET <3861..4005 CDD:225491 78/151 (52%)
SET 3867..3987 CDD:214614 67/127 (53%)
PostSET 3989..4005 CDD:214703 9/15 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158001
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D738155at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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