DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and PR-Set7

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001247100.1	Gene:	PR-Set7 / 41743	FlyBaseID:	FBgn0011474	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	176/922 - (19%)
Similarity:	293/922 - (31%)	Gaps:	348/922 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1571 NSRCHGRMSPVALPED---PLTM-------RFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNN 1625
            :|...|..|...:|.|   ||.:       ::..||..:.| ..::.||..:|....:..:|.:|
  Fly    16 SSSSGGASSGSGIPVDQALPLNVAGNLLEDQYFASPKRKDC-RLMKVTQNGQLPEATMMAHNKDN 79

  Fly  1626 YQQKNQNVILALPASAS--ENI---AGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDE 1685
            ...:...|.||..:...  ||.   ....:|....:|....|       .:||    |.:..|||
  Fly    80 KAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQL-------NLGN----QELKLDDE 133

  Fly  1686 KHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLA--QLMDM 1748
            :                   |||:.|                       |::::.:||  |:.:.
  Fly   134 E-------------------LNGQIK-----------------------LDDEVLKLADKQINEN 156

  Fly  1749 LPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAP- 1812
            ||          |.|..            .|:|...|:.......|:....|  ||..|||.:|
  Fly   157 LP----------FADEV------------DAKAEQKLMDEELQQVVEELLFD--GSSRASSNSPF 197

  Fly  1813 --AEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGA 1875
              .:|.|.|    |.::||.:|.            :|          .....||     |.|:.|
  Fly   198 YQHDMDVMQ----EIQQTPEIPH------------IK----------KVTEPLE-----GLGSLA 231

  Fly  1876 GPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVS 1940
            .      ::|..|.|:  |:......:...:.....|  :|..|:|:......::..|..:| ::
  Fly   232 D------FQTHRSALR--DSHSSTHSSSTDNIFLQEP--VLTLDIDRTPTKASSIKINRSFE-LA 285

  Fly  1941 GALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHA 2005
            ||:.:                ..|.....|...|.|.:..|..  ::|.:...:..:........
  Fly   286 GAVFS----------------SPPSVLNACLNGRFNQIVSLNG--QKEALDLPHFDLDQHDSSSC 332

  Fly  2006 HAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVAT---VMHYSELSNLLRV- 2066
            .:|:..|..|...:.||                      :...|:.||   ::..|.:...|:|
  Fly   333 DSGVACGLTANTESPAG----------------------QPRRRKPATPHRILCPSPIKTALKVT 375

  Fly  2067 GNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRI-- 2129
            |.:  ..||...|           :.|             |.:.|.....:.|.|.||...|:
  Fly   376 GGI--CKVGSADP-----------LSP-------------RKSPRKLPTTTAAVAACKSRRRLNQ 414

  Fly  2130 ---------QVQ----------------------DAGDKE----------PEREFRGSSPSAVWQ 2153
                     |:|                      |.||.|          .|||.:..:|:..
  Fly   415 PKPQAPYQPQLQKPPSQQQQQQQDDIVVVLDDDDDEGDDEDDVRALIKAAEERENQNKAPATA-- 477

  Fly  2154 QILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFP 2218
                                 :.:...:..:.:||.|:......|...        |:.||   |
  Fly   478 ---------------------NSNKAGMKTMLKPAPVKSKTKSKGPTK--------GQPPL---P 510

  Fly  2219 LAINPSGAARTE--PKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQ 2281
            ||........|:  |.:|.:   ||..|
  Fly   511 LAATNGNREMTDFFPVRRSV---RKTKT------------------------------------- 535

  Fly  2282 YKKMKQEWRNNVYLA--RSKIQGL----------GLYAARDIEKHTMIIEYIGEVIRTEVSEIRE 2334
              .:|:||...:..|  ..:..||          |:.|.|..:::..::||:|::|....:..||
  Fly   536 --AVKEEWMRGLEQAVLEERCDGLQVRHFMGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAERE 598

  Fly  2335 KQYE-SKNRGIYMF---RLDEDRVVDATL-SGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKR 2394
            |:|. .:|.|.||:   ...:...:|||: :|.|.|.||||...|.:|::|.:.:...:::.||.
  Fly   599 KRYALDENAGCYMYYFKHKSQQYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKD 663

  Fly  2395 KIYRGEELSYDY 2406
            .|..||||:|||
  Fly   664 DIEPGEELTYDY 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	14/103 (14%)
		FYRN	2068..2118	CDD:283589	6/49 (12%)
		FYRC	2126..2215	CDD:197781	17/131 (13%)
		SET	<2266..2431	CDD:225491	44/158 (28%)
		SET	2291..2413	CDD:214614	41/133 (31%)
		PostSET	2415..2431	CDD:214703
PR-Set7	NP_001247100.1	SET	566..676	CDD:279228	38/110 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840