Protein Alignment trr and trx

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Alignment Length: 2571
• Identity: 468/2571 - (18%)
• Similarity: 768/2571 - (29%)
• Gaps: 1123/2571 - (43%)

  Fly     4 PKVTTSLGAAEKAKPERVA-SVAAAAFNAVSLQKRSGDDTATPAEDPTRKKAKTELLLGTGTAAP 67
            ||:..:...|...|..::: ::|...|..:|.|:|:..:.||.|....|:......:.|..|.:.
  Fly  2136 PKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSG 2200

  Fly    68 SLPAKASSTAPQQLLYQRS-GQQAKAQVKAASEPQDVETADGVWDARDQQIIVC---NFGSGTEM 128
            |:.:|:.:.:..:..:::| |::..|:::       :...|||.|:..:..|:.   |..:....
  Fly  2201 SVRSKSFTWSAAKRYFEKSEGREEAAKMR-------IMQMDGVDDSITEFRIISGDGNLSTAQFS 2258

  Fly   129 GAIKAEDADKQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVISIEPSGSG 193
            |.:|.:..  |..||                 .:.:|.:...:.|...||:.|.|    :.||.|
  Fly  2259 GQVKCDRC--QCTYR-----------------NYDAFQRHLPSCSPTMSSNETES----DVSGQG 2300

  Fly   194 QDHAENSGKSEDLD----YVLMPASGAD---SST------SVGN-----------------STGT 228
            ..:......:|.|:    .:|..|.|.:   |:|      |:|:                 |.|:
  Fly  2301 MTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGS 2365

  Fly   229 GTPAGTPIGATTST-----IILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTT 288
            |.....|..||.:.     |..|:....|...|.|             :.:...|.|   .|...
  Fly  2366 GFFLSQPNPATQANTDDLQIYANSLQSLAANLGGG-------------FTLAQPTVT---APAQP 2414

  Fly   289 LLNRVNLHPKMKTQLMVNAKKLSEVTQT------TAKVSIGNKTISVPLLKPLMSASGAATAGGA 347
            .|..|:.:|. .||..:...:..:.|.|      |.:.:..:|.|.:||           ||.|.
  Fly  2415 QLIAVSTNPD-GTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPL-----------TAAGK 2467

  Fly   348 TIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQIK 412
            .:            .|....||||:..:|              :.:|            ||.|:|
  Fly  2468 PL------------KTVATKAAQQAAVKQ--------------RQLK------------SGHQVK 2494

  Fly   413 PANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMV 477
            |...|             ||.|.||.|||||.|..|.             :|:...|..|...:.
  Fly  2495 PIQAK-------------LQPHPQQHQQQQQTQVQQP-------------ITVMGQNLLQPQLLF 2533

  Fly   478 QDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLN 542
            |.|.          ...||:.|...::. |.|::......|.|.|.::.:|
  Fly  2534 QSST----------QTQAPQIILPQAQP-QNIISFVTGDGSQGQPLQYISI-------------- 2573

  Fly   543 CPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTF--TMASGNASDLATTSTVSVSAGTICINSP 605
              |:...:|.|....|..:...:|.|:||    |:  |.||||   |..|:|.|
  Fly  2574 --PTAGEYKPQPQPTATPTFLTTAPGAGA----TYLQTDASGN---LVLTTTPS----------- 2618

  Fly   606 MMGTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANS- 669
                       |..:.::.:::..||  |::|.|              |||..:....|.:..:
  Fly  2619 -----------NSGLQMLTAQSLQAQ--PQVIGT--------------LIQPQTIQLGGGADGNQ 2656

  Fly   670 -GS--------ATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKAKLLVKQEAVVKDST 725
             ||        .|.|.|..|:..|  |..::.::..|....||.:...:   ::..|:.|   ||
  Fly  2657 PGSNQQPLILGGTGGGSSGLEFAT--TSPQVILATQPMYYGLETIVQNT---VMSSQQFV---ST 2713

  Fly   726 GTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQ----------MATSTSTASNPSTPN 780
            ..|         |...:..:.:||.|.:.|     |::|:          :..:|..||:..|
  Fly  2714 AMP---------GMLSQNASFSATTTQVFQ-----ASKIEPIVDLPAGYVVLNNTGDASSAGT-- 2762

  Fly   781 PTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPS 845
             .:||..:..|::..:...   |:|||  ::.....:..:|    .||.|...::..::..:.|.
  Fly  2763 -FLNAASVLQQQTQDDTTT---QILQN--ANFQFQSVPTSS----GASTSMDYTSPVMVTAKIPP 2817

  Fly   846 MGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSA 910
            :.:::....|            .:|||.|
  Fly  2818 VTQIKRTNAQ------------AKAAGIS------------------------------------ 2834

  Fly   911 VAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTV 975
                  |||                      :.||.|
  Fly  2835 ------GVG----------------------KVPPQP---------------------------- 2843

  Fly   976 QIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPK 1040
            |:|:|        |...::||:.:                        .:..|.:..|:.|:|.|
  Fly  2844 QVVNK--------VLPTSIVTQQS------------------------QVQVKNSNLKQSQVKGK 2876

  Fly  1041 AVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKP 1105
            |                             |:|.....|.|
  Fly  2877 A-----------------------------ASGTGTTCGAP------------------------ 2888

  Fly  1106 GEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQP 1170
                       |.:..|.:|:                     |..:|..|.....|..|......
  Fly  2889 -----------PSIASKPLQK---------------------KTNMIRPIHKLEVKPKVMKPTPK 2921

  Fly  1171 IQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQ--IPAQMHLQVQHQLHMAVHPQQQQQQ 1233
            :|||:...:|.|.|.|..:|..:...:..|:......|  ||||...|...|..| :|..||||.
  Fly  2922 VQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQM-IHIPQQQQP 2985

  Fly  1234 LHQNQPQ-NATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLT 1297
            |.|.|.| ..::|:....:..|......||.:|.:|::...|
  Fly  2986 LQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANR----------------------- 3027

  Fly  1298 GPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSK 1362
                    ||                   |..||            |:.:||:..|
  Fly  3028 --------VQ-------------------HFSTS------------SSSSSSNCSL--------- 3044

  Fly  1363 VEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGG 1427
                                |..|:.|...:               :|::.||:.:
  Fly  3045 --------------------PTNVVNPMQQQ---------------APSTTSSSTT--------- 3065

  Fly  1428 KLKGGSRGWPLSRHLEGL---EDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSP 1489
              :..:|..|:.:..|..   .:|             |.:.|                   ...|
  Fly  3066 --RPTNRVLPMQQRQEPAPLSNEC-------------PVVSS-------------------PTPP 3096

  Fly  1490 SPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWA 1554
            .|.|.|...:|  .|:..:..|.|:.:..             ..|.:..|:...::||
  Fly  3097 KPVEQPIIHQM--TSASVSKCYAQKSTLP-------------SPVYEAELKVSSVLES------- 3139

  Fly  1555 TLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLL--RSCGEELRKTQQMELGMGP 1617
            .:|.:|                 |..: |.|.|:|.......|.  .|.||.  ||:|:.|
  Fly  3140 IVPDVT-----------------MDAI-LEEQPVTESIYTEGLYEKNSPGES--KTEQLLL---- 3180

  Fly  1618 LGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQ 1682
                .....:|.||.::        .|  |.|.| .:...:.|..|             |.:..:
  Fly  3181 ----QQQQREQLNQQLV--------NN--GYLLD-KHTFQVEPMDT-------------DVYREE 3217

  Fly  1683 DDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMD 1747
            |                                                   |||:
  Fly  3218 D---------------------------------------------------LEEE--------- 3222

  Fly  1748 MLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAP 1812
                                                           :..:.|.......|:...
  Fly  3223 -----------------------------------------------EDEDDDFSLKMATSACND 3240

  Fly  1813 AEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAG------- 1870
            .||...:||..:| |...:..|.||             .||..:.:..:.:|:|.:||
  Fly  3241 HEMSDSEEPAVKD-KISKILDNLTN-------------DDCADSIATATTMEVDASAGYQQMVED 3291

  Fly  1871 --AGTGA--GPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALW 1931
              |.|.|  .|........||:.::...|    :.|:..|...                |:....
  Fly  3292 VLATTAAQSAPTEEFEGALETAAVEAAAT----YINEMADAHV----------------LDLKQL 3336

  Fly  1932 SNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKS 1996
            .|||
  Fly  3337 QNGV------------------------------------------------------------- 3340

  Fly  1997 VHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELS 2061
                                                 .|.:.||    ::|.|   ||....|.|
  Fly  3341 -------------------------------------ELELRRR----KEEQR---TVSQEQEQS 3361

  Fly  2062 NLLRVGNMTFLNVGQLL--PHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCK 2124
            ....|.........|.:  |.::..   ||.:|
  Fly  3362 KAAIVPTAAAPEPPQPIQEPKKMTG---PHLLY-------------------------------- 3391

  Fly  2125 PEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQ----HISGEDLFGLT 2185
               .||.:|.      ..::.||.:.:|:::.:.:...|:.| .|...|:    .:.|..:.||.
  Fly  3392 ---EIQSEDG------FTYKSSSITEIWEKVFEAVQVARRAH-GLTPLPEGPLADMGGIQMIGLK 3446

  Fly  2186 EPAIVRILESLPGIETLTDYRFKYGR---------------------------------NPLLEF 2217
            ..|:..::|.|||:|..:.|..||.:                                 :.||::
  Fly  3447 TNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDY 3511

  Fly  2218 -----PLAINPSGAARTEP----KQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQ 2273
                 .|..|....||.||    .:..:..|.....::.......|              |...:
  Fly  3512 GSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQ--------------PSDNE 3562

  Fly  2274 FVHSKSS--------QYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVS 2330
            .|..:.:        :|:.:|:.:::.|.:.||.|.|.|||..:|||...|:|||.||:||:.::
  Fly  3563 LVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLT 3627

  Fly  2331 EIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRK 2395
            :.||:.|:|:..|.|||::|::.|||||:.|..||:|||.|.|||.:::|::.....|||||.|:
  Fly  3628 DKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRR 3692

  Fly  2396 IYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            |.:||||:|||||..|||  ||||:||:..|||::|
  Fly  3693 IVQGEELTYDYKFPFEDE--KIPCSCGSKRCRKYLN 3726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	34/176 (19%)
		PRK13914	<623..>851	CDD:237555	48/247 (19%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136	6/103 (6%)
		FYRN	2067..2118	CDD:461787	5/52 (10%)
		FYRC	2126..2215	CDD:197781	22/125 (18%)
		SET_KMT2C_2D	2278..2430	CDD:380948	74/159 (47%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	24/129 (19%)
		SET_KMT2A_2B	3575..3726	CDD:380947	74/152 (49%)