DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and ash1

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:2119 Identity:379/2119 - (17%)
Similarity:627/2119 - (29%) Gaps:803/2119 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   508 KILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAG 572
            |:|...::|||....||..:|.                          .|::||:||.:.     
  Fly    12 KVLETQRAQESGSENEETDSIT--------------------------DQSSQSKSIKSA----- 45

  Fly   573 TPVTFTMASGNASDL-ATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKM 636
              ..|::...:...| ...|.:..:.|.:....|....:  :|.|:.......:|.....:|.| 
  Fly    46 --TQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRK--MSTQDTESGCSEAKNRAVSKKVK- 105

  Fly   637 ITTTTLSSQAALQMHHALIQDSSADKAGSSANSG-SATSGASMQLKLTTANTPTKLSVSLAPDVV 700
            :....|:|.:.:         |.:||...|..|. ||.|..|..      :.|.|:....||.|:
  Fly   106 VKRKKLASSSGI---------SKSDKVSKSKKSQISAFSSDSED------DLPLKVHQQRAPRVL 155

  Fly   701 KLEEVGSESKAKLLVKQEAVVK--DSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQ 763
                            ..|:::  .|...||.     :||              |:...|:..|.
  Fly   156 ----------------LSAIIQAAQSASKPTL-----DIG--------------ISSSDNELPNL 185

  Fly   764 IQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSAS 828
            :|.|..       ...:.|.:.|...:.|.||:|    |.|.|..|   :|.|..:....:...:
  Fly   186 VQAAIK-------RVESDTEDTTVEGSFRKAAKD----KNLPQYQS---TLLQDFMEKTQMLGQT 236

  Fly   829 ASAPLSARKVINVRAPSMGKVRSLEDQLARP--VIPPVP---TATQAAGSSSSSGSVATSTTTTT 888
            .:|.|:..||...:..::.:......:..||  |:|.||   .:..|...|:.||.::|::||.:
  Fly   237 VNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQS 301

  Fly   889 VASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQ 953
            .......|........:||:::.:            :.|.|......:..:..:...|||..:::
  Fly   302 TTPSPKMQNENAVPTGSLPIASSS------------KPKIDMAYLDKRMYATERVLYPPPRSKRR 354

  Fly   954 QQQQ-----LHQPQQLQPSP----HQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPP- 1008
            |..:     ....::||..|    ..|.:..::.|......||..|:.|:.::..:..:..:.. 
  Fly   355 QNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDY 419

  Fly  1009 -------------PPYEM-ATAPISNVTISISTKQAAPKE--------------LQMKPKAVAMS 1045
                         ..|:. |:......|.|..::::..|.              |:|:.|..|..
  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484

  Fly  1046 LPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQK 1110
            |.....|:::.:|....|        ||::...     |::.:|.::..                
  Fly   485 LLKSSADDTVEDQDILQL--------AGLSLGQ-----SSEESNEYISK---------------- 520

  Fly  1111 RKLPMHPQLDEKQIQQQAEIPISTSLPTT-------------PTGQ----------GTPDKVQLI 1152
                                |...|||||             .|||          ..||     
  Fly   521 --------------------PSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPD----- 560

  Fly  1153 SAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQV 1217
                .::.|.....:..|..::|..:::.:....|:|       .|..:||.:        .::.
  Fly   561 ----NFISKMMNQRKETPAPSKSSCKIKSRRSSAASM-------CSSYVSGVS--------RMRR 606

  Fly  1218 QHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRT 1282
            :|          :::....|:..|....|..    .:.|...|..|:.         .:|..|.|
  Fly   607 RH----------RRKSFSHNKSLNIDSKLLT----EIEIITSTFNSRC---------RIQDDRLT 648

  Fly  1283 NLNA-----GQAGGALKDLTGPLPAGAMVQLAGMPPGT---------------------QYIQGA 1321
            ..:.     ..|......|..|.||..:....|.|..|                     ..:..:
  Fly   649 GSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSAS 713

  Fly  1322 ASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQV 1386
            ||||.:            |.|:|.|.:      ||..|.|:..:.......||        ||  
  Fly   714 ASGTPN------------GSGSSNGNT------KRRHKKSQSNDSSSPDDHKL--------PL-- 750

  Fly  1387 LEPHLNRNFHFLIGSNETSGGGSPASMSSA-----ASAGSSSAGGGKLKGGSRG----------- 1435
                  :..|:|:    |.|...||.::.|     |.|.:::|...|....::.           
  Fly   751 ------KKRHYLL----TPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKS 805

  Fly  1436 --WPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPA------ 1492
              .|..|||  ||.                 |:            .|.|:..:.|.||.      
  Fly   806 ALTPKKRHL--LEQ-----------------PT------------SVSGAGSSASNSPLRIVVDN 839

  Fly  1493 ESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLP 1557
            .|....|:|.:|........|:              |..||.|.......|||:.:..|.     
  Fly   840 NSISGGKLLDISPSSLCSLKQQ--------------RRGGAAKQKVSAAKDLVQLQSPAG----- 885

  Fly  1558 RLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNN 1622
               .||...:...:.....::....|.|..:|.....||||.:.  ::::..:.|:|        
  Fly   886 ---SYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSAL--DIKEDTKKEVG-------- 937

  Fly  1623 NNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKH 1687
                    |.|:..|......|:  :|:.....::.....|.:..:.|:  .:|.|.....||..
  Fly   938 --------QRVVETLLHKTGGNL--LLKRKRKKINRTGFPTVRRKKRKV--SVEQQTTAVIDEHE 990

  Fly  1688 VDF---KRPLSQVSHGHLRKILNGRRKLCRSCGNV-------------------------VHATG 1724
            .:|   ..||..     ||:        .||..||                         |..|.
  Fly   991 PEFDPDDEPLQS-----LRE--------TRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN 1042

  Fly  1725 LRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKD----GQAEAASLL 1785
            .:.||.||.|||.           |.|...|            ||.:..|:.    .|||||.  
  Fly  1043 QKAPRLSVVALER-----------LQRPQTP------------ARGRPRGRKPKNREQAEAAP-- 1082

  Fly  1786 LQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFS 1850
             ||...|..:.......|      ..|.:.|:::.|             ||..|.|:|       
  Fly  1083 -QPPPKSEPEIRPAKKRG------RQPKQPVLEEPP-------------PTPPPQQKK------- 1120

  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRL 1915
                      :.:|                                               |:..
  Fly  1121 ----------NKME-----------------------------------------------PNIR 1128

  Fly  1916 LNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYH 1980
            |...:|...:.:|.:            .:..:..|:||.........|| .|::          .
  Fly  1129 LPDGIDPNTNFSCKI------------RLKRRKNLEAGTQPKKEKPVQP-VTVE----------E 1170

  Fly  1981 LPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDR 2045
            :|..|                                        .|:..|:.:....:|     
  Fly  1171 IPPEI----------------------------------------PVSQEEIDAEAEAKR----- 1190

  Fly  2046 DENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNR 2110
                                                |::..|.|...|                 
  Fly  1191 ------------------------------------LDSIPTEHDPLP----------------- 1202

  Fly  2111 RCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQH 2175
                    |.....|    ..||........|.:.|:.|      |:.:::::|.:....||..|
  Fly  1203 --------ASESHNP----GPQDYASCSESSEDKASTTS------LRKLSKVKKTYLVAGLFSNH 1249

  Fly  2176 ISGEDLFGLTEPAIVRILESLPGIETLT---------DYRFKYGRNPLLEFPLAINPSGAARTE- 2230
            .. :.|  :..||.|   ...||:|...         .|..||.|...::|.|..:...|.... 
  Fly  1250 YK-QSL--MPPPAKV---NKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSK 1308

  Fly  2231 -PKQRQLLVW--RKPHTQRTAGS--------------CSTQRMANSAAIAGEVACPYS--KQFVH 2276
             |.:..:..|  ||..|...|.|              |..|         ||.:|..:  .:.|:
  Fly  1309 LPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQ---------GEKSCLDNCLNRMVY 1364

  Fly  2277 SKSSQYKKMKQEWRNNVYLARSKI-----------QGLGLYAARDIEKHTMIIEYIGEVIRTEVS 2330
            ::.|.......|...|..:.|..:           :|.|:.....|.|.|.|:||:|||      
  Fly  1365 TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEV------ 1423

  Fly  2331 EIREKQYESKNRGIYM-------FRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRI 2388
             :.||:::.:...||:       ..||...|:|....|...|::||||.|||..:...|:...|:
  Fly  1424 -VTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRM 1487

  Fly  2389 IIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCR 2427
            ::||||.|..||||:|||.|.:.:.|...||.|..|.||
  Fly  1488 VLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 12/103 (12%)
FYRN 2068..2118 CDD:283589 4/49 (8%)
FYRC 2126..2215 CDD:197781 21/97 (22%)
SET <2266..2431 CDD:225491 56/182 (31%)
SET 2291..2413 CDD:214614 45/139 (32%)
PostSET 2415..2431 CDD:214703 6/13 (46%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 10/56 (18%)
SET 1392..1512 CDD:214614 43/126 (34%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467623
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
32.870

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