Protein Alignment trr and E(z)

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 844
• Identity: 180/844 - (21%)
• Similarity: 280/844 - (33%)
• Gaps: 258/844 - (30%)

  Fly  1632 NVILALP-----ASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFK 1691
            |.:..:|     |...:|.  ::.| ..:||..|.:..::: ||.|..:|:...|.|.:.|.| |
  Fly    95 NAVTPIPTMYTWAPTQQNF--MVED-ETVLHNIPYMGDEVL-DKDGKFIEELIKNYDGKVHGD-K 154

  Fly  1692 RPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPP 1756
            .| |.:......::              |||    :.|.....|||..|..|..:
  Fly   155 DP-SFMDDAIFVEL--------------VHA----LMRSYSKELEEAAPGTATAI---------- 190

  Fly  1757 PFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEP 1821
                  .....|:.|....||..:     :...|.|.:|....||.|..     ...|....:||
  Fly   191 ------KTETLAKSKQGEDDGVVD-----VDADGESPMKLEKTDSKGDL-----TEVEKKETEEP 239

  Fly  1822 ---EDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVW 1883
               ||.|.| |.|......:|.....|.:..||:.                       |...|..
  Fly   240 LETEDADVK-PDVEEVKDKLPFPAPIIFQAISANF-----------------------PDKGTAQ 280

  Fly  1884 ETETSGLQL---EDTRQCVFCNQRGDG-QADGPSRLLNFDVDKWVH------------LNCALWS 1932
            |.:...::|   :|..:...|....|| :|:..||      ::.:|            .:|.|..
  Fly   281 ELKEKYIELTEHQDPERPQECTPNIDGIKAESVSR------ERTMHSFHTLFCRRCFKYDCFLHR 339

  Fly  1933 NGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSV 1997
            :.|......|..|.|......|......|             .||.|.|...::|:
  Fly   340 HHVQGLQGHAGPNLQKRRYPELKPFAEPC-------------SNSCYMLIDGMKEK--------- 382

  Fly  1998 HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSN 2062
                       :...:............|...|:.:|      .|.::|.|       |.:...|
  Fly   383 -----------LAADSKTPPIDSCNEASSEDSNDSNS------QFSNKDFN-------HENSKDN 423

  Fly  2063 LLRVGNMTFLNVGQLLPHQLEAFHT-------PHYIYPIGYKVSRYYWCVRRPN---RRCRYICS 2117
            .|.|.:.....:..::...:....|       ...:|.:.:||....:|....|   :.||
  Fly   424 GLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCR---- 484

  Fly  2118 IAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHI------ 2176
                        ||.:...|| :.||.       ::.:.|..|..||..|..:|:..|.
  Fly   485 ------------QVYEFAQKE-DAEFS-------FEDLRQDFTPPRKKKKKQRLWSLHCRKIQLK 529

  Fly  2177 ---SGEDLFGLTEPAIVRILESLPG---------IETLTDYRFKYGRNPLLEFPLAINPSGAART 2229
               |...::..| |.      ..||         |:|         :|...:|   .|.|...:.
  Fly   530 KDSSSNHVYNYT-PC------DHPGHPCDMNCSCIQT---------QNFCEKF---CNCSSDCQN 575

  Fly  2230 EPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEV------ACPYSKQFVHSKSSQYKKMKQE 2288
                      |.|.. |....|:|::.....|:. |.      ||         .:.|:|..|..
  Fly   576 ----------RFPGC-RCKAQCNTKQCPCYLAVR-ECDPDLCQAC---------GADQFKLTKIT 619

  Fly  2289 WRN---------NVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGI 2344
            .:|         ::.:|.|.|.|.|::.....:|:..|.||.||:|..:.::.|.|.|: |....
  Fly   620 CKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYD-KYMCS 683

  Fly  2345 YMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKF 2408
            ::|.|:.|.|||||..|...|:.|||.||||..:::.|..|.||.|||||.|..||||.:||::
  Fly   684 FLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRY 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	20/116 (17%)
		FYRN	2067..2118	CDD:461787	8/60 (13%)
		FYRC	2126..2215	CDD:197781	21/106 (20%)
		SET_KMT2C_2D	2278..2430	CDD:380948	53/140 (38%)
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	41/209 (20%)
		SANT	452..492	CDD:238096	9/55 (16%)
		preSET_CXC	579..610	CDD:408079	7/41 (17%)
		SET_EZH2	628..747	CDD:380995	49/119 (41%)