Protein Alignment trr and Ehmt1

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: XP_006233681.2
• Gene: Ehmt1 / 362078
• RGDID: 1307588
• Length: 1309
• Species: Rattus norvegicus
• Alignment Length: 1603
• Identity: 304/1603 - (18%)
• Similarity: 483/1603 - (30%)
• Gaps: 616/1603 - (38%)

  Fly  1031 APKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPH------------------ 1077
            |||..|...:|     ..::|...:...||..: ||:. |..|...|
  Rat    83 APKHTQENTRA-----SPQEGTNRVSRVAENGV-SERD-TEVGKQNHVTADDFMQTSVIGSNGYF 140

  Fly  1078 ------SGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSL 1136
                  .|.||.:....|:.|.|..|.|    .||...|.:.|                   ::|
  Rat   141 LNKPALQGQPLRTPNTLNSSLPGHAAKT----LPGGASKCRTP-------------------SAL 182

  Fly  1137 PTTPT------GQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSG 1195
            |.|||      |:|:.|                 ..:.:|..:.:..:|.   :.:.||...:.|
  Rat   183 PQTPTTAPTVPGEGSAD-----------------TEDRKPTASGTDVRVH---RARKTMPKSILG 227

  Fly  1196 QMSGQISGHAAGQ--IPAQMHLQVQHQLHMAVHPQQQQQ------QLHQNQPQNATIPLPVTGQG 1252
            .       |||.:  ...|.|.:.:..::..:....:||      .|||:.|||.........|.
  Rat   228 L-------HAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQT 285

  Fly  1253 AVPIPVPTMESKAGDQRKRR-----------KREVQKPRR--------TNLNAGQAGGALKDLTG 1298
            |.   :|.:.:.|..::|:|           |.:|.|.|.        |:...|..|..:.|.:.
  Rat   286 AC---LPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSA 347

  Fly  1299 PLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKV 1363
            ....|..:::......::.::.....                 ||.. |::.|....|..|.|..
  Rat   348 LHVNGESLEMDSEEEDSEELEDEEDR-----------------GAEQ-AAAFPTEDSRTSKESMS 394

  Fly  1364 EEDH----DAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSA 1424
            |.|.    |..:|:     .|..|                .:.|...||..:.:||.:|.
  Rat   395 ETDRAAKMDGDSEE-----EQESP----------------DTGEDEDGGDESDLSSESSI----- 433

  Fly  1425 GGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSP 1489
               |.|                     .|.|.|:.:.|.|.......|            |:|.
  Rat   434 ---KKK---------------------FLKRRGKTDSPWIKPARKRRR------------RSRK- 461

  Fly  1490 SPAESPGAE--KMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDL-------- 1544
            .|:...|:|  |..|.|..|....|.  :.:||                .:|:::||
  Rat   462 KPSSMLGSEACKSSPGSMEQAALGDS--AGYME----------------VSLDSLDLRVRGILSS 508

  Fly  1545 -VESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKT 1608
             .|:||:|         ..|.::..:|            |.|.||.          ||..|..|:
  Rat   509 QTENEGLA---------NGPDVLETDG------------LHEVPLC----------SCRMETPKS 542

  Fly  1609 QQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGN 1673
            ::    :..|.||.                ..|:|::...|....|                  :
  Rat   543 RE----ISTLANNQ----------------CMATESVDHELGRCTN------------------S 569

  Fly  1674 KLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQ 1738
            .::.:.|...:      |.||..:...|..:::  :.:.|..||....|
  Rat   570 VVKYELMRPSN------KAPLLVLCEDHRGRMV--KHQCCPGCGYFCTA---------------- 610

  Fly  1739 LPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPG 1803
                ...|:..|..|:...|    .:.|.:|.                           |..|..
  Rat   611 ----GNFMECQPESSISHRF----HKDCASRV---------------------------NNASYC 640

  Fly  1804 SFCASSTAPAEMV----------VKQEPEDE---------DEKTPSVPGNPTNIPAQRKCIVKCF 1849
            ..|...|:.|:.|          |...|..|         |..|.|:.|.|.:..:|.
  Rat   641 PHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQS------- 698

  Fly  1850 SADCFTTDSAPSGLELDGTAG-----AGTGAGPVNNTVWETETSGLQLE-------DTRQCVFCN 1902
                 |...||...:..|.||     :|...||...|: |:....|..|       ..:|..|..
  Rat   699 -----TVTQAPECFDPAGPAGFVRPTSGFSQGPGKETL-ESALIALDSEKPKKLRFHPKQLYFSA 757

  Fly  1903 QRGDGQ------ADG--PSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACS 1959
            ::|:.|      .||  |    ||.::              :::....|   ..|.:||....|.
  Rat   758 RQGELQKVLLMLVDGIDP----NFKME--------------HQSKRSPL---HAAAEAGHVDICH 801

  Fly  1960 ACHQPGATI-KCFKSRCNSLY------HLPC---------------AIREECVFYKNKSVHCSVH 2002
            ...|.||.| .|.:.:...|.      ||..               |....|:....|..|..|.
  Rat   802 MLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVV 866

  Fly  2003 GHAHAGITMGAGA---GATTGAGLGGSVADNELSSLVVHRRVFV---DRDENRQVATVMHYSELS 2061
            .:..:...|....   |..|...........:|..|::.:...:   |.:||    ..:|::..|
  Rat   867 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEEN----ICLHWAAFS 927

  Fly  2062 NLLRVGNMTF--------LNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSI 2118
            ..:.:..:..        :|:....|..:.|                         |..||.|.:
  Rat   928 GCVDIAEILLAAKCDLHAVNIHGDSPLHIAA-------------------------RENRYDCVV 967

  Fly  2119 AEAGCKPEFRIQVQDAGDKEPEREFRGSSP-------SAVWQQILQPITRLRKVHKWLQLFPQHI 2176
            .       |..:..|...|..|    |.:|       |.||..:        ::.|.||     .
  Rat   968 L-------FLSRDSDVTLKNKE----GETPLQCASLNSQVWSAL--------QMSKALQ-----D 1008

  Fly  2177 SGEDLFGLTEPAIVRIL----ESLP-----GIET-LTDYRFKYGRNPLLEFPLAINPSGAARTEP 2231
            |..|.....|..:.|.:    |.:|     .::: |....:||.....:..|:.|:
  Rat  1009 SAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNID--------- 1064

  Fly  2232 KQRQLLVWRKPHTQR--TAGSCSTQRMANSAAIAGEVA--CPYSK-----------------QFV 2275
              |.:     .|.|.  ....||     :|..:.|:::  |.|.|                 :..
  Rat  1065 --RNI-----THLQYCVCVDDCS-----SSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECN 1117

  Fly  2276 HSKSSQYKKMKQEWRN------------NVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTE 2328
            |:.|.        |||            .:.|.|::..|.|:.:.:||...|.:.||:||:|...
  Rat  1118 HACSC--------WRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDS 1174

  Fly  2329 VSEIREKQYESKNRGIYMFRLD----EDRVVDATLSGGLARYINHSCNPNCVTEIVEVD----RD 2385
            .:::||:.       .|:|.||    |...:||...|.::|:|||.|.||.|...|.:.    |.
  Rat  1175 EADVREED-------SYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRF 1232

  Fly  2386 VRIIIFAKRKIYRGEELSYDYKFDIEDESHKI-PCACGAPNCR 2427
            .||..|:.|.|..||:|.:||.....|...|: .|.||:|.||
  Rat  1233 PRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCR 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	25/133 (19%)
		FYRN	2067..2118	CDD:461787	7/58 (12%)
		FYRC	2126..2215	CDD:197781	21/105 (20%)
		SET_KMT2C_2D	2278..2430	CDD:380948	54/171 (32%)
Ehmt1	XP_006233681.2	EHMT_ZBD	527..657	CDD:411018	36/236 (15%)
		ANKYR	731..987	CDD:440430	52/317 (16%)
		ANK repeat	785..814	CDD:293786	9/31 (29%)
		ANK repeat	816..847	CDD:293786	3/30 (10%)
		ANK repeat	849..881	CDD:293786	5/31 (16%)
		ANK repeat	883..914	CDD:293786	4/30 (13%)
		ANK repeat	916..947	CDD:293786	4/34 (12%)
		ANK repeat	949..980	CDD:293786	8/62 (13%)
		SET_EHMT1	1047..1277	CDD:380933	69/265 (26%)